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smooth muscle
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Itpkb protein level is increased upon differentiation of human embryonic stem cells
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brain
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low expression level
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thyroid cells
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human glioma cell line HTB-138, InsP3 3-kinase B mRNA
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inositol trisphosphate 3-kinase B gene is expressed in all hematopoietic stem/progenitor cell populations
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non-differentiated promyelocytic-leukaemia cell line, InsP3 3-kinase B mRNA
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human cell line SH-SY5Y, InsP3 3-kinase B mRNA
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mast cell
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insulin-secreting
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aortic
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MTEC
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IP3K-A expression is highly enriched in the central nucleus of the amygdala (CeA), which plays a pivotal role in the processing and expression of emotional phenotypes in mammals. P3K-A is primarily expressed in neurons rather than glia in the amygdala. In the CeA, IP3K-A primarily colocalizes with GAD67-positive GABAergic interneurons, whereas most IP3K-A in the BLA is in CAMKIIalpha-positive excitatory pyramidal neurons
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IP3K-A expression is highly enriched in the central nucleus of the amygdala (CeA), which plays a pivotal role in the processing and expression of emotional phenotypes in mammals. P3K-A is primarily expressed in neurons rather than glia in the amygdala. In the CeA, IP3K-A primarily colocalizes with GAD67-positive GABAergic interneurons, whereas most IP3K-A in the BLA is in CAMKIIalpha-positive excitatory pyramidal neurons
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cerebral cortex astrocytes, isoform B
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highest expression of recombinant isoenzyme A in astrocytes of hippocampal cultures transfected with isoenzyme A
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1321N1 cells, isoform B
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distribution in different anatomic regions of brain
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isoenzyme A is the major isoform present in neuronal cells
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IP3K-A
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Itpka is particularly active in neurons of the hippocampus and cerebellum
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Itpkb protein level is increased in the cerebral cortex of most patients with Alzheimer's disease compared with control subjects
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high expression level in pyramidal neurons of the CA1 region and the dentate gyrus of the hippocampus
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higher expression of isozyme IP3-3KB
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Itpka is particularly active in neurons of the hippocampus and cerebellum
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ITPKA is mainly expressed in pyramidal cells of the hippocampal CA1 region and granule cells of the dentate gyrus
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cortex
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isoform A
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cortical astrocytes, isoform B
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InsP3 3-kinase A and B mRNA
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isoenzyme A is the major isoform present in neuronal cells
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isoform C
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isozymes IP33K-A, IP33K-B, and IP33K-C
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primary hippocampal and corical cultures
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Itpka is particularly active in neurons of the hippocampus and cerebellum
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Enzymes expressed in Escherichia coli
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cloning and expression in Escherichia coli
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Enzymes and their fragments expressed in Escherichia coli.
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tracheal and bronchial, multiciliated tracheal epithelial cells
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isozyme IP33K-C
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enzyme expression is highly enriched in the central nucleus of the amygdala
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enzyme expression is highly enriched in the central nucleus of the amygdala
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isoform C
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InsP3 3-kinase B mRNA
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isozymes IP33K-B, and IP33K-C
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primary
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vasopressin-stimulated cells
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endogenous isoenzyme A is localized to the dentritic spines of pyramidal neurons in primary hippocampal cultures from neonatal rats, highest expression of recombinant isoenzyme A in astrocytes
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dendritic spines
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isoform C, low expression
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high expression level
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isoform C, low expression
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higher expression of isozyme IP3-3KB
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isoform C, low expression
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predominant expression of InsP3 3-kinase B mRNA in lung
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isozyme IP33K-B
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high expression
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hippocampal neuron
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localized to the post-dendritic spines of neurons. Itpka is particularly active in neurons of the hippocampus and cerebellum
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neuron-specific isozyme
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pyramidal, in neurons, ITPKA is concentrated at postsynaptic densities (PSD) of hippocampal dendritic spines
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isozyme inositol-1,4,5-trisphosphate-3-kinase-A is a neuron-specific, actin bundling protein concentrated at dendritic spines
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isozyme IP3K-A is enriched in dendritic spines of mature neurons
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localized to the post-dendritic spines of neurons. Itpka is particularly active in neurons of the hippocampus and cerebellum
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in mature neurons, ITPKA accumulates at postsynaptic densities (PSDs), where the protein is bound to F-actin
