Information on EC 2.7.13.3 - histidine kinase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY
2.7.13.3
protein-histidine kinases without information on stereospecificity towards histidine
RECOMMENDED NAME
GeneOntology No.
histidine kinase
-
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
phospho-group transfer
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein-L-histidine N-phosphotransferase
This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). A number of histones can act as acceptor.
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
adaptive-response sensory-kinase A
-
-
aerobic respiration control sensor protein arcB
-
aerobic respiration control sensor protein arcB
-
aerobic respiration control sensor protein arcB
Q8FD66
-
aerobic respiration control sensor protein arcB
Q8FD66
-
-
aerobic respiration control sensor protein arcB homolog
-
aerobic respiration control sensor/response regulatory protein
-
-
alginate biosynthesis sensor protein KINB
-
alkaline phosphatase synthesis sensor protein phoR
-
alkaline phosphatase synthesis sensor protein phoR
-
alkaline phosphatase synthesis sensor protein phoR
-
alrO117
-
-
AtoS-AtoC two-component signal transduction system
-
-
autolysin sensor kinase
-
BA2291
Q81QX4
-
BA2291
Bacillus anthracis 34F2DELTA118
Q81QX4
-
-
bacteriophytochrome
-
bacteriophytochrome (phytochrome-like protein)
-
BarA protein
-
BarA sensor kinase (sensory histidine kinase)
-
BOS1
Botrytis cinerea UWS111
-
-
-
C4-dicarboxylate transport sensor protein dctB
-
C4-dicarboxylate transport sensor protein dctB
-
C4-dicarboxylate transport sensor protein dctS
-
chemotaxis histidine kinase
-
-
chemotaxis protein
-
chemotaxis protein cheA
-
chemotaxis protein cheA
-
chemotaxis protein cheA
-
chemotaxis protein cheA
Q8FGP1
-
chemotaxis protein cheA
Q8FGP1
-
-
chemotaxis protein cheA
-
chemotaxis protein cheA
-
chemotaxis protein cheA
-
chemotaxis protein cheA
-
chemotaxis protein cheA
-
chemotaxis protein cheA
-
chemotaxis protein CheA (sensory transducer kinase)
-
-
chemotaxis-specific histidine autokinase CheA
-
Chk1p
Candida albicans REP36-1
-
-
-
CitAP
recombinant sensory domain of CitA
class III HK
-
-
class III HK
Botrytis cinerea UWS111
-
-
-
cyanobacterial phytochrome A
-
cyanobacterial phytochrome B
-
cytokinin-independent1
-
-
DctB
Vibrio cholerae MO45
-
-
-
drug sensory protein A
-
ethanolamine two-component sensor kinase
-
ethylene receptor
-
ethylene receptor (CS-ETR1)
-
ethylene receptor (MEETR1) (Cm-ETR1)
-
ethylene receptor (PE-ETR1)
-
ethylene receptor 1 (LeETR1)
-
ethylene receptor 2 (LeETR2)
-
ethylene receptor 2 (PhETR2)
-
ethylene receptor12 (PhETR2)
-
ethylene resistant 1
-
the carboxyl-terminal part of ethylene resistant 1 consists of a histidine kinase domain and a response regulator domain
ETR1 ethylene receptor
-
-
FrzE
-
hybrid protein consisting of a CheA histidine kinase and a CheY receiver domain
gliding motility regulatory protein
-
group III two-component histidine kinase
-
heme-nitric oxide oxygen binding proteins-associated histidine kinase
-
-
high-affinity potassium transport system
-
His kinase
-
-
HISTIDIN kinase (histidine protein kinase PlnB, sensor protein)
-
HISTIDIN kinase (histidine protein kinase PlnB, sensor protein)
Lactobacillus plantarum C11
-
-
histidine autokinase CheA
-
histidine kinase
-
-
histidine kinase
Botrytis cinerea UWS111
-
-
-
histidine kinase
-
-
histidine kinase
-
histidine kinase
Brucella abortus XDB1104
-
-
histidine kinase
-
-
histidine kinase
-
-
histidine kinase
-
;
-
histidine kinase
-
-
histidine kinase
Pseudomonas syringae DC3000
-
-
-
histidine kinase
-
-
histidine kinase
-
histidine kinase BA1351
-
-
histidine kinase BA1356
-
-
histidine kinase BA1478
-
-
histidine kinase BA2291
-
-
histidine kinase BA2636
-
-
histidine kinase BA2644
-
-
histidine kinase BA3702
-
-
histidine kinase BA4223
-
-
histidine kinase BA5029
-
-
histidine kinase CikA
-
-
histidine kinase CKI1
-
-
histidine kinase DivJ
-
-
histidine kinase EnvZ
-
-
histidine kinase Hik10
-
-
histidine kinase Hik16
-
-
histidine kinase Hik33
-
-
histidine kinase Hik34
-
-
histidine kinase Hik41
-
-
histidine kinase PilS
-
-
histidine kinase PleC
-
-
histidine kinase Ppr
-
-
histidine kinase SasA
-
-
histidine kinase2
-
-
histidine kinase3
-
-
histidine protein kinase
-
-
histidine protein kinase
-
-
histidine protein kinase
-
histidine protein kinase
-
-
histidine protein kinase
Xanthomonas oryzae pv. oryzae PXO99
-
-
-
histidine protein kinase KinB
-
histidine protein kinase, sensor protein
-
-
histidine sensor kinase
-
HK cytokinin-independent1
-
-
hybrid histidine kinase
-
-
iron-sensing histidine kinase
-
-
iron-sensing histidine kinase
Streptomyces reticuli Tue54
-
;
-
KINA
Bacillus subtilis 168
-
-
-
KINA
Bacillus subtilis 1A40
-
-
light sensor histidine kinase
-
-
limited host range virA protein(LHR virA)
-
multidomain membrane sensor kinase
-
Ni2+-sensing histidine kinase NrsS
-
-
NikA
Aspergillus nidulans BPU1
-
-
-
nisin biosynthesis sensor protein nisK
-
nitrate-nitrite sensor protein
-
nitrate-responsive histidine kinase
-
nitrate/nitrite sensor protein
-
nitrate/nitrite sensor protein narQ
-
nitrate/nitrite sensor protein narQ
Q8FF85
-
nitrate/nitrite sensor protein narQ
Q8FF85
-
-
nitrate/nitrite sensor protein narQ
-
nitrate/nitrite sensor protein narX
-
-
nitrate/nitrite sensor protein narX
Q8FHZ2
-
nitrate/nitrite sensor protein narX
Q8FHZ2
-
-
nitrogen regulation protein NR(II)
Q8FBG6
-
nitrogen regulation protein NR(II)
Q8FBG6
-
-
nitrogen regulation protein NR(II)
-
nitrogen regulation protein ntrB
-
nitrogen regulation protein ntrB
-
nitrogen regulation protein ntrB
-
-
nitrogen regulation protein ntrB
-
nitrogen regulation protein ntrB
-
nitrogen regulation protein ntrB
-
nitrogen regulation protein ntrB
-
nitrogen regulation protein ntrB
-
nitrogen regulation protein ntrB
-
nitrogen regulation protein ntrY
-
nitrogen regulation protein ntrY
-
nitrogen regulation protein ntrY homolog
-
nodulation protein V
Bradyrhizobium japonicum USDA110
-
-
NreB
Staphylococcus carnosus M1
-
-
-
ornithine decarboxylase antizyme
-
osmolarity sensor protein (protein histidine)
-
-
osmolarity sensor protein envZ
-
osmolarity sensor protein envZ
Q8FCU0
-
osmolarity sensor protein envZ
Q8FCU0
-
-
osmolarity two-component system protein SLN1
-
osmosensor group III histidine kinase
-
PdhS
Brucella abortus XDB1104
-
-
phosphate regulon sensor protein phoR
-
phosphate regulon sensor protein phoR
-
phosphate regulon sensor protein phoR
-
phosphate regulon sensor protein phoR
Q8FKD0
-
phosphate regulon sensor protein phoR
Q8FKD0
-
-
phosphate regulon sensor protein phoR
-
phosphate regulon sensor protein phoR
-
phosphate regulon sensor protein phoR
-
phosphate regulon sensor protein phoR
-
phosphate regulon sensor protein phoR
-
-
phosphate-sensing histidine kinase SphS
-
-
phosphoglycerate transport system sensor protein pgtB
-
photoactive yellow protein phytochrome-related protein
-
-
phytochrome A
-
-
phytochrome-like protein cph1 (light-regulated histidine)
-
PleC-DivJ homolog sensor
-
PleC-DivJ homolog sensor
Brucella abortus XDB1104
-
-
PleCHKD
the PleC kinase domain has histidine kinase activity
positive and negative sensor protein for pho regulon
-
-
PYP phytochrome-related protein
-
-
RaxH
Xanthomonas oryzae pv. oryzae PXO99
-
-
-
receptor histidine kinase
-
-
SaeS
Staphylococcus aureus Newman
-
-
secretion system regulator:sensor component
-
SenS
Streptomyces reticuli Tue54
-
;
-
sensor histidine kinase
-
sensor histidine kinase
Q81QX4
-
sensor histidine kinase
Bacillus anthracis 34F2DELTA118
Q81QX4
-
-
sensor histidine kinase
-
-
sensor histidine kinase
-
sensor histidine kinase
-
-
sensor histidine kinase
-
sensor histidine kinase
-
-
sensor histidine kinase
two-component system formed by sensor histidine kinase and a response regulator
sensor histidine kinase
-
sensor histidine kinase
Staphylococcus aureus Newman
-
-
sensor histidine kinase A
-
-
sensor histidine kinase A
Bacillus subtilis 168
-
-
-
sensor histidine kinase mtrB
-
sensor histidine kinase mtrB
-
sensor histidine kinase mtrB
;
-
sensor histidine kinase regB (PrrB protein)
-
sensor kinase cusS
-
sensor kinase cusS
-
-
sensor kinase dpiB
-
sensor kinase dpiB
Q8FJZ9
-
sensor kinase dpiB
Q8FJZ9
-
-
sensor kinase dpiB (sensor kinase citA)
-
sensor protein afsQ2
-
sensor protein atoS
-
sensor protein atoS
Q8FFP8
-
sensor protein atoS
Q8FFP8
-
-
sensor protein baeS
-
sensor protein baeS
Q8FG01
-
sensor protein baeS
Q8FG01
-
-
sensor protein basS/pmrB
-
sensor protein basS/pmrB
Q8FAU6
-
sensor protein basS/pmrB
Q8FAU6
-
-
sensor protein chvG
Agrobacterium tumefaciens C58
-
-
sensor protein chvG
-
sensor protein chvG (histidine kinase sensory protein)
-
sensor protein citS
-
sensor protein copS
-
sensor protein creC
Q8FA38
-
sensor protein creC
Q8FA38
-
-
sensor protein czcS
-
sensor protein dcuA
-
sensor protein dcuS
-
sensor protein dcuS
-
-
sensor protein dcuS
-
sensor protein degS
-
sensor protein degS
-
sensor protein evgS precursor
-
sensor protein evgS precursor
Q8CVU5
-
sensor protein evgS precursor
Q8CVU5
-
-
sensor protein for basR
-
-
sensor protein gacS
-
sensor protein irlS
-
sensor protein irlS
-
-
sensor protein kdpD
Q8FJV6
-
sensor protein kdpD
Q8FJV6
-
-
sensor protein kdpD
-
sensor protein kdpD
-
-
sensor protein kinase (sensor protein PhoQ)
-
-
sensor protein luxN
-
sensor protein luxQ
-
sensor protein narQ homolog
-
sensor protein phoQ
-
sensor protein phoQ
-
sensor protein phoQ
-
sensor protein phoQ
-
-
sensor protein qseC
-
sensor protein qseC
Q8FDJ7
-
sensor protein qseC
-
sensor protein qseC
Q8FDJ7
-
-
sensor protein rcsC
Q8FFP9
-
sensor protein rcsC
Q8FFP9
-
-
sensor protein rcsC (capsular synthesis regulator)
-
-
sensor protein rcsC (capsular synthesis regulator)
-
sensor protein rcsC (capsular synthesis regulator)
Escherichia coli O9:K30:H12
-
-
-
sensor protein rcsC (capsular synthesis regulator)
-
sensor protein rcsC (capsular synthesis regulator)
-
sensor protein resE
-
sensor protein roxS
-
sensor protein rprX
-
sensor protein rstB
Q8FHA9
-
sensor protein rstB
Q8FHA9
-
-
sensor protein sphS
-
sensor protein torS
-
sensor protein torS
Q8FJ55
-
sensor protein torS
Q8FJ55
-
-
sensor protein uhpB
-
sensor protein uhpB
Q8FBX4
-
sensor protein uhpB
Q8FBX4
-
-
sensor protein vanS (vancomycin resistance protein vanS)
-
sensor protein vanSB (vancomycin B-type resistance)
-
sensor protein zraS
-
sensor protein zraS
Q8FB70
-
sensor protein zraS
-
sensor protein zraS
Q8FB70
-
-
sensor protein zraS
-
sensor with histidine kinase
-
-
sensor with histidine kinase
Aspergillus nidulans ABPU1
-
-
-
sensor-like histidine kinase senX3
-
sensor-like histidine kinase senX3
-
sensor-like histidine kinase senX3
-
sensor-like histidine kinase senX3
;
-
sensory histidine kinase
-
-
sensory histidine kinase
-
-
sensory histidine kinase
-
-
sensory histidine kinase
-
-
sensory histidine kinase in two-component regulatory system with ArcA
-
sensory histidine kinase in two-component regulatory system with DcuR, senses fumarate/C4-dicarboxylate
-
sensory histidine kinase in two-component regulatory system with NarP
-
sensory HK
-
-
sensory kinase (alternative) in two-component regulatory system with CreB (or alternatively PhoB), senses catabolite repression
-
sensory kinase in multi-component regulatory system with TorR
-
sensory kinase in two-component regulatory system with CpxR, senses misfolded proteins in bacterial envelope
-
sensory kinase in two-component regulatory system with PhoB, regulates pho regulon
-
sensory kinase in two-component regulatory system wtih KdpE, regulates kdp operon
-
sensory transduction histidine kinase
-
sensory transduction protein kinase
-
sensory transduction protein kinase
-
sensory transduction protein kinase
-
sensory transduction protein kinase
-
sensory/regulatory protein rpfC
-
signal transduction histidine kinase
-
-
Slr1759
-
Slr1759 is a multidomain hybrid histidine kinase
sporulation histidine kinase
-
-
sporulation kinase A (stage II sporulation protein J)
-
sporulation kinase B
-
sporulation kinase C (sensor kinase)
-
subtilin biosynthesis sensor protein spaK
-
subtilin biosynthesis sensor protein spaK
-
subtilin biosynthesis sensor protein spaK
-
tetrathionate reductase complex: sensory transduction histidine kinase
-
thermosensor histidine kinase
-
TMAO reductase S
-
TMAO reductase S
-
-
TMAO reductase S
Vibrio parahaemolyticus EB101
-
-
-
TorS
sensor histidine kinase
TorS
-
; a sensor histidine kinase
TorS
Vibrio parahaemolyticus EB101
-
; a sensor histidine kinase
-
transmembrane sensor histidine kinase transcription regulator protein
-
tricarboxylic transport: regulatory protein
-
trimethylamine-N-oxide reductase S
-
trimethylamine-N-oxide reductase S
-
-
trimethylamine-N-oxide reductase S
Vibrio parahaemolyticus EB101
-
-
-
TWO component response regulator transcription regulator protein
-
two component sensor kinase/response regulator protein RcsC
-
-
two component system histidine kinase
-
two component system histidine kinase
-
two-component regulatory protein
-
-
two-component regulatory protein sensor kinase KdpD
-
-
two-component sensor kinase czcS
-
two-component sensor kinase yesM
-
two-component sensor kinase yesM
-
two-component system sensor protein
-
-
VicK
Streptococcus pneumoniae (D39)
-
-
virulence sensor protein bvgS precursor
-
virulence sensor protein bvgS precursor
-
virulence sensor protein bvgS precursor
-
VncS, histidine kinase
-
wide host range virA protein (WHR virA)
-
wide host range virA protein (WHR virA)
-
wide host range virA protein (WHR virA)
-
wide host range virA protein (WHR virA)
Agrobacterium tumefaciens 15955
-
-
wide host range virA protein (WHR virA)
Agrobacterium tumefaciens C58
-
-
methanol utilization control sensor protein moxY
-
additional information
-
AHK5 belongs to the the canonical HK class of proteins in Arabidopsis thaliana
additional information
DcuS is a member of the periplasmic sensing histidine kinases
CAS REGISTRY NUMBER
COMMENTARY
99283-67-7
protein-histidine kinases, EC 2.7.13.1, EC 2.7.13.2, and EC 2.7.13.3 are not distinguished in Chemical Abstracts
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
histidine kinase AtBphP1; histidine kinase AtBphP2
-
-
Manually annotated by BRENDA team
strain 15955
SwissProt
Manually annotated by BRENDA team
strain C58 /ATCC 33970
SwissProt
Manually annotated by BRENDA team
strain C58 /ATCC 33970
SwissProt
Manually annotated by BRENDA team
Agrobacterium tumefaciens 15955
strain 15955
SwissProt
Manually annotated by BRENDA team
Agrobacterium tumefaciens C58
strain C58 /ATCC 33970
SwissProt
Manually annotated by BRENDA team
Agrobacterium tumefaciens C58
strain C58 /ATCC 33970
SwissProt
Manually annotated by BRENDA team
strains Abra40 and Abra363H5M
UniProt
Manually annotated by BRENDA team
19 different isolates, gene AlHK1
UniProt
Manually annotated by BRENDA team
PCC 7120
-
-
Manually annotated by BRENDA team
strain PCC 7120
SwissProt
Manually annotated by BRENDA team
; strain ABPU1
-
-
Manually annotated by BRENDA team
strain BPU1
-
-
Manually annotated by BRENDA team
Aspergillus nidulans ABPU1
strain ABPU1
-
-
Manually annotated by BRENDA team
Aspergillus nidulans BPU1
strain BPU1
-
-
Manually annotated by BRENDA team
histidine kinase BA1351; histidine kinase BA1356; histidine kinase BA1478; histidine kinase BA2291; histidine kinase BA2636; histidine kinase BA2644; histidine kinase BA3702; histidine kinase BA4223; histidine kinase BA5029
-
-
Manually annotated by BRENDA team
strain 34F2DELTA118, gene BA2291, the organism contains nine genes encoding putative sporulation histidine kinases
Q81QX4
UniProt
Manually annotated by BRENDA team
Bacillus anthracis 34F2DELTA118
strain 34F2DELTA118, gene BA2291, the organism contains nine genes encoding putative sporulation histidine kinases
Q81QX4
UniProt
Manually annotated by BRENDA team
strain 168
-
-
Manually annotated by BRENDA team
strain 1A40
SwissProt
Manually annotated by BRENDA team
wild-type strain JH642 and conditional ftsZ expression strain KP444, gene yycG
SwissProt
Manually annotated by BRENDA team
Bacillus subtilis 168
strain 168
-
-
Manually annotated by BRENDA team
Bacillus subtilis 1A40
strain 1A40
SwissProt
Manually annotated by BRENDA team
UWS111 strain
-
-
Manually annotated by BRENDA team
Botrytis cinerea UWS111
UWS111 strain
-
-
Manually annotated by BRENDA team
strain USDA110
SwissProt
Manually annotated by BRENDA team
Bradyrhizobium japonicum USDA110
strain USDA110
SwissProt
Manually annotated by BRENDA team
strain RP501 parasponia
SwissProt
Manually annotated by BRENDA team
strain RP501 parasponia
SwissProt
Manually annotated by BRENDA team
all strains derived from Brucella abortus 544 NalR, XDB1104 strain
SwissProt
Manually annotated by BRENDA team
Brucella abortus XDB1104
all strains derived from Brucella abortus 544 NalR, XDB1104 strain
SwissProt
Manually annotated by BRENDA team
strain REP36-1
-
-
Manually annotated by BRENDA team
Candida albicans REP36-1
strain REP36-1
-
-
Manually annotated by BRENDA team
histidine kinase DivJ; histidine kinase PleC
-
-
Manually annotated by BRENDA team
strain ATCC 13032
-
-
Manually annotated by BRENDA team
var. reticulatus
SwissProt
Manually annotated by BRENDA team
strain V583, a clinical isolate from humans
-
-
Manually annotated by BRENDA team
strains ATCC 29212 and ATCC 51299
-
-
Manually annotated by BRENDA team
strain O9:K30:H12
-
-
Manually annotated by BRENDA team
Enterococcus faecium BM4147
BM4147
SwissProt
Manually annotated by BRENDA team
K-12
SwissProt
Manually annotated by BRENDA team
O6
P59340, Q8CVU5, Q8FA38, Q8FAU6, Q8FB70, Q8FBG6, Q8FBX4, Q8FCU0, Q8FD66, Q8FDJ7, Q8FF85, Q8FFP8, Q8FFP9, Q8FG01, Q8FGP1, Q8FHA9, Q8FHZ2, Q8FIB8, Q8FJ55, Q8FJV6, Q8FJZ9, Q8FK37, Q8FKD0
SwissProt
Manually annotated by BRENDA team
strain K-12
SwissProt
Manually annotated by BRENDA team
strain K-12
-
-
Manually annotated by BRENDA team
strain K-12
UniProt
Manually annotated by BRENDA team
strain O157:H7
SwissProt
Manually annotated by BRENDA team
strains ATCC 25922 and ATCC 43300
-
-
Manually annotated by BRENDA team
gene dcuS
UniProt
Manually annotated by BRENDA team
O6
P59340, Q8CVU5, Q8FA38, Q8FAU6, Q8FB70, Q8FBG6, Q8FBX4, Q8FCU0, Q8FD66, Q8FDJ7, Q8FF85, Q8FFP8, Q8FFP9, Q8FG01, Q8FGP1, Q8FHA9, Q8FHZ2, Q8FIB8, Q8FJ55, Q8FJV6, Q8FJZ9, Q8FK37, Q8FKD0
SwissProt
Manually annotated by BRENDA team
Escherichia coli O9:K30:H12
strain O9:K30:H12
-
-
Manually annotated by BRENDA team
gene HP0244
UniProt
Manually annotated by BRENDA team
strain 26695
-
-
Manually annotated by BRENDA team
strain J99
-
-
Manually annotated by BRENDA team
Lactobacillus plantarum C11
strain C11
SwissProt
Manually annotated by BRENDA team
subsp. lactis
SwissProt
Manually annotated by BRENDA team
wild-type strain DZ2, gene espA
UniProt
Manually annotated by BRENDA team
var. Xanthi, histidine kinase NTHK2
Uniprot
Manually annotated by BRENDA team
strain PCC 73102
-
-
Manually annotated by BRENDA team
strain ATCC 27853
-
-
Manually annotated by BRENDA team
sensor protein, the two components are encoded by PP_0887 (roxS, sensor protein) and PP_0888 (roxR, response regulator) which are transcribed in a single unit.; strain KT2440
UniProt
Manually annotated by BRENDA team
strain KT2440
UniProt
Manually annotated by BRENDA team
pv. syringae
SwissProt
Manually annotated by BRENDA team
strain DC3000
-
-
Manually annotated by BRENDA team
Pseudomonas syringae DC3000
strain DC3000
-
-
Manually annotated by BRENDA team
biovar phaseoli
SwissProt
Manually annotated by BRENDA team
strain ATCC 29213
-
-
Manually annotated by BRENDA team
strain Newman
UniProt
Manually annotated by BRENDA team
Staphylococcus aureus Newman
strain Newman
UniProt
Manually annotated by BRENDA team
Staphylococcus carnosus M1
strain M1
-
-
Manually annotated by BRENDA team
strain (D39) ATCC 7466
UniProt
Manually annotated by BRENDA team
strain ATCC BAA-255/R6
SwissProt
Manually annotated by BRENDA team
Streptococcus pneumoniae (D39)
strain (D39) ATCC 7466
UniProt
Manually annotated by BRENDA team
strain A3(2) (ATCC BAA471D)
-
-
Manually annotated by BRENDA team
strain A3(2) (ATCC BAA471D)
-
-
Manually annotated by BRENDA team
strain Tue54, gene senS
-
-
Manually annotated by BRENDA team
strain Tue54; strain Tue54, gene senS
-
-
Manually annotated by BRENDA team
Streptomyces reticuli Tue54
strain Tue54, gene senS
-
-
Manually annotated by BRENDA team
Streptomyces reticuli Tue54
strain Tue54; strain Tue54, gene senS
-
-
Manually annotated by BRENDA team
PCC 7942, histidine kinase CikA
-
-
Manually annotated by BRENDA team
strain PCC 7942
SwissProt
Manually annotated by BRENDA team
PCC 6803
-
-
Manually annotated by BRENDA team
PCC 6803, histidine kinase Hik34
-
-
Manually annotated by BRENDA team
PCC6803, histidine kinase Hik10; PCC6803, histidine kinase Hik16; PCC6803, histidine kinase Hik33; PCC6803, histidine kinase Hik34; PCC6803, histidine kinase Hik41
-
-
Manually annotated by BRENDA team
strain PCC 6803
SwissProt
Manually annotated by BRENDA team
strain PCC 6803
SwissProt
Manually annotated by BRENDA team
strain PCC 6803, histidine kinase Hik16; strain PCC 6803, histidine kinase Hik34; strain PCC 6803, histidine kinase Hik41
-
-
Manually annotated by BRENDA team
strain MO45, gene dctB
-
-
Manually annotated by BRENDA team
Vibrio cholerae MO45
strain MO45, gene dctB
-
-
Manually annotated by BRENDA team
; strain EB101
-
-
Manually annotated by BRENDA team
Vibrio parahaemolyticus EB101
strain EB101
-
-
Manually annotated by BRENDA team
pv. campestris
SwissProt
Manually annotated by BRENDA team
Xanthomonas oryzae pv. oryzae PXO99
strain PXO99
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
-
Arabidopsis mutants lacking HK5 show reduced stomatal closure in response to H2O2, overexpression of HK5 results in constitutively less stomatal closure
malfunction
-
HP0244 deletion abolishes urease activation and assembly, impairs cytoplasmic and periplasmic pH homeostasis, and depolarizes the cells, with an about 7-log loss of survival at pH 2.5, even in 10 mM urea
malfunction
-
genetic modifications of cytokinin-independent1 activity in Arabidopsis cause dysfunction of the two-component signaling pathway and defects in procambial cell maintenance, loss-of-function histidine kinase2 and histidine kinase3 mutants show defects in procambium proliferation and an absence of secondary growth
metabolism
-
DcuS and CitA are involved in the regulation of carboxylate metabolism
physiological function
-
functional HK5 histidine kinase is required for H2O2 responses in stomatal guard cells
physiological function
the TorS histidine kinase activates the trimethylamine-N-oxide reductase pathway when sensing trimethylamine-N-oxide in the environment
physiological function
-
the TorS histidine kinase activates the trimethylamine-N-oxide reductase pathway when sensing trimethylamine-N-oxide in the environment
physiological function
the NIK1 gene is involved in ambruticin susceptibility
physiological function
-
histidine kinase Ppr functions as a UV-red light sensor
physiological function
-
NikA is responsible for the responses to fungicides such as iprodione and fludioxonil, NikA functions as sensor upstream of the response regulators SskA and SrrA in response to fungicides
physiological function
-
histidine kinase Chk1p HK is part of a functionally similar but parallel pathway to the Sho1p-Cek1p pathway that confers resistance to the cell wall inhibitors Congo red and calcofluor white
physiological function
-
the VirA receiver domain is required for efficient vir gene expression, including the transcriptional induction of virG, VirA's receiver domain acts as a recruitment and/or alignment factor that increases the availability of VirG for phosphate transfer from VirA's kinase region to the VirG receiver domain
physiological function
-
CckA has a central role in establishing the cell cycle periodicity of CtrA activity by controlling both its phosphorylation and stability
physiological function
-
HP0244 is required for inner membrane assembly of UreA, UreB, and UreE and for urease activity
physiological function
-
the histidine kinase SphS is involved in transcriptional activation of the phosphate (Pi)-acquisition system
physiological function
-
histidine kinase KinA promotes the initiation of sporulation when nutrients are limiting
physiological function
-
the AgrC receptor histidine kinase detects its autoinducing peptide ligand and generates an intracellular signal resulting in secretion of virulence factors
physiological function
-
KdpD regulates the expression of potassium transporters in response to osmolarity
physiological function
-
FixL utilizes a heme bound to an N-terminal PAS domain to detect the amount of oxygen present in the cytoplasm through direct binding
physiological function
-
HHK1 regulates polar growth, sporulation, and cell wall composition
physiological function
-
cytokinin-independent1 and Arabidopsis histidine kinase2 and 3 regulate vascular tissue development in Arabidopsis shoots, the cytokinin-independent activity of CKI1 and cytokinin-induced histidine kinase2 and histidine kinase3 are important for vascular bundle formation in Arabidopsis
physiological function
-
the histidine kinase-related domain of phytochrome A controls the spectral sensitivity and the subcellular distribution of the photoreceptor
physiological function
Aspergillus nidulans BPU1
-
NikA is responsible for the responses to fungicides such as iprodione and fludioxonil, NikA functions as sensor upstream of the response regulators SskA and SrrA in response to fungicides
-
physiological function
Candida albicans REP36-1
-
histidine kinase Chk1p HK is part of a functionally similar but parallel pathway to the Sho1p-Cek1p pathway that confers resistance to the cell wall inhibitors Congo red and calcofluor white
-
physiological function
Vibrio parahaemolyticus EB101
-
the TorS histidine kinase activates the trimethylamine-N-oxide reductase pathway when sensing trimethylamine-N-oxide in the environment
-
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ArcA + ATP
?
show the reaction diagram
-
ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His to Asp to His to Asp phosphorelay pathway
-
-
?
ArcA + ATP
?
show the reaction diagram
-
ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His to Asp to His to Asp phosphorelay pathway
-
-
-
ArcA + ATP
?
show the reaction diagram
-
the arcB gene encodes a sensor-regulator protein for anaerobic repression of the arc modulon
-
-
-
ArcA + ATP
?
show the reaction diagram
-
the ArcB and ArcA proteins constitute a two-component signal transduction system that plays a broad role in transcriptional regulation. Under anoxic or environmentally reducing conditions, the sensor kinase ArcB is stimulated to autophosphorylate at the expense of ATP and subsequently transphosphorylates the response regulator ArcA
-
-
-
ArcA + ATP
?
show the reaction diagram
-
phosphoryl group transfer from phosphorylated ArcB to ArcA, signal transmission occurs solely by His-Asp-His-Asp phosphorelay
-
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
the two-component regulatory system CzcS/CzcR is involved in transcriptional control of heavy-metal homoeostasis in Alcaligenes eutrophus
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
kinase of the alternate pathway for phosphorylating the SpoOF protein
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
enzyme is involved in early steps of competence regulation
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
photosynthesis gene expression in Rhodobacter sphaeroides is controlled in part by the two-component regulatory system composed of a membrane-bound sensor kinase PrrB and a response regulator PrrA
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
regB is part of a two-component system and encodes a sensor kinase involved in the global regulation of both anoxygenic light-dependent- and oxygenic light-independent CO2 fixation as well as anoxygenic photosystem biosynthesis
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the tyrosine kinase DivL function in cell cycle and developmental regulation is mediated, at least in part, by the global response regulator CtrA, the enzyme is essential for cell viability and division
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
enzyme is involved in signal transduction controlling chemotaxis
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the essential two-component regulatory system yycF/yycG modulates expression of the ftsAZ operon in Bacillus subtilis
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
enzyme is involved in chemotaxis
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
enzyme is involved in chemotaxis
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
enzyme is involved in chemotaxis
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Deinococcus radiodurans bacteriophytochrome functions as a light-regulated histidine kinase, which helps protect the bacterium from visible light
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
PrrB is responsive to the removal of oxygen and functions through the response regulator PrrA. Together, prrB and prrA provide the major signal involved in synthesis of the specialized intracytoplasmic membrane, harboring components essential to the light reactions of photosynthesis. PrrB is a global regulator of photosynthesis gene expression
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
regulation of the levels of OmpF and OmpC is normally controlled by a multicomponent signal-transducing regulatory pair of proteins, EnvZ and OmpR. The effect RprX and RprY have on OmpF expression is mediated at the level of transcription. Thus, RprX and RprY may be interfering with the normal regulation of OmpF by OmpR and EnvZ
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the two-component sensory transduction system chvG/chvI is required for virulence of Agrobacterium tumefaciens
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
the two-component regulatory system VanS-VanR activates a promoter used for cotranscription of the vanH, vanA, and vanX resistance genes
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the two-component signal transduction system yycF/yycG is essential for growth of Bacillus subtilis
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Agrobacterium tumefaciens C58
-
the two-component sensory transduction system chvG/chvI is required for virulence of Agrobacterium tumefaciens
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Enterococcus faecium BM4147
the two-component regulatory system VanS-VanR activates a promoter used for cotranscription of the vanH, vanA, and vanX resistance genes
-
-
ATP + BctC
?
show the reaction diagram
-
-
-
-
?
