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Literature summary for 2.7.1.127 extracted from

  • Takazawa, K.; Lemos, M.; Delvaux, A.; Lejeune, C.; Dumont, J.E.; Erneux, C.
    Rat brain inositol 1,4,5-trisphosphate 3-kinase. Ca2(+)-sensitivity, purification and antibody production (1990), Biochem. J., 268, 213-217.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.127

Inhibitors

Inhibitors Comment Organism Structure
SDS
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.011
-
 1D-myo-inositol 1,4,5-trisphosphate pH 7.5, 37°C, in absence of 2,3-bisphosphoglycerate Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ 3-6fold stimulation by Ca2+/calmodulin Rattus norvegicus
Ca2+ activation by Ca2+/calmodulin Rattus norvegicus
Ca2+ not activated by free Ca2+ Rattus norvegicus
Mg2+
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 2 * 50000, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Purification (Commentary)

Purification (Comment) Organism
403fold Rattus norvegicus
purified in the presence of SDS as a doublet of a MW of approximately 50000 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.68
-
 pH 7.5, 37°C Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 50000, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP ATP-dependent Rattus norvegicus
Calmodulin activation by Ca2+/calmodulin Rattus norvegicus
Calmodulin 3-6fold stimulation by Ca2+/calmodulin Rattus norvegicus