3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase

This is an abbreviated version!
For detailed information about 3',5'-cyclic-GMP phosphodiesterase, go to the full flat file.

Reaction

Synonyms

3',5'-cyclic GMP phosphodiesterase, 3',5'-cyclic guanosine monophosphate-specific phosphodiesterase, 3',5'-cyclic nucleotide phosphodiesterase 5, cd-PDE5, cG-PDE, cGMP 3',5'-cyclic phosphodiesterase subunit delta, cGMP binding phosphodiesterase, cGMP phosphodiesterase, cGMP phosphodiesterase 5, cGMP phosphodiesterase 6, cGMP phosphodiesterase 6alpha' subunit, cGMP phosphodiesterase6, cGMP-binding cGMP specific phosphodiesterase, cGMP-binding cGMP-specific PDE, cGMP-binding cGMP-specific phosphodiesterase, cGMP-PDE, cGMP-phosphodiesterase, cGMP-phosphodiesterase-5, cGMP-selective phosphodiesterase, cGMP-specific cGMP-binding phosphodiesterase, cGMP-specific PDE, cGMP-specific PDE5, cGMP-specific PDE5A1, cGMP-specific phosphodiesterase, cGMP-specific phosphodiesterase 5, cGMP-specific phosphodiesterase type 9, cGMP-specific phosphodiesterase-5, cGMP-stimulated phosphodiesterase, cyclic 3',5'-GMP phosphodiesterase, cyclic GMP hydrolyzing phosphodiesterase 5, cyclic GMP phosphodiesterase, cyclic GMP-phosphodiesterase, cyclic guanosine 3',5'-monophosphate phosphodiesterase, cyclic guanosine 3',5'-phosphate phosphodiesterase, cyclic guanosine monophosphate phosphodiesterase, cyclic guanosine monophosphate-specific phosphodiesterase 5, cyclic-GMP phosphodiesterase, DdPDE3, DmPDE6, Drosophila PDE6-like enzyme, GbpA, gigh-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, GMP-PDE, guanosine 3',5'-cyclicmonophosphate-specific PDE, guanosine cyclic 3',5'-phosphate phosphodiesterase, PDB5, PDE, PDE-5, PDE-6, PDE4, PDE5, PDE5/6, PDE5/PDE6cd, PDE5A, PDE5A1, PDE6, PDE6AB, PDE6alpha, PDE6alpha', PDE6B, PDE6beta, PDE6C, PDE6D, PDE6gamma, PDE6R, PDE9, PDE9A, PDE9A1, PdeD, PDEdelta, PDEgamma, PfPDE1, phospho-diesterase-5, phosphodiesterase, phosphodiesterase 5, phosphodiesterase 5 (cGMP-specific), phosphodiesterase 6C, phosphodiesterase 9, phosphodiesterase cGMP, phosphodiesterase isoenzyme 5, phosphodiesterase subtype 5, phosphodiesterase type 5, phosphodiesterase type-5, phosphodiesterase, guanosine cyclic 3',5'-phosphate, phosphodiesterase-5, phosphodiesterase-6, PrBP/delta, suPDE5, type 5 phosphodiesterase, type 9 cGMP-specific phosphodiesterase, type-5 phosphodiesterase, xGMP-specific PDE

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.4 Phosphoric-diester hydrolases

                3.1.4.35 3',5'-cyclic-GMP phosphodiesterase

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Results	in table
71	Activating Compound
2136	AA Sequence
37	Application
1	CAS Registry Number
35	Cloned(Commentary)
5	Crystallization (Commentary)
9011	Disease/ Diagnostics
6	Expression
17	General Information
3	General Stability
178	IC50 Value
421	Inhibitors
45	Ki Value [mM]
50	KM Value [mM]
47	Localization
29	Metals/Ions
22	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
424	Organism
2	Pathway
298	PDB ID
6	pH Optimum
4	pH Range
6	Posttranslational Modification
47	Protein Variants
31	Purification (Commentary)
1	Reaction
1	Reaction Type
197	Reference
242	Source Tissue
13	Specific Activity [micromol/min/mg]
4	Storage Stability
146	Substrates and Products (Substrate)
28	Subunits
297	Synonyms
1	Systematic Name
11	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.1.4.35 - 3',5'-cyclic-GMP phosphodiesterase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

3',5'-cGMP + H2O

5'-GMP

9 entries

3',5'-cGMP + H2O

guanosine 5'-phosphate

Homo sapiens

-

phosphodiesterase 5 converts the second messenger 3',5'-cGMP to its inactive form

667119

-

-

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

22 entries

additional information

?

-

20 entries

3',5'-cGMP + H2O

5'-GMP

Bos taurus

-

allosteric cGMP-binding sites of PDE5 could regulate cGMP signaling by sequestering cGMP from cGMP-dependent protein kinase and perhaps from the PDE5 catalytic site as well. The cGMP sequestered by binding of cGMP to PDE5 R domain significantly dampens activation of cGMP-dependent protein kinase and hydrolysis of cGMP by PDE5 C domain

668704

-

-

?

3',5'-cGMP + H2O

5'-GMP

Bos taurus

-

PDE5 and PDE6 show specificity for cGMP relative to cAMP

711849

-

-

?

3',5'-cGMP + H2O

5'-GMP

Homo sapiens

-

-

710776, 711409, 711619, 711841, 711934, 711948, 712091, 713068, 750045

-

-

?

3',5'-cGMP + H2O

5'-GMP

Homo sapiens

O76074

-

751213

-

-

?

3',5'-cGMP + H2O

5'-GMP

Homo sapiens

-

PDE5 is cGMP-specific

711557

-

-

?

3',5'-cGMP + H2O

5'-GMP

Mus musculus

-

-

711925, 712364, 712975, 750479

-

-

?