ATP + CpdR-L-histidine
ADP + CpdR-N-phospho-L-histidine
show the reaction diagram
-
-
-
?
ATP + CtrA-L-histidine
ADP + CtrA-N-phospho-L-histidine
show the reaction diagram
-
-
-
?
ATP + DivK
?
show the reaction diagram
-
DivJ is the main kinase of DivK
-
-
?
ATP + FixJ
?
show the reaction diagram
-
-
-
-
?
ATP + histidine kinase EnvZ
ADP + histidine kinase EnvZ N-phospho-L-histidine
show the reaction diagram
-
autophosphorylation. Probing catalytically essential domain orientation in histidine kinase EnvZ by targeted disulfide crosslinking
-
?
ATP + histidine kinase Hik34
ADP + histidine kinase Hik34 N-phospho-L-histidine
show the reaction diagram
-
histidine kinase Hik34 might negatively regulate the expression of certain heat shock genes that might by related to thermotolerance in Synechocystis, autophosphorylation, in vitro at physiological temperatures, but not at elevated temperatures, such as 44C
-
?
ATP + PhoN protein L-histidine
ADP + PhoN protein N-phospho-L-histidine
show the reaction diagram
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
-
-
-
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
AtBphP1 contains a typical two-component histidine kinase domain at its C-terminus whose activity is repressed after photoconversion to Pfr, AtBphP2 is repressed after photoconversion to Pr
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
canonical histidine kinase activity of the transmitter domain of the ETR1 ethylene receptor from Arabidopsis is not required for signal transmission
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
histidine kinase BA1351, histidine kinase BA1356 is capable of inducing sporulation, histidine kinase BA1478, histidine kinase BA2291 acts as a phosphatase on the sporulation phosphorelay, histidine kinase BA2636, histidine kinase BA2644, histidine kinase BA3702, histidine kinase BA4223 is capable of inducing sporulation in Bacillus anthracis, histidine kinase BA5029
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
histidine kinase CikA resets the circadian clock
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
histidine kinases DivJ and PleC initiate signal transduction pathways that regulate an early cell division cycle step and the gain of motility later in the Caulobacter crescentus cell cycle
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
in Synechocystis sp. PCC 6803 four histidine kinases, Hik16, Hik33, Hik34, and Hik41, perceive and transduce salt signals, in Synechocystis sp. PCC 6803 four histidine kinases, Hik16, Hik33, Hik34, and Hik41, perceive and transduce salt signals. The Hik16/Hik41 system responds only to NaCl
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
induced by dehydration and CaCl2. NTHK2 possesses Ser/Thr kinase activity in presence of Mn2+ and histidine kinase activity in presence of Ca2+
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
RodK may regulate multiple temporally separated events during fruiting body formation including stimulation of early developmental gene expression, inhibition of A-signal production and inhibition of the intercellular C-signal transduction pathway
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
the circadian clock-associated histidine kinase SasA is necessary for rubustness of the circadian rhythm of gene expression and involved in clock output
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
the gene-disrupted mutant is unable to produce normal mature fruiting bodies and produces fewer spores
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
the three-component system of histidine kinases and response regulator, His16-Hik41-Rre17, acts as transducer of hyperosmotic stress
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
the two-component histidine kinase alrO117 is involved in heterocyst development
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
the two-component system of histidine kinase and response regulator, His10-Rre3, acts as transducer of hyperosmotic stress, the two-component system of histidine kinase and response regulator, His33-Rre31, acts as transducer of hyperosmotic stress, the two-component systes of histidine kinase and response regulator, His34-Rre1, acts as transducer of hyperosmotic stress
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
Streptomyces reticuli Tue54
-
-
-
?
ATP + Spo0F protein L-histidine
ADP + Spo0F protein N-phospho-L-histidine
show the reaction diagram
-
-
-
?
ATP + VicR protein L-histidine
ADP + VicR protein N-phospho-L-histidine
show the reaction diagram
Streptococcus pneumoniae, Streptococcus pneumoniae (D39)
-
-
?
ATP + VirG-L-histidine
ADP + VirG-N-phospho-L-histidine
show the reaction diagram
-
-
-
?
ATP + YycF
ADP + phospho-YycF
show the reaction diagram
the formation of the division septum is necessary for YycG phosphorylation of YycF, a response regulator/transcription factor
-
?
BvgA + ATP
?
show the reaction diagram
-
-
-
-
?
BvgA + ATP
?
show the reaction diagram
-
the phosphorylated, purified C-terminal domain alone is sufficient for phosphotransfer to BvgA
-
-
?
BvgA + ATP
?
show the reaction diagram
-
the cytoplasmic portion of BvgS ('BvgS)
-
-
?
BvgA + ATP
?
show the reaction diagram
-
one hybrid histidine kinase consisting of the BvgS transmitter and HPt domains and of the EvgS receiver domain BvgS-TO-EvgS-R is able to phosphorylate BvgA but not EvgA. In contrast, the hybrid protein consisting of the BvgS transmitter and the EvgS receiver and HPt domains BvgS-T-EvgS-RO is unable to phosphorylate BvgA but efficiently phosphorylates EvgA
-
-
?
CitB + ATP
?
show the reaction diagram
-
a fusion protein MalE-CitAC is composed of the maltose-binding protein and the CitA kinase domain shows constitutive autokinase activity and transfers the gamma-phosphate group of ATP to its cognate response regulator CitB
-
-
?
CtrA + ATP
?
show the reaction diagram
-
-
-
?
DcuR + ATP
?
show the reaction diagram
-
the phosphoryl group of DcuS is rapidly transferred to the response regulator DcuR. Upon phosphorylation, DcuR binds specifically to dcuB promoter DNA
-
-
?
EvgA + ATP
?
show the reaction diagram
-
one hybrid histidine kinase consisting of the BvgS transmitter and HPt domains and of the EvgS receiver domain BvgS-TO-EvgS-R is able to phosphorylate BvgA but not EvgA. In contrast, the hybrid protein consisting of the BvgS transmitter and the EvgS receiver and HPt domains BvgS-T-EvgS-RO is unable to phosphorylate BvgA but efficiently phosphorylates EvgA
-
-
?
GTP + protein-L-histidine
GDP + protein N-phospho-L-histidine
show the reaction diagram
Q81QX4
the enzyme is involved the transition between the vegetative cycle and sporulation, multiple sensor histidine kinases are induced to autophosphorylate in response to sporulation specific signals in the phosphorelay, the BA2291 protein may act as a phosphatase on the sporulation phosphorelay when present at elevated levels, overview
-
r
GTP + protein-L-histidine
GDP + protein N-phospho-L-histidine
show the reaction diagram
Q81QX4
BA2291 is absolutely specific for guanine nucleotides in both the forward and reverse reactions, nucleotide specificity of BA2291, overview
-
r
GTP + protein-L-histidine
GDP + protein N-phospho-L-histidine
show the reaction diagram
Bacillus anthracis 34F2DELTA118
Q81QX4
the enzyme is involved the transition between the vegetative cycle and sporulation, multiple sensor histidine kinases are induced to autophosphorylate in response to sporulation specific signals in the phosphorelay, the BA2291 protein may act as a phosphatase on the sporulation phosphorelay when present at elevated levels, overview, BA2291 is absolutely specific for guanine nucleotides in both the forward and reverse reactions, nucleotide specificity of BA2291, overview
-
r
protein + ATP
?
show the reaction diagram
-
the cytoplasmic portion of BvgS autophosphorylates with the gamma-phosphate from [gamma-32P]ATP
-
-
?
protein + ATP
?
show the reaction diagram
-
autophosphorylation
-
-
?
protein + ATP
?
show the reaction diagram
autophosphorylation
-
-
?
protein + ATP
?
show the reaction diagram
-
autophosphorylation
-
-
?
protein + ATP
?
show the reaction diagram
-
autophosphorylation
-
-
-
protein + ATP
?
show the reaction diagram
-
autophosphorylation
-
-
?
protein + ATP
?
show the reaction diagram
-
autophosphorylation
-
-
?
protein + ATP
?
show the reaction diagram
-
autophosphorylation
-
-
?
protein + ATP
?
show the reaction diagram
autophosphorylation
-
-
?
protein + ATP
?
show the reaction diagram
-
a model of the mechanism of FrzE phosphorylation: autophosphorylation initially occurs at a conserved His residue within the "CheA" domain and then, via an intramolecular transphosphorylation, is transferred to a conserved aspartate residue within the "CheY" domain
-
-
?
protein + ATP
?
show the reaction diagram
-
DivL protein is homologous to the ubiquitous bacterial histidine protein kinases, it differs from previously studied members of this protein kinase family in that it contains a tyrosine residue Tyr550 in the conserved H-box instead of a histidine residue, which is the expected site of autophosphorylation. DivL is autophosphorylated on Tyr-550 in vitro, and this tyrosine residue is essential for cell viability and regulation of the cell division cycle
-
-
?
protein + ATP
?
show the reaction diagram
-
H243 is a site of autophosphorylation as well as transphosphorylation to the conserved D55 residue of response regulator OmpR
-
-
?
Rcp1 + ATP
?
show the reaction diagram
-
Cph1 is a light-regulated histidine kinase that mediates red, far-red reversible phosphorylation of the a small response regulator Rcp1
-
-
?
regulator protein OmpR + ATP
?
show the reaction diagram
-
-
-
?
regulator protein OmpR + ATP
?
show the reaction diagram
-
H243 is the a site of autophosphorylation as well as transphosphorylation to the conserved D55 residue of response regulator OmpR
-
-
?
TorR + ATP
?
show the reaction diagram
-
TorS is a sensor that contains three phosphorylation sites and transphosphorylates TorR via a four-step phosphorelay, His443 to Asp723 to His850 to Asp(TorR). TorS can dephosphorylate phospho-TorR when trimethylamine N-oxide is removed. Dephosphorylation probably occurs by a reverse phosphorelay, Asp(TorR) to His850 to Asp723
-
-
?
GTP + Spo0F L-histidine
GDP + Spo0F N-phospho-L-histidine
show the reaction diagram
Bacillus anthracis, Bacillus anthracis 34F2DELTA118
Q81QX4
a protein purified from Bacillus subtilis
-
r
additional information
?
-
-
mediates the transfer of phosphate to the Spo0A and Spo0F sporulation regulatory proteins. Spo0F protein is a much better phosphoreceptor for this kinase than Spo0A protein in vitro
-
-
-
additional information
?
-
-
BarA/UvrY system activated biofilm formation. UvrY resides downstream from csrA in a signaling pathway for csrB and CsrA stimulates UvrY-dependent activation of csrB expression by BarA-dependent and BarA-independent mechanisms
-
-
-
additional information
?
-
-
DNA sequences of plnB reveals that the product closely resembles members of bacterial two-component signal transduction systems. The finding that plnABCD are transcribed from a common promoter suggests that the biological role played by the bacteriocin is somehow related to the regulatory function of the two-component system located on the same operon
-
-
-
additional information
?
-
-
ompR-envZ is a two component regulatory system that plays an important role in the regulation of Vi polysaccharide synthesis in Salmonella typhi. One of the environmental signals for this regulation may be osmolarity
-
-
-
additional information
?
-
E. coli BarA-UvrY two-component system is required for efficient switching between glycolytic and gluconeogenic carbon sources
-
-
-
additional information
?
-
-
purified BarA protein is able to autophosphorylate when incubated with [gamma-(32)P]ATP but not with [alpha-(32)P]ATP or [gamma-(32)P]GTP. Phosphorylated BarA, in turn, acts as an efficient phosphoryl group donor to UvrY. BarA and UvrY constitute a new two-component system for gene regulation in Escherichia coli
-
-
-
additional information
?
-
-
enzyme is involved in adaptive responses in E. coli
-
-
-
additional information
?
-
-
the VanR B-VanS B two-component regulatory system activates a promoter located immediately downstream from the vanS B gene
-
-
-
additional information
?
-
-
CpxA functions as a transmembrane sensory protein
-
-
-
additional information
?
-
-
EnvZ modulates expression of the ompF and ompC genes through phosphotransfer signal transduction in Escherichia coli
-
-
-
additional information
?
-
-
enzyme controls the osmoregulated biosynthesis of the porin proteins OmpF and OmpC
-
-
-
additional information
?
-
-
the enzyme plays a central role in osmoregulation, a cellular adaptation process involving the His-Asp phosphorelay signal transduction system. Dimerization of the transmembrane protein is essential for its autophosphorylation and phosphorelay signal transduction functions
-
-
-
additional information
?
-
Cm-ETR1 mRNA is very high in the seeds and placenta. Marked increase of Cm-ETR1 mRNA parallels climacteric ethylene production. Cm-ETR1 plays a specific role not only in ripening but also in the early development of melon fruit
-
-
-
additional information
?
-
-
the enzyme plays an important role in coupling signals received from membrane-bound receptors to changes in the swimming behavior of the cells in order to respond appropriately to environmental signals
-
-
-
additional information
?
-
-
a complex of the proteins CheA (CheAL and CheAS) and CheW constitutes a functional unit that responds to the signaling state of the chemoreceptors. The autophosphorylation rate of CheAL is much greater when CheAL and CheAS are complexed with CheW. Moreover, the presence of mutant chemoreceptors that cause cells to tumble increases this rate. At wild-type levels of expression, the isolated CheAL/CheAS/CheW complex accounts for about 10% of the total number of CheAL, CheAS, and CheW molecules and exists in a 1:1:1 stoichiometry. This complex is also required for CheAL/CheAS and CheW binding to the phosphorylation substrate, CheY
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additional information
?
-
it is proposed that VirA acts as an environmental sensor of plant-derived inducer molecules and transmits this information to the level of vir gene expression
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-
additional information
?
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the two-component regulatory system irlR-irlS is involved in invasion of eukaryotic cells and heavy-metal resistance in Burkholderia pseudomallei
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-
-
additional information
?
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two-component regulatory system CssR-CssS, is required for the cell to survive the severe secretion stress caused by a combination of high-level production of the alpha-amylase AmyQ and reduced levels of the extracytoplasmic folding factor PrsA. The Css system is required to degrade misfolded exported proteins at the membrane-cell wall interface. CssS represents the first identified sensor for extracytoplasmic protein misfolding in a Gram-positive eubacterium
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-
additional information
?
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the CitST two-component system regulates the expression of the Mg-citrate transporter in Bacillus subtilis
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additional information
?
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the protein is involved in osmoregulation of OmpF and OmpC. EnvZ is considered to be an osmosensor which transmits signals across the membrane to OmpR, a transcriptional activator for ompF and ompC
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-
additional information
?
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UhpB and perhaps UhpC play both positive and negative roles in the control of uhpT transcription
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additional information
?
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UhpB and perhaps UhpC play both positive and negative roles in the control of uhpT transcription
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additional information
?
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regulation of nitrogen fixation genes in Rhizobium meliloti is mediated by two proteins, FixL and FixJ, in response to oxygen availability, oxygen sensor
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additional information
?
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the gene regulates transcription of the nifHDK operon and so limits the expression of nitrogen fixation activity to periods of low environmental concentrations of both oxygen and fixed nitrogen
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additional information
?
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FixL senses an environmental signal and transduces it to FixJ, a transcriptional activator of nif and fix genes
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-
additional information
?
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required for the activation of the C4-dicarboxylate transport structural gene dctA in free-living Rhizobium leguminosarum
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additional information
?
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during bacterial chemotaxis, the binding of stimulatory ligands to chemoreceptors at the cell periphery leads to a response at the flagellar motor. Three proteins appear to be required for receptor-mediated control of swimming behavior, the products of the cheA, cheW, and cheY genes
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additional information
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enzyme is required for the proper expression of the outer membrane proteins OmpC and OmpF
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additional information
?
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enzyme has an enhancing effect on the transcription of phoA, primary function may not be connected to the phosphate regulon
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additional information
?
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membrane-bound sensor of plant signal molecules
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additional information
?
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FrzE is a second messenger that relays information between the signaling protein FrzCD and the gliding motor
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additional information
?
