2.7.1.127: inositol-trisphosphate 3-kinase
This is an abbreviated version!
For detailed information about inositol-trisphosphate 3-kinase, go to the full flat file.
Reaction
+
=
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Synonyms
1D-myo-inositol-trisphosphate 3-kinase, Arg82, ArgRIII, D-myo-inositol 1,4,5-trisphosphate 3-kinase, GsIP3K-A, HsIP3K-A, inositol (1,4,5) trisphosphate 3 kinase B, inositol (1,4,5) trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase A, inositol 1,4,5-trisphosphate 3-kinase B, inositol 1,4,5-trisphosphate 3-kinase C, inositol 1,4,5-trisphosphate 3-kinases, inositol 1,4,5-trisphosphate kinase, inositol 1,4,5-trisphosphate kinase 2, inositol 1,4,5-trisphosphate-3-kinase-A, inositol polyphosphate multikinase, inositol trisphosphate 3-kinase B, inositol(1,4,5)P3 3-kinase, inositol(1,4,5)trisphosphate 3-kinase, inositol(1,4,5)trisphosphate 3-kinases, inositol-1,4,5-trisphosphate 3-kinase, inositol-1,4,5-trisphosphate 3-kinase A, inositol-1,4,5-trisphosphate 3-kinase-A, inositol-1,4,5-trisphosphate-3-kinase, inositol-1,4,5-trisphosphate-3-kinase A, inositol-1,4,5-trisphosphate-3-kinase-A, inositol-trisphosphate 3-kinase B, Ins(1,4,5)P(3) 3-kinase B, Ins(1,4,5)P3 3-kinase, Ins(1,4,5)P3 3-kinase isoform B, Ins(1,4,5)P3 kinase, InsP3 3-kinase, InsP3 3-kinase A, InsP3 3-kinase B, InsP3 3-kinase C, InsP3K, InsP3KB, InsP3Kinase, IP3 3-kinase, IP3 3-kinase 2, IP3-3K, IP3K, IP3K-A, IP3K-B, IP3K-C, IP3K1, IP3K2, IP3KA, IP3KB, IP3KC, IP3kin, Ipk2, IPMK, ITPKA, Itpkb, Itpkc, kinase (phosphorylating), inositol 1,4,5-trisphosphate 3-, More, RnIP3K-C, wavy
ECTree
Metals Ions
Metals Ions on EC 2.7.1.127 - inositol-trisphosphate 3-kinase
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additional information
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assay in presence of Triton X-100 and ethylene glycol bis-(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid
Ca2+
-
up to 30fold stimulation by Ca2+/calmodulin
Ca2+
-
maximal at 0.01-0.1 mM Ca2+, interaction between the Ca2+-calmodulin complex and enzyme
Ca2+
-
only together with calmodulin, completely reversible
Ca2+
-
6-7fold stimulation by Ca2+/calmodulin
Ca2+
-
activation by Ca2+/calmodulin
Ca2+
-
not activated by free Ca2+
Ca2+
-
mechanism of activation
Ca2+
-
at physiological concentrations
Ca2+
-
activation by Ca2+/calmodulin
Ca2+
-
only together with calmodulin, completely reversible
Ca2+
-
activation by Ca2+/calmodulin
Ca2+
-
not activated by free Ca2+
Ca2+
-
phosphorylation of Thr-311 of isoenzyme A by CaM kinase II results in a 25fold increase in sensitivity to the Ca2+/calmodulin complex
Ca2+
-
the 3 isoenzymes A, B and C can be distinguished by their sensitivity to Ca2+/calmodulin
Ca2+
-
isoenzyme C is regulated by Ca2+ to a lesser extend than isoenzymes A and B
Ca2+
-
at physiological concentrations
Ca2+
-
activation by Ca2+/calmodulin
Ca2+
-
17fold stimulation by Ca2+/calmodulin at saturating calmodulin and 0.01 mM free Ca2+
Ca2+
-
mechanism of activation
Ca2+
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activation by calmodulin in a Ca2+-dependent manner
Ca2+
-
regulatory function in concert with calmodulin
Ca2+
the enzyme is activated by Ca2+/calmodulin
Ca2+
the enzyme is activated by Ca2+/calmodulin
Ca2+
the enzyme is highly activated by Ca2+/calmodulin
Ca2+
the enzyme is highly activated by Ca2+/calmodulin
Ca2+
-
activation by Ca2+/calmodulin
Ca2+
-
activation by Ca2+/calmodulin
Ca2+
-
enzyme is Ca-dependent
Ca2+
-
IP3K-A catalytic activity regulates calcium levels by modulating the metabolism of 1D-myo-inositol 1,4,5-trisphosphate
Ca2+
the enzyme is activated by Ca2+/calmodulin
Ca2+
the enzyme is highly activated by Ca2+/calmodulin
Ca2+
the enzyme is highly activated by Ca2+/calmodulin
Ca2+
the enzyme is highly activated by Ca2+/calmodulin
Ca2+
-
1.5fold activation by Ca2+/calmodulin
Ca2+
-
phosphorylation of isoenzyme B has no effect on the sensitivity to the Ca2+/calmodulin complex
Ca2+
-
isoform C is strongly activated by Ca2+/calmodulin in a substrate concentration-dependent manner
Ca2+
-
isoforms A and B are differentially regulated by Ca2+/calmodulin, isoform A: 2.5fold stimulation, isoform B: 20fold stimulation
Ca2+
-
only together with calmodulin, completely reversible
Ca2+
-
3-6fold stimulation by Ca2+/calmodulin
Ca2+
-
2fold stimulation by Ca2+/calmodulin
Ca2+
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at physiological concentrations
Ca2+
-
activation by Ca2+/calmodulin
640735, 640736, 640737, 640738, 640739, 640749, 640751, 640753, 640756, 640757, 640758, 640759, 640761
Ca2+
-
not activated by free Ca2+
Ca2+
-
isozyme IP33K-A: 3-6fold activation by calmodulin in a Ca2+-dependent manner
Ca2+
-
IP3KA is significantly activated by Ca2+/calmodulin
Ca2+
-
IP3KB is significantly activated by Ca2+/calmodulin
Ca2+
-
IP3KC is weakly activated by Ca2+/calmodulin
Ca2+
IP3K-A catalytic activity regulates calcium levels by modulating the metabolism of 1D-myo-inositol 1,4,5-trisphosphate
Ca2+
the enzyme is activated by Ca2+/calmodulin
Ca2+
the enzyme is highly activated by Ca2+/calmodulin
Ca2+
-
effects of Ca2+/calmodulin on enzyme activity, the calmodulin antagonists W-7 or chlorpromazine inhibit the Ca2+-enhancement of enzyme activity
Ca2+
-
at physiological concentrations
Ca2+
-
activation by Ca2+/calmodulin
Ca2+
-
activation by calmodulin in a Ca2+-dependent manner
Ca2+
-
activation is mediated by calmodulin and the calmodulin-dependent protein kinase II
Ca2+
-
activation by Ca2+/calmodulin
Mg2+
-
-
Mg2+
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brain enzyme, Mg2+-dependent