Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-chloro-2'-deoxyadenosine | increases activity by increasing phosphorylation of Ser74 | Homo sapiens | |
aphidicolin | increases activity by increasing phosphorylation of Ser74 | Homo sapiens | |
etoposide | increases activity by increasing phosphorylation of Ser74 | Homo sapiens | |
genistein | increases activity by increasing phosphorylation of Ser74 | Homo sapiens | |
additional information | UV-C irradiation increases activity by increasing phosphorylation of Ser74 | Homo sapiens |
Application | Comment | Organism |
---|---|---|
analysis | deoxycytidine kinase from B-cell chronic lymphocytic leukaemia lymphocytes can be detected by use of anti-phospho-ser74 antibodies | Homo sapiens |
medicine | interindividual variability in deoxycytidine kinase activity is related to its phosphorylation level on residue Ser74 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in HEK 293T cells | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | in complex with ATP | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NTP + 2-chloro-2'-deoxyadenosine | Homo sapiens | phosphorylation of chemotherapeutically important nucleoside analogues | NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate | - |
? | |
NTP + 9-beta-D-arabinosyl-2-fluoroadenine | Homo sapiens | phosphorylation of chemotherapeutically important nucleoside analogues | NDP + 9-beta-D-arabinosyl-2-fluoroadenine 5'-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | - |
patients with B-cell chronic lymphocytic leukaemia | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | regulation of activity by phosphorylation of Ser-74 | Homo sapiens |
phosphoprotein | interindividual variability in deoxycytidine kinase activity is related to its phosphorylation level on residue Ser74 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-CLL cell | - |
Homo sapiens | - |
blood | - |
Homo sapiens | - |
lymphocyte | B-cell chronic lymphocytic leukaemia lymphocyte | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2'-deoxycytidine | - |
Homo sapiens | ADP + 2'-deoxy-CMP | - |
? | |
NTP + 2-chloro-2'-deoxyadenosine | phosphorylation of chemotherapeutically important nucleoside analogues | Homo sapiens | NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate | - |
? | |
NTP + 9-beta-D-arabinosyl-2-fluoroadenine | phosphorylation of chemotherapeutically important nucleoside analogues | Homo sapiens | NDP + 9-beta-D-arabinosyl-2-fluoroadenine 5'-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dCK | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |