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Literature summary for 2.7.1.74 extracted from

  • Van den Neste, E.; Smal, C.; Cardoen, S.; Delacauw, A.; Frankard, J.; Ferrant, A.; Van den Berghe, G.; Bontemps, F.
    Activation of deoxycytidine kinase by UV-C-irradiation in chronic lymphocytic leukemia B-lymphocytes (2003), Biochem. Pharmacol., 65, 573-580.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2-chloro-2'-deoxyadenosine
-
Homo sapiens
aphidicolin
-
Homo sapiens
etoposide
-
Homo sapiens
additional information 2- to 3-fold activation of enzyme by UV-C light irradiation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
suramin no effect in unirradiated cells, complete abolishment of UV-C light induced activation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2'-deoxycytidine Homo sapiens involved in nucleotide synthesis, involved in DNA repair ADP + 2'-deoxycytidine 5'-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
B-CLL patients
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information a posttranslational modification is suggested to be responsible for the UV-C light irradiation induced activation of the enzyme activity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood mononuclear cells used for experiments Homo sapiens
-
EHEB cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxycytidine
-
Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
?
ATP + 2'-deoxycytidine involved in nucleotide synthesis, involved in DNA repair Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
?

Synonyms

Synonyms Comment Organism
dCK
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens