Activating Compound | Comment | Organism | Structure |
---|---|---|---|
angiotensin II | angiotensin II has an activating and regulatory role for Na+-ATPase activity in healthy rats, and angiotensin II links the enzyme activity to hypertension in spontaneously hypertensive rats, where it has an inhibitory effect on Na+-ATPase activity. Ang II interacts with different receptors in spontaneously hypertensive rats and WKY wild-type rats | Rattus norvegicus | |
additional information | a system leading to activation of the enzyme in spontaneously hypertensive rats is inhibited by AT2-mediated Ang II | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
angiotensin II | angiotensin II has an activating and regulatory role for Na+-ATPase activity in healthy rats, and angiotensin II links the enzyme activity to hypertension in spontaneously hypertensive rats, where it has an inhibitory effect on Na+-ATPase activity. The Ang II inhibitory effect is completely reversed by a specific antagonist of AT2 receptor, PD123319. Ang II interacts with different receptors in spontaneously hypertensive rats and WKY wild-type rats | Rattus norvegicus | |
losartan | prevents the increase in Na+-ATPase activity observed in 14-weekold spontaneously hypertensive rats | Rattus norvegicus | |
additional information | ouabain-insensitive Na+-ATPase. A system leading to activation of the enzyme in spontaneously hypertensive rats is inhibited by AT2-mediated Ang II | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Michaelis-Menten kinetics | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Rattus norvegicus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Na+/in | Rattus norvegicus | - |
ADP + phosphate + Na+/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
WKY rats and spontaneously hypertensive rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | cortex | Rattus norvegicus | - |
renal tubule | basolateral membranes of kidney proximal tubule cells | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Na+/in | - |
Rattus norvegicus | ADP + phosphate + Na+/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Na+-ATPase | - |
Rattus norvegicus |
ouabain-insensitive Na+-ATPase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
additional information | increase in sodium reabsorption on the proximal tubule in essential hypertension. Na+-ATPase activity is enhanced in14-week-old but not in 6-week-old spontaneously hypertensive rats. correlation between AT1 receptor activation in spontaneously hypertensive rats and increased ouabaininsensitive Na+-ATPase activity. Ang II interacts with different receptors in spontaneously hypertensive rats and WKY wild-type rats. The AT1 receptor is responsible for activation in spontaneously hypertensive rats. Role of the AT2 receptor in counteracting the AT1 receptor to achieve hydroelectrolytic balance in normotensive rats | Rattus norvegicus |