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Reference on EC 3.1.4.35 - 3',5'-cyclic-GMP phosphodiesterase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Giorgi, M.; Caniglia, C.; Scarsella, G.; Augusti-Tocco, G.
Characterization of 3':5' cyclic nucleotide phosphodiesterase activities of mouse neuroblastoma N18TG2 cells
FEBS Lett.
324
76-80
1993
Mus musculus
Manually annotated by BRENDA team
Francis, S.H.; Corbin, J.D.
Purification of cGMP-binding protein phosphodiesterase from rat lung
Methods Enzymol.
159
722-729
1988
Rattus norvegicus
Manually annotated by BRENDA team
Yamazaki, A.; Bitensky, M.W.; Casnellie, J.E.
Photoaffinity labeling of high-affinity cGMP-specific noncatalytic binding sites on cGMP phosphodiesterase of rod outer segments
Methods Enzymol.
159
730-736
1988
vertebrata
Manually annotated by BRENDA team
Yamazaki, A.; Tatsumi, M.; Bitensky, M.W.
Purification of rod outer segment GTP-binding protein subunits and cGMP phosphodiesterase by single-step column chromatography
Methods Enzymol.
159
702-710
1988
Bos taurus
Manually annotated by BRENDA team
Deterre, P.; Bigay, J.; Robert, M.; Pfister, C.; Kuhn, H.; Chabre, M.
Activation of retinal rod cyclic GMP-phosphodiesterase by transducin: characterization of the complex formed by phosphodiesterase inhibitor and transducin alpha-subunit
Proteins Struct. Funct. Genet.
1
188-193
1986
Bos taurus
Manually annotated by BRENDA team
Kawamura, S.; Murakami, M.
Characterization of the light-induced increase in the Michaelis constant of the cGMP phosphodiesterase in frog rod outer segments
Biochim. Biophys. Acta
870
256-266
1986
Lithobates catesbeianus
Manually annotated by BRENDA team
Bhatnager, N.B.; Bhatnagar, R.; Venkitasubramanian, T.A.
Characterization and metabolism of cyclic guanosine 35-monophosphate in Mycobacterium smegmatis
Biochem. Biophys. Res. Commun.
121
634-640
1984
Mycobacterium tuberculosis variant bovis, Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Hurley, J.B.; Stryer, L.
Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments
J. Biol. Chem.
257
11094-11099
1982
Bos taurus
Manually annotated by BRENDA team
Hurley, J.B.
Isolation and assay of a phosphodiesterase inhibitor from retinal rod outer segments
Methods Enzymol.
81
542-547
1982
Bos taurus
Manually annotated by BRENDA team
Liebman, P.A.; Tavormina Evanczuk, A.
Real time assay of rod disk membrane cGMP phosphodiesterase and its controller enzymes
Methods Enzymol.
81
532-542
1982
Bos taurus
Manually annotated by BRENDA team
Methven, P.; Lemon, M.; Bhoola, K.
The metabolism of cyclic nucleotides in the guinea-pig pancreas. Cyclic AMP phosphodiesterase and cyclic GMP phosphodiesterase
Biochem. J.
186
491-498
1980
Cavia porcellus
Manually annotated by BRENDA team
Morishima, I.
Cylic nucleotide phosphodiesterase in silkworm. Characterization of cyclic GMP phosphodiesterase
Biochim. Biophys. Acta
410
310-317
1975
Bombyx mori
Manually annotated by BRENDA team
Hwang, T.C.; Clark, V.L.; Bernlohr, R.W.
Guanosine 3',5'-cyclic monophosphate phosphodiesterase activity of Bacillus licheniformis
Biochem. Biophys. Res. Commun.
58
707-713
1974
Bacillus licheniformis
Manually annotated by BRENDA team
Russell, T.R.; Terasaki, W.L.; Appleman, M.M.
Separate phosphodiesterases for the hydrolysis of cyclic adenosine 3,5-monophosphate and cyclic guanosine 3,5-monophosphate in rat liver
J. Biol. Chem.
248
1334-1340
1973
Rattus norvegicus
Manually annotated by BRENDA team
Caretta, A.; Stein, P.J.
Light- and nucleotide-dependent binding of phosphodiesterase to rod disk membranes: correlation with light-scattering changes and vesicle aggregation
Biochemistry
25
2335-2341
1986
Bos taurus
Manually annotated by BRENDA team
Sitaramayya, A.; Liebman, P.A.
Phosphorylation of rhodopsin and quenching of cyclic GMP phosphodiesterase activation by ATP at weak bleaches
J. Biol. Chem.
258
12106-12109
1983
Bos taurus
Manually annotated by BRENDA team
Kawamura, S.
Rhodopsin phosphorylation as a mechanism of cyclic GMP phosphodiesterase regulation by S-modulin
Nature
362
855-857
1993
Lithobates catesbeianus
Manually annotated by BRENDA team
Artemyev, N.O.; Natochin, M.; Busman, M.; Schey, K.L.; Ha mM, H.E.
Mechanism of photoreceptor cGMP phosphodiesterase inhibition by its gamma subunits
Proc. Natl. Acad. Sci. USA
93
5407-5412
1996
Bos taurus
Manually annotated by BRENDA team
Artemyev, N.O.; Hamm, H.E.
Two-site high-affinity interaction between inhibitory and catalytic subunits of rod cyclic GMP phosphodiesterase
Biochem. J.
283
273-279
1992
Bos taurus
-
Manually annotated by BRENDA team
Whalen, M.M.; Bitensky, M.W.; Takemoto, D.J.
The effect of the gamma-subunit of the cyclic GMP phosphodiesterase of bovine and frog (Rana catesbiana) retinal rod outer segments on the kinetic parameters of the enzyme
Biochem. J.
265
655-658
1990
Bos taurus, Lithobates catesbeianus
Manually annotated by BRENDA team
Srivastava, D.; Fox, D.A.; Hurwitz, R.L.
Effects of magnesium on cyclic GMP hydrolysis by the bovine retinal rod cyclic GMP phosphodiesterase
Biochem. J.
308
653-658
1995
Bos taurus
Manually annotated by BRENDA team
Oppert, B.; Cunnick, J.M.; Hurt, D.; Tamoto, D.J.
Identification of the retinal cyclic GMP phosphodiesterase inhibitory gamma-subunit interaction sites on the catalytic alpha-subunit
J. Biol. Chem.
266
16607-16613
1991
Bos taurus
Manually annotated by BRENDA team
Thomas, M.K.; Francis, S.H.; Corbin, J.D.
Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase
J. Biol. Chem.
265
14964-14970
1990
Bos taurus
Manually annotated by BRENDA team
Natochin, M.; Artemyev, N.O.
An interface of interaction between photoreceptor cGMP phosphodiesterase catalytic subunits and inhibitory gamma subunits
J. Biol. Chem.
271
19964-19969
1996
Bos taurus
Manually annotated by BRENDA team
Arshavsky, V.Y.; Dumke, C.L.; Bownds, M.D.
