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Literature summary for 2.7.13.3 extracted from

  • Angelastro, P.S.; Sliusarenko, O.; Jacobs-Wagner, C.
    Polar localization of the CckA histidine kinase and cell cycle periodicity of the essential master regulator CtrA in Caulobacter crescentus (2010), J. Bacteriol., 192, 539-552.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.13.3

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli C41(DE3) cells Caulobacter vibrioides

Protein Variants

Protein Variants Comment Organism
additional information the disruption of a PAS-like motif in the sensor domain affects the stability of CckA accumulation at the poles accompanied by a partial loss in CckA function. Shortening of an extended linker between beta-sheets within the CckA catalysis-assisting ATP-binding domain leads to a dramatic cell-to-cell variability in CpdR levels and CtrA cell cycle periodicity Caulobacter vibrioides

Organism

Organism UniProt Comment Textmining
Caulobacter vibrioides
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of CckA is required for function but is not important for polar localization Caulobacter vibrioides

Purification (Commentary)

Purification (Comment) Organism
Talon metal affinity resin chromatography Caulobacter vibrioides

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + CpdR-L-histidine
-
 Caulobacter vibrioides ADP + CpdR-N-phospho-L-histidine
-
 ?
ATP + CtrA-L-histidine
-
 Caulobacter vibrioides ADP + CtrA-N-phospho-L-histidine
-
 ?

Synonyms

Synonyms Comment Organism
CckA
-
 Caulobacter vibrioides

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Caulobacter vibrioides

General Information

General Information Comment Organism
physiological function CckA has a central role in establishing the cell cycle periodicity of CtrA activity by controlling both its phosphorylation and stability Caulobacter vibrioides