3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase

This is an abbreviated version!
For detailed information about 3',5'-cyclic-GMP phosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.35

3.1.4.35

erectile

sildenafil

arterial

hypertension

pulmonary

tadalafil

cyclase

retinal

vardenafil

erect

penile

guanylate

photoreceptors

prostate

endothelin

vasodilator

placebo

pde5is

camp

hemodynamic

zaprinast

transducin

cgmp-dependent

placebo-controlled

guanylyl

intercourse

phosphodiesterases

cavernosum

prostatectomy

rhodopsin

prostacyclins

double-blind

nitroprusside

prostanoids

on-demand

satisfaction

pkg

bosentan

no-cgmp

intracavernosal

phototransduction

intracavernous

libido

psychogenic

retropubic

urologist

6-minute

adulterated

molecular biology

medicine

analysis

alpha-blocker

peyronie

Reaction

Synonyms

3',5'-cyclic GMP phosphodiesterase, 3',5'-cyclic guanosine monophosphate-specific phosphodiesterase, 3',5'-cyclic nucleotide phosphodiesterase 5, cd-PDE5, cG-PDE, cGMP 3',5'-cyclic phosphodiesterase subunit delta, cGMP binding phosphodiesterase, cGMP phosphodiesterase, cGMP phosphodiesterase 5, cGMP phosphodiesterase 6, cGMP phosphodiesterase 6alpha' subunit, cGMP phosphodiesterase6, cGMP-binding cGMP specific phosphodiesterase, cGMP-binding cGMP-specific PDE, cGMP-binding cGMP-specific phosphodiesterase, cGMP-PDE, cGMP-phosphodiesterase, cGMP-phosphodiesterase-5, cGMP-selective phosphodiesterase, cGMP-specific cGMP-binding phosphodiesterase, cGMP-specific PDE, cGMP-specific PDE5, cGMP-specific PDE5A1, cGMP-specific phosphodiesterase, cGMP-specific phosphodiesterase 5, cGMP-specific phosphodiesterase type 9, cGMP-specific phosphodiesterase-5, cGMP-stimulated phosphodiesterase, cyclic 3',5'-GMP phosphodiesterase, cyclic GMP hydrolyzing phosphodiesterase 5, cyclic GMP phosphodiesterase, cyclic GMP-phosphodiesterase, cyclic guanosine 3',5'-monophosphate phosphodiesterase, cyclic guanosine 3',5'-phosphate phosphodiesterase, cyclic guanosine monophosphate phosphodiesterase, cyclic guanosine monophosphate-specific phosphodiesterase 5, cyclic-GMP phosphodiesterase, DdPDE3, DmPDE6, Drosophila PDE6-like enzyme, GbpA, gigh-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, GMP-PDE, guanosine 3',5'-cyclicmonophosphate-specific PDE, guanosine cyclic 3',5'-phosphate phosphodiesterase, PDB5, PDE, PDE-5, PDE-6, PDE4, PDE5, PDE5/6, PDE5/PDE6cd, PDE5A, PDE5A1, PDE6, PDE6AB, PDE6alpha, PDE6alpha', PDE6B, PDE6beta, PDE6C, PDE6D, PDE6gamma, PDE6R, PDE9, PDE9A, PDE9A1, PdeD, PDEdelta, PDEgamma, PfPDE1, phospho-diesterase-5, phosphodiesterase, phosphodiesterase 5, phosphodiesterase 5 (cGMP-specific), phosphodiesterase 6C, phosphodiesterase 9, phosphodiesterase cGMP, phosphodiesterase isoenzyme 5, phosphodiesterase subtype 5, phosphodiesterase type 5, phosphodiesterase type-5, phosphodiesterase, guanosine cyclic 3',5'-phosphate, phosphodiesterase-5, phosphodiesterase-6, PrBP/delta, suPDE5, type 5 phosphodiesterase, type 9 cGMP-specific phosphodiesterase, type-5 phosphodiesterase, xGMP-specific PDE

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.4 Phosphoric-diester hydrolases

3.1.4.35 3',5'-cyclic-GMP phosphodiesterase

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Results	in table
71	Activating Compound
2136	AA Sequence
37	Application
1	CAS Registry Number
35	Cloned(Commentary)
5	Crystallization (Commentary)
9011	Disease/ Diagnostics
6	Expression
17	General Information
3	General Stability
178	IC50 Value
421	Inhibitors
45	Ki Value [mM]
50	KM Value [mM]
47	Localization
29	Metals/Ions
22	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
424	Organism
2	Pathway
298	PDB ID
6	pH Optimum
4	pH Range
6	Posttranslational Modification
47	Protein Variants
31	Purification (Commentary)
1	Reaction
1	Reaction Type
197	Reference
242	Source Tissue
13	Specific Activity [micromol/min/mg]
4	Storage Stability
146	Substrates and Products (Substrate)
28	Subunits
297	Synonyms
1	Systematic Name
11	Turnover Number [1/s]

Localization

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Localization on EC 3.1.4.35 - 3',5'-cyclic-GMP phosphodiesterase

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splice variant PDE9A1

5634

651412

peripheral membrane protein

Bos taurus

135365

photoreceptor outer segment

5 entries

photoreceptor outer segment membrane

Lithobates pipiens

Q8UUY2, Q8UUY6, Q8UUY7

peripherally attached under dark conditions

42622

652318

plasma membrane

Drosophila melanogaster

PDE5/6 is exclusively associated with the apical membrane

approximately 45% of cGMP degradation activity is localized in the detergent-soluble fractions

692087