Noncatalytic cGMP-binding sites of amphibian rod cGMP phosphodiesterase control interaction with its inhibitory gamma-subunits
J. Biol. Chem.
267
24501-24507
1992
Rhinella marina, Lithobates catesbeianus, Lithobates grylio
Manually annotated by BRENDA team
Udovichenko, I.P.; Cunnick, J.; Gonzales, K.; Takemoto, D.J.
Phosphorylation of bovine rod photoreceptor cyclic GMP phosphodiesterase
Biochem. J.
295
49-55
1993
Bos taurus
Manually annotated by BRENDA team
Tar, A.; Ting, T.D.; Ho, Y.K.
Purification of bovine retinal cGMP phosphodiesterase
Methods Enzymol.
238
3-12
1994
Bos taurus
Manually annotated by BRENDA team
Giorgi, M.; Girodano, D.; Caniglia, C.; Biagioni, S.; Augusti-Tocco, G.
Induction of cyclic AMP and cyclic GMP 3:5-cyclic nucleotide phosphodiesterase activities in neuroblastoma lines under differentiating conditions
Int. J. Dev. Neurosci.
15
309-319
1997
Mus musculus
Manually annotated by BRENDA team
Otto-Bruc, A.; Antonny, B.; Vuong, T.M.; Chardin, P.; Chabre, M.
Interaction between the retinal cyclic GMP phosphodiesterase inhibitor and transducin. Kinetics and affinity studies
Biochemistry
32
8636-8645
1993
Bos taurus
Manually annotated by BRENDA team
Oppert, B.; Gonzalez, K.; Hurt, D.; Cunnick, J.; Takemoto, D.
Retinal cyclic-GMP phosphodiesterase gamma-subunit: use of mutant synthetic peptides to define function
Biochem. Biophys. Res. Commun.
181
306-309
1991
Bos taurus
Manually annotated by BRENDA team
Oppert, B.; Takemoto, D.J.
Identification of the gamma-subunit interaction sites in the retinal cyclic-GMP phosphodiesterase gamma-subunit
Biochem. Biophys. Res. Commun.
178
474-479
1991
Bos taurus
Manually annotated by BRENDA team
Utarabhand, P.
Partial purification of cyclic guanosine monophosphate phosphodiesterase from sea urchin (Strongylocentrotus purpuratus) sperm
Comp. Biochem. Physiol. B
104
577-581
1993
Strongylocentrotus purpuratus
-
Manually annotated by BRENDA team
Tanaka, S.; Shimooka, S.; Shimomura, H.
Changes in phosphodiesterase activity in the developing rat submandibular gland
Arch. Oral Biol.
47
567-576
2002
Rattus norvegicus
Manually annotated by BRENDA team
Lin, C.S.; Lau, A.; Tu, R.; Lue, T.F.
Expression of three isoforms of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in human penile cavernosum
Biochem. Biophys. Res. Commun.
268
628-635
2000
Homo sapiens
Manually annotated by BRENDA team
Kuwayama, H.; Snippe, H.; Derks, M.; Roelofs, J.; Van Haastert, P.J.
Identification and characterization of DdPDE3, a cGMP-selective phosphodiesterase from Dictyostelium
Biochem. J.
353
635-644
2001
Dictyostelium discoideum
Manually annotated by BRENDA team
Sudo, T.; Tachibana, K.; Toga, K.; Tochizawa, S.; Inoue, Y.; Kimura, Y.; Hidaka, H.
Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity
Biochem. Pharmacol.
59
347-356
2000
Bos taurus
Manually annotated by BRENDA team
Francis, S.H.; Turko, I.V.; Grimes, K.A.; Corbin, J.D.
Histidine-607 and histidine-643 provide important interactions for metal support of catalysis in phosphodiesterase-5
Biochemistry
39
9591-9596
2000
Bos taurus
Manually annotated by BRENDA team
Okada, D.; Asakawa, S.
Allosteric activation of cGMP-specific, cGMP-binding phosphodiesterase (PDE5) by cGMP
Biochemistry
41
9672-9679
2002
Rattus norvegicus
Manually annotated by BRENDA team
Giordano, D.; De Stefano, M.E.; Citro, G.; Modica, A.; Giorgi, M.
Expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in mouse tissues and cell lines using an antibody against the enzyme amino-terminal domain
Biochim. Biophys. Acta
1539
16-27
2001
Mus musculus
Manually annotated by BRENDA team
Hosogai, N.; Seki, J.; Goto, T.
Reciprocal regulation of cyclic GMP content by cyclic GMP-phosphodiesterase and guanylate cyclase in SHR with CsA-induced nephrotoxicity
Br. J. Pharmacol.
134
995-1002
2001
Rattus norvegicus
Manually annotated by BRENDA team
Liu, L.; Underwood, T.; Li, H.; Pamukcu, R.; Thompson, W.J.
Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase
Cell. Signal.
14
45-51
2002
Homo sapiens
Manually annotated by BRENDA team
Sopory, S.; Kaur, T.; Visweswariah, S.S.
The cGMP-binding, cGMP-specific phosphodiesterase (PDE5): intestinal cell expression, regulation and role in fluid secretion
Cell. Signal.
16
681-692
2004
Homo sapiens (O76074), Homo sapiens
Manually annotated by BRENDA team
Senzaki, H.; Smith, C.J.; Juang, G.J.; Isoda, T.; Mayer, S.P.; Ohler, A.; Paolocci, N.; Tomaselli, G.F.; Hare, J.M.; Kass, D.A.
Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure
FASEB J.
15
1718-1726
2001
Canis lupus familiaris
Manually annotated by BRENDA team
Sopory, S.; Balaji, S.; Srinivasan, N.; Visweswariah, S.S.
Modeling and mutational analysis of the GAF domain of the cGMP-binding, cGMP-specific phosphodiesterase, PDE5
FEBS Lett.
539
161-166
2003
Homo sapiens
Manually annotated by BRENDA team
Wang, P.; Wu, P.; Egan, R.W.; Billah, M.M.
Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants
Gene
314
15-27
2003
Homo sapiens (O76083), Homo sapiens
Manually annotated by BRENDA team
Yamazaki, M.; Li, N.; Bondarenko, V.A.; Yamazaki, R.K.; Baehr, W.; Yamazaki, A.
Binding of cGMP to GAF domains in amphibian rod photoreceptor cGMP phosphodiesterase (PDE). Identification of GAF domains in PDE alphabeta subunits and distinct domains in the PDE gamma subunit involved in stimulation of cGMP binding to GAF domains
J. Biol. Chem.
277
40675-40686
2002
Lithobates pipiens (Q8UUY2), Lithobates pipiens (Q8UUY6), Lithobates pipiens (Q8UUY7)
Manually annotated by BRENDA team
O'Grady, S.M.; Jiang, X.; Maniak, P.J.; Birmachu, W.; Scribner, L.R.; Bulbulian, B.; Gullikson, G.W.
Cyclic AMP-dependent Cl secretion is regulated by multiple phosphodiesterase subtypes in human colonic epithelial cells
J. Membr. Biol.
185
137-144
2002
Homo sapiens
Manually annotated by BRENDA team
van Staveren, W.C.; Glick, J.; Markerink-van Ittersum, M.; Shimizu, M.; Beavo, J.A.; Steinbusch, H.W.; de Vente, J.
