Literature summary for 3.1.4.35 extracted from

Day, J.P.; Houslay, M.D.; Davies, S.A.
A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP (2006), Biochem. J., 393, 481-488.

Cloned(Commentary)

Cloned (Comment)	Organism
generation of transgenic animals with targeted expression of DmPDE6 to tubule type I (principal) cells. This reveals localization of DmPDE6 primarily at the apical membranes. Overexpression of DmPDE6 results in elevated cG-PDE activity and decreased tubule cGMP content. Such targeted overexpression of DmPDE6 creates phenotype that manifests itself in inhibition of the active transport and efflux of cGMP by tubules	Drosophila sp. (in: flies)

Cloned (Comment)

Organism

generation of transgenic animals with targeted expression of DmPDE6 to tubule type I (principal) cells. This reveals localization of DmPDE6 primarily at the apical membranes. Overexpression of DmPDE6 results in elevated cG-PDE activity and decreased tubule cGMP content. Such targeted overexpression of DmPDE6 creates phenotype that manifests itself in inhibition of the active transport and efflux of cGMP by tubules

Drosophila sp. (in: flies)

Inhibitors

Inhibitors	Comment	Organism	Structure
zaprinast	-	Drosophila sp. (in: flies)

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	generation of transgenic animals with targeted expression of DmPDE6 to tubule type I (principal) cells. This reveals localization of DmPDE6 primarily at the apical membranes	Drosophila sp. (in: flies)	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Drosophila sp. (in: flies)	role for cG-PDE in modulating cGMP transport and efflux	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Drosophila sp. (in: flies)	-	generation of transgenic animals with targeted expression of DmPDE6 to tubule type I (principal) cells. This reveals localization of DmPDE6 primarily at the apical membranes. Overexpression of DmPDE6 results in elevated cG-PDE activity and decreased tubule cGMP content. Such targeted overexpression of DmPDE6 creates a novel phenotype that manifests itself in inhibition of the active transport and efflux of cGMP by tubules	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	role for cG-PDE in modulating cGMP transport and efflux	Drosophila sp. (in: flies)	?	-	?

Synonyms

Synonyms	Comment	Organism
cG-PDE	-	Drosophila sp. (in: flies)
DmPDE6	-	Drosophila sp. (in: flies)
Drosophila PDE6-like enzyme	-	Drosophila sp. (in: flies)