Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli RosettaTM2 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-benzyl-2-[4-[2-(2-phenyl-1H-benzimidazol-1-yl)ethoxy]phenyl]-1H-benzimidazole | - |
Homo sapiens | |
1-benzyl-2-[4-[2-cyclohexyl-2-(2-phenyl-1H-benzimidazol-1-yl)ethoxy]phenyl]-1H-benzimidazole | - |
Homo sapiens | |
deltarasin | - |
Homo sapiens | |
deltazinone 1 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | Homo sapiens | - |
5'-GMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
GSH-Sepharose column chromatography and Superdex 75 gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | - |
Homo sapiens | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cGMP 3',5'-cyclic phosphodiesterase subunit delta | - |
Homo sapiens |
PDE6D | - |
Homo sapiens |
PDEdelta | - |
Homo sapiens |
PrBP/delta | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | subunit PDEdelta is a prenyl binding protein that is essential for the shuttling of small GTPases between different membrane compartments and, thus, for their proper functioning. Farnesylated 2',3'-cyclic-nucleotide 3'-phosphodiesterase, RAB23, CDC42 and CNP are PDEdelta-interacting proteins. Subunit PDEdelta also associates with the lamin A mutant progerin in a prenyl-dependent manner | Homo sapiens |