Reference on EC 2.7.1.74 - deoxycytidine kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gaubert, G.; Gosselin, G.; Boudou, V.; Imbach, J.L.; Eriksson, S.; Maury, G.
Low enantioselectivities of human deoxycytidine kinase and human deoxyguanosine kinase with respect to 2'-deoxyadenosine, 2'-deoxyguanosine and their analogs
Biochimie
81
1041-1047
1999
Homo sapiens
Ikeda, S.; Ma, G.T.; Ives, D.H.
Heterodimeric deoxynucleoside kinases of Lactobacillus acidophilus R-26: functional assignment of subunits using limited proteolysis controlled by end-product inhibitors
Biochemistry
33
5328-5334
1994
Lactobacillus acidophilus
Yamada, Y.; Goto, H.; Ogasawara, N.
Purine nucleoside kinases in human T- and B-lymphoblasts
Biochim. Biophys. Acta
761
34-40
1983
Homo sapiens
Kessel, D.
Properties of deoxycytidine kinase partially purified from L1210 cells
J. Biol. Chem.
243
4739-4744
1968
Mus musculus
Momparler, R.L.; Fischer, G.A.
Mammalian deoxynucleoside kinase. I. Deoxycytidine kinase: purification, properties, and kinetic studies with cytosine arabinoside
J. Biol. Chem.
243
4298-4304
1968
Bos taurus
Durham, J.P.; Ives, D.H.
Deoxycytidine kinase. II. Purification and general properties of the calf thymus enzyme
J. Biol. Chem.
245
2276-2284
1970
Bos taurus
Ives, D.H.; Durham, J.P.
Deoxycytidine kinase. 3. Kinetics and allosteric regulation of the calf thymus enzyme
J. Biol. Chem.
245
2285-2294
1970
Bos taurus
Meyers, M.B.; Kreis, W.
Purification of deoxycytidine kinases from two P815 murine neoplasms and their separation from deoxyguanosine kinase
Arch. Biochem. Biophys.
177
10-15
1976
Mus musculus
Kozai, Y.; Sonoda, S.; Kobayashi, S.; Sugino, Y.
Metabolism in deoxyribonucleotides. IV. Purification and properties of deoxycytidine kinase of calf thymus
J. Biochem.
71
485-496
1972
Bos taurus
Krenitsky, T.A.; Tuttle, J.V.; Koszalka, G.W.; Chen, I.S.; Beacham, L.M.; Rideout, J.L.; Elion, G.B.
Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity
J. Biol. Chem.
251
4055-4061
1976
Bos taurus
Ives, D.H.; Wang, S.M.
Deoxycytidine kinase from calf thymus
Methods Enzymol.
51
337-345
1978
Bos taurus
Kierdaszuk, B.; Eriksson, S.
Selective inactivation of the deoxyadenosine phosphorylating activity of pure human deoxycytidine kinase: stabilization of different forms of the enzyme by substrates and biological detergents
Biochemistry
29
4109-4114
1990
Homo sapiens
Wang, L.M.; Kucera, G.L.; Capizzi, R.L.
Purification and characterization of deoxycytidine kinase from acute myeloid leukemia cell mitochondria
Biochim. Biophys. Acta
1202
309-316
1993
Homo sapiens
Eriksson, S.; Cederlund, E.; Bergman, T.; Jrnvall, H.; Bohman, C.
Characterization of human deoxycytidine kinase. Correlation with cDNA sequences
FEBS Lett.
280
363-366
1991
Homo sapiens
Kim, M.Y.; Ives, D.H.
Human deoxycytidine kinase: kinetic mechanism and end product regulation
Biochemistry
28
9043-9047
1989
Homo sapiens
Datta, N.S.; Shewach, D.S.; Mitchell, B.S.; Fox, I.H.
Kinetic properties and inhibition of human T lymphoblast deoxycytidine kinase
J. Biol. Chem.
264
9359-9364
1989
Homo sapiens
Datta, N.S.; Shewach, D.S.; Hurley, M.C.; Mitchell, B.S.; Fox, I.H.
Human T-lymphoblast deoxycytidine kinase: purification and properties
Biochemistry
28
114-123
1989
Homo sapiens
Bohman, C.; Eriksson, S.
Deoxycytidine kinase from human leukemic spleen: preparation and characteristics of homogeneous enzyme
Biochemistry
27
4258-4265
1988
Homo sapiens
Kim, M.Y.; Ikeda, S.; Ives, D.H.
Affinity purification of human deoxycytidine kinase: avoidance of structural and kinetic artifacts arising from limited proteolysis
Biochem. Biophys. Res. Commun.
156
92-98
1988
Homo sapiens
Baxter, A.; Currie, L.M.; Durham, J.P.
A general method for purification of deoxycytidine kinase
Biochem. J.
173
1005-1008
1978
Bos taurus, Homo sapiens, Sus scrofa
Shewach, D.S.; Reynolds, K.K.; Hertel, L.
Nucleotide specificity of human deoxycytidine kinase
Mol. Pharmacol.
42
518-524
1992
Homo sapiens
Habteyesus, A.; Nordenskjoeld, A.; Bohman, C.; Eriksson, S.
Deoxynucleoside phosphorylating enzymes in monkey and human tissues show great similarities, while mouse deoxycytidine kinase has a different substrate specificity
Biochem. Pharmacol.
42
1829-1836
1991
Aotus trivirgatus, Homo sapiens, Mus musculus
Coleman, C.N.; Stoller, R.G.; Drake, J.C.; Chabner, B.A.
Deoxycytidine kinase: properties of the enzyme from human leukemic granulocytes
Blood
46
791-803
1975
Homo sapiens
Leung, W.C.; Dubbs, D.R.; Trkula, D.; Kit, S.
Mitochondrial and herpesvirus-specific deoxypyrimidine kinases
J. Virol.
16
486-497
1975
Aotus trivirgatus, Gallus gallus, Mus musculus
Deibler, R.D.; Reznik, R.B.; Ives, D.H.
Deoxynucleoside kinases from Lactobacilli. Separate interacting sites for deoxycytidine and deoxyadenosine
J. Biol. Chem.
252
8240-8244
1977
Lactobacillus acidophilus
Johansson, M.; Karlsson, A.
Differences in kinetic properties of pure recombinant human and mouse deoxycytidine kinase
Biochem. Pharmacol.
50
163-168
1995
Homo sapiens, Mus musculus
Csapo, Z.; Sasvari-Szekely, M.; Spasokoukotskaja, T.; Talianidis, I.; Eriksson, S.; Staub, M.
Activation of deoxycytidine kinase by inhibition of DNA synthesis in human lymphocytes
Biochem. Pharmacol.
61
191-197
2001
Homo sapiens
Beausejour, C.M.; Gagnon, J.; Primeau, M.; Momparler, R.L.
Cytotoxic activity of 2',2'-difluorodeoxycytidine, 5-aza-2'-deoxycytidine and cytosine arabinoside in cells transduced with deoxycytidine kinase gene
Biochem. Biophys. Res. Commun.
293
1478-1484
2002
Mus musculus
Spasokoukotskaja, T.; Sasvari-Szekely, M.; Keszler, G.; Albertioni, F.; Eriksson, S.; Staub, M.
Treatment of normal and malignant cells with nucleoside analogues and etoposide enhances deoxycytidine kinase activity
Eur. J. Cancer
35
1862-1867
1999
Homo sapiens
Csapo, Z.; Keszler, G.; Safrany, G.; Spasokoukotskaja, T.; Talianidis, I.; Staub, M.; Sasvari-Szekely, M.
Activation of deoxycytidine kinase by gamma-irradiation and inactivation by hyperosmotic shock in human lymphocytes
Biochem. Pharmacol.
65
2031-2039
2003
Homo sapiens
Hughes, T.L.; Hahn, T.M.; Reynolds, K.K.; Shewach, D.S.
Kinetic analysis of human deoxycytidine kinase with the true phosphate donor uridine triphosphate
Biochemistry
36
7540-7547
1997
Homo sapiens
Wang, J.; Choudhury, D.; Chattopadhyaya, J.; Eriksson, S.
Stereoisomeric selectivity of human deoxyribonucleoside kinases
Biochemistry
38
16993-16999
1999
Homo sapiens
Hatzis, P.; Al-Madhoon, A.S.; Jullig, M.; Petrakis, T.G.; Eriksson, S.; Talianidis, I.
The intracellular localization of deoxycytidine kinase
J. Biol. Chem.
273
30239-30243
1998
Homo sapiens
Usova, E.V.; Eriksson, S.
The effects of high salt concentrations on the regulation of the substrate specificity of human recombinant deoxycytidine kinase
Eur. J. Biochem.
248
762-766
1997
Homo sapiens
Eriksson, S.; Wang, L.
Substrate specificities, expression and primary sequences of deoxynucleoside kinases; implications for chemotherapy
Nucleosides Nucleotides
16
653-659
1997
Homo sapiens
-
Shafiee, M.; Boudoua, V.; Griffon, J.F.; Pompon, A.; Gosselin, G.; Eriksson, S.; Imbach, J.L.; Maury, G.
