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0.0121
(-)-6-(3-(3-cyclopropyl-3-((1R,2R)-2-hydroxycyclohexyl)ureido)-propoxy)-2(1H)-quinolinone
Bos taurus
-
IC50: 0.0121 mM, PDE5
0.00067
(2Z)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one
Homo sapiens
-
IC50: 0.00067 mM, PDE5
0.053
(E)-1-(3-(cyclopentyloxy)-4-methoxyphenyl)ethanone O-carbamoyl oxime
Homo sapiens
-
-
0.019
1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium
Homo sapiens
-
-
0.000055 - 0.0001
1-(2-chlorophenyl)-6-((2R)-3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one
0.0000004
1-(2-ethoxyethyl)-3-ethyl-5-(piperazin-1-yl)-N-(pyridin-2-yl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00001
1-(3-chloro-4-methoxybenzyl)-3-(cis-4-hydroxycyclohexyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine-6-carbonitrile
Homo sapiens
-
-
0.0000037
1-[4-[(1,3-benzodioxol-5-ylmethyl)amino]-6-chloroquinazolin-2-yl]piperidine-4-carboxylic acid
Homo sapiens
-
-
0.00069
2,2',2'',2'''-[(4,8-dipiperidin-1-ylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol
Homo sapiens
-
-
0.000005
2-(2-ethoxyphenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one
Homo sapiens
-
-
0.23
2-(2-methylpyridin-4-yl)methyl-4-(3,4,5-trimethoxyphenyl)-8-(pyrimidin-2-yl)methoxy-1,2-dihydro-1-oxo-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride
Canis lupus familiaris
-
i.e. T-0156, IC50: 0.23 mM, potent and highly selective phosphodiesterase type 5 inhibitor
0.00001
2-(2-propoxyphenyl)-1,7-dihydro-6H-purin-6-one
Homo sapiens
-
-
0.0000017
2-(5-amino-2-propoxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-one
Homo sapiens
-
-
0.0000065
2-(5-[[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl]-2-propoxyphenyl)-5-methylquinazolin-4(3H)-one
Homo sapiens
-
-
0.0027
2-cyclohexyl-2-methyl-N1-[3-(2-oxo-1,2-dihydro-6-quinolyl,oxy)propyl]-1-hydrazinecarboxamide
Bos taurus
-
IC50: 0.0027 mM, PDE5
0.00001
2-methoxy-7-methyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazin-6(5H)-one
Homo sapiens
-
-
0.002
2-[1-(2,4-dichlorobenzyl)-2-methyl-5-(methylmercapto)-1H-indol-3-yl] ethanaminium chloride
Homo sapiens
-
IC50: 0.002 mM, PDE5
0.0000007
2-[2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one
Homo sapiens
-
-
0.00000022
3-(4-ethylpiperazin-1-yl)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0035
3-(cyclopentylmethoxy)-N-(2,6-dichlorophenyl)-4-methoxybenzamide
Homo sapiens
-
-
0.017
3-(cyclopropylmethoxy)-N-(2,6-dichlorophenyl)-4-(difluoromethoxy)benzamide
Homo sapiens
-
-
0.00000112
3-([2-[(2-hydroxyethyl)amino]ethyl]amino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000648
3-ethyl-5-(4-methyl-1,4-diazepan-1-yl)-N-(pyrimidin-4-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00000392
3-ethyl-5-(morpholin-4-yl)-N-(pyrimidin-4-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.0000003
3-ethyl-5-(piperazin-1-yl)-1-(2-propoxyethyl)-N-(pyridin-2-yl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00000086
3-ethyl-5-(piperazin-1-yl)-1-[2-(propan-2-yloxy)ethyl]-N-(pyridin-2-yl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00000065
3-ethyl-5-(piperazin-1-yl)-N-(pyridin-2-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00000015