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mediates the transfer of phosphate to the Spo0A and Spo0F sporulation regulatory proteins
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additional information
?
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RcsC is the sensor components of the two-component regulatory system which regulates expression of the slime polysaccharide colanic acid. rcs system is essential for expression of high levels of the group I capsular polysaccharide in lon+ E. coli K30
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additional information
?
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the two-component regulatory system phoP/phoQ controls Salmonella typhimurium virulence
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additional information
?
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colanic acid capsule synthesis in Escherichia coli K-12 is regulated by RcsB and RcsC. RcsC acts as the sensor and RcsB acts as the receiver or effector to stimulate capsule synthesis from cps genes
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additional information
?
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bvgS and bvgA control the expression of the virulence-associated genes in Bordetella species by a system similar to the two-component systems used by a variety of bacterial species to respond to environmental stimuli
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additional information
?
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the PhoP-PhoQ system exerts a master regulatory function for preventing bacterial overgrowth within fibroblasts
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additional information
?
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the HydH/G system senses high periplasmic Zn2+ and Pb2+ concentrations and contributes to metal tolerance by activating the expression of zraP
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additional information
?
-
the HydH/G system senses high periplasmic Zn2+ and Pb2+ concentrations and contributes to metal tolerance by activating the expression of zraP
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additional information
?
-
NodV and NodW proteins are members of the family of two-component regulatory systems, NodV responds to an environmental stimulus and, after signal transduction, NodW may be required to positively regulate the transcription of one or several unknown genes involved in the nodulation process
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additional information
?
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the enzyme is involved in chemical sensing
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additional information
?
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genes dctB and dctD form a two-component system which responds to the presence of C4-dicarboxylates to regulate expression of a transport protein encoded by dctA
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additional information
?
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narL and narX mediate nitrate induction of nitrate reductase synthesis and nitrate repression of fumarate reductase synthesis
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additional information
?
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in free-living cells, the regulatory dctBD genes are absolutely required for the expression of the dctA gene
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additional information
?
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dctB-encoded protein includes a putative periplasmic N-terminal domain that senses the presence of dicarboxylates and a C-terminal cytoplasmic domain that activates the dctD-encoded protein
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additional information
?
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enzyme is involved in signal transduction
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additional information
?
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the enzyme is a regulator of chemotaxis
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additional information
?
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enzyme is responsible for regulation of subtilin biosynthesis
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additional information
?
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enzyme is responsible for regulation of subtilin biosynthesis
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additional information
?
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enzyme is involved in the regulation of expression of phosphoglycerate transport in Salmonella typhimurium. pgtB and pgtC genes are involved in the induction of the pgtP expression by modulating derepressor activity
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additional information
?
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moxY is part of the two-component regulatory system controlling methanol dehydrogenase synthesis
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additional information
?
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either of two functionally redundant sensor proteins, NarX and NarQ, is sufficient for nitrate regulation in Escherichia coli K-12. NarQ and NarX may have subtle functional differences
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additional information
?
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activation role for ResD, and to a lesser extent ResE, in global regulation of aerobic and anaerobic respiration in Bacillus subtilis
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additional information
?
-
PgtB and PgtC polypeptides modulate PgtA activity
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additional information
?
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narQ is a nitrate sensor for nitrate-dependent gene regulation in Escherichia coli
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additional information
?
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the enzyme is a biological oxygen sensors that restricts the expression of specific genes to hypoxic conditions
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additional information
?
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the two-component sensor-effector system KdpD /KdpE controls expression of the kdpABC operon
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additional information
?
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the two-component sensor-effector system KdpD /KdpE controls expression of the kdpABC operon
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additional information
?
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FixL and FixJ proteins are members of the two-component sensor/regulator family
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additional information
?
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PilS/PilR is a two-component transcriptional regulatory system controlling expression of type 4 fimbriae in Pseudomonas aeruginosa. PilS is a sensor protein which when stimulated by the appropriate environmental signals activates PilR through kinase activity. PilR then activates transcription of pilA, probably by interacting with RNA polymerase containing RpoN
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additional information
?
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the TorS/TorR two-component system induces the expression of the tor structural operon encoding the trimethylamine N-oxide reductase respiratory system in response to substrate availability. TorS belongs to a sensor subfamily that includes a classical transmitter domain, a receiver, and a C-terminal alternative transmitter domain
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additional information
?
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ETR1 acts as an ethylene receptor
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additional information
?
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ETR1 acts as an ethylene receptor
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additional information
?
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TorS is a sensor that contains three phosphorylation sites and transphosphorylates TorR via a four-step phosphorelation, His443--Asp723--His850--Asp(TorR)
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additional information
?
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QseBC is a two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli strains EHEC and K-12
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additional information
?
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TorS mediates the induction of the tor structural genes in response to trimethylamine N-oxide
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additional information
?
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enzyme is involved in positive regulation of synthesis of extracellular enzymes and polysaccharide in Xanthomonas campestris pathovar campestris
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additional information
?
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enzyme is involved in regulation of the phosphate regulon
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additional information
?
-
enzyme is involved in regulation of the phosphate regulon
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additional information
?
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the two-component regulatory system DcuSR of Escherichia coli controls the expression of genes of C4-dicarboxylate metabolism in response to extracellular C4-dicarboxylates such as fumarate or succinate. The phosphoryl group of DcuS is rapidly transferred to the response regulator DcuR. Upon phosphorylation, DcuR binds specifically to dcuB promoter DNA
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additional information
?
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citrate, Na+, and oxygen exert their regulatory effects via the CitA/CitB system. In the presence of these signals, the citAB gene products induce their own synthesis. The positive autoregulation occurs via co-transcription of citAB with citS and oadGAB
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additional information
?
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the genes encoding the anaerobic fumarate respiratory system are transcriptionally regulated by C4-dicarboxylates. The regulation is effected by a two-component regulatory system, DcuSR, consisting of a sensory histidine kinase DcuS and a response regulator DcuR
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additional information
?
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periplasmic loop of DcuS serves as a C4-dicarboxylate sensor. The cytosolic region of DcuS contains two domains: a central PAS domain possibly acting as a second sensory domain and a C-terminal transmitter domain
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additional information
?
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the two-component system regulates an osmosensing MAP kinase cascade
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additional information
?
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expression of cusC is induced by high concentrations of copper ions, the cusRS two-component signal transduction system is required for copper-induced expression of pcoE, a plasmid-borne gene from the E. coli copper resistance operon pco. The genes cusRS are also required for the copper-dependent expression of at least one chromosomal gene, designated cusC, which is allelic to the recently identified virulence gene ibeB in E. coli K1. The cus locus may comprise a copper ion efflux system
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additional information
?
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the antizyme is a bifunctional protein serving as both an inhibitor of polyamine biosynthesis as well as a transcriptional regulator of an as yet unknown set of genes
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additional information
?
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the enzyme is involved in chemotaxis
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additional information
?
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two-component regulatory system CopR/CopS is required for copper-inducible expression of the copper resistance operon
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additional information
?
-
the two-component regulatory system, NtrY/NtrX is involved in nitrogen fixation and metabolism. NtrY is likely to represent the transmembrane sensor protein element in a two-component regulatory system
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additional information
?
-
the two-component regulatory system afsQ1/afsQ2 is involved in secondary metabolism
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additional information
?
-
the two-component systemDpiA/DpiB is involved in regulation of plasmid inheritance
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additional information
?
-
the cutR-cutS operon regulates copper metabolism in Streptomyces
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additional information
?
-
the periplasmic domain of the histidine autokinase CitA functions as a highly specific citrate receptor
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additional information
?
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the ExoS-ChvI two-component regulatory system regulates succinoglycan production. ChvG is the sensor protein of the ChvG-ChvI two-component regulatory system
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additional information
?
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the enzyme is involved in regulation of density-dependent expression of luminescence in Vibrio harveyi
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additional information
?
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the enzyme is involved in regulation of density-dependent expression of luminescence in Vibrio harveyi
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additional information
?
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the two-component regulatory system PfeR/PfeS is involved in the expression of the ferric enterobactin receptor PfeA
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additional information
?
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deletion of PilS results in a non-pilated phenotype
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additional information
?
-
autophosphorylation activity
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additional information
?
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autophosphorylation of MtrB-Strep in proteoliposomes in the presence of ATP
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additional information
?
-
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full-length His-RaxH shows autophosphorylation activities
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-
-
additional information
?
-
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neither HK1 nor HK2 is able to autophosphorylate itself, HK1 is an ATP binding protein, acts as a functional kinase and phosphorylates HK2 by interacting with it, transfer of a phosphoryl group from HK2 to the response regulator TcrA
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additional information
?
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-
no autophosphorylation of wild-type, is caused by the rate of dephosphorylation being higher than the rate of autophosphorylation
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additional information
?
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upon illumination in the presence of ATP, the enzyme undergoes autophosphorylation
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-
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additional information
?
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a chemical or other stimulus is detected by the periplasmic sensor domain of a transmembrane histidine kinase sensor, which in turn relays a signal through a phosphotransfer cascade to the cognate cytoplasmic response regulator. Such systems lead ultimately to changes in gene expression or cell motility. Mechanisms of ligand binding and signal transduction through the cell membrane, overview
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additional information
?
-
AlHK1p is important for, but not the sole factor responsible for Alternaria longipes resistance to dicarboximide fungicides, e.g. dimethachlon, molecular basis of the fungicide resistance, overview
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additional information
?
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DcuS is the C4-dicarboxylate sensor of Escherichia coli catalyzing transmembrane sensing
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-
additional information
?
-
Q81QX4
genes for orthologs of the sensor domain of the BA2291 kinase exist in virulence plasmids in this organism, and these proteins, when expressed, inhibit sporulation by converting BA2291 to an apparent phosphatase of the sporulation phosphorelay
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additional information
?
-
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histidine kinases are part of two-component signal transduction systems that act to integrate environmental stimuli into a cellular response via a phosphotransfer relay mechanism, e.g. involved in stomatal guard cell response to H2O2, regulation of the physiological function, overview
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additional information
?
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Myxococcus xanthus undergoes a complex starvation-induced developmental program that results in cells forming multicellular fruiting bodies by aggregating into mounds and then differentiating into spores. This developmental program involves EspA, which plays a key role in the timing of expression of genes necessary for progression of cells through the developmental program, overview
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additional information
?
-
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role of the C-terminal domains in the photocycle of a light sensor histidine kinase Ppr having a photoactive yellow protein, PYP, domain as the photosensor domain, photocycles of the PYP domain of Ppr and of the full-length Ppr. The, overview
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additional information
?
-
signal transduction mechanism in the bacteriophytochrome, overview
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-
-
additional information
?
-
significant number of genes are influenced directly or indirectly by the RoxSR two-component system. 173 genes are found showing reduced expression in EU58 (RoxSR mutant strain) in comparison to the wild type, whereas 84 genes are upregulated in the mutant
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additional information
?
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the enzyme HP0244 is not only required to regulate flagellar gene expression via its cognate response regulator, HP0703, but also to generate a response to declining medium pH. Although not required for survival at pH 4.5, HP0244 is required for survival at pH 2.5, overview
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-
-
additional information
?
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the N-terminal Per-ARNT-Sim domain plays a critical role in the catalytic activity of this enzyme, a significant decrease occurs of the autophosphorylation rate of a KinA protein lacking this domain
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-
-
additional information
?
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the SenS/SenR system of Streptomyces reticuli regulates the expression of the redox regulator FurS, the catalase-peroxidase CpeB and the heme-binding protein HbpS. SenS/SenR also participates in sensing redox changes, mediated by HbpS. The heme-binding protein HbpS regulates the activity of the Streptomyces reticuli iron-sensing histidine kinase SenS in a redox-dependent manner, presence of SenS/SenR leads to the synthesis of extracellular redox active proteins, overview
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-
-
additional information
?
-
The sensor histidine kinase YycG acts in a two-component system with response regulator/transcription factor YycF in Bacillus subtilis controling the synthesis of autolysins and autolysin inhibitors, that function in cell wall remodelling and cell separation, YycG sensor histidine kinase is a component of and perceives infirmation at the division septum in growing cells constituting a positive feedback loop, that serves to co-ordinate cell division with cell wall homeostasis, overview
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-
additional information
?
-
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the sensory histidine kinase acts in the two-component system with the response regulator as RR-HK17, EF1633-EF1632, in the regulation of ethanolamine utilization, which can be the sole carbon source for the organism, mechanism, overview
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-
-
additional information
?
-
The two-component system is implicated in redox signaling and cytochrome oxidase activity, in expression of the cell density-dependent gene ddcA and in bacterial colonization of plant surfaces. The RoxS/RoxR regulon includes genes involved in sugar and amino acid metabolism and the sulfur starvation response and elements of the respiratory chain (a cbb3 cytochrome oxidase, Fe-S clusters, and cytochrome c-related proteins) or genes participating in the maintenance of the redox balance. The RoxS/RoxR system controls a broad set of functions that have an influence on energy metabolism, such as formaldehyde and formate dehydrogenases.
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additional information
?
-
Q81QX4
BA2291 performs GTP-dependent autophosphorylation
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-
-
additional information
?
-
histidine kinase domain and response regulator domain form a two-component system
-
-
-
additional information
?
-
KinA performs autophosphorylation
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-
additional information
?
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-
SenS performs autophosphorylation. HbpS/SenS interaction analysis, overview
-
-
-
additional information
?
-
structure-function relationship: the bacteriophytochrome possesses a histidine kinase domain and undergoes conformational changes during photoconversion, local structural changes originating in the photosensory domain modulate interactions between long, crossdomain signaling helices at the dimer interface and are transmitted to the spatially distant effector domain, thereby regulating its histidine kinase activity, overview
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-
additional information
?
-
-
the enzyme performs regulatory autophosphorylation
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-
-
additional information
?
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-
Cek1p phosphorylation via Sho1p does not require histidine kinase Chk1p
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-
-
additional information
?
-
-
FrzE autophosphorylates the kinase domain at His-49, and phosphoryl groups are transferred to aspartate residues (Asp-52 and Asp-220) in the two receiver domains of FrzA. The FrzE receiver domain inhibits autophosphorylation of the FrzE kinase domain
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-
-
additional information
?
-
Escherichia coli O9:K30:H12
-
RcsC is the sensor components of the two-component regulatory system which regulates expression of the slime polysaccharide colanic acid. rcs system is essential for expression of high levels of the group I capsular polysaccharide in lon+ E. coli K30
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-
-
additional information
?
-
Pseudomonas syringae DC3000
-
upon illumination in the presence of ATP, the enzyme undergoes autophosphorylation
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-
-
additional information
?
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Agrobacterium tumefaciens 15955
membrane-bound sensor of plant signal molecules
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-
additional information
?
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Lactobacillus plantarum C11
-
DNA sequences of plnB reveals that the product closely resembles members of bacterial two-component signal transduction systems. The finding that plnABCD are transcribed from a common promoter suggests that the biological role played by the bacteriocin is somehow related to the regulatory function of the two-component system located on the same operon
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-
-
additional information
?
-
-
neither HK1 nor HK2 is able to autophosphorylate itself, HK1 is an ATP binding protein, acts as a functional kinase and phosphorylates HK2 by interacting with it, transfer of a phosphoryl group from HK2 to the response regulator TcrA
-
-
-
additional information
?
-
Xanthomonas oryzae pv. oryzae PXO99
-
full-length His-RaxH shows autophosphorylation activities
-
-
-
additional information
?
-
Streptomyces reticuli Tue54
-
the SenS/SenR system of Streptomyces reticuli regulates the expression of the redox regulator FurS, the catalase-peroxidase CpeB and the heme-binding protein HbpS. SenS/SenR also participates in sensing redox changes, mediated by HbpS. The heme-binding protein HbpS regulates the activity of the Streptomyces reticuli iron-sensing histidine kinase SenS in a redox-dependent manner, presence of SenS/SenR leads to the synthesis of extracellular redox active proteins, overview, SenS performs autophosphorylation. HbpS/SenS interaction analysis, overview
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-
-
additional information
?
-
Streptomyces reticuli Tue54
-
the SenS/SenR system of Streptomyces reticuli regulates the expression of the redox regulator FurS, the catalase-peroxidase CpeB and the heme-binding protein HbpS. SenS/SenR also participates in sensing redox changes, mediated by HbpS. The heme-binding protein HbpS regulates the activity of the Streptomyces reticuli iron-sensing histidine kinase SenS in a redox-dependent manner, presence of SenS/SenR leads to the synthesis of extracellular redox active proteins, overview, SenS performs autophosphorylation. HbpS/SenS interaction analysis, overview
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-
-
additional information
?
