Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.74 extracted from

  • Costantino, C.L.; Witkiewicz, A.K.; Kuwano, Y.; Cozzitorto, J.A.; Kennedy, E.P.; Dasgupta, A.; Keen, J.C.; Yeo, C.J.; Gorospe, M.; Brody, J.R.
    The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase (2009), Cancer Res., 69, 4567-4572.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxycytidine
-
Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
?
ATP + gemcitabine
-
Homo sapiens ADP + gemcitabine 5'-phosphate
-
?

Synonyms

Synonyms Comment Organism
dCK
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens RNA-binding protein HuR silencing reduces dCK protein expression in pancreatic cancer cells down
Homo sapiens RNA-binding protein HuR overexpression elevates dCK protein expression in pancreatic cancer cells up