Cloning and localization of the cGMP-specific phosphodiesterase type 9 in the rat brain
J. Neurocytol.
31
729-741
2002
Mus musculus (O70628), Mus musculus, Rattus norvegicus (Q8QZV1)
Manually annotated by BRENDA team
Ni, X.P.; Safai, M.; Gardner, D.G.; Humphreys, M.H.
Increased cGMP phosphodiesterase activity mediates renal resistance to ANP in rats with bile duct ligation
Kidney Int.
59
1264-1273
2001
Rattus norvegicus
Manually annotated by BRENDA team
Wang, P.; Wu, P.; Myers, J.G.; Stamford, A.; Egan, R.W.; Billah, M.M.
Characterization of human, dog and rabbit corpus cavernosum type 5 phosphodiesterases
Life Sci.
68
1977-1987
2001
Canis lupus familiaris, Oryctolagus cuniculus, Homo sapiens
Manually annotated by BRENDA team
Cote, R.H.
Kinetics and regulation of cGMP binding to noncatalytic binding sites on photoreceptor phosphodiesterase
Methods Enzymol.
315
646-672
2000
Rana sp.
Manually annotated by BRENDA team
Meima, M.E.; Biondi, R.M.; Schaap, P.
Identification of a novel type of cGMP phosphodiesterase that is defective in the chemotactic stmF mutants
Mol. Biol. Cell
13
3870-3877
2002
Dictyostelium discoideum (Q8MLZ3)
Manually annotated by BRENDA team
Bosgraaf, L.; Russcher, H.; Snippe, H.; Bader, S.; Wind, J.; Van Haastert, P.J.M.
Identification and characterization of two unusual cGMP-stimulated phosphodiesterases in Dictyostelium
Mol. Biol. Cell
13
3878-3889
2002
Dictyostelium
Manually annotated by BRENDA team
Sung, B.J.; Hwang, K.Y.; Jeon, Y.H.; Lee, J.I.; Heo, Y.S.; Kim, J.H.; Moon, J.; Yoon, J.M.; Hyun, Y.L.; Kim, E.; Eum, S.J.; Park, S.Y.; Lee, J.O.; Lee, T.G.; Ro, S.; Cho, J.M.
Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
Nature
425
98-102
2003
Homo sapiens (O76074), Homo sapiens
Manually annotated by BRENDA team
Burnett, A.L.
Phosphodiesterase 5 mechanisms and therapeutic applications
Am. J. Cardiol.
96
29M-31M
2005
Homo sapiens
Manually annotated by BRENDA team
Buhimschi, C.S.; Garfield, R.E.; Weiner, C.P.; Buhimschi, I.A.
The presence and function of phosphodiesterase type 5 in the rat myometrium
Am. J. Obstet. Gynecol.
190
268-274
2004
Rattus norvegicus
Manually annotated by BRENDA team
Dolci, S.; Belmonte, A.; Santone, R.; Giorgi, M.; Pellegrini, M.; Carosa, E.; Piccione, E.; Lenzi, A.; Jannini, E.A.
Subcellular localization and regulation of type-1C and type-5 phosphodiesterases
Biochem. Biophys. Res. Commun.
341
837-846
2006
Homo sapiens
Manually annotated by BRENDA team
Day, J.P.; Dow, J.A.T.; Houslay, M.D.; Davies, S.A.
Cyclic nucleotide phosphodiesterases in Drosophila melanogaster
Biochem. J.
388
333-342
2005
Drosophila melanogaster
Manually annotated by BRENDA team
Yuasa, K.; Mi-Ichi, F.; Kobayashi, T.; Yamanouchi, M.; Kotera, J.; Kita, K.; Omori, K.
PfPDE1, a novel cGMP-specific phosphodiesterase from the human malaria parasite Plasmodium falciparum
Biochem. J.
392
221-229
2005
Plasmodium falciparum (Q2V2M6), Plasmodium falciparum
Manually annotated by BRENDA team
Day, J.P.; Houslay, M.D.; Davies, S.A.
A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP
Biochem. J.
393
481-488
2006
Drosophila sp. (in: flies)
Manually annotated by BRENDA team
Ko, W.C.; Shih, C.M.; Lai, Y.H.; Chen, J.H.; Huang, H.L.
Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships
Biochem. Pharmacol.
68
2087-2094
2004
Cavia porcellus
Manually annotated by BRENDA team
Zhang, J.; Kuvelkar, R.; Wu, P.; Egan, R.W.; Billah, M.M.; Wang, P.
Differential inhibitor sensitivity between human recombinant and native photoreceptor cGMP-phosphodiesterases (PDE6s)
Biochem. Pharmacol.
68
867-873
2004
Homo sapiens
Manually annotated by BRENDA team
Castro, L.R.; Verde, I.; Cooper, D.M.; Fischmeister, R.
Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes
Circulation
113
2221-2228
2006
Rattus norvegicus
Manually annotated by BRENDA team
Mochida, H.; Noto, T.; Inoue, H.; Yano, K.; Kikkawa, K.
T-0156, a novel phosphodiesterase type 5 inhibitor, and sildenafil have different pharmacological effects on penile tumescence and electroretinogram in dogs
Eur. J. Pharmacol.
485
283-288
2004
Canis lupus familiaris
Manually annotated by BRENDA team
Kotera, J.; Francis, S.H.; Grimes, K.A.; Rouse, A.; Blount, M.A.; Corbin, J.D.
Allosteric sites of phosphodiesterase-5 sequester cyclic GMP
Front. Biosci.
9
378-386
2004
Bos taurus
Manually annotated by BRENDA team
Scipioni, A.; Stefanini, S.; Santone, R.; Giorgi, M.
Immunohistochemical localisation of PDE5 in Leydig and myoid cells of prepuberal and adult rat testis
Histochem. Cell Biol.
124
401-407
2005
Rattus norvegicus
Manually annotated by BRENDA team
Bischoff, E.
Potency, selectivity, and consequences of nonselectivity of PDE inhibition
Int. J. Impot. Res.
16
S11-S14
2004
Bos taurus, Homo sapiens, Bos taurus PDE6
Manually annotated by BRENDA team
Weeks, J.L.; Zoraghi, R.; Beasley, A.; Sekhar, K.R.; Francis, S.H.; Corbin, J.D.
High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients
Int. J. Impot. Res.
17
5-9
2005
Homo sapiens
Manually annotated by BRENDA team
Dell'Agli, M.; Galli, G.V.; Vrhovsek, U.; Mattivi, F.; Bosisio, E.
In vitro inhibition of human cGMP-specific phosphodiesterase-5 by polyphenols from red grapes
J. Agric. Food Chem.
53
1960-1965
2005
Homo sapiens
Manually annotated by BRENDA team
Huai, Q.; Liu, Y.; Francis, S.H.; Corbin, J.D.; Ke, H.
Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity
J. Biol. Chem.
279
13095-13101
2004
Homo sapiens (O76074)
Manually annotated by BRENDA team
Mo, E.; Amin, H.; Bianco, I.H.; Garthwaite, J.
Kinetics of a cellular nitric oxide/cGMP/phosphodiesterase-5 pathway
J. Biol. Chem.
279
26149-26158
2004
Rattus norvegicus
Manually annotated by BRENDA team
Huang, D.; Hinds, T.R.; Martinez, S.E.; Doneanu, C.; Beavo, J.A.
Molecular determinants of cGMP binding to chicken cone photoreceptor phosphodiesterase
J. Biol. Chem.
279
48143-48151
2004
Gallus gallus (P52731)
Manually annotated by BRENDA team
Giordano, D.; Giorgi, M.; Tata, A.M.; Modica, A.; Augusti-Tocco, G.
Expression of PDE5 splice variants during ontogenesis of chick dorsal root ganglia
J. Neurosci. Res.
78
815-823
2004
Gallus gallus
Manually annotated by BRENDA team
Belmonte, A.; Ticconi, C.; Dolci, S.; Giorgi, M.; Zicari, A.; Lenzi, A.; Jannini, E.A.; Piccione, E.
Regulation of phosphodiesterase 5 expression and activity in human pregnant and non-pregnant myometrial cells by human chorionic gonadotropin
J. Soc. Gynecol. Investig.
12
570-577
2005
Homo sapiens
Manually annotated by BRENDA team
Pentia, D.C.; Hosier, S.; Collupy, R.A.; Valeriani, B.A.; Cote, R.H.
Purification of PDE6 isozymes from mammalian retina
Methods Mol. Biol.
307
125-140
2005
Bos taurus
Manually annotated by BRENDA team
Keravis, T.; Thaseldar-Roumie, R.; Lugnier, C.
Assessment of phosphodiesterase isozyme contribution in cell and tissue extracts
Methods Mol. Biol.
307
63-74
2005
Rattus norvegicus
Manually annotated by BRENDA team
Su, Y.H.; Vacquier, V.D.
Cyclic GMP-specific phosphodiesterase-5 regulates motility of sea urchin spermatozoa
Mol. Biol. Cell
17
114-121
2006
Strongylocentrotus purpuratus
Manually annotated by BRENDA team
Mancina, R.; Filippi, S.; Marini, M.; Morelli, A.; Vignozzi, L.; Salonia, A.; Montorsi, F.; Mondaini, N.; Vannelli, G.B.; Donati, S.; Lotti, F.; Forti, G.; Maggi, M.
Expression and functional activity of phosphodiesterase type 5 in human and rabbit vas deferens
Mol. Hum. Reprod.
11
107-115
2005
Oryctolagus cuniculus, Homo sapiens
Manually annotated by BRENDA team
Blount, M.A.; Beasley, A.; Zoraghi, R.; Sekhar, K.R.; Bessay, E.P.; Francis, S.H.; Corbin, J.D.
Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation
Mol. Pharmacol.
66
144-152
2004
Bos taurus
Manually annotated by BRENDA team
Wunder, F.; Tersteegen, A.; Rebmann, A.; Erb, C.; Fahrig, T.; Hendrix, M.
Characterization of the first potent and selective PDE9 inhibitor using a cGMP reporter cell line
Mol. Pharmacol.
68
1775-1781
2005
Homo sapiens, Mus musculus (O70628), Mus musculus
Manually annotated by BRENDA team
White, J.B.; Thompson, W.J.; Pittler, S.J.
Characterization of 3',5' cyclic nucleotide phosphodiesterase activity in Y79 retinoblastoma cells: absence of functional PDE6
Mol. Vis.
10
738-749
2004
no activity in Homo sapiens
Manually annotated by BRENDA team
Bender, A.T.; Beavo, J.A.
Specific localized expression of cGMP PDEs in Purkinje neurons and macrophages
Neurochem. Int.
45
853-857
2004
Mus musculus
Manually annotated by BRENDA team
Dell'Agli, M.; Galli, G.V.; Bosisio, E.
Inhibition of cGMP-phosphodiesterase-5 by biflavones of Ginkgo biloba
Planta Med.
72
468-470
2006
Homo sapiens
Manually annotated by BRENDA team
Oelke, M.; Hedlund, P.; Albrecht, K.; Ellinghaus, P.; Stief, C.G.; Jonas, U.; Andersson, K.E.; Uckert, S.
Expression of cAMP and cGMP-phosphodiesterase isoenzymes 3, 4, and 5 in the human clitoris: immunohistochemical and molecular biology study
Urology
67
1111-1116
2006
Homo sapiens
Manually annotated by BRENDA team
Waldkirch, E.; Uckert, S.; Yildirim, H.; Sohn, M.; Jonas, U.; Stief, C.G.; Andersson, K.E.; Hedlund, P.
Cyclic AMP-specific and cyclic GMP-specific phosphodiesterase isoenzymes in human cavernous arteries--immunohistochemical distribution and functional significance
World J. Urol.
23
405-410
2005
Homo sapiens
Manually annotated by BRENDA team
Knight, S.; Snellen, H.; Humphreys, M.; Baylis, C.
Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to ANP in the pregnant rat
Am. J. Physiol. Renal Physiol.
292
F655-F659
2007
Rattus norvegicus
Manually annotated by BRENDA team
Bader, S.; Kortholt, A.; Van Haastert, P.J.
Seven Dictyostelium discoideum phosphodiesterases degrade three pools of cAMP and cGMP
Biochem. J.
402
153-161
2007
Dictyostelium discoideum
Manually annotated by BRENDA team
Zoraghi, R.; Francis, S.H.; Corbin, J.D.
Critical amino acids in phosphodiesterase-5 catalytic site that provide for high-affinity interaction with cyclic guanosine monophosphate and inhibitors
Biochemistry
46
13554-13563
2007
Homo sapiens (O76074)
Manually annotated by BRENDA team
Biswas, K.H.; Sopory, S.; Visweswariah, S.S.
The GAF domain of the cGMP-binding, cGMP-specific phosphodiesterase (PDE5) is a sensor and a sink for cGMP
Biochemistry
47
3534-3543
2008
Homo sapiens (O76074)
Manually annotated by BRENDA team
Witwicka, H.; Kobialka, M.; Siednienko, J.; Mitkiewicz, M.; Gorczyca, W.A.
Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages
Biochim. Biophys. Acta
1773
209-218
2007
Rattus norvegicus
Manually annotated by BRENDA team
Xiong, Y.; Lu, H.T.; Li, Y.; Yang, G.F.; Zhan, C.G.
Characterization of a catalytic ligand bridging metal ions in phosphodiesterases 4 and 5 by molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations
Biophys. J.
91
1858-1867
2006
Homo sapiens (O76074)
Manually annotated by BRENDA team
Werkstroem, V.; Svensson, A.; Andersson, K.E.; Hedlund, P.
Phosphodiesterase 5 in the female pig and human urethra: morphological and functional aspects
BJU Int.
98
414-423
2006
Sus scrofa
Manually annotated by BRENDA team
Murthy, K.S.
Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1
Br. J. Pharmacol.
2008
1-11
2008
Oryctolagus cuniculus
Manually annotated by BRENDA team
Nagendran, J.; Archer, S.L.; Soliman, D.; Gurtu, V.; Moudgil, R.; Haromy, A.; St Aubin, C.; Webster, L.; Rebeyka, I.M.; Ross, D.B.; Light, P.E.; Dyck, J.R.; Michelakis, E.D.
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility
Circulation
116
238-248
2007
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Lin, C.S.; Lin, G.; Xin, Z.C.; Lue, T.F.
Expression, distribution and regulation of phosphodiesterase 5
Curr. Pharm. Des.
12
3439-3457
2006
Homo sapiens
Manually annotated by BRENDA team
Filippi, S.; Morelli, A.; Sandner, P.; Fibbi, B.; Mancina, R.; Marini, M.; Gacci, M.; Vignozzi, L.; Vannelli, G.B.; Carini, M.; Forti, G.; Maggi, M.
Characterization and functional role of androgen-dependent PDE5 activity in the bladder
Endocrinology
148
1019-1029
2007
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Rutten, K.; Prickaerts, J.; Hendrix, M.; van der Staay, F.J.; Sik, A.; Blokland, A.
Time-dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors
Eur. J. Pharmacol.
558
107-112
2007
Rattus norvegicus
Manually annotated by BRENDA team
Uckert, S.; Oelke, M.; Stief, C.G.; Andersson, K.E.; Jonas, U.; Hedlund, P.
Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate
Eur. Urol.
49
740-745
2006
Homo sapiens
Manually annotated by BRENDA team
Wilson, S.J.; Smyth, E.M.
Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6
J. Biol. Chem.
281
11780-11786
2006
Homo sapiens
Manually annotated by BRENDA team
Guo, L.W.; Muradov, H.; Hajipour, A.R.; Sievert, M.K.; Artemyev, N.O.; Ruoho, A.E.
The inhibitory gamma subunit of the rod cGMP phosphodiesterase binds the catalytic subunits in an extended linear structure
J. Biol. Chem.
281
15412-15422
2006
Bos taurus
Manually annotated by BRENDA team
Grant, J.E.; Guo, L.W.; Vestling, M.M.; Martemyanov, K.A.; Arshavsky, V.Y.; Ruoho, A.E.
The N terminus of GTP gamma S-activated transducin alpha-subunit interacts with the C terminus of the cGMP phosphodiesterase gamma-subunit
J. Biol. Chem.
281
6194-6202
2006
Bos taurus
Manually annotated by BRENDA team
de Vente, J.; Markerink-van Ittersum, M.; Vles, J.S.
The role of phosphodiesterase isoforms 2, 5, and 9 in the regulation of NO-dependent and NO-independent cGMP production in the rat cervical spinal cord
J. Chem. Neuroanat.
31
275-303
2006
Rattus norvegicus (O54735)
Manually annotated by BRENDA team
Tsang, S.H.; Woodruff, M.L.; Chen, C.K.; Yamashita, C.Y.; Cilluffo, M.C.; Rao, A.L.; Farber, D.B.; Fain, G.L.
GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase
J. Neurosci.
26
4472-4480
2006
Mus musculus
Manually annotated by BRENDA team
Blount, M.A.; Zoraghi, R.; Bessay, E.P.; Beasley, A.; Francis, S.H.; Corbin, J.D.
Conversion of phosphodiesterase-5 (PDE5) catalytic site to higher affinity by PDE5 inhibitors
J. Pharmacol. Exp. Ther.
323
730-737
2007
Bos taurus
Manually annotated by BRENDA team
Guo, L.W.; Assadi-Porter, F.M.; Grant, J.E.; Wu, H.; Markley, J.L.; Ruoho, A.E.
One-step purification of bacterially expressed recombinant transducin alpha-subunit and isotopically labeled PDE6 gamma-subunit for NMR analysis
Protein Expr. Purif.
51
187-197
2007
Bos taurus
Manually annotated by BRENDA team
Day, J.P.; Cleghon, V.; Houslay, M.D.; Davies, S.A.
Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein
Biochem. J.
414
363-374
2008
Drosophila melanogaster
Manually annotated by BRENDA team
Almeida, C.B.; Traina, F.; Lanaro, C.; Canalli, A.A.; Saad, S.T.; Costa, F.F.; Conran, N.
High expression of the cGMP-specific phosphodiesterase, PDE9A, in sickle cell disease (SCD) and the effects of its inhibition in erythroid cells and SCD neutrophils
Br. J. Haematol.
142
836-844
2008
Homo sapiens
Manually annotated by BRENDA team
Domek-Lopacinska, K.; Strosznajder, J.B.
The effect of selective inhibition of cyclic GMP hydrolyzing phosphodiesterases 2 and 5 on learning and memory processes and nitric oxide synthase activity in brain during aging
Brain Res.
1216
68-77
2008
Rattus norvegicus
Manually annotated by BRENDA team
Eros, D.; Szantai-Kis, C.; Kiss, R.; Keri, G.; Hegymegi-Barakonyi, B.; Koevesdi, I.; Orfi, L.
Structure-activity relationships of PDE5 inhibitors
Curr. Med. Chem.
15
1570-1585
2008
Homo sapiens
Manually annotated by BRENDA team
Guo, L.W.; Ruoho, A.E.
The retinal cGMP phosphodiesterase gamma-subunit - a chameleon
Curr. Protein Pept. Sci.
9
611-625
2008
Mus musculus
Manually annotated by BRENDA team
Sasseville, M.; Cote, N.; Gagnon, M.C.; Richard, F.J.
Up-regulation of 3',5'-cyclic guanosine monophosphate-specific phosphodiesterase in the porcine cumulus-oocyte complex affects steroidogenesis during in vitro maturation
Endocrinology
149
5568-5576
2008
Sus scrofa, Sus scrofa (Q864F1)
Manually annotated by BRENDA team
Santos-Silva, A.J.; Cairrao, E.; Morgado, M.; Alvarez, E.; Verde, I.
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries
Eur. J. Pharmacol.
582
102-109
2008
Homo sapiens (O76074), Homo sapiens
Manually annotated by BRENDA team
Wang, S.; Ning, G.; Chen, X.; Yang, J.; Ouyang, H.; Zhang, H.; Tai, P.; Mu, X.; Zhou, B.; Zhang, M.; Xia, G.
PDE5 modulates oocyte spontaneous maturation via cGMP-cAMP but not cGMP-PKG signaling
Front. Biosci.
13
7087-7095
2008
Mus musculus
Manually annotated by BRENDA team
Chan, A.L.; Huang, H.L.; Chien, H.C.; Chen, C.M.; Lin, C.N.; Ko, W.C.
Inhibitory effects of quercetin derivatives on phosphodiesterase isozymes and high-affinity [3H]-rolipram binding in guinea pig tissues
Invest. New Drugs
26
417-424
2008
Cavia porcellus
Manually annotated by BRENDA team
Davis, R.J.; Tosi, J.; Janisch, K.M.; Kasanuki, J.M.; Wang, N.K.; Kong, J.; Tsui, I.; Cilluffo, M.; Woodruff, M.L.; Fain, G.L.; Lin, C.S.; Tsang, S.H.
Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q)
Invest. Ophthalmol. Vis. Sci.
49
5067-5076
2008
Mus musculus
Manually annotated by BRENDA team
Maschi, O.; Cero, E.D.; Galli, G.V.; Caruso, D.; Bosisio, E.; DellAgli, M.
Inhibition of human cAMP-phosphodiesterase as a mechanism of the spasmolytic effect of Matricaria recutita L
J. Agric. Food Chem.
56
5015-5020
2008
Homo sapiens
Manually annotated by BRENDA team
Heikaus, C.C.; Stout, J.R.; Sekharan, M.R.; Eakin, C.M.; Rajagopal, P.; Brzovic, P.S.; Beavo, J.A.; Klevit, R.E.
Solution structure of the cGMP binding GAF domain from phosphodiesterase 5: insights into nucleotide specificity, dimerization, and cGMP-dependent conformational change
J. Biol. Chem.
283
22749-22759
2008
Mus musculus (Q8CG03)
Manually annotated by BRENDA team
Martinez, S.E.; Heikaus, C.C.; Klevit, R.E.; Beavo, J.A.
The structure of the GAF A domain from phosphodiesterase 6C reveals determinants of cGMP binding, a conserved binding surface, and a large cGMP-dependent conformational change
J. Biol. Chem.
283
25913-25919
2008
Gallus gallus (P52731), Gallus gallus
Manually annotated by BRENDA team
Reingruber, J.; Holcman, D.
Estimating the rate constant of cyclic GMP hydrolysis by activated phosphodiesterase in photoreceptors
J. Chem. Phys.
129
145102
2008
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Nishiwaki, Y.; Komori, A.; Sagara, H.; Suzuki, E.; Manabe, T.; Hosoya, T.; Nojima, Y.; Wada, H.; Tanaka, H.; Okamoto, H.; Masai, I.
Mutation of cGMP phosphodiesterase 6alpha-subunit gene causes progressive degeneration of cone photoreceptors in zebrafish
Mech. Dev.
125
932-946
2008
Danio rerio
Manually annotated by BRENDA team
Chen, J.; Yoshida, T.; Bitensky, M.W.
Light-induced translocation of cyclic-GMP phosphodiesterase on rod disc membranes in rat retina
Mol. Vis.
14
2509-2517
2008
Rattus norvegicus
Manually annotated by BRENDA team
Song, J.; Guo, L.W.; Muradov, H.; Artemyev, N.O.; Ruoho, A.E.; Markley, J.L.
Intrinsically disordered gamma-subunit of cGMP phosphodiesterase encodes functionally relevant transient secondary and tertiary structure
Proc. Natl. Acad. Sci. USA
105
1505-1510
2008
Homo sapiens
Manually annotated by BRENDA team
Goncalves, R.L.; Lugnier, C.; Keravis, T.; Lopes, M.J.; Fantini, F.A.; Schmitt, M.; Cortes, S.F.; Lemos, V.S.
The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue
Eur. J. Pharmacol.
620
78-83
2009
Bos taurus
Manually annotated by BRENDA team
Chen, C.Y.; Chang, Y.H.; Bau, D.T.; Huang, H.J.; Tsai, F.J.; Tsai, C.H.; Chen, C.Y.
Discovery of potent inhibitors for phosphodiesterase 5 by virtual screening and pharmacophore analysis
Acta Pharmacol. Sin.
30
1186-1194
2009
Homo sapiens
Manually annotated by BRENDA team
Tsertsvadze, A.; Fink, H.A.; Yazdi, F.; MacDonald, R.; Bella, A.J.; Ansari, M.T.; Garritty, C.; Soares-Weiser, K.; Daniel, R.; Sampson, M.; Fox, S.; Moher, D.; Wilt, T.J.
Oral phosphodiesterase-5 inhibitors and hormonal treatments for erectile dysfunction: a systematic review and meta-analysis
Ann. Intern. Med.
151
650-661
2009
Homo sapiens
Manually annotated by BRENDA team
Tollefson, M.B.; Acker, B.A.; Jacobsen, E.J.; Hughes, R.O.; Walker, J.K.; Fox, D.N.; Palmer, M.J.; Freeman, S.K.; Yu, Y.; Bond, B.R.
1-(2-(2,2,2-Trifluoroethoxy)ethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors
Bioorg. Med. Chem. Lett.
20
3125-3128
2010
Homo sapiens
Manually annotated by BRENDA team
Taylor, J.; Baldo, O.B.; Storey, A.; Cartledge, J.; Eardley, I.
Differences in side-effect duration and related bother levels between phosphodiesterase type 5 inhibitors
BJU Int.
103
1392-1395
2009
Homo sapiens
Manually annotated by BRENDA team
Cortes-Gonzalez, J.R.; Glina, S.
Have phosphodiesterase-5 inhibitors changed the indications for penile implants?
BJU Int.
103
1518-1521
2009
Homo sapiens
Manually annotated by BRENDA team
Matsumoto, S.; Hanai, T.; Uemura, H.; Levin, R.M.
Effects of chronic treatment with vardenafil, a phosphodiesterase 5 inhibitor, on female rat bladder in a partial bladder outlet obstruction model
BJU Int.
103
987-990
2009
Rattus norvegicus
Manually annotated by BRENDA team
Tamimi, N.A.; Mincik, I.; Haughie, S.; Lamb, J.; Crossland, A.; Ellis, P.
A placebo-controlled study investigating the efficacy and safety of the phosphodiesterase type 5 inhibitor UK-369,003 for the treatment of men with lower urinary tract symptoms associated with clinical benign prostatic hyperplasia
BJU Int.
106
674-680
2010
Homo sapiens
Manually annotated by BRENDA team
Kim, T.E.; Kim, B.H.; Kim, J.R.; Lim, K.S.; Hong, J.H.; Kim, K.P.; Kim, H.S.; Shin, S.G.; Jang, I.J.; Yu, K.S.
Effect of food on the pharmacokinetics of the oral phosphodiesterase 5 inhibitor udenafil for the treatment of erectile dysfunction
Br. J. Clin. Pharmacol.
68
43-46
2009
Homo sapiens
Manually annotated by BRENDA team
Murthy, K.S.
Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1
Br. J. Pharmacol.
153
1214-1224
2008
Homo sapiens
Manually annotated by BRENDA team
Radovits, T.; Boemicke, T.; Koekeny, G.; Arif, R.; Loganathan, S.; Kecsan, K.; Korkmaz, S.; Barnucz, E.; Sandner, P.; Karck, M.; Szabo, G.
The phosphodiesterase-5 inhibitor vardenafil improves cardiovascular dysfunction in experimental diabetes mellitus
Br. J. Pharmacol.
156
909-919
2009
Rattus norvegicus
Manually annotated by BRENDA team
Ibishev, K.h.S.
