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Literature summary for 3.1.4.35 extracted from

  • Tsang, S.H.; Woodruff, M.L.; Chen, C.K.; Yamashita, C.Y.; Cilluffo, M.C.; Rao, A.L.; Farber, D.B.; Fain, G.L.
    GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase (2006), J. Neurosci., 26, 4472-4480.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
alpha-subunit of transducin in presence of transducin alpha-subunit-GTP, the inhibitory gamma subunit of PDE6 remains attached to the rest of the PDE6 molecule, but after conversion to transducin alpha-subunit-GDP, the PDE6 gamma subunit may dissociate from PDE6 and exchange with a cytoplasmic pool Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of enzyme gamma subunit in mouse Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information overexpression of PDE6 gamma subunit in rod photoreceptors decreases the rate of rise of the rod response at dim intensities and also produces a marked acceleration in the falling phase of the light response and more rapid recovery of sensitivity and circulating current after prolonged light exposure Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 isoform PDE6
-

Source Tissue

Source Tissue Comment Organism Textmining
retinal rod rod photoreceptor Mus musculus
-

Subunits

Subunits Comment Organism
More binding sites of catalytic subunits alpha and beta of PDE6 are accessible to excess inhibitory subunit gamma in the light, once endogenous gamma subunit has been displaced from its binding site by transducin alpha-subunit-GTP Mus musculus