Information on EC 2.7.13.3 - histidine kinase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY hide
2.7.13.3
protein-histidine kinases without information on stereospecificity towards histidine
RECOMMENDED NAME
GeneOntology No.
histidine kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
phospho-group transfer
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein-L-histidine N-phosphotransferase
This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). A number of histones can act as acceptor.
CAS REGISTRY NUMBER
COMMENTARY hide
99283-67-7
protein-histidine kinases, EC 2.7.13.1, EC 2.7.13.2, and EC 2.7.13.3 are not distinguished in Chemical Abstracts
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain 15955
SwissProt
Manually annotated by BRENDA team
strains Abra40 and Abra363H5M
UniProt
Manually annotated by BRENDA team
19 different isolates, gene AlHK1
UniProt
Manually annotated by BRENDA team
strain ABPU1
-
-
Manually annotated by BRENDA team
strain BPU1
-
-
Manually annotated by BRENDA team
Bacillus anthracis 34F2DELTA118
strain 34F2DELTA118, gene BA2291, the organism contains nine genes encoding putative sporulation histidine kinases
Q81QX4
UniProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
strain 168
-
-
Manually annotated by BRENDA team
strain 1A40
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
Borrelia burgdorferi
-
SwissProt
Manually annotated by BRENDA team
UWS111 strain
-
-
Manually annotated by BRENDA team
UWS111 strain
-
-
Manually annotated by BRENDA team
strain USDA110
SwissProt
Manually annotated by BRENDA team
strain RP501 parasponia
SwissProt
Manually annotated by BRENDA team
strain RP501 parasponia
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
all strains derived from Brucella abortus 544 NalR, XDB1104 strain
SwissProt
Manually annotated by BRENDA team
strain REP36-1
-
-
Manually annotated by BRENDA team
strain REP36-1
-
-
Manually annotated by BRENDA team
strain ATCC 13032
-
-
Manually annotated by BRENDA team
var. reticulatus
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
BM4147
SwissProt
Manually annotated by BRENDA team
gene dcuS
UniProt
Manually annotated by BRENDA team
O6
P59340, Q8CVU5, Q8FA38, Q8FAU6, Q8FB70, Q8FBG6, Q8FBX4, Q8FCU0, Q8FD66, Q8FDJ7, Q8FF85, Q8FFP8, Q8FFP9, Q8FG01, Q8FGP1, Q8FHA9, Q8FHZ2, Q8FIB8, Q8FJ55, Q8FJV6, Q8FJZ9, Q8FK37, Q8FKD0
SwissProt
Manually annotated by BRENDA team
Escherichia coli O9:K30:H12
strain O9:K30:H12
-
-
Manually annotated by BRENDA team
strain 26695
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
strain C11
SwissProt
Manually annotated by BRENDA team
subsp. lactis
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
var. Xanthi, histidine kinase NTHK2
Uniprot
Manually annotated by BRENDA team
strain PCC 73102
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
strain DC3000
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
strain Newman
UniProt
Manually annotated by BRENDA team
strain M1
-
-
Manually annotated by BRENDA team
strain M1
-
-
Manually annotated by BRENDA team
strain (D39) ATCC 7466
UniProt
Manually annotated by BRENDA team
strain A3(2) (ATCC BAA471D)
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
strain MO45, gene dctB
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-
Manually annotated by BRENDA team
strain MO45, gene dctB
-
-
Manually annotated by BRENDA team
; strain EB101
-
-
Manually annotated by BRENDA team
strain EB101
-
-
Manually annotated by BRENDA team
pv. campestris
SwissProt
Manually annotated by BRENDA team
strain PXO99
-
-
Manually annotated by BRENDA team
strain PXO99
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
-
DcuS and CitA are involved in the regulation of carboxylate metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ArcA + ATP
?
show the reaction diagram
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + ArsR
?
show the reaction diagram
ATP + BctC
?
show the reaction diagram
-
-
-
-
?
ATP + CpdR-L-histidine
ADP + CpdR-N-phospho-L-histidine
show the reaction diagram
-
-
-
-
?
ATP + CtrA-L-histidine
ADP + CtrA-N-phospho-L-histidine
show the reaction diagram
-
-
-
-
?