3-ethyl-5-(piperazin-1-yl)-N-(pyrimidin-4-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00000007
3-ethyl-5-[(3R)-3-methylpiperazin-1-yl]-N-(pyrimidin-4-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00000009
3-ethyl-N-(4-fluorophenyl)-5-(piperazin-1-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00000328
3-ethyl-N-(4-methylpyridin-2-yl)-5-(piperazin-1-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00000101
3-ethyl-N-(6-methylpyridin-2-yl)-5-(piperazin-1-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00000035
3-ethyl-N5-(1-methylpiperidin-4-yl)-N7-(pyrimidin-4-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidine-5,7-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0000019 - 0.032
3-isobutyl-1-methylxanthine
0.00000014
3-methyl-5-[(3R)-3-methylpiperazin-1-yl]-N-(pyrimidin-4-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00000094
3-methyl-5-[(3S)-3-methylpiperazin-1-yl]-N-(pyrimidin-4-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00000184
3-methyl-N-(4-methylpyridin-2-yl)-5-(piperazin-1-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00000078
3-methyl-N-(6-methylpyridin-2-yl)-5-(piperazin-1-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00000238
3-[(1R,4R)-2,5-diazabicyclo[2.2.1]hept-2-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000025
3-[(2-aminoethyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000021
3-[4-(2,2-dihydroxypropyl)-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000072
3-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0000002
3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]-pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0000002
3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000108
3-[4-(3-hydroxypropyl)-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000018
3-[4-(3-hydroxypropyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000023
3-[4-[(2R)-2-hydroxypropyl]-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0000003
3-[4-[(2R,3R)-3-hydroxybutan-2-yl]-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000031
3-[4-[(2S)-2-hydroxypropyl]-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000033
3-[4-[(2S,3R)-3-hydroxybutan-2-yl]-1,4-diazepan-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000014
4-(1,3-benzodioxol-5-ylmethoxy)-2-(1H-imidazol-1-yl)-5-phenylpyrimidine
Homo sapiens
-
-
0.053
4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexanecarboxylic acid
Homo sapiens
-
-
0.00000296
4-[3-ethyl-7-(pyrimidin-4-ylamino)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-5-yl]piperazin-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00000315
5-(1,4-diazepan-1-yl)-3-ethyl-N-(pyrimidin-4-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00000979
5-(1,4-diazepan-1-yl)-3-methyl-N-(pyrimidin-4-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidin-7-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.081
5-(2-propoxyphenyl)-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
Homo sapiens
-
-
0.0025
6-(3-(3-cyclooctyl-3-((1R,2R)-2-hydroxycyclohexyl)ureido)-propoxy)-2(1H)-quinolinone
Bos taurus
-
IC50: 0.0025 mM, PDE5
0.00000328
7-(6-methoxypyridin-3-yl)-3-(piperazin-1-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00000034
