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2.5.1.47: cysteine synthase

This is an abbreviated version!
For detailed information about cysteine synthase, go to the full flat file.

Word Map on EC 2.5.1.47

Reaction

O-acetyl-L-serine
+
hydrogen sulfide
=
L-cysteine
 +
acetate

Synonyms

(OAS-TL)-like protein, acetylserine sulfhydrylase, At-OASS, ATCC 23270 protein, BAbS19_I09950, beta-cyano-alanine synthase, beta-cyano-L-alanine synthase, CS-A, CS-B, CS1, CS26, CS3, CSase, CSase A, CSase B, CSaseLP, CSC, Cys synthase complex, cysK, CysK1, CysK2, CYSL, CysL-1, cysl-2, CysM, Cysteine synthase, cysteine synthase 1, cysteine synthase A, cysteine synthase B, cysteine synthase, chloroplastic/chromoplastic, cysteine synthase, mitochondrial, cysteine synthetase, DcsD, EC 4.2.99.8, EhCS, EhCS1, EhCS3, EhOASS, Fn1220, GmOAS-TL1, GmOAS-TL2, GmOAS-TL3, GmOAS-TL4, GmOAS-TL6, GmOAS-TL7, GmOASTL4, GsOAS-TL1, GYY4137, HiOASS, HiOASS-A, lanthionine synthase, LbrCS, MCSA1, Nt-OAS-TL, O -acetylserine (thiol)-lyase, O-acetyl-L-serine (thiol) lyase, O-acetyl-L-serine acetate-lyase (adding hydrogen sulfide), O-acetyl-L-serine sulfhydrylase, O-acetyl-L-serine sulfhydrylase B, O-acetyl-L-serine sulfohydrolase, O-acetyl-L-serine(thiol)lyase, O-acetyl-serine (thiol) lyase, O-acetylserine (thiol) lyase, O-acetylserine (Thiol)-lyase, O-acetylserine (thiol)-lyase A, O-acetylserine (thiol)-lyase B, O-acetylserine (thiol)lyase, O-acetylserine sulfhydrylase, O-acetylserine sulfhydrylase A, O-acetylserine sulfhydrylase B, O-acetylserine sulfhydrylase isoenzyme B, O-acetylserine sulfhydrylase-A, O-acetylserine sulfhydrylase-B, O-acetylserine thiol lyase, O-acetylserine(thiol)lyase, O-acetylserine-(thiol)lyase, O-acetylserine-O-acetylhomoserine sulfhydro-lyase, O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase, OAS Shase, OAS thiol-lyases, OAS-TL, OAS-TL A, OAS-TL B, OAS-TL C, OASA1, OASB, OASS, OASS-A, OASS-B, OASTL, OASTL-A, OASTL-A1, old3-1, OPSS, Os01g0290600, Os03g53650, protein ONSET OF LEAF DEATH 3, RCS3, S-sulfocysteine synthase, SSC synthase, StOASTL A, StOASTL B, sulfhydrylase/cysteine synthase, synthase, cysteine, TvCS1

