2.7.1.127: inositol-trisphosphate 3-kinase This is an abbreviated version! For detailed information about inositol-trisphosphate 3-kinase, go to the full flat file .
Reaction
ATP +
1D-myo-inositol 1,4,5-trisphosphate =
ADP +
1D-myo-inositol 1,3,4,5-tetrakisphosphate
Synonyms 1D-myo-inositol-trisphosphate 3-kinase, Arg82, ArgRIII, D-myo-inositol 1,4,5-trisphosphate 3-kinase, GsIP3K-A, HsIP3K-A, inositol (1,4,5) trisphosphate 3 kinase B, inositol (1,4,5) trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase A, inositol 1,4,5-trisphosphate 3-kinase B, inositol 1,4,5-trisphosphate 3-kinase C, inositol 1,4,5-trisphosphate 3-kinases, inositol 1,4,5-trisphosphate kinase, inositol 1,4,5-trisphosphate kinase 2, inositol 1,4,5-trisphosphate-3-kinase-A, inositol polyphosphate multikinase, inositol trisphosphate 3-kinase B, inositol(1,4,5)P3 3-kinase, inositol(1,4,5)trisphosphate 3-kinase, inositol(1,4,5)trisphosphate 3-kinases, inositol-1,4,5-trisphosphate 3-kinase, inositol-1,4,5-trisphosphate 3-kinase A, inositol-1,4,5-trisphosphate 3-kinase-A, inositol-1,4,5-trisphosphate-3-kinase, inositol-1,4,5-trisphosphate-3-kinase A, inositol-1,4,5-trisphosphate-3-kinase-A, inositol-trisphosphate 3-kinase B, Ins(1,4,5)P(3) 3-kinase B, Ins(1,4,5)P3 3-kinase, Ins(1,4,5)P3 3-kinase isoform B, Ins(1,4,5)P3 kinase, InsP3 3-kinase, InsP3 3-kinase A, InsP3 3-kinase B, InsP3 3-kinase C, InsP3K, InsP3KB, InsP3Kinase, IP3 3-kinase, IP3 3-kinase 2, IP3-3K, IP3K, IP3K-A, IP3K-B, IP3K-C, IP3K1, IP3K2, IP3KA, IP3KB, IP3KC, IP3kin, Ipk2, IPMK, ITPKA, Itpkb, Itpkc, kinase (phosphorylating), inositol 1,4,5-trisphosphate 3-, More, RnIP3K-C, wavy
ECTree
Cofactor
Cofactor on EC 2.7.1.127 - inositol-trisphosphate 3-kinase
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ATP
-
-
ATP
-
-
640733 , 640734 , 640751 , 640752 , 640755 , 640756 , 640758 , 660978 , 661446 , 662346 , 761786
ATP
-
-
640731 , 640736 , 640739 , 640746 , 640749 , 640751 , 640753 , 640756 , 640757 , 640758 , 640759 , 640760 , 640761 , 661334 , 661446 , 661488 , 662346 , 663233
ATP
-
binding site structure
ATP
-
binding site structure, role of ATP-binding in the catalytic mechanism and substrate inhibition of the catalytic domain
ATP
-
Involved in inhibitor binding.
ATP
Involved in inhibitor binding.
Calmodulin
-
6-7fold stimulation by Ca2+/calmodulin
Calmodulin
-
effects of Ca2+/calmodulin on enzyme activity
Calmodulin
-
activation by Ca2+/calmodulin
Calmodulin
-
activation by Ca2+/calmodulin
Calmodulin
-
activation by Ca2+/calmodulin
Calmodulin
-
activation by Ca2+/calmodulin
Calmodulin
-
activation by Ca2+/calmodulin
640735 , 640736 , 640737 , 640738 , 640739 , 640749 , 640751 , 640753 , 640756 , 640757 , 640758 , 640759 , 640761
Calmodulin
-
activation by Ca2+/calmodulin
Calmodulin
-
activation by Ca2+/calmodulin
Calmodulin
-
activation by Ca2+/calmodulin
Calmodulin
-
activation by Ca2+/calmodulin
Calmodulin
-
phosphorylation of Thr-311 of isoenzyme A by CaM kinase II results in a 25fold increase in sensitivity to the Ca2+/calmodulin complex, maximally 2-2.5fold stimulation by the Ca2+/calmodulin complex
Calmodulin
-
phosphorylation of isoenzyme B has no effect on the sensitivity to the Ca2+/calmodulin complex
Calmodulin
-
isoforms A and B are differentially regulated by Ca2+/calmodulin, isoform A: 2.5fold stimulation, isoform B: 20fold stimulation
Calmodulin
-
up to 30fold stimulation by Ca2+/calmodulin
Calmodulin
-
isoform C is strongly activated by Ca2+/calmodulin in a substrate concentration-dependent manner
Calmodulin
-
maximally 5fold stimulation by 0.01 mM Ca2+/calmodulin, reversible
Calmodulin
-
Ca2+/calmodulin-dependent, 10fold stimulation, reversed upon chelation of Ca2+ by EGTA
Calmodulin
-
mechanism of activation
Calmodulin
-
mechanism of activation
Calmodulin
-
17fold stimulation by Ca2+/calmodulin at saturating calmodulin and 0.01 mM free Ca2+
Calmodulin
-
3-6fold stimulation by Ca2+/calmodulin
Calmodulin
-
mediates activation by Ca2+
Calmodulin
-
the 3 isoenzymes A, B and C can be distinguished by their sensitivity to Ca2+/calmodulin
Calmodulin
-
1.5fold activation by Ca2+/calmodulin
Calmodulin
-
maximal at 50 nM calmodulin, reversed by EGTA, interaction between the Ca2+-calmodulin complex and enzyme
Calmodulin
The binding domain is present in all IP3K isoforms
Calmodulin
-
The binding domain is present in all IP3K isoforms, involved in inhibitor binding.
Calmodulin
The binding domain is present in all IP3K isoforms, involved in inhibitor binding.