2.7.1.127: inositol-trisphosphate 3-kinase This is an abbreviated version! For detailed information about inositol-trisphosphate 3-kinase, go to the full flat file .
Reaction
ATP +
1D-myo-inositol 1,4,5-trisphosphate =
ADP +
1D-myo-inositol 1,3,4,5-tetrakisphosphate
Synonyms 1D-myo-inositol-trisphosphate 3-kinase, Arg82, ArgRIII, D-myo-inositol 1,4,5-trisphosphate 3-kinase, GsIP3K-A, HsIP3K-A, inositol (1,4,5) trisphosphate 3 kinase B, inositol (1,4,5) trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase A, inositol 1,4,5-trisphosphate 3-kinase B, inositol 1,4,5-trisphosphate 3-kinase C, inositol 1,4,5-trisphosphate 3-kinases, inositol 1,4,5-trisphosphate kinase, inositol 1,4,5-trisphosphate kinase 2, inositol 1,4,5-trisphosphate-3-kinase-A, inositol polyphosphate multikinase, inositol trisphosphate 3-kinase B, inositol(1,4,5)P3 3-kinase, inositol(1,4,5)trisphosphate 3-kinase, inositol(1,4,5)trisphosphate 3-kinases, inositol-1,4,5-trisphosphate 3-kinase, inositol-1,4,5-trisphosphate 3-kinase A, inositol-1,4,5-trisphosphate 3-kinase-A, inositol-1,4,5-trisphosphate-3-kinase, inositol-1,4,5-trisphosphate-3-kinase A, inositol-1,4,5-trisphosphate-3-kinase-A, inositol-trisphosphate 3-kinase B, Ins(1,4,5)P(3) 3-kinase B, Ins(1,4,5)P3 3-kinase, Ins(1,4,5)P3 3-kinase isoform B, Ins(1,4,5)P3 kinase, InsP3 3-kinase, InsP3 3-kinase A, InsP3 3-kinase B, InsP3 3-kinase C, InsP3K, InsP3KB, InsP3Kinase, IP3 3-kinase, IP3 3-kinase 2, IP3-3K, IP3K, IP3K-A, IP3K-B, IP3K-C, IP3K1, IP3K2, IP3KA, IP3KB, IP3KC, IP3kin, Ipk2, IPMK, ITPKA, Itpkb, Itpkc, kinase (phosphorylating), inositol 1,4,5-trisphosphate 3-, More, RnIP3K-C, wavy
ECTree
Subunits
Subunits on EC 2.7.1.127 - inositol-trisphosphate 3-kinase
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x * 50000, SDS-PAGE
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x * 53000, isoenzyme A, SDS-PAGE
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x * 88000, isoform B, SDS-PAGE, Western blot analysis
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x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C
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x * 50000, isozyme Itpka, SDS-PAGE
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x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE
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x * 90000, about, SDS-PAGE
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x * 50000, isozyme Itpka, SDS-PAGE
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x * 50000, recombinant IP3K overexpressed in Escherichia coli, SDS-PAGE
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x * 74500, calculated from the amino acid sequence
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x * 59000, recombinant isoform A, x * 92000, recombinant isoform B, SDS-PAGE
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x * 53000, isoenzyme A, SDS-PAGE
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x * 88000, isoform B, SDS-PAGE, Western blot analysis
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x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C
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x * 50000, isozyme Itpka from rat brain, SDS-PAGE
dimer
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2 * 50000, SDS-PAGE
dimer
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2 * 53000, native enzyme consists of a dimer of 2 catalytic subunits with 1 calmodulin molecule associated with each catalytic subunit, SDS-PAGE
monomer
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1 * 52000, 1 * 38000, 1 * 35000, 3 bands with InsP3 3-kinase activity: isoenzymes or degradation products, SDS-PAGE
monomer
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1 * 69000-70000, platelet, SDS-PAGE
monomer
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1 * 36000, additional 53 kDa polypeptide with enzyme activity, SDS-PAGE
monomer
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1 * 53000, SDS-PAGE
monomer
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1 * 93000, SDS-PAGE
additional information
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structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain
additional information
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structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain
additional information
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the enzyme possesses a DCK264 motif, an IP-lobe G266-G329, and an IDFG motif
additional information
isozyme Itpka contains an F-actin binding site at the N-terminal part
additional information
isozyme Itpka contains an F-actin binding site at the N-terminal part
additional information
isozyme Itpka contains an F-actin binding site at the N-terminal part
additional information
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isozyme Itpka contains an F-actin binding site at the N-terminal part
additional information
isozyme Itpkb contains an F-actin binding site at the N-terminal part
additional information
isozyme Itpkb contains an F-actin binding site at the N-terminal part
additional information
isozyme Itpkb contains an F-actin binding site at the N-terminal part
additional information
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isozyme Itpkb contains an F-actin binding site at the N-terminal part
additional information
the N-terminus harbors the actin binding domain, the C-terminus of ITPKA acts as spacer between actin filaments
additional information
isozyme Itpka contains an F-actin binding site at the N-terminal part
additional information
isozyme Itpka contains an F-actin binding site at the N-terminal part
additional information
isozyme Itpka contains an F-actin binding site at the N-terminal part
additional information
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isozyme Itpka contains an F-actin binding site at the N-terminal part
additional information
isozyme Itpkb contains an F-actin binding site at the N-terminal part
additional information
isozyme Itpkb contains an F-actin binding site at the N-terminal part
additional information
isozyme Itpkb contains an F-actin binding site at the N-terminal part
additional information
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isozyme Itpkb contains an F-actin binding site at the N-terminal part
additional information
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structure analysis, the isozyme A contains a F-actin binding domain, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain
additional information
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the enzyme contains a catalytic domain and a 4-helix substrate binding domain, both are in an open conformation with respect to each other, thus substrate recognition and catalysis involve a dynamic conformational cycle
additional information
isozyme Itpka contains an F-actin binding site at the N-terminal part
additional information
isozyme Itpka contains an F-actin binding site at the N-terminal part
additional information
isozyme Itpka contains an F-actin binding site at the N-terminal part
additional information
isozyme Itpkb contains an F-actin binding site at the N-terminal part
additional information
isozyme Itpkb contains an F-actin binding site at the N-terminal part
additional information
isozyme Itpkb contains an F-actin binding site at the N-terminal part
additional information
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structure analysis, the enzyme contains 2 major domains, a highly conserved C-terminal catalytic domain and a divergent N-terminal regulatory domain