Efficiency of combined therapy with impaza and type 5 phosphodiesterase inhibitors in prophylactics of posttraumatic erectile dysfunction
Bull. Exp. Biol. Med.
148
322-324
2009
Homo sapiens
Manually annotated by BRENDA team
Schaefer, S.; Ellinghaus, P.; Janssen, W.; Kramer, F.; Lustig, K.; Milting, H.; Kast, R.; Klein, M.
Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular remodelling
Cardiovasc. Res.
82
30-39
2009
Rattus norvegicus
Manually annotated by BRENDA team
Dadvar, P.; Kovanich, D.; Folkers, G.E.; Rumpel, K.; Raijmakers, R.; Heck, A.J.
Phosphatidylethanolamine-binding proteins, including RKIP, exhibit affinity for phosphodiesterase-5 inhibitors
ChemBioChem
10
2654-2662
2009
Rattus norvegicus (O54735)
Manually annotated by BRENDA team
Toque, H.A.; Priviero, F.B.; Zemse, S.M.; Antunes, E.; Teixeira, C.E.; Webb, R.C.
Effect of the phosphodiesterase 5 inhibitors sildenafil, tadalafil and vardenafil on rat anococcygeus muscle: functional and biochemical aspects
Clin. Exp. Pharmacol. Physiol.
36
358-366
2009
Rattus norvegicus
Manually annotated by BRENDA team
Sun, X.Z.; Li, Z.F.; Liu, Y.; Fang, P.; Li, M.X.
Inhibition of cGMP phosphodiesterase 5 suppresses matrix metalloproteinase-2 production in pulmonary artery smooth muscles cells
Clin. Exp. Pharmacol. Physiol.
37
362-367
2010
Rattus norvegicus
Manually annotated by BRENDA team
Gotshall, R.W.; Hamilton, K.L.; Foreman, B.; van Patot, M.C.; Irwin, D.C.
Glutaraldehyde-polymerized bovine hemoglobin and phosphodiesterase-5 inhibition
Crit. Care Med.
37
1988-1993
2009
Rattus norvegicus
Manually annotated by BRENDA team
Kato, N.; Mashita, Y.; Kato, S.; Mitsufuji, S.; Yoshikawa, T.; Takeuchi, K.
Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats via a NO/cGMP-dependent mechanism
Digest. Dis. Sci.
54
2346-2356
2009
Rattus norvegicus
Manually annotated by BRENDA team
Laties, A.M.
Vision disorders and phosphodiesterase type 5 inhibitors: a review of the evidence to date
Drug Saf.
32
1-18
2009
Homo sapiens
Manually annotated by BRENDA team
Barren, B.; Gakhar, L.; Muradov, H.; Boyd, K.K.; Ramaswamy, S.; Artemyev, N.O.
Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit
EMBO J.
28
3613-3622
2009
Bos taurus
Manually annotated by BRENDA team
Liu, C.Q.; Leung, F.P.; Lee, V.W.; Lau, C.W.; Yao, X.; Lu, L.; Huang, Y.
Prevention of nitroglycerin tolerance in vitro by T0156, a selective phosphodiesterase type 5 inhibitor
Eur. J. Pharmacol.
590
250-254
2008
Rattus norvegicus
Manually annotated by BRENDA team
Korkmaz, S.; Radovits, T.; Barnucz, E.; Neugebauer, P.; Arif, R.; Hirschberg, K.; Loganathan, S.; Seidel, B.; Karck, M.; Szabo, G.
Dose-dependent effects of a selective phosphodiesterase-5-inhibitor on endothelial dysfunction induced by peroxynitrite in rat aorta
Eur. J. Pharmacol.
615
155-162
2009
Rattus norvegicus
Manually annotated by BRENDA team
Sejima, H.; Tominaga, K.; Egawa, T.; Ikeda, M.; Shibuya, K.; Kameyama, N.; Yamauchi, A.; Shuto, H.; Kataoka, Y.
Gender differences in tail-skin flushing induced by nitrates and phosphodiesterase type 5 inhibitors in a climacteric mouse model
Eur. J. Pharmacol.
624
66-70
2009
Mus musculus
Manually annotated by BRENDA team
Koehler, T.S.; McVary, K.T.
The relationship between erectile dysfunction and lower urinary tract symptoms and the role of phosphodiesterase type 5 inhibitors
Eur. Urol.
55
38-48
2009
Homo sapiens
Manually annotated by BRENDA team
Gur, S.; Sikka, S.C.; Hellstrom, W.J.
Novel phosphodiesterase-5 (PDE5) inhibitors in the alleviation of erectile dysfunction due to diabetes and ageing-induced oxidative stress
Expert Opin. Investig. Drugs
17
855-864
2008
Homo sapiens
Manually annotated by BRENDA team
Cheon, Y.K.; Cho, Y.D.; Moon, J.H.; Im, H.H.; Jung, Y.; Lee, J.S.; Lee, M.S.; Shim, C.S.
Effects of vardenafil, a phosphodiesterase type-5 inhibitor, on sphincter of Oddi motility in patients with suspected biliary sphincter of Oddi dysfunction
Gastrointest. Endosc.
69
1111-1116
2009
Homo sapiens
Manually annotated by BRENDA team
Speranza, L.; Franceschelli, S.; Pesce, M.; Vinciguerra, I.; De Lutiis, M.A.; Grilli, A.; Felaco, M.; Patruno, A.
Phosphodiesterase type-5 inhibitor and oxidative stress
Int. J. Immunopathol. Pharmacol.
21
879-889
2009
Homo sapiens
Manually annotated by BRENDA team
Das, A.; Xi, L.; Kukreja, R.C.
Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta
J. Biol. Chem.
283
29572-29585
2008
Mus musculus
Manually annotated by BRENDA team
Muradov, H.; Boyd, K.K.; Haeri, M.; Kerov, V.; Knox, B.E.; Artemyev, N.O.
Characterization of human cone phosphodiesterase-6 ectopically expressed in Xenopus laevis rods
J. Biol. Chem.
284
32662-32669
2009
Homo sapiens
Manually annotated by BRENDA team
Iseri, S.O.; Ersoy, Y.; Ercan, F.; Yuksel, M.; Atukeren, P.; Gumustas, K.; Alican, I.
The effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat
J. Gastroenterol. Hepatol.
24
1142-1148
2009
Rattus norvegicus
Manually annotated by BRENDA team
Botha, P.; Parry, G.; Dark, J.H.; Macgowan, G.A.
Acute hemodynamic effects of intravenous sildenafil citrate in congestive heart failure: comparison of phosphodiesterase type-3 and -5 inhibition
J. Heart Lung Transplant.
28
676-682
2009
Homo sapiens
Manually annotated by BRENDA team
Okuyucu, S.; Guven, O.E.; Akoglu, E.; Ucar, E.; Dagli, S.