3',5'-cGMP + H2O

5'-GMP

Rattus norvegicus

-

-

711687, 711829, 712621, 712815, 750479

-

-

?

3',5'-cGMP + H2O

5'-GMP

Rattus norvegicus

O54735

PDE5 specifically targets 3',5'-cyclic GMP

711744

-

-

?

3',5'-cGMP + H2O

5'-GMP

Strongylocentrotus purpuratus

-

suPDE5 regulates cGMP levels in sperm, which in turn modulate sperm motility

670209

-

-

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Bos taurus

-

-

650012

-

650012

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Canis lupus familiaris

-

-

651222

-

651222

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Canis lupus familiaris

-

-

653097

-

653097

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Dictyostelium

-

-

653180

-

653180

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Dictyostelium discoideum

Q8MLZ3

-

653179

-

653179

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Dictyostelium discoideum

-

very low activity with cAMP

649701

-

649701

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Homo sapiens

-

-

649549

-

649549

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Homo sapiens

-

-

650811

-

650811

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Homo sapiens

-

-

651322

-

651322

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Homo sapiens

-

-

653097

-

653097

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Homo sapiens

O76074

-

650813

-

650813

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Homo sapiens

O76074

-

653343

-

653343

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Homo sapiens

O76083

-

651412

-

651412

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Lithobates pipiens

Q8UUY2, Q8UUY6, Q8UUY7

-

652318

-

652318

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Mus musculus

-

-

650342

-

650342

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Mus musculus

O70628

-

652975

-

652975

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Oryctolagus cuniculus

-

-

653097

-

653097

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Rana sp.

-

-

653124

-

653124

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Rattus norvegicus

-

-

650180

-

650180

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Rattus norvegicus

-

-

650737

-

650737

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Rattus norvegicus

-

-

653083

-

653083

?

guanosine 3',5'-cyclic phosphate + H2O

guanosine 5'-phosphate

Rattus norvegicus

Q8QZV1

-

652975

-

652975

?

additional information

?

-

Bos taurus

-

preincubation with cGMP increases catalytic activity for cGMP degradation, thus elevated cellular cGMP initiates a physiological negative feedback on the cGMP pathway by increasing the affinity of the PDE5 catalytic site for cGMP

681583

-

-

?

additional information

?

-

Bos taurus

-

analysis of diverse complxes formed by subunits Pgamma with GTP or GDP and outer segments, the complexes are extracted from membranes and isolated. Analysis of the function of the single complexes in PDE regulation, overview

716198

-

-

?

additional information

?

-

Bos taurus

-

interaction between the PDE6 gamma subunit with tubulin alpha and beta, specificity and mechanism, detailed overview

716349

-

-

?

additional information

?

-

Drosophila melanogaster

-

prenylation of the enzyme is required for plasma-membrane targeting

690833

-

-

?

additional information

?

-

Drosophila sp. (in: flies)

-

role for cG-PDE in modulating cGMP transport and efflux

667521

-

-

?

additional information

?

-

Gallus gallus

P52731

PDE6 contains two regulatory GAF domains, of which one (GAF A) binds cGMP and regulates the activity of the PDE6 holoenzyme

693132

-

-

?

additional information

?

-

Gallus gallus

-

PDE6 contains two regulatory GAF domains, of which one (GAF A) binds cGMP and regulates the activity of the PDE6 holoenzyme

693132

-

-

?

additional information

?

-

Homo sapiens

-

human chorionic gonadotropin reduces PDE5 expression and enzyme activity in smooth muscle cells, possibly through a pathway involving cAMP

670025

-

-

?

additional information

?

-

Homo sapiens

-

PDE5 gene expression and activity are androgen-dependent in vas deferens

670287

-

-

?

additional information

?

-

Homo sapiens

-

PDE5 may be involved in the cyclic nucleotide-mediated control of smooth muscle tone

670983

-

-

?

additional information

?

-

Homo sapiens

-

PDE5 regulation of cGMP intracellular levels is not involved in the control of progression of smooth muscle cell cycle, but may represent one of the markers of the contractile phenotype

667433

-

-

?

additional information

?

-

Homo sapiens

-

isoform PDE5 regulation of cGMP intracellular levels is not involved in the control of smooth muscle cell cycle progression, but may represent one of the markers of the contractile phenotype

667433

-

-

?

additional information

?

-

Mus musculus

-

PDE5 in Pukinje neurons may play a role in limiting the cGMP-mediated long-term depression response

670387

-

-

?

additional information

?

-

Mus musculus

-

interaction between the PDE6 gamma subunit with tubulin alpha and beta, specificity and mechanism, detailed overview

716349

-

-

?

additional information

?

-

Oryctolagus cuniculus

-

PDE5 gene expression and activity are androgen-dependent in vas deferens

670287

-

-

?

additional information

?

-

Rattus norvegicus

-

in mammals the enzyme might play key roles in the aquisition and maintenance of the myoid cell contractile phenotype and more generally in the testis maturation

668864

-

-

?

additional information

?

-

Rattus norvegicus

-

kinetics of a cellular nitric oxide/cGMP/phosphodiesterase-5 pathway

669232

-

-

?

additional information

?

-

Rattus norvegicus

-

PDE5 controls the soluble but not the particulate pool of cGMP in rat cardiomyocytes

668269

-

-

?

additional information

?

-

Rattus norvegicus

O54735

cGMP levels in the spinal cord are controlled by a number of enzyme isoforms, that can be present in the same cell. Role of NO-cGMP signaling in nociceptive processing

681045

-

-

?

additional information

?

-

Rattus norvegicus

-

isoform PDE5 regulates bladder smooth muscle tone, strongly limiting the nitric oxide/cGMP signaling

679518

-

-

?