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.47 cysteine synthase

Substrates Products

Substrates Products on EC 2.5.1.47 - cysteine synthase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 L-cysteine
(2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) + H2S
show the reaction diagram
-
-
-
?
3-chloro-L-alanine + NaHS
L-cysteine + ?
show the reaction diagram
-
beta-replacement reaction, enzyme can be induced by 3-chloro-L-alanine
-
?
5-thio-2-nitrobenzoate + O-acetyl-L-serine
acetate + ?
show the reaction diagram
-
-
-
-
?
beta-chloro-L-alanine + 2-nitro-5-thiobenzoate
?
show the reaction diagram
-
-
-
-
?
chloroalanine + sulfide
cysteine + chloride
show the reaction diagram
cyanide + cysteine
beta-cyanoalanine + sulfide
show the reaction diagram
-
-
-
?
cysteine + CN-
cyanoalanine + H2S
show the reaction diagram
L-Cys + acetate
?
show the reaction diagram
-
involved in mobilization of sulfide from cysteine for Fe-S cluster formation, significance in vivo unclear
-
-
?
L-Cys + acetate
O-acetyl-L-Ser + H2S
show the reaction diagram
L-Cys + dithiothreitol
beta-cyanoalanine + H2S
show the reaction diagram
-
-
-
?
L-cysteine + cyanide
cyanoalanine + H2S
show the reaction diagram
-
-
-
?
L-cysteine + dithiothreitol
S-(2,3-hydroxy-4-thiobutyl)-L-cysteine + H2S
show the reaction diagram
L-cysteine + H2O
L-serine + H2S
show the reaction diagram
A0A1J9VES8
-
-
-
?
L-cysteine + L-cysteine
L-lanthionine + H2S
show the reaction diagram
L-cysteine + L-homocysteine
L-cystathionine + H2S
show the reaction diagram
L-homocysteine + L-serine
L-cystathionine + H2O
show the reaction diagram
-
-
-
?
L-homoserine + sulfide
?
show the reaction diagram
-
1.6% of the activity with O-acetyl-L-serine
-
-
?
NaN3 + O-acetyl-Ser
beta-azidoalanine + sodium acetate
show the reaction diagram
O-acetyl-L-Ser + 1,2,3,4-tetrazole
?
show the reaction diagram
-
-
-
-
?
O-acetyl-L-Ser + 1,2,3-benzotriazole
?
show the reaction diagram
-
weak activity
-
-
?
O-acetyl-L-Ser + 1,2,4-triazole
?
show the reaction diagram
-
-
-
-
?
O-acetyl-L-Ser + 1-propanethiol
?
show the reaction diagram
-
-
-
-
?
O-acetyl-L-Ser + 2-propene-1-thiol
S-allyl-L-cysteine + ?
show the reaction diagram
O-acetyl-L-Ser + 3-mercapto-1,2,4-triazole
?
show the reaction diagram
-
-
-
-
?
O-acetyl-L-Ser + 5-mercapto-2-nitrobenzoate
S-(3-carboxy-4-nitrophenyl)-L-cysteine + ?
show the reaction diagram
-
-
-
?
O-acetyl-L-Ser + benzenethiol
L-cys + benzylacetate
show the reaction diagram
-
-
-
-
?
O-acetyl-L-Ser + cysteamine
?
show the reaction diagram
-
weak activity
-
-
?
O-acetyl-L-Ser + H2S
L-Cys + acetate
show the reaction diagram
O-acetyl-L-Ser + hydrogen sulfide
L-Cys + acetate
show the reaction diagram
O-acetyl-L-Ser + isoxazolin-5-one
?
show the reaction diagram
O-acetyl-L-Ser + mercaptoacetic acid
S-carboxymethyl-L-cysteine
show the reaction diagram
O-acetyl-L-Ser + methyl mercaptan
S-methylcysteine + acetate
show the reaction diagram
O-acetyl-L-Ser + NaCN
beta-cyanoalanine + sodium acetate
show the reaction diagram
O-acetyl-L-Ser + pyrazole
?
show the reaction diagram
-
weak activity
-
-
?
O-acetyl-L-Ser + S2O32-
S-sulfocysteine + ?
show the reaction diagram
O-acetyl-L-Ser + sodium azide
?
show the reaction diagram
-
weak activity
-
-
?
O-acetyl-L-Ser + sodium thiosulfate
?
show the reaction diagram
O-acetyl-L-Ser + sulfide
L-Cys + acetate
show the reaction diagram
O-acetyl-L-Ser + thiosulfate
S-sulfocysteine + sodium acetate
show the reaction diagram
O-acetyl-L-serine
L-cysteine + acetate
show the reaction diagram
O-acetyl-L-serine + 5-thio-2-nitrobenzoate
? + acetate
show the reaction diagram
O-acetyl-L-serine + H2O
pyruvate + acetate + NH3
show the reaction diagram
-
-
-
?
O-acetyl-L-serine + H2S
L-cysteine + acetic acid
show the reaction diagram
A0A1J9VES8
-
-
-
?
O-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
show the reaction diagram
O-acetyl-L-serine + L-homocysteine
cystathionine + acetate
show the reaction diagram
O-acetyl-L-serine + sulfide
L-Cys + acetate
show the reaction diagram
-
-
-
?
O-acetyl-L-serine + thiosulfate
S-sulfo-L-cysteine + acetate
show the reaction diagram
O-acetyl-L-serine + thiosulfate
S-sulfo-L-cysteine + acetate + H+
show the reaction diagram
-
-
-
-
?
O-acetyl-Ser + selenide
selenocysteine + acetate
show the reaction diagram
-
maximal 40% rate of cysteine synthesis
-
?
O-acetylhomoserine + H2S
homocysteine + ?
show the reaction diagram
O-diazoacetyl-L-serine + sulfide
?
show the reaction diagram
O-phosphoserine + H2S
L-Cys + phosphate
show the reaction diagram
-
-
-
-
?
O-succinyl-L-homoserine + sulfide
?
show the reaction diagram
O3-acetyl-L-serine
alpha-aminoacrylate
show the reaction diagram
-
-
in absence of S2- and at 50°C, not below
-
?
O3-acetyl-L-serine + 2-nitro-5-thiobenzoate
?
show the reaction diagram
O3-acetyl-L-serine + 5-thio-2-nitrobenzoate
? + acetate
show the reaction diagram
O3-acetyl-L-serine + benzylmercaptan
S-benzyl-L-cysteine + acetate
show the reaction diagram
-
-
-
?
O3-acetyl-L-serine + cyanide
beta-cyano-L-alanine + acetate
show the reaction diagram
-
-
-
?
O3-acetyl-L-serine + ethylmercaptan
S-ethyl-L-cysteine + acetate
show the reaction diagram
-
-
-
?
O3-acetyl-L-serine + hydrogen sulfide
L-cysteine + acetate
show the reaction diagram
O3-acetyl-L-serine + hydrogensulfide
L-cysteine + acetate
show the reaction diagram
-
-
-
-
?
O3-acetyl-L-serine + methylmercaptan
S-methyl-L-cysteine + acetate
show the reaction diagram
-
-
-
?
O3-acetyl-L-serine + phenol
O-phenyl-L-serine + acetate
show the reaction diagram
-
-
-
?
O3-acetyl-L-serine + phenylmercaptan
S-phenyl-L-cysteine + acetate
show the reaction diagram
-
-
-
?
O3-acetyl-L-serine + propylmercaptan
S-propyl-L-cysteine + acetate
show the reaction diagram
-
-
-
?
O3-acetyl-L-serine + sulfide
L-cysteine + acetate
show the reaction diagram
-
-
-
-
?
Ser + sulfide
?
show the reaction diagram
-
1.8% of the activity with O-acetyl-L-serine
-
-
?
additional information
?
-