-
Bacillus anthracis 34F2DELTA118
Q81QX4
genes for orthologs of the sensor domain of the BA2291 kinase exist in virulence plasmids in this organism, and these proteins, when expressed, inhibit sporulation by converting BA2291 to an apparent phosphatase of the sporulation phosphorelay, BA2291 performs GTP-dependent autophosphorylation
-
-
-
additional information
?
-
Bacillus subtilis 1A40
the N-terminal Per-ARNT-Sim domain plays a critical role in the catalytic activity of this enzyme, a significant decrease occurs of the autophosphorylation rate of a KinA protein lacking this domain, KinA performs autophosphorylation
-
-
-
additional information
?
-
the two-component regulatory system irlR-irlS is involved in invasion of eukaryotic cells and heavy-metal resistance in Burkholderia pseudomallei
-
-
-
additional information
?
-
Candida albicans REP36-1
-
Cek1p phosphorylation via Sho1p does not require histidine kinase Chk1p
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ArcA + ATP
?
show the reaction diagram
-
ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response regulator ArcA through a His to Asp to His to Asp phosphorelay pathway
-
-
-
ArcA + ATP
?
show the reaction diagram
-
the arcB gene encodes a sensor-regulator protein for anaerobic repression of the arc modulon
-
-
-
ArcA + ATP
?
show the reaction diagram
-
the ArcB and ArcA proteins constitute a two-component signal transduction system that plays a broad role in transcriptional regulation. Under anoxic or environmentally reducing conditions, the sensor kinase ArcB is stimulated to autophosphorylate at the expense of ATP and subsequently transphosphorylates the response regulator ArcA
-
-
-
ArcA + ATP
?
show the reaction diagram
-
phosphoryl group transfer from phosphorylated ArcB to ArcA, signal transmission occurs solely by His-Asp-His-Asp phosphorelay
-
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Q44007
the two-component regulatory system CzcS/CzcR is involved in transcriptional control of heavy-metal homoeostasis in Alcaligenes eutrophus
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
kinase of the alternate pathway for phosphorylating the SpoOF protein
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
P0A4I6
enzyme is involved in early steps of competence regulation
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
photosynthesis gene expression in Rhodobacter sphaeroides is controlled in part by the two-component regulatory system composed of a membrane-bound sensor kinase PrrB and a response regulator PrrA
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
regB is part of a two-component system and encodes a sensor kinase involved in the global regulation of both anoxygenic light-dependent- and oxygenic light-independent CO2 fixation as well as anoxygenic photosystem biosynthesis
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the tyrosine kinase DivL function in cell cycle and developmental regulation is mediated, at least in part, by the global response regulator CtrA, the enzyme is essential for cell viability and division
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Q48768
enzyme is involved in signal transduction controlling chemotaxis
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the essential two-component regulatory system yycF/yycG modulates expression of the ftsAZ operon in Bacillus subtilis
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
enzyme is involved in chemotaxis
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
enzyme is involved in chemotaxis
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Q53135
enzyme is involved in chemotaxis
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Q9RZA4
Deinococcus radiodurans bacteriophytochrome functions as a light-regulated histidine kinase, which helps protect the bacterium from visible light
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Q3J6C1
PrrB is responsive to the removal of oxygen and functions through the response regulator PrrA. Together, prrB and prrA provide the major signal involved in synthesis of the specialized intracytoplasmic membrane, harboring components essential to the light reactions of photosynthesis. PrrB is a global regulator of photosynthesis gene expression
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Q08408
regulation of the levels of OmpF and OmpC is normally controlled by a multicomponent signal-transducing regulatory pair of proteins, EnvZ and OmpR. The effect RprX and RprY have on OmpF expression is mediated at the level of transcription. Thus, RprX and RprY may be interfering with the normal regulation of OmpF by OmpR and EnvZ
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the two-component sensory transduction system chvG/chvI is required for virulence of Agrobacterium tumefaciens
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Q06240
the two-component regulatory system VanS-VanR activates a promoter used for cotranscription of the vanH, vanA, and vanX resistance genes
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
-
the two-component signal transduction system yycF/yycG is essential for growth of Bacillus subtilis
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Agrobacterium tumefaciens C58
-
the two-component sensory transduction system chvG/chvI is required for virulence of Agrobacterium tumefaciens
-
-
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
Enterococcus faecium BM4147
Q06240
the two-component regulatory system VanS-VanR activates a promoter used for cotranscription of the vanH, vanA, and vanX resistance genes
-
-
ATP + histidine kinase Hik34
ADP + histidine kinase Hik34 N-phospho-L-histidine
show the reaction diagram
-
histidine kinase Hik34 might negatively regulate the expression of certain heat shock genes that might by related to thermotolerance in Synechocystis
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
O34757
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
Q66WP9
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
AtBphP1 contains a typical two-component histidine kinase domain at its C-terminus whose activity is repressed after photoconversion to Pfr, AtBphP2 is repressed after photoconversion to Pr
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
canonical histidine kinase activity of the transmitter domain of the ETR1 ethylene receptor from Arabidopsis is not required for signal transmission
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
histidine kinase BA1351, histidine kinase BA1356 is capable of inducing sporulation, histidine kinase BA1478, histidine kinase BA2291 acts as a phosphatase on the sporulation phosphorelay, histidine kinase BA2636, histidine kinase BA2644, histidine kinase BA3702, histidine kinase BA4223 is capable of inducing sporulation in Bacillus anthracis, histidine kinase BA5029
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
histidine kinase CikA resets the circadian clock
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
histidine kinases DivJ and PleC initiate signal transduction pathways that regulate an early cell division cycle step and the gain of motility later in the Caulobacter crescentus cell cycle
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
in Synechocystis sp. PCC 6803 four histidine kinases, Hik16, Hik33, Hik34, and Hik41, perceive and transduce salt signals, in Synechocystis sp. PCC 6803 four histidine kinases, Hik16, Hik33, Hik34, and Hik41, perceive and transduce salt signals. The Hik16/Hik41 system responds only to NaCl
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
O48929
induced by dehydration and CaCl2. NTHK2 possesses Ser/Thr kinase activity in presence of Mn2+ and histidine kinase activity in presence of Ca2+
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
RodK may regulate multiple temporally separated events during fruiting body formation including stimulation of early developmental gene expression, inhibition of A-signal production and inhibition of the intercellular C-signal transduction pathway
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
the circadian clock-associated histidine kinase SasA is necessary for rubustness of the circadian rhythm of gene expression and involved in clock output
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
Q9Z5F5
the gene-disrupted mutant is unable to produce normal mature fruiting bodies and produces fewer spores
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
the three-component system of histidine kinases and response regulator, His16-Hik41-Rre17, acts as transducer of hyperosmotic stress
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
the two-component histidine kinase alrO117 is involved in heterocyst development
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
the two-component system of histidine kinase and response regulator, His10-Rre3, acts as transducer of hyperosmotic stress, the two-component system of histidine kinase and response regulator, His33-Rre31, acts as transducer of hyperosmotic stress, the two-component systes of histidine kinase and response regulator, His34-Rre1, acts as transducer of hyperosmotic stress
-
?
ATP + YycF
ADP + phospho-YycF
show the reaction diagram
Q45614
the formation of the division septum is necessary for YycG phosphorylation of YycF
-
?
GTP + protein-L-histidine
GDP + protein N-phospho-L-histidine
show the reaction diagram
Bacillus anthracis, Bacillus anthracis 34F2DELTA118
Q81QX4
the enzyme is involved the transition between the vegetative cycle and sporulation, multiple sensor histidine kinases are induced to autophosphorylate in response to sporulation specific signals in the phosphorelay, the BA2291 protein may act as a phosphatase on the sporulation phosphorelay when present at elevated levels, overview
-
r
Rcp1 + ATP
?
show the reaction diagram
-
Cph1 is a light-regulated histidine kinase that mediates red, far-red reversible phosphorylation of the a small response regulator Rcp1
-
-
-
GTP + Spo0F L-histidine
GDP + Spo0F N-phospho-L-histidine
show the reaction diagram
Bacillus anthracis, Bacillus anthracis 34F2DELTA118
Q81QX4
a protein purified from Bacillus subtilis
-
r
additional information
?
-
-
BarA/UvrY system activated biofilm formation. UvrY resides downstream from csrA in a signaling pathway for csrB and CsrA stimulates UvrY-dependent activation of csrB expression by BarA-dependent and BarA-independent mechanisms
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-
-
additional information
?
-
-
DNA sequences of plnB reveals that the product closely resembles members of bacterial two-component signal transduction systems. The finding that plnABCD are transcribed from a common promoter suggests that the biological role played by the bacteriocin is somehow related to the regulatory function of the two-component system located on the same operon
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-
-
additional information
?
-
-
ompR-envZ is a two component regulatory system that plays an important role in the regulation of Vi polysaccharide synthesis in Salmonella typhi. One of the environmental signals for this regulation may be osmolarity
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-
-
additional information
?
-
P0AEC7
E. coli BarA-UvrY two-component system is required for efficient switching between glycolytic and gluconeogenic carbon sources
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-
-
additional information
?
-
-
purified BarA protein is able to autophosphorylate when incubated with [gamma-(32)P]ATP but not with [alpha-(32)P]ATP or [gamma-(32)P]GTP. Phosphorylated BarA, in turn, acts as an efficient phosphoryl group donor to UvrY. BarA and UvrY constitute a new two-component system for gene regulation in Escherichia coli
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-
-
additional information
?
-
-
enzyme is involved in adaptive responses in E. coli
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-
-
additional information
?
-
-
the VanR B-VanS B two-component regulatory system activates a promoter located immediately downstream from the vanS B gene
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-
-
additional information
?
-
-
CpxA functions as a transmembrane sensory protein
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-
-
additional information
?
-
-
EnvZ modulates expression of the ompF and ompC genes through phosphotransfer signal transduction in Escherichia coli
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-
-
additional information
?
-
-
enzyme controls the osmoregulated biosynthesis of the porin proteins OmpF and OmpC
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-
-
additional information
?
-
-
the enzyme plays a central role in osmoregulation, a cellular adaptation process involving the His-Asp phosphorelay signal transduction system. Dimerization of the transmembrane protein is essential for its autophosphorylation and phosphorelay signal transduction functions
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-
-
additional information
?
-
O82436
Cm-ETR1 mRNA is very high in the seeds and placenta. Marked increase of Cm-ETR1 mRNA parallels climacteric ethylene production. Cm-ETR1 plays a specific role not only in ripening but also in the early development of melon fruit
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-
-
additional information
?
-
-
the enzyme plays an important role in coupling signals received from membrane-bound receptors to changes in the swimming behavior of the cells in order to respond appropriately to environmental signals
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-
-
additional information
?
-
-
a complex of the proteins CheA (CheAL and CheAS) and CheW constitutes a functional unit that responds to the signaling state of the chemoreceptors. The autophosphorylation rate of CheAL is much greater when CheAL and CheAS are complexed with CheW. Moreover, the presence of mutant chemoreceptors that cause cells to tumble increases this rate. At wild-type levels of expression, the isolated CheAL/CheAS/CheW complex accounts for about 10% of the total number of CheAL, CheAS, and CheW molecules and exists in a 1:1:1 stoichiometry. This complex is also required for CheAL/CheAS and CheW binding to the phosphorylation substrate, CheY
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-
-
additional information
?
-
P07167, P07168
it is proposed that VirA acts as an environmental sensor of plant-derived inducer molecules and transmits this information to the level of vir gene expression
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-
-
additional information
?
-
I1WSZ3
the two-component regulatory system irlR-irlS is involved in invasion of eukaryotic cells and heavy-metal resistance in Burkholderia pseudomallei
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-
-
additional information
?
-
O32193
two-component regulatory system CssR-CssS, is required for the cell to survive the severe secretion stress caused by a combination of high-level production of the alpha-amylase AmyQ and reduced levels of the extracytoplasmic folding factor PrsA. The Css system is required to degrade misfolded exported proteins at the membrane-cell wall interface. CssS represents the first identified sensor for extracytoplasmic protein misfolding in a Gram-positive eubacterium
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-
-
additional information
?
-
-
the CitST two-component system regulates the expression of the Mg-citrate transporter in Bacillus subtilis
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-
-
additional information
?
-
-
the protein is involved in osmoregulation of OmpF and OmpC. EnvZ is considered to be an osmosensor which transmits signals across the membrane to OmpR, a transcriptional activator for ompF and ompC
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-
-
additional information
?
-
-
UhpB and perhaps UhpC play both positive and negative roles in the control of uhpT transcription
-
-
-
additional information
?
-
P27668
UhpB and perhaps UhpC play both positive and negative roles in the control of uhpT transcription
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-
-
additional information
?
-
-
regulation of nitrogen fixation genes in Rhizobium meliloti is mediated by two proteins, FixL and FixJ, in response to oxygen availability, oxygen sensor
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-
-
additional information
?
-
-
the gene regulates transcription of the nifHDK operon and so limits the expression of nitrogen fixation activity to periods of low environmental concentrations of both oxygen and fixed nitrogen
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-
-
additional information
?
-
-
FixL senses an environmental signal and transduces it to FixJ, a transcriptional activator of nif and fix genes
-
-
-
additional information
?
-
P10047
required for the activation of the C4-dicarboxylate transport structural gene dctA in free-living Rhizobium leguminosarum
-
-
-
additional information
?
-
P09384
during bacterial chemotaxis, the binding of stimulatory ligands to chemoreceptors at the cell periphery leads to a response at the flagellar motor. Three proteins appear to be required for receptor-mediated control of swimming behavior, the products of the cheA, cheW, and cheY genes
-
-
-
additional information
?
-
P08982
enzyme is required for the proper expression of the outer membrane proteins OmpC and OmpF
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-
-
additional information
?
-
-
enzyme has an enhancing effect on the transcription of phoA, primary function may not be connected to the phosphate regulon
-
-
-
additional information
?
-
P10799
membrane-bound sensor of plant signal molecules
-
-
-
additional information
?
-
P18769
FrzE is a second messenger that relays information between the signaling protein FrzCD and the gliding motor
-
-
-
additional information
?
-
-
mediates the transfer of phosphate to the Spo0A and Spo0F sporulation regulatory proteins
-
-
-
additional information
?
-
-
RcsC is the sensor components of the two-component regulatory system which regulates expression of the slime polysaccharide colanic acid. rcs system is essential for expression of high levels of the group I capsular polysaccharide in lon+ E. coli K30
-
-
-
additional information
?
-
-
the two-component regulatory system phoP/phoQ controls Salmonella typhimurium virulence
-
-
-
additional information
?
-
P0DMC5
colanic acid capsule synthesis in Escherichia coli K-12 is regulated by RcsB and RcsC. RcsC acts as the sensor and RcsB acts as the receiver or effector to stimulate capsule synthesis from cps genes
-
-
-
additional information
?
-
-
bvgS and bvgA control the expression of the virulence-associated genes in Bordetella species by a system similar to the two-component systems used by a variety of bacterial species to respond to environmental stimuli
-
-
-
additional information
?
-
P0DM80
the PhoP-PhoQ system exerts a master regulatory function for preventing bacterial overgrowth within fibroblasts
-
-
-
additional information
?
-
P14377
the HydH/G system senses high periplasmic Zn2+ and Pb2+ concentrations and contributes to metal tolerance by activating the expression of zraP
-
-
-
additional information
?
-
Q9APE0
the HydH/G system senses high periplasmic Zn2+ and Pb2+ concentrations and contributes to metal tolerance by activating the expression of zraP
-
-
-
additional information
?
-
P15939
NodV and NodW proteins are members of the family of two-component regulatory systems, NodV responds to an environmental stimulus and, after signal transduction, NodW may be required to positively regulate the transcription of one or several unknown genes involved in the nodulation process
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-
-
additional information
?
-
P20169
the enzyme is involved in chemical sensing
-
-
-
additional information
?
-
-
genes dctB and dctD form a two-component system which responds to the presence of C4-dicarboxylates to regulate expression of a transport protein encoded by dctA
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-
-
additional information
?
-
-
narL and narX mediate nitrate induction of nitrate reductase synthesis and nitrate repression of fumarate reductase synthesis
-
-
-
additional information
?
-
-
in free-living cells, the regulatory dctBD genes are absolutely required for the expression of the dctA gene
-
-
-
additional information
?
