2.7.1.127: inositol-trisphosphate 3-kinase

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For detailed information about inositol-trisphosphate 3-kinase, go to the full flat file.

Word Map on EC 2.7.1.127

2.7.1.127

1,3,4,5-tetrakisphosphate

kawasaki

vasculitis

5-phosphatase

tetrakisphosphate

diagnostics

medicine

Reaction

1D-myo-inositol 1,3,4,5-tetrakisphosphate

Synonyms

1D-myo-inositol-trisphosphate 3-kinase, Arg82, ArgRIII, D-myo-inositol 1,4,5-trisphosphate 3-kinase, GsIP3K-A, HsIP3K-A, inositol (1,4,5) trisphosphate 3 kinase B, inositol (1,4,5) trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase A, inositol 1,4,5-trisphosphate 3-kinase B, inositol 1,4,5-trisphosphate 3-kinase C, inositol 1,4,5-trisphosphate 3-kinases, inositol 1,4,5-trisphosphate kinase, inositol 1,4,5-trisphosphate kinase 2, inositol 1,4,5-trisphosphate-3-kinase-A, inositol polyphosphate multikinase, inositol trisphosphate 3-kinase B, inositol(1,4,5)P3 3-kinase, inositol(1,4,5)trisphosphate 3-kinase, inositol(1,4,5)trisphosphate 3-kinases, inositol-1,4,5-trisphosphate 3-kinase, inositol-1,4,5-trisphosphate 3-kinase A, inositol-1,4,5-trisphosphate 3-kinase-A, inositol-1,4,5-trisphosphate-3-kinase, inositol-1,4,5-trisphosphate-3-kinase A, inositol-1,4,5-trisphosphate-3-kinase-A, inositol-trisphosphate 3-kinase B, Ins(1,4,5)P(3) 3-kinase B, Ins(1,4,5)P3 3-kinase, Ins(1,4,5)P3 3-kinase isoform B, Ins(1,4,5)P3 kinase, InsP3 3-kinase, InsP3 3-kinase A, InsP3 3-kinase B, InsP3 3-kinase C, InsP3K, InsP3KB, InsP3Kinase, IP3 3-kinase, IP3 3-kinase 2, IP3-3K, IP3K, IP3K-A, IP3K-B, IP3K-C, IP3K1, IP3K2, IP3KA, IP3KB, IP3KC, IP3kin, Ipk2, IPMK, ITPKA, Itpkb, Itpkc, kinase (phosphorylating), inositol 1,4,5-trisphosphate 3-, More, RnIP3K-C, wavy

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.127 inositol-trisphosphate 3-kinase

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Results	in table
55	Activating Compound
24	AA Sequence
2	Application
1	CAS Registry Number
51	Cloned(Commentary)
130	Cofactor
3	Crystallization (Commentary)
330	Disease/ Diagnostics
8	Expression
78	General Information
13	General Stability
69	IC50 Value
135	Inhibitors
16	Ki Value [mM]
45	KM Value [mM]
88	Localization
142	Metals/Ions
40	Molecular Weight [Da]
95	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
324	Organism
5	Pathway
6	PDB ID
40	pH Optimum
6	pH Range
1	pH Stability
16	Posttranslational Modification
29	Protein Variants
44	Purification (Commentary)
4	Reaction
7	Reaction Type
102	Reference
257	Source Tissue
36	Specific Activity [micromol/min/mg]
8	Storage Stability
152	Substrates and Products (Substrate)
38	Subunits
184	Synonyms
1	Systematic Name
32	Temperature Optimum [°C]

Molecular Weight

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Molecular Weight on EC 2.7.1.127 - inositol-trisphosphate 3-kinase

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100000

Rattus norvegicus

x * 100000, SDS-PAGE

640753

125000

Mus musculus

x * 53000, recombinant isozyme IP3-3KA, SDS-PAGE, x * 98000, recombinant isozyme IP3-3KC, SDS-PAGE, x * 125000, recombinant isozyme IP3-3KB, SDS-PAGE, x * 48000, native brain isozyme IP3-3KA, SDS-PAGE, x * 110000-120000, native isozyme IP3-3KB, tissue-dependent, SDS-PAGE

660884

150000 - 160000

Rattus norvegicus

in the presence of Ca2+/calmodulin, gel filtration, the interaction of calmodulin with the monomeric catalytic subunit promotes dimerization of the enzyme

640735

35000

Bos taurus

1 * 52000, 1 * 38000, 1 * 35000, 3 bands with InsP3 3-kinase activity: isoenzymes or degradation products, SDS-PAGE

640741

36000

Homo sapiens

1 * 36000, additional 53 kDa polypeptide with enzyme activity, SDS-PAGE

640734

36250

Gallus gallus

IP3K-A, determined with MALDI-TOF-MS. Calculated mass is 36228 Da

687650

38000

Bos taurus

1 * 52000, 1 * 38000, 1 * 35000, 3 bands with InsP3 3-kinase activity: isoenzymes or degradation products, SDS-PAGE

44000

48000

50000

50900

x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C

661446

52000

Bos taurus

1 * 52000, 1 * 38000, 1 * 35000, 3 bands with InsP3 3-kinase activity: isoenzymes or degradation products, SDS-PAGE

640741

53000

5 entries

53500

Homo sapiens

x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C

661446

58000

Homo sapiens

minor peaks with MW of 39 kDa and 32 kDa, HPLC gel filtration

640734

59000

Rattus norvegicus

x * 59000, recombinant isoform A, x * 92000, recombinant isoform B, SDS-PAGE

70000

gel filtration

74000

x * 50900, isozyme IP33K-A, x * 74000, isozyme IP33K-B, x * 74500, isozyme IP33K-C

661446

74500

2 entries

75200

Homo sapiens

x * 50000, isozyme IP33K-A, x * 53500, isozyme IP33K-B, x * 75200, isozyme IP33K-C

84000

gel filtration

88000

90000

x * 90000, about, SDS-PAGE

737403

92000

Rattus norvegicus

x * 59000, recombinant isoform A, x * 92000, recombinant isoform B, SDS-PAGE

93000

1 * 93000, SDS-PAGE

98000