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in the CeA, IP3K-A primarily colocalizes with GAD67-positive GABAergic interneurons, whereas most IP3K-A in the BLA is in CAMKIIalpha-positive excitatory pyramidal neurons
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isozyme inositol-1,4,5-trisphosphate-3-kinase-A is a neuron-specific, actin bundling protein concentrated at dendritic spines
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in the CeA, IP3K-A primarily colocalizes with GAD67-positive GABAergic interneurons, whereas most IP3K-A in the BLA is in CAMKIIalpha-positive excitatory pyramidal neurons
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isozyme IP3K-A is enriched in dendritic spines of mature neurons
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endogenous isoenzyme A is localized to the dentritic spines of pyramidal neurons in primary hippocampal cultures
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aberrantly sustained neuronal activity down-regulates the expression of IP3K A in vivo and in cultured neurons
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localized to the post-dendritic spines of neurons. Itpka is particularly active in neurons of the hippocampus and cerebellum
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epididymal spermatozoa
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IP3K-A is identified mainly in brain and testis and shows an exclusive F-actin localization
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high expression level
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high expression level
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InsP3 3-kinase A and B mRNA
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isoform C
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isozymes IP33K-A, IP33K-B, and IP33K-C
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higher expression of isozyme IP3-3KB
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isolation of a cDNA clone encoding InsP3 3-kinase B from a thymus cDNA library
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isozyme IP33K-B
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strongest expression of isoform C in tongue epithelium
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isozyme IP33K-C
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low expression level
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additional information
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isoenzymes A and B are specifically expressed in different tissues and cells, expression pattern
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additional information
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isoenzyme C is not found in brain
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
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additional information
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enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
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additional information
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enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
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additional information
ITPKA is expressed in a broad range of tumor types but shows limited expression in normal cells. ITPKA enzyme expression analysis, overview
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additional information
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ITPKA is expressed in a broad range of tumor types but shows limited expression in normal cells. ITPKA enzyme expression analysis, overview
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additional information
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tissue-dependent expression of isozyme IP3-3KB
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
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additional information
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enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
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additional information
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enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
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additional information
enzyme tissue expression analysis by immunohistochemic analysis and situ hybridization. Cells positive for ITPKC express either a multicilium (tracheal and bronchial epithelia, brain ependymal cells), microvilli forming a brush border (small and large intestine, and kidney proximal tubule cells) or a flagellum (spermatozoa)
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additional information
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enzyme tissue expression analysis by immunohistochemic analysis and situ hybridization. Cells positive for ITPKC express either a multicilium (tracheal and bronchial epithelia, brain ependymal cells), microvilli forming a brush border (small and large intestine, and kidney proximal tubule cells) or a flagellum (spermatozoa)
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additional information
ubiquitous tissue expression of isozyme Itpkb, the Itpkb protein contributes mainly to the majority of the Ins(1,4,5)P3 3-kinase activity in resting T and B lymphocytes as well as in neutrophils and mast cells
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additional information
cells positive for ITPKC in the studied tissues express either a multicilium (tracheal and bronchial epithelia, brain ependymal cells), microvilli forming a brush border (small and large intestine, and kidney proximal tubule cells) or a flagellum (spermatozoa), suggesting a role for ITPKC either in the development or the function of these specialized cellular structures. Tissue expression and localization study, overview
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additional information
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cells positive for ITPKC in the studied tissues express either a multicilium (tracheal and bronchial epithelia, brain ependymal cells), microvilli forming a brush border (small and large intestine, and kidney proximal tubule cells) or a flagellum (spermatozoa), suggesting a role for ITPKC either in the development or the function of these specialized cellular structures. Tissue expression and localization study, overview
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additional information
isozyme ITPKA is mainly expressed in neurons of the central nervous system and is also overexpressed in tumor cells
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additional information
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isoenzymes A and B are specifically expressed in different tissues and cells, expression pattern
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additional information
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widespread tissue distribution of isoform B
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
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additional information
enzyme activity determined in cell homogenates with Ins(1,4,5)P3 and ATP as substrate is generally very low compared to Ins(1,4,5)P3 5-phosphatase, EC 3.1.3.56, except in a few tissues such as brain, testis, thymus or intestine. Itpkb and Itpkc are widespread expressed in many different tissues and cell lines
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