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2'-O-anthraniloyl cGMP + H2O
2'-O-anthraniloyl GMP
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-
-
?
2'-O-anthraniloyl-cGMP + H2O
?
3',5'-cGMP + H2O
guanosine 5'-phosphate
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
additional information
?
-
2'-O-anthraniloyl-cGMP + H2O
?
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phosphorylation increases affinity for hydrolysis of 2'-O-anthraniloyl-cGMP by about 3fold
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?
2'-O-anthraniloyl-cGMP + H2O
?
-
phosphorylation increases affinity for hydrolysis of 2'-O-anthraniloyl-cGMP by about 3fold
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-
?
3',5'-cAMP + H2O
5'-AMP
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?
3',5'-cAMP + H2O
5'-AMP
-
activity with 3',5'-cAMP is higher than with 3',5'-cGMP, PDE6
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?
3',5'-cAMP + H2O
5'-AMP
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activity with 3',5'-cAMP is higher than with 3',5'-cGMP, PDE6
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?
3',5'-cAMP + H2O
5'-AMP
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-
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?
3',5'-cAMP + H2O
5'-AMP
very low activity
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?
3',5'-cGMP + H2O
5'-GMP
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-
-
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?
3',5'-cGMP + H2O
5'-GMP
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?
3',5'-cGMP + H2O
5'-GMP
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-
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?
3',5'-cGMP + H2O
5'-GMP
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?
3',5'-cGMP + H2O
5'-GMP
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-
-
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?
3',5'-cGMP + H2O
5'-GMP
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allosteric cGMP-binding sites of PDE5 could regulate cGMP signaling by sequestering cGMP from cGMP-dependent protein kinase and perhaps from the PDE5 catalytic site as well. The cGMP sequestered by binding of cGMP to PDE5 R domain significantly dampens activation of cGMP-dependent protein kinase and hydrolysis of cGMP by PDE5 C domain
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?
3',5'-cGMP + H2O
5'-GMP
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activity with 3',5'-cAMP is higher than with 3',5'-cGMP, PDE6
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?
3',5'-cGMP + H2O
5'-GMP
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PDE5 and PDE6 show specificity for cGMP relative to cAMP
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?
3',5'-cGMP + H2O
5'-GMP
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activity with 3',5'-cAMP is higher than with 3',5'-cGMP, PDE6
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?
3',5'-cGMP + H2O
5'-GMP
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?
3',5'-cGMP + H2O
5'-GMP
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?
3',5'-cGMP + H2O
5'-GMP
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?
3',5'-cGMP + H2O
5'-GMP
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specific for 3',5'-cGMP
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?
3',5'-cGMP + H2O
5'-GMP
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-
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?
3',5'-cGMP + H2O
5'-GMP
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-
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?
3',5'-cGMP + H2O
5'-GMP
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-
667547, 691533, 691945, 692724, 693333, 694879, 710776, 711409, 711619, 711841, 711934, 711948, 712091, 713068, 750045 -
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?
3',5'-cGMP + H2O
5'-GMP
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-
-
?
3',5'-cGMP + H2O
5'-GMP
-
PDE5A1
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?
3',5'-cGMP + H2O
5'-GMP
-
selective for 3',5'-cGMP, PDE9
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?
3',5'-cGMP + H2O
5'-GMP
-
specific for 3',5'-cGMP
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?
3',5'-cGMP + H2O
5'-GMP
PDE5 hydrolyses selectively 3',5'-cGMP with high affinity
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?
3',5'-cGMP + H2O
5'-GMP
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PDE5 is cGMP-specific
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?
3',5'-cGMP + H2O
5'-GMP
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PDE6 shows specificity for cGMP relative to cAMP
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?
3',5'-cGMP + H2O
5'-GMP
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-
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?
3',5'-cGMP + H2O
5'-GMP
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-
-
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?
3',5'-cGMP + H2O
5'-GMP
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-
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?
3',5'-cGMP + H2O
5'-GMP
specific for 3',5'-cGMP
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?
3',5'-cGMP + H2O
5'-GMP
-
PDE5 is specific for cGMP
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?
3',5'-cGMP + H2O
5'-GMP
PDE5A has a higher selectivity for cGMP due to much lower cAMP binding affinity
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?
3',5'-cGMP + H2O
5'-GMP
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-
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?
3',5'-cGMP + H2O
5'-GMP
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-
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?
3',5'-cGMP + H2O
5'-GMP
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-
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?
3',5'-cGMP + H2O
5'-GMP
Q2V2M6
specific for 3',5'-cGMP
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?