Effect of phosphodiesterase-5 inhibitor on hearing
J. Laryngol. Otol.
123
718-722
2009
Homo sapiens
Manually annotated by BRENDA team
Hughes, R.O.; Rogier, D.J.; Jacobsen, E.J.; Walker, J.K.; Macinnes, A.; Bond, B.R.; Zhang, L.L.; Yu, Y.; Zheng, Y.; Rumsey, J.M.; Walgren, J.L.; Curtiss, S.W.; Fobian, Y.M.; Heasley, S.E.; Cubbage, J.W.; Moon, J.B.; Brown, D.L.; Acker, B.A.; Maddux, T.M.; Tollefson, M.B.; Mischke, B.V.; Owen, D.R.; Freskos, J.N.; Molyneaux, J.M.; Benson, A.G.; Blevis-Bal, R.M.
Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5)
J. Med. Chem.
53
2656-2660
2010
Rattus norvegicus
Manually annotated by BRENDA team
Pifarre, P.; Prado, J.; Giralt, M.; Molinero, A.; Hidalgo, J.; Garcia, A.
Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury
J. Neurochem.
112
807-817
2010
Rattus norvegicus
Manually annotated by BRENDA team
Zou, P.; Hou, P.; Oh, S.S.; Ge, X.; Bloodworth, B.C.; Low, M.Y.; Koh, H.L.
Identification of benzamidenafil, a new class of phosphodiesterase-5 inhibitor, as an adulterant in a dietary supplement
J. Pharm. Biomed. Anal.
47
255-259
2008
Homo sapiens
Manually annotated by BRENDA team
Donato, M.A.; Saraiva, K.L.; Soares e Silva, A.K.; Wanderley, M.I.; Peixoto, C.A.
Follicle development and luteal cell morphology altered by phosphodiesterase-5 inhibitor
Micron
40
845-850
2009
Mus musculus
Manually annotated by BRENDA team
Taylor, C.J.; McRobert, L.; Baker, D.A.
Disruption of a Plasmodium falciparum cyclic nucleotide phosphodiesterase gene causes aberrant gametogenesis
Mol. Microbiol.
69
110-118
2008
Plasmodium falciparum
Manually annotated by BRENDA team
Rybalkina, I.G.; Tang, X.B.; Rybalkin, S.D.
Multiple affinity states of cGMP-specific phosphodiesterase for sildenafil inhibition defined by cGMP-dependent and cGMP-independent mechanisms
Mol. Pharmacol.
77
670-677
2010
Homo sapiens
Manually annotated by BRENDA team
Li, M.; Sun, X.; Li, Z.; Liu, Y.
Inhibition of cGMP phosphodiesterase 5 suppresses serotonin signalling in pulmonary artery smooth muscles cells
Pharmacol. Res.
59
312-318
2009
Rattus norvegicus
Manually annotated by BRENDA team
Clark, A.S.; Meerts, S.H.; Guarraci, F.A.
Zaprinast, a phosphodiesterase type-5 inhibitor, alters paced mating behavior in female rats
Physiol. Behav.
96
289-293
2009
Rattus norvegicus
Manually annotated by BRENDA team
Al-Shaiji, T.F.; Brock, G.B.
Peyronies disease: evolving surgical management and the role of phosphodiesterase 5 inhibitors
ScientificWorldJournal
9
822-845
2009
Homo sapiens
Manually annotated by BRENDA team
Crosby, R.; Yarber, W.L.; Sanders, S.A.; Graham, C.A.
Is phosphodiesterase type 5 inhibitor use associated with condom breakage?
Sex. Transm. Infect.
85
404-405
2009
Homo sapiens
Manually annotated by BRENDA team
Wang, H.G.; Yan, X.Y.; Cai, Y.M.; Wang, H.G.; Chen, J.Y.
The effect of phosphodiesterase isoenzyme 5 inhibitors on ureteropelvic junction obstruction in rabbits
Urol. Int.
83
316-322
2009
Oryctolagus cuniculus
Manually annotated by BRENDA team
Tsang, S.H.; Woodruff, M.L.; Lin, C.S.; Jacobson, B.D.; Naumann, M.C.; Hsu, C.W.; Davis, R.J.; Cilluffo, M.C.; Chen, J.; Fain, G.L.
Effect of the ILE86TER mutation in the gamma subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling
Cell. Signal.
24
181-188
2011
Mus musculus
Manually annotated by BRENDA team
Giachini, F.R.; Lima, V.V.; Carneiro, F.S.; Tostes, R.C.; Webb, R.C.
Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1
Hypertension
57
655-663
2011
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Tosi, J.; Davis, R.J.; Wang, N.K.; Naumann, M.; Lin, C.S.; Tsang, S.H.
shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa
J. Cell. Mol. Med.
15
1778-1787
2011
Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Yamazaki, A.; Bondarenko, V.A.; Matsuura, I.; Tatsumi, M.; Kurono, S.; Komori, N.; Matsumoto, H.; Hayashi, F.; Yamazaki, R.K.; Usukura, J.
Mechanism for the regulation of mammalian cGMP phosphodiesterase6. 1: identification of its inhibitory subunit complexes and their roles
Mol. Cell. Biochem.
339
215-233
2010
Bos taurus
Manually annotated by BRENDA team
Yamazaki, A.; Tatsumi, M.; Bondarenko, V.A.; Kurono, S.; Komori, N.; Matsumoto, H.; Matsuura, I.; Hayashi, F.; Yamazaki, R.K.; Usukura, J.
Mechanism for the regulation of mammalian cGMP phosphodiesterase6. 2: isolation and characterization of the transducin-activated form
Mol. Cell. Biochem.
339
235-251
2010
Bos taurus
Manually annotated by BRENDA team
Lakics, V.; Karran, E.H.; Boess, F.G.
Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues
Neuropharmacology
59
367-374
2010
Homo sapiens (O76074), Homo sapiens (O76083)
Manually annotated by BRENDA team
Chu, U.B.; Song, J.; Mavlyutov, T.A.; Guo, L.W.
In vitro interaction of tubulin with the photoreceptor cGMP phosphodiesterase gamma-subunit
Neurosci. Lett.
482
225-229
2010
Bos taurus, Mus musculus
Manually annotated by BRENDA team
Kelly, M.P.; Adamowicz, W.; Bove, S.; Hartman, A.J.; Mariga, A.; Pathak, G.; Reinhart, V.; Romegialli, A.; Kleiman, R.J.
Select 3,5-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain
Cell. Signal.
26
383-397
2014
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Kuechler, P.; Zimmermann, G.; Winzker, M.; Janning, P.; Waldmann, H.; Ziegler, S.
Identification of novel PDEdelta interacting proteins
Bioorg. Med. Chem.
26
1426-1434
2018
Homo sapiens
Manually annotated by BRENDA team
Guo, L.; Luo, L.; Ju, R.; Chen, C.; Zhu, L.; Li, J.; Yu, X.; Ye, C.; Zhang, D.
Carboxyamidotriazole A novel inhibitor of both cAMP-phosphodiesterases and cGMP-phosphodiesterases
Eur. J. Pharmacol.
746
14-21
2015
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Kay?k, G.; Tuezuen, N.?.; Durdagi, S.
Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development
J. Enzyme Inhib. Med. Chem.
32
311-330
2017
Homo sapiens (O76074)
Manually annotated by BRENDA team