Literature summary for 2.7.13.3 extracted from

Hyyrylainen, H.L.; Bolhuis, A.; Darmon, E.; Muukkonen, L.; Koski, P.; Vitikainen, M.; Sarvas, M.; Pragai, Z.; Bron, S.; van Dijl, J.M.; Kontinen, V.P.
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress (2001), Mol. Microbiol., 41, 1159-1172.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Bacillus subtilis	two-component regulatory system CssR-CssS, is required for the cell to survive the severe secretion stress caused by a combination of high-level production of the alpha-amylase AmyQ and reduced levels of the extracytoplasmic folding factor PrsA. The Css system is required to degrade misfolded exported proteins at the membrane-cell wall interface. CssS represents the first identified sensor for extracytoplasmic protein misfolding in a Gram-positive eubacterium	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	O32193	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	two-component regulatory system CssR-CssS, is required for the cell to survive the severe secretion stress caused by a combination of high-level production of the alpha-amylase AmyQ and reduced levels of the extracytoplasmic folding factor PrsA. The Css system is required to degrade misfolded exported proteins at the membrane-cell wall interface. CssS represents the first identified sensor for extracytoplasmic protein misfolding in a Gram-positive eubacterium	Bacillus subtilis	?	-	?

Synonyms

Synonyms	Comment	Organism
sensor protein cssS	-	Bacillus subtilis

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Release 2023.1 (January 2023)