8-(5-[[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]sulfonyl]-2-propoxyphenyl)-6-propyl-6,6a,9,9a-tetrahydro-5H-[1,2,4]triazolo[3,4-i]purin-5-one
Homo sapiens
-
-
0.0055
8-methoxymethyl-isobutylmethylxanthine
Bos taurus
-
isoform PDE5, pH and temperature not specified in the publication
0.0117
amentoflavone
Homo sapiens
-
IC50: 0.0117 mM
0.2296
amrinone
Bos taurus
-
IC50: 0.2296 mM, PDE5
0.0000011 - 0.00002
benzamidenafil
0.00152
bilobetin
Homo sapiens
-
IC50: 0.00152 mM
0.000429 - 0.0115
carboxyamidotriazole
0.0000405 - 0.0152
Cilostamide
0.0044
cilostazol
Bos taurus
-
IC50: 0.0044 mM, PDE5
0.023
dioclein
Bos taurus
-
isoform PDE5, pH and temperature not specified in the publication
0.015
diosmetin
Cavia porcellus
-
IC50: 0.015 mM, PDB5
0.0000109 - 0.023
dipyridamole
0.046
E4021
Plasmodium falciparum
Q2V2M6
IC50: 0.046 mM
0.073
genistein
Cavia porcellus
-
IC50: 0.073 mM, PDB5
0.00059
ginkgetin
Homo sapiens
-
IC50: 0.00059 mM
0.0193
luteolin
Cavia porcellus
-
IC50: 0.0193 mM, PDB5
0.0354
malvidin
Homo sapiens
-
IC50: 0.0354 mM
0.0116
malvidin-3-O-beta-glucoside
Homo sapiens
-
IC50: 0.0116 mM
0.0491
Milrinone
Bos taurus
-
IC50: 0.0491 mM, PDE5
0.0000026
N-(3-chloro-4-methoxybenzyl)-2-pyridin-4-yl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-amine
Homo sapiens
-
-
0.000003
N-[3-(1,3-dimethyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxyphenyl]methanesulfonamide
Homo sapiens
-
-
0.0000035
N-[3-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-4-propoxyphenyl]piperidine-1-carboxamide
Homo sapiens
-
-
0.000018
N-[3-(4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-2-yl)-4-propoxyphenyl]morpholine-4-carboxamide
Homo sapiens
-
-
0.00000952
N5-(2-aminoethyl)-3-ethyl-N7-(pyrimidin-4-yl)-1-[2-(2,2,2-trifluoroethoxy)ethyl]-1H-pyrazolo[4,3-d]pyrimidine-5,7-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0137
quercetin-3,5,7,3',4'-O-pentamethylether
Cavia porcellus
-
PDE5
0.0111
quercetin-3-O-methyl-5,7,3',4'-O-tetraacetate
Cavia porcellus
-
PDE5
0.0869
quercetin-3-O-methylether
Cavia porcellus
-
PDE5
0.000021
quinazolinamine
Homo sapiens
-
IC50: 0.000021 mM, PDE5
0.0089
RP-73401
Homo sapiens
-
IC50: 0.0089 mM, PDE5
0.00324
sciadopitysin
Homo sapiens
-
IC50: 0.00324 mM
0.0199
sequoiaflavone
Homo sapiens
-
IC50: 0.0199 mM
0.0000013 - 0.056
sildenafil
0.041
T-1032
Strongylocentrotus purpuratus
-
IC50: 0.041 mM
0.0000018 - 0.01
tadalafil
0.0000004
trans-4-([2-[(3-chloro-4-methoxyphenyl)carbamoyl]-4-cyanophenyl]carbamoyl)cyclohexanecarboxylic acid
Homo sapiens
-
-
0.00000006 - 0.00337
vardenafil
0.0000088 - 0.24
zaprinast
0.000055
1-(2-chlorophenyl)-6-((2R)-3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one
Homo sapiens
-
i.e. BAY 73-6691, IC50: 55 nM
0.0001
1-(2-chlorophenyl)-6-((2R)-3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one
Mus musculus
i.e. BAY 73-6691, IC50: 100 nM
0.0000019
3-isobutyl-1-methylxanthine
Homo sapiens
mutant Y612F, pH 7.5, 30°C
0.000003
3-isobutyl-1-methylxanthine
Homo sapiens
mutant L765A, pH 7.5, 30°C
0.0000035
3-isobutyl-1-methylxanthine
Homo sapiens
wild-type, pH 7.5, 30°C
0.0000423
3-isobutyl-1-methylxanthine
Homo sapiens
mutant H613A, pH 7.5, 30°C
0.0000425
3-isobutyl-1-methylxanthine
Homo sapiens
mutant V782A, pH 7.5, 30°C
0.0000433
3-isobutyl-1-methylxanthine
