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Literature summary for 2.7.1.74 extracted from

  • Sigmond, J.; Haveman, J.; Kreder, N.C.; Loves, W.J.; van Bree, C.; Franken, N.A.; Peters, G.J.
    Enhanced activity of deoxycytidine kinase after pulsed low dose rate and single dose gamma irradiation (2006), Nucleosides Nucleotides Nucleic Acids, 25, 1177-1180.
    View publication on PubMed
Search for more literature for 2.7.1.74

Activating Compound

Activating Compound Comment Organism Structure
additional information irradiation of intact cells increases enzyme activity, upregulation of activity might be caused by phosphorylation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens essential for the synthesis of deoxynucleotides required for DNA repair and involved in deoxynucleoside analogue activation ?
-
 ?
NTP + 2',2'-difluorodeoxycytidine Homo sapiens substrate also termed gemcitabine NDP + 2',2'-difluorodeoxycytidine 5'-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information irradiation induced phosphorylation suggested to be involved in the regulation of enzyme activity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
SW-1573 cell cells irradiated in the late exponential growth phase for experiments Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information essential for the synthesis of deoxynucleotides required for DNA repair and involved in deoxynucleoside analogue activation Homo sapiens ?
-
 ?
NTP + 2',2'-difluorodeoxycytidine substrate also termed gemcitabine Homo sapiens NDP + 2',2'-difluorodeoxycytidine 5'-phosphate
-
 ?
NTP + 2-chloro-2'-deoxyadenosine
-
 Homo sapiens NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
dCK
-
 Homo sapiens