3',5'-cGMP + H2O
5'-GMP
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-
135314, 135340, 691558, 694285, 711626, 711687, 711772, 711773, 711829, 711920, 711923, 712621, 712815, 713199, 750479 -
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?
3',5'-cGMP + H2O
5'-GMP
PDE5 specifically targets 3',5'-cyclic GMP
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?
3',5'-cGMP + H2O
5'-GMP
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-
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?
3',5'-cGMP + H2O
5'-GMP
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-
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?
3',5'-cGMP + H2O
5'-GMP
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suPDE5 regulates cGMP levels in sperm, which in turn modulate sperm motility
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?
3',5'-cGMP + H2O
5'-GMP
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specific for 3',5'-cGMP, no activity with 3',5'-cAMP
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?
3',5'-cGMP + H2O
5'-GMP
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-
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?
3',5'-cGMP + H2O
guanosine 5'-phosphate
-
PDE5
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?
3',5'-cGMP + H2O
guanosine 5'-phosphate
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phosphodiesterase 5 converts the second messenger 3',5'-cGMP to its inactive form
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?
cGMP + H2O
5'-GMP
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degradation of intracellular cGMP
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?
cGMP + H2O
5'-GMP
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?
cGMP + H2O
5'-GMP
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-
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?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
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-
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?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
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-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
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-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
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-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
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-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
very low activity with cAMP
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?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
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-
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?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
-
-
-
-
?
additional information
?
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preincubation with cGMP increases catalytic activity for cGMP degradation, thus elevated cellular cGMP initiates a physiological negative feedback on the cGMP pathway by increasing the affinity of the PDE5 catalytic site for cGMP
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?
additional information
?
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tadalafil is not degraded by PDE5
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?
additional information
?
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analysis of diverse complxes formed by subunits Pgamma with GTP or GDP and outer segments, the complexes are extracted from membranes and isolated. Analysis of the function of the single complexes in PDE regulation, overview
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?
additional information
?
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interaction between the PDE6 gamma subunit with tubulin alpha and beta, specificity and mechanism, detailed overview
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?
additional information
?
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prenylation of the enzyme is required for plasma-membrane targeting
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?
additional information
?
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Drosophila sp. (in: flies)
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role for cG-PDE in modulating cGMP transport and efflux
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?
additional information
?
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PDE6 contains two regulatory GAF domains, of which one (GAF A) binds cGMP and regulates the activity of the PDE6 holoenzyme
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?
additional information
?
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PDE6 contains two regulatory GAF domains, of which one (GAF A) binds cGMP and regulates the activity of the PDE6 holoenzyme
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?
additional information
?
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human chorionic gonadotropin reduces PDE5 expression and enzyme activity in smooth muscle cells, possibly through a pathway involving cAMP
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?
additional information
?
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PDE5 gene expression and activity are androgen-dependent in vas deferens
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?
additional information
?
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PDE5 may be involved in the cyclic nucleotide-mediated control of smooth muscle tone
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?
additional information
?
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PDE5 regulation of cGMP intracellular levels is not involved in the control of progression of smooth muscle cell cycle, but may represent one of the markers of the contractile phenotype
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?
additional information
?
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isoform PDE5 regulation of cGMP intracellular levels is not involved in the control of smooth muscle cell cycle progression, but may represent one of the markers of the contractile phenotype
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?
additional information
?
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tadalafil is not degraded by PDE5
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?
additional information
?
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PDE5 in Pukinje neurons may play a role in limiting the cGMP-mediated long-term depression response
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?
additional information
?
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interaction between the PDE6 gamma subunit with tubulin alpha and beta, specificity and mechanism, detailed overview
-
-
?
additional information
?
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PDE5 gene expression and activity are androgen-dependent in vas deferens
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?
additional information
?
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in mammals the enzyme might play key roles in the aquisition and maintenance of the myoid cell contractile phenotype and more generally in the testis maturation
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?
additional information
?
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kinetics of a cellular nitric oxide/cGMP/phosphodiesterase-5 pathway
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?
additional information
?
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PDE5 controls the soluble but not the particulate pool of cGMP in rat cardiomyocytes
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?
additional information
?
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cGMP levels in the spinal cord are controlled by a number of enzyme isoforms, that can be present in the same cell. Role of NO-cGMP signaling in nociceptive processing
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?
additional information
?
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isoform PDE5 regulates bladder smooth muscle tone, strongly limiting the nitric oxide/cGMP signaling
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?