Homo sapiens
mutant F786A, pH 7.5, 30°C
0.000152
3-isobutyl-1-methylxanthine
Homo sapiens
mutant Y612A, pH 7.5, 30°C
0.000214
3-isobutyl-1-methylxanthine
Homo sapiens
mutant Q817A, pH 7.5, 30°C
0.000327
3-isobutyl-1-methylxanthine
Homo sapiens
mutant F820A, pH 7.5, 30°C
0.032
3-isobutyl-1-methylxanthine
Strongylocentrotus purpuratus
-
IC50: 0.032 mM
0.0000011
benzamidenafil
Homo sapiens
-
PDE-5, pH and temperature not specified in the publication
0.00002
benzamidenafil
Homo sapiens
-
PDE-6, pH and temperature not specified in the publication
0.000429
carboxyamidotriazole
Mus musculus
-
enzyme from lung, at pH 8.0 and 30°C
0.00267
carboxyamidotriazole
Mus musculus
-
enzyme from peritoneal macrophage, at pH 8.0 and 30°C
0.00475
carboxyamidotriazole
Rattus norvegicus
-
enzyme from brain, at pH 8.0 and 30°C
0.00705
carboxyamidotriazole
Mus musculus
-
enzyme from RAW264.7 cells, at pH 8.0 and 30°C
0.00898
carboxyamidotriazole
Mus musculus
-
enzyme from Lewis lung carcinoma cells, at pH 8.0 and 30°C
0.0115
carboxyamidotriazole
Mus musculus
-
enzyme from L1210 cells, at pH 8.0 and 30°C
0.0000405
Cilostamide
Homo sapiens
-
bladder homogenate, 30°C, pH 7.0
0.006
Cilostamide
Homo sapiens
-
IC50: 0.006 mM, PDE5
0.0152
Cilostamide
Bos taurus
-
IC50: 0.0152 mM, PDE5
0.0000109
dipyridamole
Homo sapiens
-
bladder homogenate, 30°C, pH 7.0
0.00026
dipyridamole
Bos taurus
-
IC50: 0.00026 mM, PDE5
0.022
dipyridamole
Plasmodium falciparum
Q2V2M6
IC50: 0.022 mM
0.023
dipyridamole
Strongylocentrotus purpuratus
-
IC50: 0.023 mM
0.0000013
sildenafil
Homo sapiens
mutant Y612F, pH 7.5, 30°C
0.0000016
sildenafil
Homo sapiens
-
non-activated PDE5 from blood platelets, at 0.0001 mM cGMP, at pH 7.5 and 30°C
0.00000193
sildenafil
Mus musculus
-
enzyme from lung, at pH 8.0 and 30°C
0.000002
sildenafil
Bos taurus
-
isoform PDE5, pH and temperature not specified in the publication
0.0000032
sildenafil
Homo sapiens
-
bladder homogenate, 30°C, pH 7.0
0.0000033
sildenafil
Homo sapiens
wild-type, pH 7.5, 30°C
0.0000036
sildenafil
Canis lupus familiaris
-
IC50: 3.6 nM
0.0000037
sildenafil
Bos taurus
-
IC50: 3.7 nM
0.0000037
sildenafil
Homo sapiens
-
IC50: 3.7 nM, 1000fold selectivity for PDE5A1 compared to PDE11A4. This drug (PDE5 inhibitor in treatment of erectile dysfunction) is very unlikely to crossreact with PDE11A4 in patients taking the prescribed dosage of this medication
0.0000043
sildenafil
Homo sapiens
-
PDE-5, pH and temperature not specified in the publication
0.000005
sildenafil
Homo sapiens
-
cGMP-activated PDE5 from blood platelets, at 0.0001 mM cGMP, at pH 7.5 and 30°C
0.0000078
sildenafil
Oryctolagus cuniculus
-
IC50: 7.8 nM
0.0000085
sildenafil
Homo sapiens
-
IC50: 8.5 nM, PDE5
0.0000101
sildenafil
Homo sapiens
mutant L765A, pH 7.5, 30°C
0.0000132
sildenafil
Homo sapiens
mutant H613A, pH 7.5, 30°C
0.000015
sildenafil
Homo sapiens
-
PDE-6, pH and temperature not specified in the publication
0.0000206
sildenafil
Homo sapiens
mutant F786A, pH 7.5, 30°C
0.000025
sildenafil
Drosophila melanogaster
-
IC50: 0.000025 mM
0.0000319
sildenafil
Homo sapiens
mutant V782A, pH 7.5, 30°C
0.000049
sildenafil
Bos taurus
-
IC50: 49 nM, PDE6
0.0000983
sildenafil
Homo sapiens
mutant Y612A, pH 7.5, 30°C
0.000141
sildenafil