Study of the enantioselectivity of enzymes involved in nucleoside analog metabolism: deoxycytidine kinase
Nucleosides Nucleotides
16
1767-1770
1997
Homo sapiens
-
Kierdaszuk, B.; Krawiec, K.; Kazimierczuk, Z.; Jacobsson, U.; Johansson, N.G.; Munch-Petersen, B.; Eriksson, S.; Shugar, D.
Substrate/inhibitor properties of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) towards the sugar moiety of nucleosides, including O'-alkyl analogues
Nucleosides Nucleotides
18
1883-1903
1999
Homo sapiens
Mani, R.S.; Usova, E.V.; Eriksson, S.; Cass, C.E.
Hydrodynamic and spectroscopic studies of substrate binding to human recombinant deoxycytidine kinase
Nucleosides, Nucleotides Nucleic Acids
22
175-192
2003
Homo sapiens
Kim, M.Y.
Purification of deoxycytidine kinase from various human leukemic cells by endo-product analog affinity chromatography
J. Biochem. Mol. Biol.
28
281-289
1995
Homo sapiens
-
Spasokoukotskaja, T.; Sasvari-Szekely, M.; Hullan, L.; Albertioni, F.; Eriksson, S.; Staub, M.
Activation of deoxycytidine kinase by various nucleoside analogues
Adv. Exp. Med. Biol.
431
641-645
1998
Homo sapiens
Spasokoukotskaja, T.; Csapo, Z.; Sasvari-Szekely, M.; Virga, S.; Talianidis, I.; Eriksson, S.; Staub, M.
Effect of phosphorylation on deoxycytidine kinase activity
Adv. Exp. Med. Biol.
486
281-285
2000
Homo sapiens
Someya, H.; Shaddix, S.C.; Tiwari, K.N.; Secrist, J.A., 3rd; Parker, W.B.
Phosphorylation of 4'-thio-beta-D-arabinofuranosylcytosine and its analogs by human deoxycytidine kinase
J. Pharmacol. Exp. Ther.
304
1314-1322
2003
Homo sapiens
Shafiee, M.; Gosselin, G.; Imbach, J.L.; Divita, G.; Eriksson, S.; Maury, G.
Study of human deoxycytidine kinase binding properties using intrinsic fluorescence or new fluorescent ligands
Eur. J. Med. Chem.
34
423-431
1999
Homo sapiens
-
Csapo, Z.; Sasvari-Szekely, M.; Spasokoukotskaja, T.; Staub, M.
Modulation of human deoxycytidine kinase activity as a response to cellular stress induced by NaF
Acta Biochim. Pol.
48
251-256
2001
Homo sapiens
Keszler, G.; Szikla, K.; Kazimierczuk, Z.; Spasokoukotskaja, T.; Sasvari-Szekely, M.; Staub, M.
Selective activation of deoxycytidine kinase by thymidine-5'-thiosulphate and release by deoxycytidine in human lymphocytes
Biochem. Pharmacol.
65
563-571
2003
Homo sapiens
Keszler, G.; Virga, S.; Spasokoukotskaja, T.; Bauer, P.I.; Sasvari-Szekely, M.; Staub, M.
Activation of deoxycytidine kinase by deoxyadenosine: implications in deoxyadenosine-mediated cytotoxicity
Arch. Biochem. Biophys.
436
69-77
2005
Homo sapiens
Feng, J.Y.; Parker, W.B.; Krajewski, M.L.; Deville-Bonne, D.; Veron, M.; Krishnan, P.; Cheng, Y.C.; Borroto-Esoda, K.
Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5'-phosphates by mammalian phosphotransferases
Biochem. Pharmacol.
68
1879-1888
2004
Homo sapiens
Rylova, S.N.; Albertioni, F.; Flygh, G.; Eriksson, S.
Activity profiles of deoxynucleoside kinases and 5'-nucleotidases in cultured adipocytes and myoblastic cells: insights into mitochondrial toxicity of nucleoside analogs
Biochem. Pharmacol.
69
951-960
2005
Homo sapiens
Johnsamuel, J.; Eriksson, S.; Oliveira, M.; Tjarks, W.
Docking simulation with a purine nucleoside specific homology model of deoxycytidine kinase, a target enzyme for anticancer and antiviral therapy
Bioorg. Med. Chem.
13
4160-4167
2005
Homo sapiens
Eriksson, S.; Munch-Petersen, B.; Johansson, K.; Eklund, H.
Structure and function of cellular deoxyribonucleoside kinases
Cell. Mol. Life Sci.
