Protein Variants | Comment | Organism |
---|---|---|
additional information | deletion of exon 3 inactivates dCK function. Generation of enzyme knockout mice that show 90fold decrease in thymic cellularity compared to wild-type, lymphocyte numbers in the dCK KO mice are 5 to 13fold below normal values | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NTP + deoxycytidine | Mus musculus | - |
NDP + dCMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Mus musculus | - |
bone marrow | - |
Mus musculus | - |
T-lymphocyte | - |
Mus musculus | - |
thymus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine | - |
Mus musculus | ADP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine monophosphate | - |
? | |
NTP + deoxycytidine | - |
Mus musculus | NDP + dCMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dCK | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | dCK inactivation selectively and profoundly affects T and B cell development, severe impact of dCK inactivation on lymphopoiesis. Inactivation of dCK induces a partial block in B cell development | Mus musculus |
metabolism | dCK function in the context of cytosolic deoxycytidine metabolism, model, overview | Mus musculus |
physiological function | deoxycytidine kinase is a rate-limiting enzyme in deoxyribonucleoside salvage, a metabolic pathway that recycles products of DNA degradation. The enzyme phosphorylates and therefore activates nucleoside analogue prodrugs frequently used in cancer, autoimmunity, and viral infections. Normal lymphocyte development critically requires the deoxyribonucleoside salvage pathway | Mus musculus |