7.2.2.3: P-type Na+ transporter
This is an abbreviated version!
For detailed information about P-type Na+ transporter, go to the full flat file.
Word Map on EC 7.2.2.3
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7.2.2.3
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cardiac
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erythrocyte
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ouabain-sensitive
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atpases
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hypertension
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myosin
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sarcoplasmic
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electrogenic
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contractile
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ca2+-atpase
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nerve
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arterial
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gill
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basolateral
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glycoside
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sodium-potassium
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tubule
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na,k-atpase
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depolarization
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migraine
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alpha-subunits
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digoxin
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hyperpolarization
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cotransporter
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myofibrillar
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vanadate
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normotensive
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inotropic
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h+-atpase
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cytochemical
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cardiotonic
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amiloride
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sarcolemmal
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mg2+-dependent
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transepithelial
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digitalis
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aura
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k+-dependent
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phosphoenzyme
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oligomycin
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rb+
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actomyosin
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branchial
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osmoregulatory
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dicyclohexylcarbodiimide
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natriuresis
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hemiplegia
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menkes
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proton-translocating
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serca
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medicine
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biotechnology
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pharmacology
- 7.2.2.3
- cardiac
- erythrocyte
-
ouabain-sensitive
- atpases
- hypertension
- myosin
- sarcoplasmic
-
electrogenic
-
contractile
- ca2+-atpase
- nerve
- arterial
- gill
-
basolateral
- glycoside
-
sodium-potassium
- tubule
- na,k-atpase
-
depolarization
- migraine
- alpha-subunits
- digoxin
-
hyperpolarization
-
cotransporter
- myofibrillar
- vanadate
-
normotensive
-
inotropic
- h+-atpase
-
cytochemical
-
cardiotonic
- amiloride
-
sarcolemmal
-
mg2+-dependent
-
transepithelial
- digitalis
- aura
-
k+-dependent
- phosphoenzyme
- oligomycin
- rb+
- actomyosin
-
branchial
-
osmoregulatory
- dicyclohexylcarbodiimide
-
natriuresis
- hemiplegia
- menkes
-
proton-translocating
- serca
- medicine
- biotechnology
- pharmacology
Reaction
Synonyms
adenosine 5'-triphosphatase, adenosine triphosphatase, ATP hydrolase, ATP1A2, ATP4, ATPase, complex V (mitochondrial electron transport), EC 3.6.3.7, EC 3.6.3.9, ENA, Ena1, Ena1p, KPA1, KPA2, Na+ stimulated P-type ATPase, Na+,K+-ATPase, Na+-ATPase, Na+-exporting ATPase, Na+-K+-ATPase alpha-2 subunit, Na+-stimulated ATPase, Na+/K+-ATPase, Na+/K+-ATPase sodium pump, NtpK, ouabain-insensitive Na+-ATPase, P-type ATPase, P-Type Na+ ATPase, P-type Na+-ATPase, P2-type ATPase, renal Na+-ATPase, sodium ATPase, sodium pump, sodium pump alpha1 subunit, sodium pump Ena1p, sodium-pump ATPase, TcENA, vacuolar-type ATPase
ECTree
7.2.2.3 P-type Na+ transporterAdvanced search results
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results (Activating Compound
Activating Compound on EC 7.2.2.3 - P-type Na+ transporter
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
ATP
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ATPase activity increases as ATP increased and the activity is saturated at about 6 mM ATP
bile salt
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induction of enzyme expression and increase in enzymic activity with concomitant decrease in intracellular ATP levels. In a bile salt-resistant mtant strain, tolerance of acidic pH-value is better than in parent strain. Expression and activity of enzyme are increased in the mutant
lysophosphatidic acid
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stimulates the enzyme to 120% at 0.01 nM. Protein kinase C mediates the modulation of Na+-ATPase activity by lysophosphatidic acid
PacC transcription factor
required for efficient cation efflux at alkaline ambient pH
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angiotensin II
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angiotensin II has an activating and regulatory role for Na+-ATPase activity in healthy rats, and angiotensin II links the enzyme activity to hypertension in spontaneously hypertensive rats, where it has an inhibitory effect on Na+-ATPase activity. Ang II interacts with different receptors in spontaneously hypertensive rats and WKY wild-type rats
angiotensin II
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physiological activation at femtomolar concentration. The activation by angiotensin II is completely abolished in the adult progeny of rats that are undernourished during lactation
angiotensin II
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stimulates the proximal tubule Na+-ATPase through the AT1 receptor/phosphoinositide phospholipase Cbeta/protein kinase C pathway, molecular mechanisms, overview. Ang II induces fast and correlated activation of Na+-ATPase and PKC activities with the maximal effect of 115% activation observed at 1 min and sustained for 30 min. Involvement of phospholipase A2, PLA2, on the modulation of Na+-ATPase activity by Ang II, and modulation of the effect of Ang II on Na+-ATPase activity by PLA2 inhibitors, e.g. quinacrine, PACOCF3 and a specific inhibitor, BEL, overview
angiotensin II
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stimulates the renal Na+-ATPase, reversed by Ang-(1-7) via MAS and the A779-sensitive MAS receptor in a Gs/PKA pathway, molecular mechanism, overview
additional information
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a system leading to activation of the enzyme in spontaneously hypertensive rats is inhibited by AT2-mediated Ang II
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additional information
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a saponin mixture isolated from the roots of Ampelozizyphus amazonicus (50 mg/kg) significantly increases the activity of renal Na+-ATPase
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additional information
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phopshatidic acid stimulates the enzyme via activation of phospholipase A2, PLA2, which is inhibited by specific PLA2 inhibitors, overview
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additional information
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the addition of 0.001 mM guanosine 5-O-(2-thiodiphosphate) does not change the enzyme activity
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