2.7.1.127: inositol-trisphosphate 3-kinase This is an abbreviated version! For detailed information about inositol-trisphosphate 3-kinase, go to the full flat file .
Reaction
ATP +
1D-myo-inositol 1,4,5-trisphosphate =
ADP +
1D-myo-inositol 1,3,4,5-tetrakisphosphate
Synonyms 1D-myo-inositol-trisphosphate 3-kinase, Arg82, ArgRIII, D-myo-inositol 1,4,5-trisphosphate 3-kinase, GsIP3K-A, HsIP3K-A, inositol (1,4,5) trisphosphate 3 kinase B, inositol (1,4,5) trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase A, inositol 1,4,5-trisphosphate 3-kinase B, inositol 1,4,5-trisphosphate 3-kinase C, inositol 1,4,5-trisphosphate 3-kinases, inositol 1,4,5-trisphosphate kinase, inositol 1,4,5-trisphosphate kinase 2, inositol 1,4,5-trisphosphate-3-kinase-A, inositol polyphosphate multikinase, inositol trisphosphate 3-kinase B, inositol(1,4,5)P3 3-kinase, inositol(1,4,5)trisphosphate 3-kinase, inositol(1,4,5)trisphosphate 3-kinases, inositol-1,4,5-trisphosphate 3-kinase, inositol-1,4,5-trisphosphate 3-kinase A, inositol-1,4,5-trisphosphate 3-kinase-A, inositol-1,4,5-trisphosphate-3-kinase, inositol-1,4,5-trisphosphate-3-kinase A, inositol-1,4,5-trisphosphate-3-kinase-A, inositol-trisphosphate 3-kinase B, Ins(1,4,5)P(3) 3-kinase B, Ins(1,4,5)P3 3-kinase, Ins(1,4,5)P3 3-kinase isoform B, Ins(1,4,5)P3 kinase, InsP3 3-kinase, InsP3 3-kinase A, InsP3 3-kinase B, InsP3 3-kinase C, InsP3K, InsP3KB, InsP3Kinase, IP3 3-kinase, IP3 3-kinase 2, IP3-3K, IP3K, IP3K-A, IP3K-B, IP3K-C, IP3K1, IP3K2, IP3KA, IP3KB, IP3KC, IP3kin, Ipk2, IPMK, ITPKA, Itpkb, Itpkc, kinase (phosphorylating), inositol 1,4,5-trisphosphate 3-, More, RnIP3K-C, wavy
ECTree
Specific Activity
Specific Activity on EC 2.7.1.127 - inositol-trisphosphate 3-kinase
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0.00044
-
mouse brain second particulate fraction
0.00072
-
in absence of calmodulin
0.0026
-
recombinant enzyme in the first particulate fraction of transfected COS-7 cells
0.0048
-
37°C, isoenzyme A, rat cortical slices
0.75 - 1.45
-
pH 7.4, 37°C, platelet, in presence of free Ca2+ and calmodulin
1.4
-
isoform B, in absence of the Ca2+/calmodulin complex
1.7
-
pH 7.4, 37°C, purified recombinant isoenzyme A overexpressed in CHO cells
14
-
purified recombinant K268E catalytic/CaM binding domain
15.77
-
pH 7.5, 37°C, recombinant isoform B
20
-
recombinant IP3K overexpressed in Escherichia coli, in absence of calmodulin
28.9
-
pH 7.5, 37°C, in absence of calmodulin
3.5
-
30°C, fully activated enzyme in presence of Ca2+/calmodulin
36.32
-
pH 7.5, 37°C, recombinant isoform A
60
-
pH 7.5, 37°C, in presence of calmodulin
15
-
purified recombinant wild-type catalytic/CaM binding domain
15
-
recombinant enzyme fragment comprising calmodulin binding domain
16
-
purified recombinant K272D catalytic/CaM binding domain
16
-
IP3K-A, K336Q mutant
16
-
purified catalytic binding domain
16
IP3K-C, recombinant enzyme fragment comprising catalytic domain
3
-
purified recombinant catalytic/CaM binding domain
3
IP3K-C, recombinant enzyme fragment comprising calmodulin binding and catalytic domain
additional information
-
-
additional information
-
-
additional information
activity of ITPKA is reduced by 94-95% in H1299 knock-down cells as compared to controls
additional information
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activity of ITPKA is reduced by 94-95% in H1299 knock-down cells as compared to controls
additional information
high ITPKA activity can significantly reduce the concentration of the 1D-myo-inositol 1,4,5-trisphosphate signal by rapidly removing the Ca2+ releasing second messenger
additional information
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high ITPKA activity can significantly reduce the concentration of the 1D-myo-inositol 1,4,5-trisphosphate signal by rapidly removing the Ca2+ releasing second messenger
additional information
-
-