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3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase

This is an abbreviated version!
For detailed information about 3',5'-cyclic-GMP phosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.35

Reaction

guanosine 3',5'-cyclic phosphate
+
H2O
=
GMP

Synonyms

3',5'-cyclic GMP phosphodiesterase, 3',5'-cyclic guanosine monophosphate-specific phosphodiesterase, 3',5'-cyclic nucleotide phosphodiesterase 5, cd-PDE5, cG-PDE, cGMP 3',5'-cyclic phosphodiesterase subunit delta, cGMP binding phosphodiesterase, cGMP phosphodiesterase, cGMP phosphodiesterase 5, cGMP phosphodiesterase 6, cGMP phosphodiesterase 6alpha' subunit, cGMP phosphodiesterase6, cGMP-binding cGMP specific phosphodiesterase, cGMP-binding cGMP-specific PDE, cGMP-binding cGMP-specific phosphodiesterase, cGMP-PDE, cGMP-phosphodiesterase, cGMP-phosphodiesterase-5, cGMP-selective phosphodiesterase, cGMP-specific cGMP-binding phosphodiesterase, cGMP-specific PDE, cGMP-specific PDE5, cGMP-specific PDE5A1, cGMP-specific phosphodiesterase, cGMP-specific phosphodiesterase 5, cGMP-specific phosphodiesterase type 9, cGMP-specific phosphodiesterase-5, cGMP-stimulated phosphodiesterase, cyclic 3',5'-GMP phosphodiesterase, cyclic GMP hydrolyzing phosphodiesterase 5, cyclic GMP phosphodiesterase, cyclic GMP-phosphodiesterase, cyclic guanosine 3',5'-monophosphate phosphodiesterase, cyclic guanosine 3',5'-phosphate phosphodiesterase, cyclic guanosine monophosphate phosphodiesterase, cyclic guanosine monophosphate-specific phosphodiesterase 5, cyclic-GMP phosphodiesterase, DdPDE3, DmPDE6, Drosophila PDE6-like enzyme, GbpA, gigh-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, GMP-PDE, guanosine 3',5'-cyclicmonophosphate-specific PDE, guanosine cyclic 3',5'-phosphate phosphodiesterase, PDB5, PDE, PDE-5, PDE-6, PDE4, PDE5, PDE5/6, PDE5/PDE6cd, PDE5A, PDE5A1, PDE6, PDE6AB, PDE6alpha, PDE6alpha', PDE6B, PDE6beta, PDE6C, PDE6D, PDE6gamma, PDE6R, PDE9, PDE9A, PDE9A1, PdeD, PDEdelta, PDEgamma, PfPDE1, phospho-diesterase-5, phosphodiesterase, phosphodiesterase 5, phosphodiesterase 5 (cGMP-specific), phosphodiesterase 6C, phosphodiesterase 9, phosphodiesterase cGMP, phosphodiesterase isoenzyme 5, phosphodiesterase subtype 5, phosphodiesterase type 5, phosphodiesterase type-5, phosphodiesterase, guanosine cyclic 3',5'-phosphate, phosphodiesterase-5, phosphodiesterase-6, PrBP/delta, suPDE5, type 5 phosphodiesterase, type 9 cGMP-specific phosphodiesterase, type-5 phosphodiesterase, xGMP-specific PDE

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.35 3',5'-cyclic-GMP phosphodiesterase

Cloned

Cloned on EC 3.1.4.35 - 3',5'-cyclic-GMP phosphodiesterase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
baculovirus-expressed PDE5 in Sf9 cells
-
catalytic domain (COOH-terminal half-containing the catalytic domain Thr540-Ile949), expression in bacteria
-
chimaeric PDE5/PDE6 catalytic domain is expressed in Escherichia coli BL21-codon plus cells
-
cloning of cDNA, expression of PDE5A GAF domain in Escherichia coli
-
cloning of cDNA, expression of PDE9A5 in HEK293 cells
cloning of cGMP-binding domain and expression as GST-fusion protein in Escherichia coli
-
cloning of rod PDE6 alpha and beta subunits and cone PDE6alpha', expression in Sf9 cells
-
ectopic expression of the enhanced green fluorescent protein fusion protein of human cone PDE6C in rods of transgenic Xenopus laevis
-
expressed in Escherichia coli
-
expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli RosettaTM2 cells
-
expression in Drosophila S2 cells
-
expression in Escherichia coli
expression in Sf9 system
-
expression of DdPDE3 catalytic domain in Escherichia coli and Dictyostelium
-
expression of his-tagged protein in baculovirus/Sf9 system
expression of isoform PDE5A1 in COS-7 cells
-
expression of isoform PDE6 gamma-subunit in Escherichia coli as an intein-fusion with chitin binding domain. Preparation of homogeneous and isotopically labeled protein for NMR analysis
-
expression of PDE isoenzymes PDEA1, PDEA2 and PDEA3 in COS-7 cells
-
expression of PDE5 in Sf9 insect cells
-
expression of PdeD-YFP fusion protein in Escherichia coli and Dictyostelium
expression of the catalytic domain of PDE5A1 in Escherichia coli
fusion protein of wild-type and mutant F163A GAFa domain of enzyme to Green Fluorescent Protein or Renilla luciferase
generation of transgenic animals with targeted expression of DmPDE6 to tubule type I (principal) cells. This reveals localization of DmPDE6 primarily at the apical membranes. Overexpression of DmPDE6 results in elevated cG-PDE activity and decreased tubule cGMP content. Such targeted overexpression of DmPDE6 creates phenotype that manifests itself in inhibition of the active transport and efflux of cGMP by tubules
Drosophila sp. (in: flies)
-
overexpression of enzyme gamma subunit in mouse
-
splice variants PDE5A1 and PDE5A2