59
1327-1346
2002
Homo sapiens (P27707)
Piskur, J.; Sandrini, M.P.B.; Knecht, W.; Munch-Petersen, B.
Animal deoxyribonucleoside kinases: 'forward' and 'retrograde' evolution of their substrate specificity
FEBS Lett.
560
3-6
2004
Homo sapiens (P27707), Mus musculus (P43346)
Hubeek, I.; Peters, G.J.; Broekhuizen, A.J.F.; Talianidis, I.; Sigmond, J.; Gibson, B.E.S.; Creutzig, U.; Giaccone, G.; Kaspers, G.J.L.
Immunocytochemical detection of deoxycytidine kinase in haematological malignancies and solid tumours
J. Clin. Pathol.
58
695-699
2005
Homo sapiens
Mani, R.S.; Usova, E.V.; Eriksson, S.; Cass, C.E.
Fluorescence studies of substrate binding to human recombinant deoxycytidine kinase
Nucleosides Nucleotides Nucleic Acids
23
1343-1346
2004
Homo sapiens
Hubeek, I.; Peters, G.J.; Broekhuizen, A.J.F.; Talianidis, I.; Schouten van Meeteren, A.Y.N.; van Wering, E.R.; Gibson, B.; Creutzig, U.; Kaspers, G.J.L.
Immunocytochemical detection of deoxycytidine kinase in pediatric malignancies in relation to in vitro cytarabine sensitivity
Nucleosides Nucleotides Nucleic Acids
23
1351-1356
2004
Homo sapiens
Al-Madhoun, A.S.; Eriksson, S.; Wang, Z.X.; Naimi, E.; Knaus, E.E.; Wiebe, L.I.
Phosphorylation of isocarbostyril- and difluorophenyl-nucleoside thymidine mimics by the human deoxynucleoside kinases
Nucleosides Nucleotides Nucleic Acids
23
1865-1874
2004
Homo sapiens
Van Rompay, A.R.; Johansson, M.; Karlsson, A.
Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases
Pharmacol. Ther.
100
119-139
2003
Homo sapiens (P27707)
Zhang, Y.; Secrist, J.A.; Ealick, S.E.
The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation
Acta Crystallogr. Sect. D
62
133-139
2006
Homo sapiens (P27707), Homo sapiens
Fyrberg, A.; Albertioni, F.; Lotfi, K.
Cell cycle effect on the activity of deoxynucleoside analogue metabolising enzymes
Biochem. Biophys. Res. Commun.
357
847-853
2007
Homo sapiens
Van den Neste, E.; Smal, C.; Cardoen, S.; Delacauw, A.; Frankard, J.; Ferrant, A.; Van den Berghe, G.; Bontemps, F.
Activation of deoxycytidine kinase by UV-C-irradiation in chronic lymphocytic leukemia B-lymphocytes
Biochem. Pharmacol.
65
573-580
2003
Homo sapiens
Smal, C.; Cardoen, S.; Betrand, L.; Delacauw, A.; Ferrant, A.; Van den Berghe, G.; Van den Neste, E.; Bontemps, F.
Activation of deoxycytidine kinase by protein kinase inhibitors and okadaic acid in leukemic cells
Biochem. Pharmacol.
69
95-103
2003
Homo sapiens
Mani, R.S.; Usova, E.V.; Cass, C.E.; Eriksson, S.
Fluorescence energy transfer studies of human deoxycytidine kinase: role of cysteine 185 in the conformational changes that occur upon substrate binding
Biochemistry
45
3534-3541
2006
Homo sapiens (P27707), Homo sapiens
Godsey, M.H.; Ort, S.; Sabini, E.; Konrad, M.; Lavie, A.
Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: Illuminating the role of main-chain reorganization
Biochemistry
45
452-461
2006
Homo sapiens (P27707), Homo sapiens
Pauwels, B.; Korst, A.E.; Pattyn, G.G.; Lambrechts, H.A.; Kamphuis, J.A.; De Pooter, C.M.; Peters, G.J.; Lardon, F.; Vermorken, J.B.
The relation between deoxycytidine kinase activity and the radiosensitising effect of gemcitabine in eight different human tumour cell lines
BMC Cancer
6
142
2006
Homo sapiens
Bierau, J.; van Gennip, A.H.; Leen, R.; Meinsma, R.; Caron, H.N.; van Kuilenburg, A.B.
Cyclopentenyl cytosine-induced activation of deoxycytidine kinase increases gemcitabine anabolism and cytotoxicity in neuroblastoma
Cancer Chemother. Pharmacol.
