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Literature summary for 7.2.2.3 extracted from

  • Queiroz-Madeira, E.P.; Lara, L.S.; Wengert, M.; Landgraf, S.S.; Libano-Soares, J.D.; Zapata-Sudo, G.; Sudo, R.T.; Takiya, C.M.; Gomes-Quintana, E.; Lopes, A.G.; Caruso-Neves, C.
    Na+-ATPase in spontaneous hypertensive rats: possible AT1 receptor target in the development of hypertension (2010), Biochim. Biophys. Acta, 1798, 360-366.
    View publication on PubMed
Search for more literature for 7.2.2.3

Activating Compound

Activating Compound Comment Organism Structure
angiotensin II angiotensin II has an activating and regulatory role for Na+-ATPase activity in healthy rats, and angiotensin II links the enzyme activity to hypertension in spontaneously hypertensive rats, where it has an inhibitory effect on Na+-ATPase activity. Ang II interacts with different receptors in spontaneously hypertensive rats and WKY wild-type rats Rattus norvegicus
additional information a system leading to activation of the enzyme in spontaneously hypertensive rats is inhibited by AT2-mediated Ang II Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
angiotensin II angiotensin II has an activating and regulatory role for Na+-ATPase activity in healthy rats, and angiotensin II links the enzyme activity to hypertension in spontaneously hypertensive rats, where it has an inhibitory effect on Na+-ATPase activity. The Ang II inhibitory effect is completely reversed by a specific antagonist of AT2 receptor, PD123319. Ang II interacts with different receptors in spontaneously hypertensive rats and WKY wild-type rats Rattus norvegicus
losartan prevents the increase in Na+-ATPase activity observed in 14-weekold spontaneously hypertensive rats Rattus norvegicus
additional information ouabain-insensitive Na+-ATPase. A system leading to activation of the enzyme in spontaneously hypertensive rats is inhibited by AT2-mediated Ang II Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Michaelis-Menten kinetics Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+/in Rattus norvegicus
-
 ADP + phosphate + Na+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 WKY rats and spontaneously hypertensive rats
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney cortex Rattus norvegicus
-
renal tubule basolateral membranes of kidney proximal tubule cells Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in
-
 Rattus norvegicus ADP + phosphate + Na+/out
-
 ?

Synonyms

Synonyms Comment Organism
Na+-ATPase
-
 Rattus norvegicus
ouabain-insensitive Na+-ATPase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Rattus norvegicus

General Information

General Information Comment Organism
additional information increase in sodium reabsorption on the proximal tubule in essential hypertension. Na+-ATPase activity is enhanced in14-week-old but not in 6-week-old spontaneously hypertensive rats. correlation between AT1 receptor activation in spontaneously hypertensive rats and increased ouabaininsensitive Na+-ATPase activity. Ang II interacts with different receptors in spontaneously hypertensive rats and WKY wild-type rats. The AT1 receptor is responsible for activation in spontaneously hypertensive rats. Role of the AT2 receptor in counteracting the AT1 receptor to achieve hydroelectrolytic balance in normotensive rats Rattus norvegicus