-
-
dctB-encoded protein includes a putative periplasmic N-terminal domain that senses the presence of dicarboxylates and a C-terminal cytoplasmic domain that activates the dctD-encoded protein
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-
-
additional information
?
-
-
enzyme is involved in signal transduction
-
-
-
additional information
?
-
-
the enzyme is a regulator of chemotaxis
-
-
-
additional information
?
-
P33113
enzyme is responsible for regulation of subtilin biosynthesis
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-
-
additional information
?
-
-
enzyme is responsible for regulation of subtilin biosynthesis
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-
-
additional information
?
-
-
enzyme is involved in the regulation of expression of phosphoglycerate transport in Salmonella typhimurium. pgtB and pgtC genes are involved in the induction of the pgtP expression by modulating derepressor activity
-
-
-
additional information
?
-
P29905
moxY is part of the two-component regulatory system controlling methanol dehydrogenase synthesis
-
-
-
additional information
?
-
-
either of two functionally redundant sensor proteins, NarX and NarQ, is sufficient for nitrate regulation in Escherichia coli K-12. NarQ and NarX may have subtle functional differences
-
-
-
additional information
?
-
-
activation role for ResD, and to a lesser extent ResE, in global regulation of aerobic and anaerobic respiration in Bacillus subtilis
-
-
-
additional information
?
-
P37433
PgtB and PgtC polypeptides modulate PgtA activity
-
-
-
additional information
?
-
-
narQ is a nitrate sensor for nitrate-dependent gene regulation in Escherichia coli
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-
-
additional information
?
-
-
the enzyme is a biological oxygen sensors that restricts the expression of specific genes to hypoxic conditions
-
-
-
additional information
?
-
P21865
the two-component sensor-effector system KdpD /KdpE controls expression of the kdpABC operon
-
-
-
additional information
?
-
-
the two-component sensor-effector system KdpD /KdpE controls expression of the kdpABC operon
-
-
-
additional information
?
-
-
FixL and FixJ proteins are members of the two-component sensor/regulator family
-
-
-
additional information
?
-
P33639
PilS/PilR is a two-component transcriptional regulatory system controlling expression of type 4 fimbriae in Pseudomonas aeruginosa. PilS is a sensor protein which when stimulated by the appropriate environmental signals activates PilR through kinase activity. PilR then activates transcription of pilA, probably by interacting with RNA polymerase containing RpoN
-
-
-
additional information
?
-
-
the TorS/TorR two-component system induces the expression of the tor structural operon encoding the trimethylamine N-oxide reductase respiratory system in response to substrate availability. TorS belongs to a sensor subfamily that includes a classical transmitter domain, a receiver, and a C-terminal alternative transmitter domain
-
-
-
additional information
?
-
P49333
ETR1 acts as an ethylene receptor
-
-
-
additional information
?
-
-
ETR1 acts as an ethylene receptor
-
-
-
additional information
?
-
-
TorS is a sensor that contains three phosphorylation sites and transphosphorylates TorR via a four-step phosphorelation, His443--Asp723--His850--Asp(TorR)
-
-
-
additional information
?
-
P40719, Q8X524
QseBC is a two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli strains EHEC and K-12
-
-
-
additional information
?
-
-
TorS mediates the induction of the tor structural genes in response to trimethylamine N-oxide
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-
-
additional information
?
-
-
enzyme is involved in positive regulation of synthesis of extracellular enzymes and polysaccharide in Xanthomonas campestris pathovar campestris
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-
-
additional information
?
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P45608
enzyme is involved in regulation of the phosphate regulon
-
-
-
additional information
?
-
P45609
enzyme is involved in regulation of the phosphate regulon
-
-
-
additional information
?
-
-
the two-component regulatory system DcuSR of Escherichia coli controls the expression of genes of C4-dicarboxylate metabolism in response to extracellular C4-dicarboxylates such as fumarate or succinate. The phosphoryl group of DcuS is rapidly transferred to the response regulator DcuR. Upon phosphorylation, DcuR binds specifically to dcuB promoter DNA
-
-
-
additional information
?
-
P52687
citrate, Na+, and oxygen exert their regulatory effects via the CitA/CitB system. In the presence of these signals, the citAB gene products induce their own synthesis. The positive autoregulation occurs via co-transcription of citAB with citS and oadGAB
-
-
-
additional information
?
-
-
the genes encoding the anaerobic fumarate respiratory system are transcriptionally regulated by C4-dicarboxylates. The regulation is effected by a two-component regulatory system, DcuSR, consisting of a sensory histidine kinase DcuS and a response regulator DcuR
-
-
-
additional information
?
-
-
periplasmic loop of DcuS serves as a C4-dicarboxylate sensor. The cytosolic region of DcuS contains two domains: a central PAS domain possibly acting as a second sensory domain and a C-terminal transmitter domain
-
-
-
additional information
?
-
-
the two-component system regulates an osmosensing MAP kinase cascade
-
-
-
additional information
?
-
P77485
expression of cusC is induced by high concentrations of copper ions, the cusRS two-component signal transduction system is required for copper-induced expression of pcoE, a plasmid-borne gene from the E. coli copper resistance operon pco. The genes cusRS are also required for the copper-dependent expression of at least one chromosomal gene, designated cusC, which is allelic to the recently identified virulence gene ibeB in E. coli K1. The cus locus may comprise a copper ion efflux system
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-
-
additional information
?
-
Q06067
the antizyme is a bifunctional protein serving as both an inhibitor of polyamine biosynthesis as well as a transcriptional regulator of an as yet unknown set of genes
-
-
-
additional information
?
-
-
the enzyme is involved in chemotaxis
-
-
-
additional information
?
-
Q02541
two-component regulatory system CopR/CopS is required for copper-inducible expression of the copper resistance operon
-
-
-
additional information
?
-
Q04850
the two-component regulatory system, NtrY/NtrX is involved in nitrogen fixation and metabolism. NtrY is likely to represent the transmembrane sensor protein element in a two-component regulatory system
-
-
-
additional information
?
-
Q04943
the two-component regulatory system afsQ1/afsQ2 is involved in secondary metabolism
-
-
-
additional information
?
-
P77510
the two-component systemDpiA/DpiB is involved in regulation of plasmid inheritance
-
-
-
additional information
?
-
P0A4I7
the cutR-cutS operon regulates copper metabolism in Streptomyces
-
-
-
additional information
?
-
P52687
the periplasmic domain of the histidine autokinase CitA functions as a highly specific citrate receptor
-
-
-
additional information
?
-
-
the ExoS-ChvI two-component regulatory system regulates succinoglycan production. ChvG is the sensor protein of the ChvG-ChvI two-component regulatory system
-
-
-
additional information
?
-
P0C5S6
the enzyme is involved in regulation of density-dependent expression of luminescence in Vibrio harveyi
-
-
-
additional information
?
-
P54302
the enzyme is involved in regulation of density-dependent expression of luminescence in Vibrio harveyi
-
-
-
additional information
?
-
-
the two-component regulatory system PfeR/PfeS is involved in the expression of the ferric enterobactin receptor PfeA
-
-
-
additional information
?
-
-
deletion of PilS results in a non-pilated phenotype
-
-
-
additional information
?
-
P0AEC8
a chemical or other stimulus is detected by the periplasmic sensor domain of a transmembrane histidine kinase sensor, which in turn relays a signal through a phosphotransfer cascade to the cognate cytoplasmic response regulator. Such systems lead ultimately to changes in gene expression or cell motility. Mechanisms of ligand binding and signal transduction through the cell membrane, overview
-
-
-
additional information
?
-
Q09JB2, Q09JB3, Q09JB4, Q09JB6, Q09JB7, Q09JB8, Q09JB9
AlHK1p is important for, but not the sole factor responsible for Alternaria longipes resistance to dicarboximide fungicides, e.g. dimethachlon, molecular basis of the fungicide resistance, overview
-
-
-
additional information
?
-
-
DcuS is the C4-dicarboxylate sensor of Escherichia coli catalyzing transmembrane sensing
-
-
-
additional information
?
-
Q81QX4
genes for orthologs of the sensor domain of the BA2291 kinase exist in virulence plasmids in this organism, and these proteins, when expressed, inhibit sporulation by converting BA2291 to an apparent phosphatase of the sporulation phosphorelay
-
-
-
additional information
?
-
-
histidine kinases are part of two-component signal transduction systems that act to integrate environmental stimuli into a cellular response via a phosphotransfer relay mechanism, e.g. involved in stomatal guard cell response to H2O2, regulation of the physiological function, overview
-
-
-
additional information
?
-
Q95434
Myxococcus xanthus undergoes a complex starvation-induced developmental program that results in cells forming multicellular fruiting bodies by aggregating into mounds and then differentiating into spores. This developmental program involves EspA, which plays a key role in the timing of expression of genes necessary for progression of cells through the developmental program, overview
-
-
-
additional information
?
-
-
role of the C-terminal domains in the photocycle of a light sensor histidine kinase Ppr having a photoactive yellow protein, PYP, domain as the photosensor domain, photocycles of the PYP domain of Ppr and of the full-length Ppr. The, overview
-
-
-
additional information
?
-
Q9HWR3
signal transduction mechanism in the bacteriophytochrome, overview
-
-
-
additional information
?
-
Q88PG3
significant number of genes are influenced directly or indirectly by the RoxSR two-component system. 173 genes are found showing reduced expression in EU58 (RoxSR mutant strain) in comparison to the wild type, whereas 84 genes are upregulated in the mutant
-
-
-
additional information
?
-
Q25026
the enzyme HP0244 is not only required to regulate flagellar gene expression via its cognate response regulator, HP0703, but also to generate a response to declining medium pH. Although not required for survival at pH 4.5, HP0244 is required for survival at pH 2.5, overview
-
-
-
additional information
?
-
P16497
the N-terminal Per-ARNT-Sim domain plays a critical role in the catalytic activity of this enzyme, a significant decrease occurs of the autophosphorylation rate of a KinA protein lacking this domain
-
-
-
additional information
?
-
-
the SenS/SenR system of Streptomyces reticuli regulates the expression of the redox regulator FurS, the catalase-peroxidase CpeB and the heme-binding protein HbpS. SenS/SenR also participates in sensing redox changes, mediated by HbpS. The heme-binding protein HbpS regulates the activity of the Streptomyces reticuli iron-sensing histidine kinase SenS in a redox-dependent manner, presence of SenS/SenR leads to the synthesis of extracellular redox active proteins, overview
-
-
-
additional information
?
-
Q45614
The sensor histidine kinase YycG acts in a two-component system with response regulator/transcription factor YycF in Bacillus subtilis controling the synthesis of autolysins and autolysin inhibitors, that function in cell wall remodelling and cell separation, YycG sensor histidine kinase is a component of and perceives infirmation at the division septum in growing cells constituting a positive feedback loop, that serves to co-ordinate cell division with cell wall homeostasis, overview
-
-
-
additional information
?
-
-
the sensory histidine kinase acts in the two-component system with the response regulator as RR-HK17, EF1633-EF1632, in the regulation of ethanolamine utilization, which can be the sole carbon source for the organism, mechanism, overview
-
-
-
additional information
?
-
Q88PG3
The two-component system is implicated in redox signaling and cytochrome oxidase activity, in expression of the cell density-dependent gene ddcA and in bacterial colonization of plant surfaces. The RoxS/RoxR regulon includes genes involved in sugar and amino acid metabolism and the sulfur starvation response and elements of the respiratory chain (a cbb3 cytochrome oxidase, Fe-S clusters, and cytochrome c-related proteins) or genes participating in the maintenance of the redox balance. The RoxS/RoxR system controls a broad set of functions that have an influence on energy metabolism, such as formaldehyde and formate dehydrogenases.
-
-
-
additional information
?
-
Escherichia coli O9:K30:H12
-
RcsC is the sensor components of the two-component regulatory system which regulates expression of the slime polysaccharide colanic acid. rcs system is essential for expression of high levels of the group I capsular polysaccharide in lon+ E. coli K30
-
-
-
additional information
?
-
Agrobacterium tumefaciens 15955
P10799
membrane-bound sensor of plant signal molecules
-
-
-
additional information
?
-
Lactobacillus plantarum C11
-
DNA sequences of plnB reveals that the product closely resembles members of bacterial two-component signal transduction systems. The finding that plnABCD are transcribed from a common promoter suggests that the biological role played by the bacteriocin is somehow related to the regulatory function of the two-component system located on the same operon
-
-
-
additional information
?
-
Streptomyces reticuli Tue54
-
the SenS/SenR system of Streptomyces reticuli regulates the expression of the redox regulator FurS, the catalase-peroxidase CpeB and the heme-binding protein HbpS. SenS/SenR also participates in sensing redox changes, mediated by HbpS. The heme-binding protein HbpS regulates the activity of the Streptomyces reticuli iron-sensing histidine kinase SenS in a redox-dependent manner, presence of SenS/SenR leads to the synthesis of extracellular redox active proteins, overview
-
-
-
additional information
?
-
Bacillus anthracis 34F2DELTA118
Q81QX4
genes for orthologs of the sensor domain of the BA2291 kinase exist in virulence plasmids in this organism, and these proteins, when expressed, inhibit sporulation by converting BA2291 to an apparent phosphatase of the sporulation phosphorelay
-
-
-
additional information
?
-
Bacillus subtilis 1A40
P16497
the N-terminal Per-ARNT-Sim domain plays a critical role in the catalytic activity of this enzyme, a significant decrease occurs of the autophosphorylation rate of a KinA protein lacking this domain
-
-
-
additional information
?
