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3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase

This is an abbreviated version!
For detailed information about 3',5'-cyclic-GMP phosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.35

Reaction

guanosine 3',5'-cyclic phosphate
+
H2O
=
GMP

Synonyms

3',5'-cyclic GMP phosphodiesterase, 3',5'-cyclic guanosine monophosphate-specific phosphodiesterase, 3',5'-cyclic nucleotide phosphodiesterase 5, cd-PDE5, cG-PDE, cGMP 3',5'-cyclic phosphodiesterase subunit delta, cGMP binding phosphodiesterase, cGMP phosphodiesterase, cGMP phosphodiesterase 5, cGMP phosphodiesterase 6, cGMP phosphodiesterase 6alpha' subunit, cGMP phosphodiesterase6, cGMP-binding cGMP specific phosphodiesterase, cGMP-binding cGMP-specific PDE, cGMP-binding cGMP-specific phosphodiesterase, cGMP-PDE, cGMP-phosphodiesterase, cGMP-phosphodiesterase-5, cGMP-selective phosphodiesterase, cGMP-specific cGMP-binding phosphodiesterase, cGMP-specific PDE, cGMP-specific PDE5, cGMP-specific PDE5A1, cGMP-specific phosphodiesterase, cGMP-specific phosphodiesterase 5, cGMP-specific phosphodiesterase type 9, cGMP-specific phosphodiesterase-5, cGMP-stimulated phosphodiesterase, cyclic 3',5'-GMP phosphodiesterase, cyclic GMP hydrolyzing phosphodiesterase 5, cyclic GMP phosphodiesterase, cyclic GMP-phosphodiesterase, cyclic guanosine 3',5'-monophosphate phosphodiesterase, cyclic guanosine 3',5'-phosphate phosphodiesterase, cyclic guanosine monophosphate phosphodiesterase, cyclic guanosine monophosphate-specific phosphodiesterase 5, cyclic-GMP phosphodiesterase, DdPDE3, DmPDE6, Drosophila PDE6-like enzyme, GbpA, gigh-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, GMP-PDE, guanosine 3',5'-cyclicmonophosphate-specific PDE, guanosine cyclic 3',5'-phosphate phosphodiesterase, PDB5, PDE, PDE-5, PDE-6, PDE4, PDE5, PDE5/6, PDE5/PDE6cd, PDE5A, PDE5A1, PDE6, PDE6AB, PDE6alpha, PDE6alpha', PDE6B, PDE6beta, PDE6C, PDE6D, PDE6gamma, PDE6R, PDE9, PDE9A, PDE9A1, PdeD, PDEdelta, PDEgamma, PfPDE1, phospho-diesterase-5, phosphodiesterase, phosphodiesterase 5, phosphodiesterase 5 (cGMP-specific), phosphodiesterase 6C, phosphodiesterase 9, phosphodiesterase cGMP, phosphodiesterase isoenzyme 5, phosphodiesterase subtype 5, phosphodiesterase type 5, phosphodiesterase type-5, phosphodiesterase, guanosine cyclic 3',5'-phosphate, phosphodiesterase-5, phosphodiesterase-6, PrBP/delta, suPDE5, type 5 phosphodiesterase, type 9 cGMP-specific phosphodiesterase, type-5 phosphodiesterase, xGMP-specific PDE

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.35 3',5'-cyclic-GMP phosphodiesterase

Organism

Organism on EC 3.1.4.35 - 3',5'-cyclic-GMP phosphodiesterase

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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
silkworm
-
-
Manually annotated by BRENDA team
PDE6
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strains AX3 and DH1
-
-
Manually annotated by BRENDA team
Drosophila sp. (in: flies)
generation of transgenic animals with targeted expression of DmPDE6 to tubule type I (principal) cells. This reveals localization of DmPDE6 primarily at the apical membranes. Overexpression of DmPDE6 results in elevated cG-PDE activity and decreased tubule cGMP content. Such targeted overexpression of DmPDE6 creates a novel phenotype that manifests itself in inhibition of the active transport and efflux of cGMP by tubules
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
no activity in Homo sapiens
functional PDE6 not detected in Y79 retinoblastoma cells. Attempts to enhance iexpression with cell culture or with introduction of virus expressing PDE6 are not successful. The results indicate that expression of a fully active stable PDE6 enzyme requires other post-transcriptional events that do not occur or are inhibited in Y79 cells
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-
Manually annotated by BRENDA team
frog
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
overview
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-
Manually annotated by BRENDA team