ATP + DivK
?
show the reaction diagram
-
DivJ is the main kinase of DivK
-
-
?
ATP + FixJ
?
show the reaction diagram
-
-
-
-
?
ATP + histidine kinase EnvZ
ADP + histidine kinase EnvZ N-phospho-L-histidine
show the reaction diagram
-
autophosphorylation. Probing catalytically essential domain orientation in histidine kinase EnvZ by targeted disulfide crosslinking
-
-
?
ATP + histidine kinase Hik34
ADP + histidine kinase Hik34 N-phospho-L-histidine
show the reaction diagram
ATP + PhoN protein L-histidine
ADP + PhoN protein N-phospho-L-histidine
show the reaction diagram
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
ATP + Spo0F protein L-histidine
ADP + Spo0F protein N-phospho-L-histidine
show the reaction diagram
-
-
-
-
?
ATP + VicR protein L-histidine
ADP + VicR protein N-phospho-L-histidine
show the reaction diagram
ATP + VirG-L-histidine
ADP + VirG-N-phospho-L-histidine
show the reaction diagram
-
-
-
-
?
ATP + YycF
ADP + phospho-YycF
show the reaction diagram
BvgA + ATP
?
show the reaction diagram
CitB + ATP
?
show the reaction diagram
-
a fusion protein MalE-CitAC is composed of the maltose-binding protein and the CitA kinase domain shows constitutive autokinase activity and transfers the gamma-phosphate group of ATP to its cognate response regulator CitB
-
-
?
CtrA + ATP
?
show the reaction diagram
-
-
-
?
DcuR + ATP
?
show the reaction diagram
-
the phosphoryl group of DcuS is rapidly transferred to the response regulator DcuR. Upon phosphorylation, DcuR binds specifically to dcuB promoter DNA
-
-
?
EvgA + ATP
?
show the reaction diagram
-
one hybrid histidine kinase consisting of the BvgS transmitter and HPt domains and of the EvgS receiver domain BvgS-TO-EvgS-R is able to phosphorylate BvgA but not EvgA. In contrast, the hybrid protein consisting of the BvgS transmitter and the EvgS receiver and HPt domains BvgS-T-EvgS-RO is unable to phosphorylate BvgA but efficiently phosphorylates EvgA
-
-
?
GTP + protein-L-histidine
GDP + protein N-phospho-L-histidine
show the reaction diagram
GTP + Spo0F L-histidine
GDP + Spo0F N-phospho-L-histidine
show the reaction diagram
protein + ATP
?
show the reaction diagram
Rcp1 + ATP
?
show the reaction diagram
-
Cph1 is a light-regulated histidine kinase that mediates red, far-red reversible phosphorylation of the a small response regulator Rcp1
-
-
?
regulator protein OmpR + ATP
?
show the reaction diagram
TorR + ATP
?
show the reaction diagram
-
TorS is a sensor that contains three phosphorylation sites and transphosphorylates TorR via a four-step phosphorelay, His443 to Asp723 to His850 to Asp(TorR). TorS can dephosphorylate phospho-TorR when trimethylamine N-oxide is removed. Dephosphorylation probably occurs by a reverse phosphorelay, Asp(TorR) to His850 to Asp723
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ArcA + ATP
?
show the reaction diagram
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + histidine kinase Hik34
ADP + histidine kinase Hik34 N-phospho-L-histidine
show the reaction diagram
-
histidine kinase Hik34 might negatively regulate the expression of certain heat shock genes that might by related to thermotolerance in Synechocystis
-
-
?
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
ATP + YycF
ADP + phospho-YycF
show the reaction diagram
Q45614
the formation of the division septum is necessary for YycG phosphorylation of YycF
-
-
?
GTP + protein-L-histidine
GDP + protein N-phospho-L-histidine
show the reaction diagram
GTP + Spo0F L-histidine
GDP + Spo0F N-phospho-L-histidine
show the reaction diagram
Rcp1 + ATP
?
show the reaction diagram
-
Cph1 is a light-regulated histidine kinase that mediates red, far-red reversible phosphorylation of the a small response regulator Rcp1
-
-
-
additional information
?
-