-
I1WSZ3
the two-component regulatory system irlR-irlS is involved in invasion of eukaryotic cells and heavy-metal resistance in Burkholderia pseudomallei
-
-
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
FAD
-
Slr1759-Var I protein contains 0.11-0.26 mM cofactor per 1 mM protein
flavin
-
flavin-containing histidine kinase functions as a photoreceptor, the flavin chromophore, upon illumination, forms a cysteinyl-flavin adduct, which is the signaling state that activates the histidine kinase, regulates Brucella abortus virulence
flavin
-
flavin-containing histidine kinase functions as a photoreceptor, the flavin chromophore, upon illumination, forms a cysteinyl-flavin adduct, which is the signaling state that activates the histidine kinase
GDP
Q81QX4
this kinase is uniquely specific for GTP in the forward and GDP in the reverse reaction. The G1 motif of BA2291 is highly modified from ATP specific histidine kinases, binding structure, modeling, overview
GTP
Q81QX4
this kinase is uniquely specific for GTP in the forward and GDP in the reverse reaction. The G1 motif of BA2291 is highly modified from ATP specific histidine kinases, binding structure, modeling, overview
heme
-
FixL is an oxygen-binding hemoprotein, the heme domain serves as the dioxygen switch in the FixL/FixJ two-component system
heme
-
the oxygen-detecting domain is a heme binding region that controls the activity of an attached histidine kinase. In the absence of bound ligand, the heme domain permits kinase activity. In the presence of bound ligand, this domain turns off kinase activity
additional information
Q81QX4
no activity with ATP, TTP, or CTP in autophosphorylation
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ag+
specifically activated by silver
Cu2+
specifically activated by 0.01 mM copper
Cu2+
-
essential cofactor
Fe
-
enzyme contains 2-labile 1-2 iron-sulphur [4Fe-4S]2+ clusters of the FNR-type
Fe2+
-
the presence of iron ions alone or in combination with H2O2 or dithiothreitol leads to significantly increased phosphorylation levels of SenS. 0.005 mM Fe2+ is able to enhance the phosphorylation level of SenS by a factor of 10 relative to the basal level, a combination of FeCl2 and H2O2 increases autophosphorylation activity by a factor of 20
Fe3+
-
0.005 mM Fe3+ is able to enhance the phosphorylation level of SenS by a factor of 10 relative to the basal level
FeCl2
-
enhances SenS autokinase activity in presence of HbpS, the activation is unaffected by DTT, but is enhanced by H2O2
FeCl3
-
enhances SenS autokinase activity strongly in presence of HbpS, H2O2 and DTT inhibit the activation
Mg2+
-
required for HK1 activity
additional information
-
the autokinase activity of SenS is not affeted by Zn2+, H2O2, and DTT
additional information
-
the autokinase activity of SenS is not affeted by Zn2+, H2O2, and DTT; the combination of 5 mM dithiothreitol and 0.005 mM FeCl2, or 5 mM dithiothreitol and 0.005 mM FeCl3, or 0.005 mM FeCl3 and 5 mM H2O2 has no effect on phosphorylation level of SenS, H2O2 prevents the activation by Fe3+; ZnCl2 is not able to change the autokinase activity of SenS
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(3-decanoyl-4,5,7-trihydroxynaphthalen-2-yl)acetic acid
-
IC50 of 0.0095 mg/ml
(4-[2-[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl]ethoxy]phenyl)methanaminium chloride
-
-
2-(3,4-dimethoxyphenyl)-N-[(5-phenylfuran-2-yl)methyl]ethanaminium
-
2-(4-[2-[4-(4-chlorobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl]ethoxy]phenyl)ethanaminium chloride
-
-
2-(4-[2-[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl]ethoxy]phenyl)ethanaminium chloride
-
-
2-[[(4-amino-1,2,5-oxadiazol-3-yl)carbonyl]amino]-N-[4-(thiophen-2-ylmethoxy)benzyl]ethanaminium
-
2-[[(4-amino-1,2,5-oxadiazol-3-yl)carbonyl]amino]-N-[[5-(3-chloro-4-methoxyphenyl)furan-2-yl]methyl]ethanaminium
-
3,6-diamino-5-cyano-4-phenyl-thieno[2,3-b]pyridine-2-carboxylic acid (4-bromo-phenyl)amide
-
competitive inhibitor of the coupled reaction of histidine kinase HpkA HK and the cognate response regulator DrrA RR
Art1
-
IC50 of 0.0095 mg/ml
cyanide
-
autokinase activity of the purified ethylene resistant 1 is completely abolished by 2 mM cyanide
ethylene
-
autokinase activity of the purified ethylene resistant 1 is completely abolished by 2 mM ethylene
Fe(II)-CO complex
-
the Fe(II)-CO complex of the heme nitric oxide/oxygen protein inhibits the autophosphorylation of the operon-associated histidine kinase
Fe(II)-NO complex
-
the Fe(II)-NO complex of the heme nitric oxide/oxygen protein inhibits the autophosphorylation of the operon-associated histidine kinase, whereas the ligand-free heme nitric oxide/oxygen protein has no effect on the kinase
fludioxonil
-
-
HbpS
-
heme-free HbpS represses the autokinase activity of SenS
-
HCl
-
cytoplasmic phosphorylated AtoS is sensitive to treatment with 1 N HCl but stable in the presence of 1 N NaOH
heme-binding protein HbpS
-
inhibits autophosphorylation activity of the enzyme in absence of redox reagents and hemin, but activates slightly in presence of hemin and strongly in presence of FeCl2 and FeCl3, DTT increases the activation with FeCl2, but inhibits activation with FeCl3, while H2O2 strongly increases the activation by FeCl2 and completely inhibits activation with FeCl3, overview
-
iprodione
-
-
kinase inhibitor protein
-
the kinase inhibitor protein KipI prevents sporulation by binding KinA and inhibiting the autophosphorylation reaction
-
menadione
-
-
N,N'-bis(1H-benzimidazol-2-yl)biphenyl-4,4'-diamine
-
N-[[5-(2-fluorophenyl)furan-2-yl]methyl]-3-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]propan-1-aminium
-
N-[[5-(3-chloro-4-fluorophenyl)furan-2-yl]methyl]-3-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]propan-1-aminium
-
paraquat
-
-
quintozene
-
-
Sda
-
potent inhibitor of KinB autophosphorylation, Sda directly inhibits sporulation histidine kinase in response to DNA damage and replication defects, Sda acts to sterically block communication between the catalytic ATP-binding and dimerization/histidinephosphotransfer domains required for autophosphorylation, as well as to sterically block communication between the response regulator Spo0F and DHp domain required for phosphotransfer and phosphatase activities
-
suppressor of dnaA
-
Sda, inhibits KinA by directly binding to the autokinase domain
-
Mg2+
-
PhoQ is strongly repressed in divalent cation-replete medium at 10 mM Mg2+
additional information
-
thermal transition of HK1 is a two-state process and that of HK2 is a three-state process. Urea denaturation of HK1 and HK2 is a three-state and two-state process, respectively
-
additional information
-
in the dark, roughly an order of magnitude fewer bacteria survive, a survival rate no better than that of the LOV-HK knockout mutant
-
additional information
Q81QX4
the virulence plasmid-encoded sensor domains of BA2291 have a regulatory effect in vivo on the activity of full-length BA2291, by converting it from a normally functional sporulation kinase to an enzyme that inhibits sporulation, molecular mechanism
-
additional information
-
not inhibited by Fe2+
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
alanine
-
stimulates, stimulation pattern of MtrA is similar to that of MtrB
auto-inducible protein I
-
dose-dependent activation by autoinducing peptide
-
betaine
-
stimulates, stimulation pattern of MtrA is similar to that of MtrB
citrate
-
effector of CitA
DivK
-
acts as a stimulator of both PleC and DivJ kinase activity
-
ethanolamine
-
induces a 15fold increase in the rate of autophosphorylation in vitro of the HK17 sensor histidine kinase
FixT
-
stimulates FixL-mediated dephosphorylation of FixJ
-
fructose
-
stimulates, stimulation pattern of MtrA is similar to that of MtrB
fumarate
-
effector of DcuS
glucose
-
stimulates, stimulation pattern of MtrA is similar to that of MtrB
glutamate
-
stimulates, stimulation pattern of MtrA is similar to that of MtrB
heme-binding protein HbpS
-
inhibits autophosphorylation activity of the enzyme in absence of redox reagents and hemin, but activates slightly in presence of hemin and strongly in presence of FeCl2 and FeCl3, DTT increases the activation with FeCl2, but inhibits activation with FeCl3, while H2O2 strongly increases the activation by FeCl2 and completely inhibits activation with FeCl3, overview
-
Hemin
-
activates slightly in presence of HbpS
L-glutamate
-
stimulates, more efficient stimulation of MtrB than MtrA
LprF
-
direct regulator of KdpD
-
LprJ
-
direct regulator of KdpD
-
lysine
-
stimulates, stimulation pattern of MtrA is similar to that of MtrB
maltoheptaose
-
stimulates, stimulation pattern of MtrA is similar to that of MtrB
maltose
-
stimulates, stimulation pattern of MtrA is similar to that of MtrB
NaCl
-
provides minor activation
proline
-
stimulates, stimulation pattern of MtrA is similar to that of MtrB
sorbitol
-
-
Ssl3451 protein
-
enhances the autophosphorylation activity of the histidine kinase Hik33 by associating with it with a 1:1 stoichiometry both in vitro and in vivo, but does not affect its dephosphorylation
-
Sucrose
-
stimulates, stimulation pattern of MtrA is similar to that of MtrB
trehalose
-
stimulates, stimulation pattern of MtrA is similar to that of MtrB
UhpC
-
UhpC stimulates UhpB autophosphorylation in the presence of D-glucose 6-phosphate
-
maltotriose
-
stimulates, stimulation pattern of MtrA is similar to that of MtrB
additional information
-
liposome shrinkage is not necessary for MtrB activation, MtrB is activated upon the addition of various chemical compounds, like sugars, amino acids, and polyethylene glycols, these may act via a change of the hydration state of the protein shifting MtrB into the active state, for activation it is essential that solutes are added at the same side as the cytoplasmic domains of the kinase are located
-
additional information
-
light-activated
-
additional information
-
light-activated, 2fold increase in transcription of the LOV-HK gene at a pH similar to that within infected macrophages
-
additional information
-
light-activated
-
additional information
Q81QX4
the virulence plasmid-encoded sensor domains of BA2291 have a regulatory effect in vivo on the activity of full-length BA2291, by converting it from a normally functional sporulation kinase to an enzyme that inhibits sporulation, molecular mechanism
-
additional information
-
hemin-treated HbpS enhances SenS autophosphorylation by 30fold under redox conditions using either H2O2 or dithiothreitol
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.1
ATP
-
mutant D657N/D782N/D909N
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.000167
ATP
Myxococcus xanthus
-
mutant D657N/D782N/D909N
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00062
3,6-diamino-5-cyano-4-phenyl-thieno[2,3-b]pyridine-2-carboxylic acid (4-bromo-phenyl)amide
-
-
0.1
AMP-PNP
-
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.084
Fe(II)-CO complex
Shewanella oneidensis
-
pH 8.0, 25C
0.009
Fe(II)-NO complex
Shewanella oneidensis
-
pH 8.0, 25C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
1.3
KinA autophosphorylation, purified recombinant mutant I95A
2.3
KinA autophosphorylation, purified recombinant wild-type enzyme
2.8
KinA autophosphorylation, purified recombinant mutant I108A
4
KinA autophosphorylation, purified recombinant mutant Y29A
additional information
-
activities of wild-type and truncated mutant SenS under different conditions, overview
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.5
-
assay at
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5.4 - 8.1
-
the light/dark difference spectra of Ppr-PYP are pH sensitive, pH-dependent equilibrium change between Ppr-PYPL and Ppr-PYPM, overview
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
22
assay at room temperature
22
-
assay at room temperature
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
histidine kinases of the organism show temporally and spatially different expression during the life cycle, e.g. expression of HK genes during sexual and asexual development, overview
Manually annotated by BRENDA team
Aspergillus nidulans ABPU1
-
histidine kinases of the organism show temporally and spatially different expression during the life cycle, e.g. expression of HK genes during sexual and asexual development, overview
-
Manually annotated by BRENDA team
Aspergillus nidulans ABPU1
-
-
-
Manually annotated by BRENDA team
Aspergillus nidulans ABPU1
-
conidial head
-
Manually annotated by BRENDA team
expressed in geranium florets long before they are receptive to pollination and transcript levels remain constant throughout floral development; expressed in geranium florets long before they are receptive to pollination and transcript levels remain constant throughout floral development
Manually annotated by BRENDA team
the level of expression of PE-ETR1 does not significantly change over the course of ripening, however, the mRNA levels of PE-ETR1 is much higher in arils than in seeds
Manually annotated by BRENDA team
-
; expressed at low levels in guard cells
Manually annotated by BRENDA team
Aspergillus nidulans ABPU1
-
-
-
Manually annotated by BRENDA team
LeETR2 mRNA expression is down-regulated in senescing leaf petioles
Manually annotated by BRENDA team
Cm-ETR1 mRNA is very high
Manually annotated by BRENDA team
LeETR2 mRNA is expressed at low levels throughout the plant but is induced in imbibing seeds prior to germination
Manually annotated by BRENDA team
Cm-ETR1 mRNA is very high
Manually annotated by BRENDA team
LeETR2 mRNA expression is down-regulated in elongating seedlings
Manually annotated by BRENDA team
-
vascular tissues of inflorescence stems
Manually annotated by BRENDA team
-
RodK is present in vegetative cells and remains present until the late aggregation stage, after which the level decreases in a manner that depends on the intracellular A-signal
Manually annotated by BRENDA team
additional information
LeETR1 is expressed constitutively in all plant tissues examined
Manually annotated by BRENDA team
additional information
-
FrzE is clearly present during vegetative growth and at much lower levels during development
Manually annotated by BRENDA team
additional information
-
mRNA is constitutively expressed in vegetative and reproductive tissues
Manually annotated by BRENDA team
additional information
EspA developmental expression pattern, mutational analysis, overview
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Vibrio cholerae MO45
-
-
-
-
Manually annotated by BRENDA team
-
RodK is a soluble cytoplasmic protein, which contains an N-terminal sensor domain, a histidine protein kinase domain and three receiver domains
Manually annotated by BRENDA team
is localized at the old pole of the large cell, after division and growth, the small cell acquires PdhS at its old pole, polar localization of PdhS is maintained during a cellular infection by bovine macrophages
Manually annotated by BRENDA team
Brucella abortus XDB1104
-
is localized at the old pole of the large cell, after division and growth, the small cell acquires PdhS at its old pole, polar localization of PdhS is maintained during a cellular infection by bovine macrophages
-
Manually annotated by BRENDA team
-
enzyme is anchored to the cytoplasmic membrane by the amino-terminal region
-
Manually annotated by BRENDA team
-
structure-function relationship in the cytoplasmic PAS domain, the multidomain protein DcuS possesses functional domains in the periplasm, within the membrane and in the cytoplasm, the localization depends on the functional state, overview
Manually annotated by BRENDA team
Staphylococcus carnosus M1
-
-
-
Manually annotated by BRENDA team
-
ETR1 of Arabidopsis contains transmembrane domains responsible for ethylene binding and membrane localization
Manually annotated by BRENDA team
-
the enzyme is distributed evenly about the membrane of Escherichia coli
-
Manually annotated by BRENDA team
-
bound, PilS is retained to the poles of Pseudomonas aeruginosa
-
Manually annotated by BRENDA team
-
EnvZ with a N-terminal cytoplasmic tail (residues 1-15), two transmembrane domains (residues 16-34 and residues 163-179) flanking a periplasmic domain (residues 48-162), and a cytoplasmic domain (residues 180-450). The cytoplasmic domain can be further dissected into a linker or HAMP domain (residues 180-222), domain A (dimerization and histidine containing domain, residues 223-289) and domain B (catalysis assisting and ATP binding domain, residues 290-450), UhpB contains eight transmembrane segments
-
Manually annotated by BRENDA team
NH2-terminal periplasmic domain
Manually annotated by BRENDA team
-
cytoplasmic side of inner membrane
Manually annotated by BRENDA team
-
EnvZ is a transmembrane protein with histidine kinase activity in its cytoplasmic region. The cytoplasmic region contains two functional domains: domain A, residues 223-289, contains the conserved histidine residue H243, a site of autophosphorylation as well as transphosphorylation to the conserved D55 residue of response regulator OmpR
Manually annotated by BRENDA team
-
transmembrane regions of EnvZ play roles in transmembrane signaling
Manually annotated by BRENDA team
-
transmembrane protein
Manually annotated by BRENDA team
-
the region between the hydrophobic segments of CpxA is periplasmic, whereas the region carboxy-terminal to the second such segment is cytoplasmic. CpxA functions as a trans-membrane sensory protein
Manually annotated by BRENDA team
-
may be a membrane protein
Manually annotated by BRENDA team
-
a large periplasmic domain is lacking and an extended cytoplasmic domain is present besides the kinase domain
Manually annotated by BRENDA team
-
EnvZ contained two hydrophobic stretches typical of transmembrane regions
Manually annotated by BRENDA team
N-terminal region may be located in the periplasm and its C-terminal region in the cytoplasm
Manually annotated by BRENDA team
-
FixL has features of a transmembrane protein
Manually annotated by BRENDA team
-
FixL is a membrane protein containing four possible transmembrane segments
Manually annotated by BRENDA team
-
dctB-encoded protein includes a putative periplasmic N-terminal domain that senses the presence of dicarboxylates and a C-terminal cytoplasmic domain that activates the dctD-encoded protein
Manually annotated by BRENDA team
-
transmembrane protein
Manually annotated by BRENDA team
-
KdpD is anchored to the membrane by four membrane-spanning segments near its middle, with both C-terminal and N-terminal portions in the cytoplasm
Manually annotated by BRENDA team
-
KdpD has four membrane-spanning segments in the middle of the polypeptide chain, whereas N and C terminus are both cytoplasmic
Manually annotated by BRENDA team
-
membrane-bound protein comprising at least three cytoplasmic domains
Manually annotated by BRENDA team
membrane-bound sensor-kinase with two potential membrane-spanning sequences in the N-terminal region
Manually annotated by BRENDA team
-
DcuS contains two putative transmembrane helices flanking an approximately 140-residue N-terminal domain apparently located in the periplasm
Manually annotated by BRENDA team
-
DcuS is a membrane-integral sensor kinase, and the sensory and kinase domains are located on opposite sides of the cytoplasmic membrane
Manually annotated by BRENDA team
-
CitA contains in the N-terminal half, two putative transmembrane helices which enclosed a presumably periplasmic domain of about 130 amino acids
Manually annotated by BRENDA team
-
CitA represents a membrane-bound sensor kinase consisting of a periplasmic domain flanked by two transmembrane helices, a linker domain and the conserved kinase or transmitter domain
Manually annotated by BRENDA team
NtrY is likely to represent the transmembrane sensor protein element in the two-component regulatory system
Manually annotated by BRENDA team
-
transmembrane enzyme
Manually annotated by BRENDA team
-
FixL contains four transmembrane segments
Manually annotated by BRENDA team
-
Hik33 perceives the cold signal via rigidification of membrane lipids
Manually annotated by BRENDA team
-
membrane-integral protein, DcuS and CitA accumulate at the cell poles
Manually annotated by BRENDA team
-
integral membrane protein
Manually annotated by BRENDA team
Agrobacterium tumefaciens 15955
-
-
-
Manually annotated by BRENDA team
-
the multidomain protein DcuS possesses functional domains in the periplasm, within the membrane and in the cytoplasm, the localization depends on the functional state, overview
-
Manually annotated by BRENDA team
-
the multidomain protein DcuS possesses functional domains in the periplasm, within the membrane and in the cytoplasm, the localization depends on the functional state, overview
Manually annotated by BRENDA team
Streptomyces reticuli Tue54
-
;
-
Manually annotated by BRENDA team
additional information
periplasmic sensor domains
-
Manually annotated by BRENDA team
additional information
-
periplasmic sensor domains
-
Manually annotated by BRENDA team
additional information
YycG is located at the division septum in growing cells, YycG localization is dependent upon FtsZ, but independent of YycH and YycI
-
Manually annotated by BRENDA team
additional information
Vibrio cholerae MO45
-
periplasmic sensor domains
-
-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
UNIPROT
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Burkholderia pseudomallei (strain 1710b)
Burkholderia pseudomallei (strain K96243)
Burkholderia pseudomallei (strain K96243)
Burkholderia pseudomallei (strain K96243)
Burkholderia pseudomallei (strain K96243)
Caulobacter crescentus (strain ATCC 19089 / CB15)
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Erythrobacter litoralis (strain HTCC2594)
Erythrobacter litoralis (strain HTCC2594)
Erythrobacter litoralis (strain HTCC2594)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain UCBPP-PA14)
Pseudomonas syringae pv. tomato (strain DC3000)
Rhizobium meliloti (strain 1021)
Rhizobium meliloti (strain 1021)
Rhizobium meliloti (strain 1021)
Rhizobium meliloti (strain 1021)
Rhizobium meliloti (strain 1021)
Rhizobium meliloti (strain 1021)
Rhizobium meliloti (strain 1021)
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Rhodopseudomonas palustris (strain TIE-1)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Synechococcus elongatus (strain PCC 7942)
Synechococcus elongatus (strain PCC 7942)
Synechococcus elongatus (strain PCC 7942)
Synechococcus sp. (strain JA-2-3B'a(2-13))
Synechococcus sp. (strain JA-2-3B'a(2-13))
Synechococcus sp. (strain JA-2-3B'a(2-13))
Synechococcus sp. (strain JA-2-3B'a(2-13))
Synechococcus sp. (strain JA-2-3B'a(2-13))
Synechocystis sp. (strain PCC 6803 / Kazusa)
Synechocystis sp. (strain PCC 6803 / Kazusa)
Syntrophus aciditrophicus (strain SB)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
31500
-
truncated His-tagged RaxH, predicted
682036
46000
-
YbdK-transmembrane domain dodecyl-phosphocholine complex, solution state NMR T1/T2 relaxation analysis
702080
48900
-
His-tagged RaxH, predicted
682036
50000
SDS-PAGE
704312
51000
delta517ThkA, experimental estimates
681392
75000
gel filtration
701250
75000
-
gel filtration
701250
76000
delta408ThkA, experimental estimates
681392
88000
Q81QX4
about, gel filtration
692901
130000
SDS-PAGE
701785
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
?