57
105-113
2006
Homo sapiens
Smal, C.; Van Den Neste, E.; Maerevoet, M.; Poire, X.; Theate, I.; Bontemps, F.
Positive regulation of deoxycytidine kinase activity by phosphorylation of Ser-74 in B-cell chronic lymphocytic leukemia lymphocytes
Cancer Lett.
253
68-73
2007
Homo sapiens
Sebastiani, V.; Ricci, F.; Rubio-Viqueira, B.; Rubio-Viquiera, B.; Kulesza, P.; Yeo, C.J.; Hidalgo, M.; Klein, A.; Laheru, D.; Iacobuzio-Donahue, C.A.
Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mechanisms of gemcitabine resistance and survival
Clin. Cancer Res.
12
2492-2497
2006
Homo sapiens
Smal, C.; Vertommen, D.; Bertrand, L.; Ntamashimikiro, S.; Rider, M.H.; Van Den Neste, E.; Bontemps, F.
Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity
J. Biol. Chem.
281
4887-4893
2006
Homo sapiens (P27707), Homo sapiens
Lamba, J.K.; Crews, K.; Pounds, S.; Schuetz, E.; Gresham, J.; Gandhi, V.; Plunkett, W.; Rubnitz, J.; Ribeiro, R.
Pharmacogenetics of deoxycytidine kinase: Identification and characterization of novel genetic variants
J. Pharmacol. Exp. Ther.
323
935-945
2007
Homo sapiens, Homo sapiens (P27707)
Sabini, E.; Hazra, S.; Konrad, M.; Burley, S.K.; Lavie, A.
Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase
Nucleic Acids Res.
35
186-192
2007
Homo sapiens, Homo sapiens (P27707)
Sigmond, J.; Haveman, J.; Kreder, N.C.; Loves, W.J.; van Bree, C.; Franken, N.A.; Peters, G.J.
Enhanced activity of deoxycytidine kinase after pulsed low dose rate and single dose gamma irradiation
Nucleosides Nucleotides Nucleic Acids
25
1177-1180
2006
Homo sapiens
Fyrberg, A.; Mirzaee, S.; Lotfi, K.
Cell cycle dependent regulation of deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5-nucleotidase I activity in MOLT-4 cells
Nucleosides Nucleotides Nucleic Acids
25
1201-1204
2006
Homo sapiens
Wachsman, J.T.; Morgan, D.D.
Demonstration of a deoxycytidine kinase activity in extracts of Bacillus megaterium KM
Appl. Microbiol.
25
506-508
1973
Priestia megaterium, Priestia megaterium KM / ATCC 13632
Soriano, E.V.; Clark, V.C.; Ealick, S.E.
Structures of human deoxycytidine kinase product complexes
Acta Crystallogr. Sect. D
63
1201-1207
2007
Homo sapiens (P27707), Homo sapiens
Ohhashi, S.; Ohuchida, K.; Mizumoto, K.; Fujita, H.; Egami, T.; Yu, J.; Toma, H.; Sadatomi, S.; Nagai, E.; Tanaka, M.
Down-regulation of deoxycytidine kinase enhances acquired resistance to gemcitabine in pancreatic cancer
Anticancer Res.
28
2205-2212
2008
Homo sapiens
Rylova, S.N.; Mirzaee, S.; Albertioni, F.; Eriksson, S.
Expression of deoxynucleoside kinases and 5-nucleotidases in mouse tissues: implications for mitochondrial toxicity
Biochem. Pharmacol.
74
169-175
2007
Mus musculus
Iyidogan, P.; Lutz, S.
Systematic exploration of active site mutations on human deoxycytidine kinase substrate specificity
Biochemistry
47
4711-4720
2008
Homo sapiens (P27707), Homo sapiens
Szatmari, T.; Huszty, G.; Desaknai, S.; Spasokoukotskaja, T.; Sasvari-Szekely, M.; Staub, M.; Esik, O.; Safrany, G.; Lumniczky, K.
Adenoviral vector transduction of the human deoxycytidine kinase gene enhances the cytotoxic and radiosensitizing effect of gemcitabine on experimental gliomas
Cancer Gene Ther.
15
154-164
2008
Homo sapiens
Kocabas, N.A.; Aksoy, P.; Pelleymounter, L.L.; Moon, I.; Ryu, J.S.; Gilbert, J.A.; Salavaggione, O.E.; Eckloff, B.W.; Wieben, E.D.; Yee, V.; Weinshilboum, R.M.; Ames, M.M.
Gemcitabine pharmacogenomics: deoxycytidine kinase and cytidylate kinase gene resequencing and functional genomics
Drug Metab. Dispos.
36
1951-1959
2008
Homo sapiens (P27707)
McSorley, T.; Ort, S.; Hazra, S.; Lavie, A.; Konrad, M.
Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues
FEBS Lett.
582
720-724
2008
Homo sapiens (P27707), Homo sapiens
Sabini, E.; Hazra, S.; Konrad, M.; Lavie, A.
Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides
J. Med. Chem.
50
3004-3014
2007
Homo sapiens (P27707), Homo sapiens
Sabini, E.; Hazra, S.; Konrad, M.; Lavie, A.
Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase
J. Med. Chem.
51
4219-4225
2008
Homo sapiens (P27707), Homo sapiens
Joachims, M.L.; Marble, P.; Knott-Craig, C.; Pastuszko, P.; Blackburn, M.R.; Thompson, L.F.
Inhibition of deoxynucleoside kinases in human thymocytes prevents dATP accumulation and induction of apoptosis
Nucleosides Nucleotides Nucleic Acids
27
816-820
2008
Homo sapiens
Hazra, S.; Sabini, E.; Ort, S.; Konrad, M.; Lavie, A.
Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase
Biochemistry
48
1256-1263
2009
Homo sapiens (P27707), Homo sapiens
Tarver, J.E.; Jessop, T.C.; Carlsen, M.; Augeri, D.J.; Fu, Q.; Healy, J.P.; Heim-Riether, A.; Xu, A.; Taylor, J.A.; Shen, M.; Keyes, P.E.; David Kimball, S.; Yu, X.C.; Miranda, M.; Liu, Q.; Swaffield, J.C.; Nouraldeen, A.; Wilson, A.G.; Finch, R.; Jhaver, K.; Foushee, A.M.; Anderson, S.; Oravecz, T.; Carson, K.G.
5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase
Bioorg. Med. Chem. Lett.
19
6780-6783
2009
Mus musculus
Jessop, T.C.; Tarver, J.E.; Carlsen, M.; Xu, A.; Healy, J.P.; Heim-Riether, A.; Fu, Q.; Taylor, J.A.; Augeri, D.J.; Shen, M.; Stouch, T.R.; Swanson, R.V.; Tari, L.W.; Hunter, M.; Hoffman, I.; Keyes, P.E.; Yu, X.C.; Miranda, M.; Liu, Q.; Swaffield, J.C.; David Kimball, S.; Nouraldeen, A.; Wilson, A.G.; Foushee, A.M.
Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors
Bioorg. Med. Chem. Lett.
19
6784-6787
2009
Homo sapiens (P27707)
Costantino, C.L.; Witkiewicz, A.K.; Kuwano, Y.; Cozzitorto, J.A.; Kennedy, E.P.; Dasgupta, A.; Keen, J.C.; Yeo, C.J.; Gorospe, M.; Brody, J.R.
The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase
Cancer Res.
69
4567-4572
2009
Homo sapiens
Kim, S.R.; Saito, Y.; Maekawa, K.; Sugiyama, E.; Kaniwa, N.; Ueno, H.; Okusaka, T.; Ikeda, M.; Morizane, C.; Yamamoto, N.; Yoshida, T.; Kamatani, N.; Furuse, J.; Ishii, H.; Saijo, N.; Ozawa, S.; Sawada, J.
Twenty novel genetic variations and haplotype structures of the DCK gene encoding human deoxycytidine kinase (dCK)
Drug Metab. Pharmacokinet.
23
379-384
2008
Homo sapiens
Yu, X.C.; Miranda, M.; Liu, Z.; Patel, S.; Nguyen, N.; Carson, K.; Liu, Q.; Swaffield, J.C.
Novel potent inhibitors of deoxycytidine kinase identified and compared by multiple assays
J. Biomol. Screen.
15
72-79
2010
Homo sapiens
Shord, S.; Patel, S.
Paclitaxel alters the expression and specific activity of deoxycytidine kinase and cytidine deaminase in non-small cell lung cancer cell lines
J. Exp. Clin. Cancer Res.
28
76
2009
Homo sapiens
Funamizu, N.; Okamoto, A.; Kamata, Y.; Misawa, T.; Uwagawa, T.; Gocho, T.; Yanaga, K.; Manome, Y.
Is the resistance of gemcitabine for pancreatic cancer settled only by overexpression of deoxycytidine kinase?
Oncol. Rep.
23
471-475
2010
Homo sapiens
Mirzaee, S.; Eriksson, S.; Albertioni, F.
