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Literature summary for 3.1.4.35 extracted from

  • Kuechler, P.; Zimmermann, G.; Winzker, M.; Janning, P.; Waldmann, H.; Ziegler, S.
    Identification of novel PDEdelta interacting proteins (2018), Bioorg. Med. Chem., 26, 1426-1434 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli RosettaTM2 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-benzyl-2-[4-[2-(2-phenyl-1H-benzimidazol-1-yl)ethoxy]phenyl]-1H-benzimidazole
-
Homo sapiens
1-benzyl-2-[4-[2-cyclohexyl-2-(2-phenyl-1H-benzimidazol-1-yl)ethoxy]phenyl]-1H-benzimidazole
-
Homo sapiens
deltarasin
-
Homo sapiens
deltazinone 1
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3',5'-cGMP + H2O Homo sapiens
-
5'-GMP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
GSH-Sepharose column chromatography and Superdex 75 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cGMP + H2O
-
Homo sapiens 5'-GMP
-
?

Synonyms

Synonyms Comment Organism
cGMP 3',5'-cyclic phosphodiesterase subunit delta
-
Homo sapiens
PDE6D
-
Homo sapiens
PDEdelta
-
Homo sapiens
PrBP/delta
-
Homo sapiens

General Information

General Information Comment Organism
physiological function subunit PDEdelta is a prenyl binding protein that is essential for the shuttling of small GTPases between different membrane compartments and, thus, for their proper functioning. Farnesylated 2',3'-cyclic-nucleotide 3'-phosphodiesterase, RAB23, CDC42 and CNP are PDEdelta-interacting proteins. Subunit PDEdelta also associates with the lamin A mutant progerin in a prenyl-dependent manner Homo sapiens