-
x * 102452, calculation from nucleotide sequence
?
-
x * 50000
?
x * 38409, calculation from nucleotide sequence
?
-
x * 52000
?
-
x * 49666
?
-
x * 49772, calculation from nucleotide sequence
?
-
x * 67275, calculation from nucleotide sequence
?
-
x * 69170
?
-
x * 83000
?
-
x * 74500
?
-
x * 99000
?
-
x * 55290
?
-
x * 99000, SDS-PAGE
?
-
x * 44600, calculation from nucleotide sequence
?
x * 46389, calculation from nucleotide sequence
?
-
x * 48846, calculation from nucleotide sequence
?
-
x * 50597, calculation from nucleotide sequence
?
-
x * 47774, calculation from nucleotide sequence
?
-
x * 54000, SDS-PAGE of MtrB
?
x * 83000, SDS-PAGE
dimer
-
2 * 79000
dimer
-
the Cph1 protein forms dimers through the C-terminal region
dimer
crystallography
dimer
wild-type KinA PAS-A, NMR, SDS-PAGE and gel filtration
dimer
Q81QX4
2 * 44000, SDS-PAGE
dimer
-
the signal transduction histidine kinase domain, H-NOXA revealing a Per-Arnt-Sim fold, monomers dimerize in a parallel arrangement juxtaposing their N-terminal helices and preceding residues, overview
dimer
dimeric PaBphP-PCD structure with PAS, GAF, and PHY domains, interdomain and histidine kinase domain, domain structure, overview
dimer
the isolated TorS sensor domain dimerizes in solution
dimer
-
the isolated TorS sensor domain dimerizes in solution
dimer
-
SDS-PAGE
dimer
-
x-ray crystallography
dimer
-
x-ray crystallography
dimer
-
AgrC forms ligand-independent dimers that undergo trans-autophosphorylation upon interaction with autoinducing peptide
dimer
Bacillus anthracis 34F2DELTA118
-
2 * 44000, SDS-PAGE
-
dimer
Bacillus subtilis 1A40
-
wild-type KinA PAS-A, NMR, SDS-PAGE and gel filtration
-
dimer
Vibrio parahaemolyticus EB101
-
the isolated TorS sensor domain dimerizes in solution
-
homodimer
-
YbdK-transmembrane domain forms homodimers in dodecyl-phosphocholine micelles, cross-linking assay and analytical ultracentrifugation analysis
homodimer
x-ray crystallography
monomer
gel filtration
monomer
gel filtration
additional information
-
the periplasmic region of histidine kinase EnvZ(Ala38-Arg162) forms a dimer in solution
additional information
determination of the importance of several residues at the dimer interface for KinA enzymatic activity in vitro and in vivo, KinA architecture and domain structure, and PAS-A domain organization and secondary structure, overview
additional information
-
the N-terminus of HK17 forms a GAF domain, structure of the RR-HK17 two-component system
additional information
-
the N-terminal domain in an STHK from Nostoc punctiforme is homologous to the central region in soluble guanylyl cyclase, the main receptor for nitric oxide, structure-function analysis and dimerization mechanism, overview
additional information
DcuS shows a mixed alpha/beta-structure containing two subdomains of similar folds, each consisting of a five-stranded antiparallel beta-sheet flanked by helices on either side, structure analysis, residues 42-181 comprise the sensory domain of the enzyme, dimerization of DcuS-42181, overview
additional information
-
DctB shows a mixed alpha/beta-structure containing two subdomains of similar folds, each consisting of a five-stranded antiparallel beta-sheet flanked by helices on either side, structure analysis, residues 28-286 comprise the sensory domain of the enzyme, overview
additional information
-
NMR structure analysis, localization and structural model, detailed overview
additional information
-
Ppr is composed of three domains, a PYP domain, a bacteriophytochrome Bph domain, and a histidine kinase domain, in the order from the N- to the C-terminal of Ppr
additional information
modeling of the full-length bacteriophytochrome structure, including its output histidine kinase domain, structure-function relationship, overview
additional information
Bacillus subtilis 1A40
-
determination of the importance of several residues at the dimer interface for KinA enzymatic activity in vitro and in vivo, KinA architecture and domain structure, and PAS-A domain organization and secondary structure, overview
-
additional information
Vibrio cholerae MO45
-
DctB shows a mixed alpha/beta-structure containing two subdomains of similar folds, each consisting of a five-stranded antiparallel beta-sheet flanked by helices on either side, structure analysis, residues 28-286 comprise the sensory domain of the enzyme, overview
-
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
-
autophosphorylation
phosphoprotein
Q81QX4
BA2291 performs GTP-dependent autophosphorylation
phosphoprotein
Bacillus anthracis 34F2DELTA118
-
BA2291 performs GTP-dependent autophosphorylation
-
phosphoprotein
-
autophosphorylation
phosphoprotein
KinA performs autophosphorylation
phosphoprotein
Bacillus subtilis 1A40
-
KinA performs autophosphorylation
-
phosphoprotein
-
autophosphorylation
phosphoprotein
-
-
phosphoprotein
-
phosphorylation of CckA is required for function but is not important for polar localization
phosphoprotein
-
-
phosphoprotein
-
the enzyme HK17 performs autophosphorylation stimulated by ethanolamine
phosphoprotein
-
His243 is the major site of phosphorylation on EnvZ
phosphoprotein
-
autophosphorylation; enzyme undergoes phosphorylation in the presence of ATP
phosphoprotein
-
purified BarA protein is able to autophosphorylate when incubated with [gamma-(32)P]ATP but not with [alpha-(32)P]ATP or [gamma-(32)P]GTP. Phosphorylated BarA, in turn, acts as an efficient phosphoryl group donor to UvrY. BarA and UvrY constitute a new two-component system for gene regulation in Escherichia coli
phosphoprotein
-
autophosphorylation; His243 is the a site of autophosphorylation as well as transphosphorylation to the conserved D55 residue of response regulator OmpR
phosphoprotein
-
autophosphorylation; the major site at which NRII is autophosphorylated is contained within a peptide consisting of amino acid residues 136-142 of NRII, and thus probably corresponds to H139. A minor site of phosphorylation, accounting for about 2% of the phosphate in NRII-P, is found in a peptide that corresponds to residues 158-169
phosphoprotein
-
the phosphotransfer domain, CheA1-134, contains the site of phosphorylation, His48, and two other histidine residues, His26 and His67
phosphoprotein
-
autophosphorylation
phosphoprotein
-
autophosphorylation, histidine-398 in the conserved H-box is the phospho-accepting site
phosphoprotein
-
-
phosphoprotein
-
autophosphorylation in the presence of ATP
phosphoprotein
-
low pH triggers the autophosphorylation of the histidine kinase ArsS
phosphoprotein
-
low pH triggers the autophosphorylation of the histidine kinase ArsS
-
phosphoprotein
-
autophosphorylation
phosphoprotein
the enzyme autophosphorylates in vitro on the conserved histidine residue and then transfers the phosphoryl group to the conserved aspartate residue in the associated receiver domain
phosphoprotein
-
FrzCD stimulates FrzE autophosphorylation
phosphoprotein
autophosphorylation; in the presence of [gamma-32P]ATP, the purified COOH-terminal KinB protein undergoes progressive autophosphorylation in vitro. Substitutions of the residues conserved among histidine protein kinases abolishes KinB autophosphorylation
phosphoprotein
-
histidine kinases autophosphorylate prior to transferring the phosphate to a response regulator
phosphoprotein
-
-
phosphoprotein
-
AgrC forms ligand-independent dimers that undergo trans-autophosphorylation upon interaction with autoinducing peptide
phosphoprotein
-
SenS performs autophosphorylation
phosphoprotein
-
; SenS performs autophosphorylation
phosphoprotein
Streptomyces reticuli Tue54
-
; SenS performs autophosphorylation; SenS performs autophosphorylation
-
phosphoprotein
-
autophosphorylation
phosphoprotein
-
the Slr1759 histidine kinase domain undergoes autophosphorylation in vitro
phosphoprotein
-
autophosphorylation
phosphoprotein
-
-
additional information
-
the enzyme performs regulatory autophosphorylation
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
hanging drop vapor diffusion method, using 2.54 M ammonium sulfate, 15.9% (v/v) glycerol, and 0.1 M MES buffer pH 5.05
-
purified recombinant residues 10-117 of KinA, fused to an N-terminal His6Gbeta1-tag and a TEV protease site in the tag-protein linker, free or as selenomethionine-tagged variant, hanging-drop vapor-diffusion method, 20C, mixing of 0.001 ml 7 mg/mL protein solution containing 25 mM Tris pH 8.0, 100 mM NaCl, with 0.001 ml well solution containing 13-15% w/v PEG 10000, 0.1 M ammonium acetate, and 0.1 M bis-Tris, pH 5.5, and with 20 mM DTT in case of the selenomethionine-labeled protein, 4 days, cryoprotetion using 25% v/v glycerol, X-ray diffraction structure determination and analysis at 1.7-2.0 A resolution
the phosphorylated cytoplasmic domain of DesK is crystallized by hanging drop vapor diffusion, using 10% (w/v) PEG 3000, 0.1 M CHES, pH 9.5, and 10 mM MgCl2, at 18C
crystal structure at 2.0 A resolution of the complex of the Escherichia coli chemotaxis response regulator CheY and the phosphoacceptor-binding domain P2 of the kinase CheA
-
crystal structure of the C-terminal HPt domain of ArcB
-
crystal structure of the histidine-containing phosphotransfer domain
-
crystal structure, at 2.95 A resolution, of the response regulator of bacterial chemotaxis, CheY, bound to the recognition domain from its cognate histidine kinase, CheA
-
crystallization of a complex between a novel C-terminal transmitter, HPt domain, of the anaerobic sensor kinase ArcB and the chemotaxis response regulator CheY
-
free and in complex with nitrate, hanging drop vapor diffusion method, using 0.1 M Tris-HCl (pH 8.5) and 2 M NH4H2PO4 at 4C (enzyme in complex with nitrate) or using 23% (w/v) polyethylene glycol 3350, 1% (v/v) isopropanol, and 0.1 M HEPES (pH 7.5) at 4C (free apo-enzyme)
hanging drop vapor diffusion method, at 4C against a buffer containing 5%10% (v/v) 1-4 butanediol, 0.1 M Na-aetate (pH 5.5), 25100 mM NH4SO4
purified recombinant selenomethionine-labeled and wild-type GST-tagged DcuS residues 42-181 in complex with C4-dicarboxylate ligand, 18.5 mg/ml protein, hanging-drop vapor diffusion, using a reservoir buffer containing 20-24% PEG monoethyl ether 2000, 15% isopropyl alcohol, 0.2 M ammonium citrate, and 0.1 M sodium acetate, pH 4.5, at 4 C, 1 week, X-ray diffraction structure determination and analysis
in complex with inhibitor Sda, crystals only form in the presence of ADP-Mg2+ (but not with ATP or AMPPNP, and not in the absence of nucleotide)
-
hanging drop vapor diffusion method, using 8% (v/v) isopropanol, 2% (w/v) PEG 3350, 150 mM calcium acetate, and 100 mM MES, pH 6.0, at 4C
citrate-free or citrate-bound CitA, hanging drop vapor diffusion method, using either 0.1 M HEPES, pH 7.5, 1.6 M (NH4)2SO4, and 5 mM sodium citrate or using 20 mM HEPES, pH 7.5, 0.63 M NaH2PO4 and 0.63 M KH2PO4
-
hanging drop vapor diffusion method
dimerized signal transduction histidine kinase domain H-NOXA domain residues 8-121, 4C, sitting-drop vapor diffusion, 20 mg/ml NpSTHK8121 in 5 mM Tris, pH 7.5, 100 mM NaCl, 1 mM 2-mercaptoethanol, is mixed with an equal volume of reservoir solution containing 1.7-1.9 M ammonium sulfate, 100 mM Tris-HCl, pH 7.7-9.0, for crystallization of the full-length enzyme, 15 mg/ml protein is mixed with equal volume of 0.1 M HEPES, pH 7.5, and 1.5 M lithium sulfate monohydrate, crystals appear after 3 days at 20C, X-ray diffraction structure determination and analysis at 2.1 A resolution
-
wild-type and mutant bacteriophytochrome with an intact, fully photoactive photosensory core domain in its darkadapted Pfr state, X-ray diffraction structure determination and analysis at 2.9 A resolution, molecular replacement
ThkA complexed with the response regulator TrrA, by the batch method, X-ray crystallography at a resolution of 4.2 A, 2fold symmetry, two monomeric TrrAs bind to the ThkA dimer
recombinant selenomethionine-labeled DctB residues 28-286 in complex with C4-dicarboxylate ligand, by hanging-drop vapor diffusion at 4C against a buffer containing 6% isopropyl alcohol, 0.2 M calcium acetate, and 0.1 M Tris-HCl, pH 7.5, the protein concentration is 8.5 mg/ml with a protein to buffer ratio of 1:1, 2 weeks, X-ray diffraction structure determination and analysis
-
hanging drop vapor diffusion method, at 4C against a buffer containing 7%13% (w/v) PEG 4000, 0.1 M Tris (pH 7.5)
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
40
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HK2 is stable up to 40C and reaches an intermediate state at 60C. On raising the temperature to 100C, the second stage of denaturation is observed
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60
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HK1 relatively stable up to 60C, gets completely denatured at 90C
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