7.2.2.3: P-type Na+ transporter
This is an abbreviated version!
For detailed information about P-type Na+ transporter, go to the full flat file.
Word Map on EC 7.2.2.3
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7.2.2.3
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cardiac
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erythrocyte
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ouabain-sensitive
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atpases
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hypertension
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myosin
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sarcoplasmic
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electrogenic
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contractile
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ca2+-atpase
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nerve
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arterial
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gill
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basolateral
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glycoside
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sodium-potassium
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tubule
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na,k-atpase
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depolarization
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migraine
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alpha-subunits
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digoxin
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hyperpolarization
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cotransporter
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myofibrillar
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vanadate
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normotensive
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inotropic
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h+-atpase
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cytochemical
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cardiotonic
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amiloride
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sarcolemmal
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mg2+-dependent
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transepithelial
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digitalis
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aura
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k+-dependent
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phosphoenzyme
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oligomycin
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rb+
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actomyosin
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branchial
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osmoregulatory
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dicyclohexylcarbodiimide
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natriuresis
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hemiplegia
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menkes
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proton-translocating
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serca
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medicine
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biotechnology
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pharmacology
- 7.2.2.3
- cardiac
- erythrocyte
-
ouabain-sensitive
- atpases
- hypertension
- myosin
- sarcoplasmic
-
electrogenic
-
contractile
- ca2+-atpase
- nerve
- arterial
- gill
-
basolateral
- glycoside
-
sodium-potassium
- tubule
- na,k-atpase
-
depolarization
- migraine
- alpha-subunits
- digoxin
-
hyperpolarization
-
cotransporter
- myofibrillar
- vanadate
-
normotensive
-
inotropic
- h+-atpase
-
cytochemical
-
cardiotonic
- amiloride
-
sarcolemmal
-
mg2+-dependent
-
transepithelial
- digitalis
- aura
-
k+-dependent
- phosphoenzyme
- oligomycin
- rb+
- actomyosin
-
branchial
-
osmoregulatory
- dicyclohexylcarbodiimide
-
natriuresis
- hemiplegia
- menkes
-
proton-translocating
- serca
- medicine
- biotechnology
- pharmacology
Reaction
Synonyms
adenosine 5'-triphosphatase, adenosine triphosphatase, ATP hydrolase, ATP1A2, ATP4, ATPase, complex V (mitochondrial electron transport), EC 3.6.3.7, EC 3.6.3.9, ENA, Ena1, Ena1p, KPA1, KPA2, Na+ stimulated P-type ATPase, Na+,K+-ATPase, Na+-ATPase, Na+-exporting ATPase, Na+-K+-ATPase alpha-2 subunit, Na+-stimulated ATPase, Na+/K+-ATPase, Na+/K+-ATPase sodium pump, NtpK, ouabain-insensitive Na+-ATPase, P-type ATPase, P-Type Na+ ATPase, P-type Na+-ATPase, P2-type ATPase, renal Na+-ATPase, sodium ATPase, sodium pump, sodium pump alpha1 subunit, sodium pump Ena1p, sodium-pump ATPase, TcENA, vacuolar-type ATPase
ECTree
7.2.2.3 P-type Na+ transporterAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 7.2.2.3 - P-type Na+ transporter
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
(3beta,22alpha,25R)-26-(beta-D-glucopyranosyloxy)-2-methoxyfurost-5-en-3-yl O-D-apio-beta-D-furanosyl-(1-2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-4)]-beta-D-glucopyranoside
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(3beta,22alpha,25R)-spirostan-3-yl O-D-apio-beta-D-furanosyl-(1-2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-4)]-beta-D-glucopyranoside
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angiotensin II
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angiotensin II has an activating and regulatory role for Na+-ATPase activity in healthy rats, and angiotensin II links the enzyme activity to hypertension in spontaneously hypertensive rats, where it has an inhibitory effect on Na+-ATPase activity. The Ang II inhibitory effect is completely reversed by a specific antagonist of AT2 receptor, PD123319. Ang II interacts with different receptors in spontaneously hypertensive rats and WKY wild-type rats
atrial natriuretic peptide
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selectively inhibits the enzyme in basolateral membranes of kidney proximal tubules by activation of guanylyl cyclase activity, which is inhibited by LY83583
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ceramide
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mediates enzyme inhibition to about 60% by activating protein kinase A and protein kinase Czeta, that regulate ion transporter activities. Inhibition of the kinase reverses the inhibitory effect of ceramide on Na+-ATPase
cipargamin
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previously known as KAE609 and NITD609, complete inhibition at 500 nM
Fe2+
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dithiothreitol exerts considerable protective effect on the activity of the Fe2+-inhibited enzyme
losartan
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prevents the increase in Na+-ATPase activity observed in 14-weekold spontaneously hypertensive rats
N,NÂ’-dicyclohexylcarbodiimide
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78% residual activity at 1 mM in the presence of 10 mM NaCl. Inhibition in the absence of NaCl occurs after 20 min yielding 80 and 70% inhibition at pH 7.6 and pH 9.0, respectively
prostaglandin E2
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dose-dependent inhibition with maximal effect at 1 nM. The addition of 0.001 mM prostaglandin E2 decreases Na+-ATPase activity by 41%. The inhibitory effect of prostaglandin E2 on proximal tubule Na+-ATPase activity involves G protein and the activation of protein kinase A. The protein A-mediated inhibitory effect of prostaglandin E2 on Na+-ATPase activity requires previous activation of protein kinase C
urodilatin
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selectively inhibits the enzyme transiently in basolateral membranes of kidney proximal tubules by activation of guanylyl cyclase activity, which is inhibited by LY83583
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Carbonyl cyanide m-chlorophenylhydrazone
0.1 mM, only partial inhibition
Ouabain
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binding of inhibitor to enzyme results in activation of the proliferation and survival pathways involving PI3K, Akt activation, stimulation of eNOS, and production of NO in human umbilical cord endothelial cells
Ouabain
shows moderate selectivity (approximately 2.5fold) for alpha1 over alpha2 subunits of the enzyme
additional information
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not inhibited by 0.2 mM amiloride, 0.01 mM orthovanadate, 0.5 mM NEM, 50 mM KNO3, 20 mM KSCN, 1 mM CCP, and 1 mM ouabain
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additional information
high affinity Na+ uptake is not inhibited by Ba2+
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additional information
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ouabain-insensitive Na+-ATPase. A system leading to activation of the enzyme in spontaneously hypertensive rats is inhibited by AT2-mediated Ang II
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additional information
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guanylyl cyclase inhibitor LY83583 alone does not change the enzyme activity
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