Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the addition of 0.001 mM guanosine 5-O-(2-thiodiphosphate) does not change the enzyme activity | Sus scrofa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Furosemide | - |
Sus scrofa | |
prostaglandin E2 | dose-dependent inhibition with maximal effect at 1 nM. The addition of 0.001 mM prostaglandin E2 decreases Na+-ATPase activity by 41%. The inhibitory effect of prostaglandin E2 on proximal tubule Na+-ATPase activity involves G protein and the activation of protein kinase A. The protein A-mediated inhibitory effect of prostaglandin E2 on Na+-ATPase activity requires previous activation of protein kinase C | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Sus scrofa | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
renal proximal tubule | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Na+/in | - |
Sus scrofa | ADP + phosphate + Na+/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Na+-ATPase | - |
Sus scrofa |