Homo sapiens
mutant Q817A, pH 7.5, 30°C
0.000235
sildenafil
Homo sapiens
mutant F820A, pH 7.5, 30°C
0.00127
sildenafil
Mus musculus
-
enzyme from Lewis lung carcinoma cells, at pH 8.0 and 30°C
0.00185
sildenafil
Rattus norvegicus
-
enzyme from brain, at pH 8.0 and 30°C
0.00301
sildenafil
Mus musculus
-
enzyme from L1210 cells, at pH 8.0 and 30°C
0.00332
sildenafil
Mus musculus
-
enzyme from RAW264.7 cells, at pH 8.0 and 30°C
0.00436
sildenafil
Mus musculus
-
enzyme from peritoneal macrophage, at pH 8.0 and 30°C
0.005
sildenafil
Strongylocentrotus purpuratus
-
IC50: 0.005 mM
0.01
sildenafil
Homo sapiens
-
IC50: above 10000 nM, PDE9
0.056
sildenafil
Plasmodium falciparum
Q2V2M6
IC50: 0.056 mM
0.0000018
tadalafil
Bos taurus
-
IC50: 1.8 nM
0.0000018
tadalafil
Homo sapiens
-
IC50: 1.8 nM, 40fold selectivity for PDE5A1 compared to PDE11A4. This drug (PDE5 inhibitor in treatment of erectile dysfunction) is very unlikely to crossreact with PDE11A4 in patients taking the prescribed dosage of this medication
0.0000022
tadalafil
Homo sapiens
wild-type, pH 7.5, 30°C
0.0000058
tadalafil
Homo sapiens
mutant Y612F, pH 7.5, 30°C
0.00000607
tadalafil
Homo sapiens
-
bladder homogenate, 30°C, pH 7.0
0.0000067
tadalafil
Homo sapiens
mutant V782A, pH 7.5, 30°C
0.0000091
tadalafil
Homo sapiens
mutant L765A, pH 7.5, 30°C
0.0000094
tadalafil
Homo sapiens
-
IC50: 9.4 nM, PDE5
0.0000375
tadalafil
Homo sapiens
mutant F786A, pH 7.5, 30°C
0.000081
tadalafil
Homo sapiens
mutant H613A, pH 7.5, 30°C
0.000112
tadalafil
Homo sapiens
mutant Y612A, pH 7.5, 30°C
0.00021
tadalafil
Homo sapiens
mutant Q817A, pH 7.5, 30°C
0.000301
tadalafil
Homo sapiens
mutant F820A, pH 7.5, 30°C
0.01
tadalafil
Homo sapiens
-
IC50: above 10000 nM, PDE9
0.00000006
vardenafil
Homo sapiens
mutant Y612F, pH 7.5, 30°C
0.000000091
vardenafil
Bos taurus
-
IC50: 0.091 nM
0.00000012
vardenafil
Homo sapiens
wild-type, pH 7.5, 30°C
0.0000003
vardenafil
Homo sapiens
-
bladder homogenate, 30°C, pH 7.0
0.00000049
vardenafil
Homo sapiens
mutant L765A, pH 7.5, 30°C
0.00000078
vardenafil
Homo sapiens
mutant H613A, pH 7.5, 30°C
0.00000083
vardenafil
Homo sapiens
mutant F786A, pH 7.5, 30°C
0.00000089
vardenafil
Homo sapiens
-
IC50: 0.89 nM, PDE5
0.000011
vardenafil
Bos taurus
-
IC50: 11 nM, PDE6
0.0000147
vardenafil
Homo sapiens
mutant Y612A, pH 7.5, 30°C
0.0000275
vardenafil
Homo sapiens
mutant V782A, pH 7.5, 30°C
0.0000537
vardenafil
Homo sapiens
mutant F820A, pH 7.5, 30°C
0.0000613
vardenafil
Homo sapiens
mutant Q817A, pH 7.5, 30°C
0.000091
vardenafil
Homo sapiens
-
IC50: 0.091 nM, 9300fold selectivity for PDE5A1 compared to PDE11A4. This drug (PDE5 inhibitor in treatment of erectile dysfunction) is very unlikely to crossreact with PDE11A4 in patients taking the prescribed dosage of this medication
0.00337
vardenafil
Homo sapiens
-
IC50: 3370 nM, PDE9
0.0000088
zaprinast
Homo sapiens
-
bladder homogenate, 30°C, pH 7.0
0.00013
zaprinast
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00065
zaprinast
Drosophila melanogaster
-
IC50: 0.00065 mM
0.0023
zaprinast
Cavia porcellus
-
PDE5
0.0038
zaprinast
Plasmodium falciparum
Q2V2M6
IC50: 0.0038 mM for wild-type enzyme and 0.0056 for mutant enzyme G788A
0.24
zaprinast
Strongylocentrotus purpuratus
-
IC50: 0.24 mM