2.7.1.127: inositol-trisphosphate 3-kinase

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For detailed information about inositol-trisphosphate 3-kinase, go to the full flat file.

Reaction

Synonyms

1D-myo-inositol-trisphosphate 3-kinase, Arg82, ArgRIII, D-myo-inositol 1,4,5-trisphosphate 3-kinase, GsIP3K-A, HsIP3K-A, inositol (1,4,5) trisphosphate 3 kinase B, inositol (1,4,5) trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase A, inositol 1,4,5-trisphosphate 3-kinase B, inositol 1,4,5-trisphosphate 3-kinase C, inositol 1,4,5-trisphosphate 3-kinases, inositol 1,4,5-trisphosphate kinase, inositol 1,4,5-trisphosphate kinase 2, inositol 1,4,5-trisphosphate-3-kinase-A, inositol polyphosphate multikinase, inositol trisphosphate 3-kinase B, inositol(1,4,5)P3 3-kinase, inositol(1,4,5)trisphosphate 3-kinase, inositol(1,4,5)trisphosphate 3-kinases, inositol-1,4,5-trisphosphate 3-kinase, inositol-1,4,5-trisphosphate 3-kinase A, inositol-1,4,5-trisphosphate 3-kinase-A, inositol-1,4,5-trisphosphate-3-kinase, inositol-1,4,5-trisphosphate-3-kinase A, inositol-1,4,5-trisphosphate-3-kinase-A, inositol-trisphosphate 3-kinase B, Ins(1,4,5)P(3) 3-kinase B, Ins(1,4,5)P3 3-kinase, Ins(1,4,5)P3 3-kinase isoform B, Ins(1,4,5)P3 kinase, InsP3 3-kinase, InsP3 3-kinase A, InsP3 3-kinase B, InsP3 3-kinase C, InsP3K, InsP3KB, InsP3Kinase, IP3 3-kinase, IP3 3-kinase 2, IP3-3K, IP3K, IP3K-A, IP3K-B, IP3K-C, IP3K1, IP3K2, IP3KA, IP3KB, IP3KC, IP3kin, Ipk2, IPMK, ITPKA, Itpkb, Itpkc, kinase (phosphorylating), inositol 1,4,5-trisphosphate 3-, More, RnIP3K-C, wavy

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.127 inositol-trisphosphate 3-kinase

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Results	in table
55	Activating Compound
24	AA Sequence
2	Application
1	CAS Registry Number
51	Cloned(Commentary)
130	Cofactor
3	Crystallization (Commentary)
330	Disease/ Diagnostics
8	Expression
78	General Information
13	General Stability
69	IC50 Value
135	Inhibitors
16	Ki Value [mM]
45	KM Value [mM]
88	Localization
142	Metals/Ions
40	Molecular Weight [Da]
95	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
324	Organism
5	Pathway
6	PDB ID
40	pH Optimum
6	pH Range
1	pH Stability
16	Posttranslational Modification
29	Protein Variants
44	Purification (Commentary)
4	Reaction
7	Reaction Type
102	Reference
257	Source Tissue
36	Specific Activity [micromol/min/mg]
8	Storage Stability
152	Substrates and Products (Substrate)
38	Subunits
184	Synonyms
1	Systematic Name
32	Temperature Optimum [°C]

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Application on EC 2.7.1.127 - inositol-trisphosphate 3-kinase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

diagnostics

Homo sapiens

P23677

in lung and breast cancer expression of ITPKA is stimulated by gene body methylation, ITPKA gene body methylation occurs early in tumor development. ITPKA enzyme expression may serve as biomarker for early detection of lung cancer

760540

medicine

Homo sapiens

P23677

the actin bundling enzyme inositol-trisphosphate 3-kinase A (ITPKA) is a target in tumor therapy, because it is upregulated in tumor but not in corresponding normal cells. Downregulation of ITPKA in lung adenocarcinoma cancers reduced both, tumor growth and metastasis

760540