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Literature summary for 2.7.1.74 extracted from

  • Toy, G.; Austin, W.R.; Liao, H.I.; Cheng, D.; Singh, A.; Campbell, D.O.; Ishikawa, T.O.; Lehmann, L.W.; Satyamurthy, N.; Phelps, M.E.; Herschman, H.R.; Czernin, J.; Witte, O.N.; Radu, C.G.
    Requirement for deoxycytidine kinase in T and B lymphocyte development (2010), Proc. Natl. Acad. Sci. USA, 107, 5551-5556.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information deletion of exon 3 inactivates dCK function. Generation of enzyme knockout mice that show 90fold decrease in thymic cellularity compared to wild-type, lymphocyte numbers in the dCK KO mice are 5 to 13fold below normal values Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NTP + deoxycytidine Mus musculus
-
NDP + dCMP
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
Mus musculus
-
bone marrow
-
Mus musculus
-
T-lymphocyte
-
Mus musculus
-
thymus
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine
-
Mus musculus ADP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine monophosphate
-
?
NTP + deoxycytidine
-
Mus musculus NDP + dCMP
-
?

Synonyms

Synonyms Comment Organism
dCK
-
Mus musculus

General Information

General Information Comment Organism
malfunction dCK inactivation selectively and profoundly affects T and B cell development, severe impact of dCK inactivation on lymphopoiesis. Inactivation of dCK induces a partial block in B cell development Mus musculus
metabolism dCK function in the context of cytosolic deoxycytidine metabolism, model, overview Mus musculus
physiological function deoxycytidine kinase is a rate-limiting enzyme in deoxyribonucleoside salvage, a metabolic pathway that recycles products of DNA degradation. The enzyme phosphorylates and therefore activates nucleoside analogue prodrugs frequently used in cancer, autoimmunity, and viral infections. Normal lymphocyte development critically requires the deoxyribonucleoside salvage pathway Mus musculus