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Literature summary for 2.7.1.74 extracted from

  • Coleman, C.N.; Stoller, R.G.; Drake, J.C.; Chabner, B.A.
    Deoxycytidine kinase: properties of the enzyme from human leukemic granulocytes (1975), Blood, 46, 791-803.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Cytosine arabinoside triphosphate weak Homo sapiens
dCTP cytosine arabinoside as substrate Homo sapiens
deoxycytidine cytosine arabinoside as substrate Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0033 0.0093 deoxycytidine
-
Homo sapiens
0.02 0.04 cytosine arabinoside D-isomer Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
leukemia cell from acute myeloid leukemia (AML) patients Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxycytidine
-
Homo sapiens ADP + 5'-dCMP
-
?
GTP + 2'-deoxycytidine
-
Homo sapiens GDP + 2'-deoxy-CMP
-
?
NTP + cytosine arabinoside
-
Homo sapiens NDP + cytosine arabinoside 5'-monophosphate
-
?
NTP + deoxycytidine
-
Homo sapiens NDP + dCMP
-
?