Differences in cytosolic and mitochondrial 5'-nucleotidase and deoxynucleoside kinase activities in Sprague-Dawley rat and CD-1 mouse tissues: Implication for the toxicity of nucleoside analogs in animal models
Toxicology
267
159-164
2010
Mus musculus, Rattus norvegicus
Stalhandske, P.; Wang, L.; Westberg, S.; von Euler, H.; Groth, E.; Gustafsson, S.A.; Eriksson, S.; Lennerstrand, J.
Homogeneous assay for real-time and simultaneous detection of thymidine kinase 1 and deoxycytidine kinase activities
Anal. Biochem.
432
155-164
2013
Homo sapiens
Amsailale, R.; Van Den Neste, E.; Arts, A.; Starczewska, E.; Bontemps, F.; Smal, C.
Phosphorylation of deoxycytidine kinase on Ser-74: impact on kinetic properties and nucleoside analog activation in cancer cells
Biochem. Pharmacol.
84
43-51
2012
Homo sapiens
Hazra, S.; Ort, S.; Konrad, M.; Lavie, A.
Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues
Biochemistry
49
6784-6790
2010
Homo sapiens (P27707), Homo sapiens
Hazra, S.; Szewczak, A.; Ort, S.; Konrad, M.; Lavie, A.
Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release
Biochemistry
50
2870-2880
2011
Homo sapiens (P27707), Homo sapiens
Nagai, S.; Takenaka, K.; Nachagari, D.; Rose, C.; Domoney, K.; Sun, D.; Sparreboom, A.; Schuetz, J.D.
Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity
Cancer Res.
71
1781-1791
2011
Homo sapiens
Weng, T.; Karmouty-Quintana, H.; Garcia-Morales, L.J.; Molina, J.G.; Pedroza, M.; Bunge, R.R.; Bruckner, B.A.; Loebe, M.; Seethamraju, H.; Blackburn, M.R.
Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease
FASEB J.
27
2013-2026
2013
Homo sapiens, Mus musculus
Hazra, S.; Konrad, M.; Lavie, A.
The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analogues
J. Med. Chem.
53
5792-5800
2010
Homo sapiens (P27707), Homo sapiens
Shu, C.J.; Campbell, D.O.; Lee, J.T.; Tran, A.Q.; Wengrod, J.C.; Witte, O.N.; Phelps, M.E.; Satyamurthy, N.; Czernin, J.; Radu, C.G.
Novel PET probes specific for deoxycytidine kinase
J. Nucl. Med.
51
1092-1098
2010
Homo sapiens, Mus musculus, Mus musculus C57/BL6J
Neschadim, A.; Wang, J.; Sato, T.; Fowler, D.; Lavie, A.; Medin, J.
Cell fate control gene therapy based on engineered variants of human deoxycytidine kinase
Mol. Ther.
20
1002-1013
2012
Homo sapiens
Yang, C.; Lee, M.; Hao, J.; Cui, X.; Guo, X.; Smal, C.; Bontemps, F.; Ma, S.; Liu, X.; Engler, D.; Parker, W.B.; Xu, B.
Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage
Nucleic Acids Res.
40
9621-9632
2012
Homo sapiens
Smal, C.; Ntamashimikiro, S.; Arts, A.; Van Den Neste, E.; Bontemps, F.
Influence of phosphorylation of THR-3, SER-11, and SER-15 on deoxycytidine kinase activity and stability
Nucleosides Nucleotides Nucleic Acids
29
404-407
2010
Homo sapiens
Ohmine, K.; Kawaguchi, K.; Ohtsuki, S.; Motoi, F.; Egawa, S.; Unno, M.; Terasaki, T.
Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line: targeted proteomic and metabolomic analyses in PK9 cells
Pharm. Res.
29
2006-2016
2012
Homo sapiens
Toy, G.; Austin, W.R.; Liao, H.I.; Cheng, D.; Singh, A.; Campbell, D.O.; Ishikawa, T.O.; Lehmann, L.W.; Satyamurthy, N.; Phelps, M.E.; Herschman, H.R.; Czernin, J.; Witte, O.N.; Radu, C.G.
Requirement for deoxycytidine kinase in T and B lymphocyte development
Proc. Natl. Acad. Sci. USA
107
5551-5556
2010
Mus musculus
Muthu, P.; Chen, H.X.; Lutz, S.
Redesigning human 2'-deoxycytidine kinase enantioselectivity for L-nucleoside analogues as reporters in positron emission tomography
ACS Chem. Biol.
9
2326-2333
2014
Homo sapiens (P27707), Homo sapiens
Nomme, J.; Murphy, J.M.; Su, Y.; Sansone, N.D.; Armijo, A.L.; Olson, S.T.; Radu, C.; Lavie, A.
Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules
Acta Crystallogr. Sect. D
70
68-78
2014
Homo sapiens (P27707), Homo sapiens
Yamanishi, M.; Narazaki, H.; Asano, T.
Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase
Exp. Hematol.
43
207-214
2015
Homo sapiens
Fan, W.; Zhou, Z.Y.; Huang, X.F.; Bao, C.D.; Du, F.
Deoxycytidine kinase promotes the migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients
Int. J. Clin. Exp. Pathol.
6
2733-2744
2013
Homo sapiens
Hao, W.; Yang, L.; Wang, J.; Hsu, C.; Chang, L.; Hsu, K.
Facile method for determination of deoxycytidine kinase activity in biological milieus
J. Food Drug Anal.
22
236-241
2014
Homo sapiens
-
Murphy, J.M.; Armijo, A.L.; Nomme, J.; Lee, C.H.; Smith, Q.A.; Li, Z.; Campbell, D.O.; Liao, H.I.; Nathanson, D.A.; Austin, W.R.; Lee, J.T.; Darvish, R.; Wei, L.; Wang, J.; Su, Y.; Damoiseaux, R.; Sadeghi, S.; Phelps, M.E.; Herschman, H.R.; Czernin, J.; Alexandrova, A.N.; Jung, M.E.; Lavie, A.; Radu, C.G.
Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography
J. Med. Chem.
56
6696-6708
2013
Homo sapiens (P27707)
Gao, J.; Zhang, Y.; Wan, X.; Yang, X.; Yu, H.; Xu, J.
Expression and enzymatic activity analysis of deoxycytidine kinase in silk worm larvae using dual promoters BmNPV/Bac-to-Bac system
J. Pure Appl. Microbiol.
8
1837-1844
2014
Bombyx mori
-
Coulibaly, S.T.; Rossolillo, P.; Winter, F.; Kretzschmar, F.K.; Braye, M.; Martin, D.P.; Lener, D.; Negroni, M.
Potent sensitisation of cancer cells to anticancer drugs by a quadruple mutant of the human deoxycytidine kinase
PLoS ONE
10
e0140741
2015
Homo sapiens
Koduvayur, S.P.; Su, Y.; Kay, B.K.; Lavie, A.
Targeted delivery of deoxycytidine kinase to Her2-positive cells enhances the efficacy of the nucleoside analog fludarabine
PLoS ONE
11
e0157114
2016
Homo sapiens
Sun, R.; Eriksson, S.; Wang, L.
The expression and activity of thymidine kinase 1 and deoxycytidine kinase are modulated by hydrogen peroxide and nucleoside analogs
Nucleosides Nucleotides Nucleic Acids
39
1347-1358
2020
Homo sapiens (P27707)
Hellendahl, K.; Kamel, S.; Wetterwald, A.; Neubauer, P.; Wagner, A.
Human deoxycytidine kinase is a valuable biocatalyst for the synthesis of nucleotide analogues
Catalysts
9
997
2019
Homo sapiens (P27707)
-
Degwert, N.; Latuske, E.; Vohwinkel, G.; Stamm, H.; Klokow, M.; Bokemeyer, C.; Fiedler, W.; Wellbrock, J.
Deoxycytidine kinase is downregulated under hypoxic conditions and confers resistance against cytarabine in acute myeloid leukaemia
Eur. J. Haematol.
97
239-244
2016
Homo sapiens (P27707), Homo sapiens
Zhong, R.; Xin, R.; Chen, Z.; Liang, N.; Liu, Y.; Ma, S.; Liu, X.
The role of deoxycytidine kinase (dCK) in radiation-induced cell death
Int. J. Mol. Sci.
17
1939
2016
Homo sapiens (P27707)
Zhong, R.; Liang, B.; Xin, R.; Zhu, X.; Liu, Z.; Chen, Q.; Hou, Y.; Jin, Z.; Qi, M.; Ma, S.; Liu, X.
Deoxycytidine kinase participates in the regulation of radiation-induced autophagy and apoptosis in breast cancer cells
Int. J. Oncol.
52
1000-1010
2018
Homo sapiens (P27707)
Mutahir, Z.; Christiansen, L.S.; Clausen, A.R.; Berchtold, M.W.; Gojkovic, Z.; Munch-Petersen, B.; Knecht, W.; Piskur, J.
Gene duplications and losses among vertebrate deoxyribonucleoside kinases of the non-TK1 family
Nucleosides Nucleotides Nucleic Acids
35
677-690
2016
Xenopus laevis (A0A1L8HV70), Xenopus laevis, Gallus gallus (Q5ZMF3), Gallus gallus
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