7.2.2.3: P-type Na+ transporter
This is an abbreviated version!
For detailed information about P-type Na+ transporter, go to the full flat file.
Word Map on EC 7.2.2.3
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7.2.2.3
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cardiac
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erythrocyte
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ouabain-sensitive
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atpases
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hypertension
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myosin
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sarcoplasmic
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electrogenic
-
contractile
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ca2+-atpase
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nerve
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arterial
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gill
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basolateral
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glycoside
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sodium-potassium
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tubule
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na,k-atpase
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depolarization
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migraine
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alpha-subunits
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digoxin
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hyperpolarization
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cotransporter
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myofibrillar
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vanadate
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normotensive
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inotropic
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h+-atpase
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cytochemical
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cardiotonic
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amiloride
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sarcolemmal
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mg2+-dependent
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transepithelial
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digitalis
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aura
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k+-dependent
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phosphoenzyme
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oligomycin
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rb+
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actomyosin
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branchial
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osmoregulatory
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dicyclohexylcarbodiimide
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natriuresis
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hemiplegia
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menkes
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proton-translocating
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serca
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medicine
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biotechnology
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pharmacology
- 7.2.2.3
- cardiac
- erythrocyte
-
ouabain-sensitive
- atpases
- hypertension
- myosin
- sarcoplasmic
-
electrogenic
-
contractile
- ca2+-atpase
- nerve
- arterial
- gill
-
basolateral
- glycoside
-
sodium-potassium
- tubule
- na,k-atpase
-
depolarization
- migraine
- alpha-subunits
- digoxin
-
hyperpolarization
-
cotransporter
- myofibrillar
- vanadate
-
normotensive
-
inotropic
- h+-atpase
-
cytochemical
-
cardiotonic
- amiloride
-
sarcolemmal
-
mg2+-dependent
-
transepithelial
- digitalis
- aura
-
k+-dependent
- phosphoenzyme
- oligomycin
- rb+
- actomyosin
-
branchial
-
osmoregulatory
- dicyclohexylcarbodiimide
-
natriuresis
- hemiplegia
- menkes
-
proton-translocating
- serca
- medicine
- biotechnology
- pharmacology
Reaction
Synonyms
adenosine 5'-triphosphatase, adenosine triphosphatase, ATP hydrolase, ATP1A2, ATP4, ATPase, complex V (mitochondrial electron transport), EC 3.6.3.7, EC 3.6.3.9, ENA, Ena1, Ena1p, KPA1, KPA2, Na+ stimulated P-type ATPase, Na+,K+-ATPase, Na+-ATPase, Na+-exporting ATPase, Na+-K+-ATPase alpha-2 subunit, Na+-stimulated ATPase, Na+/K+-ATPase, Na+/K+-ATPase sodium pump, NtpK, ouabain-insensitive Na+-ATPase, P-type ATPase, P-Type Na+ ATPase, P-type Na+-ATPase, P2-type ATPase, renal Na+-ATPase, sodium ATPase, sodium pump, sodium pump alpha1 subunit, sodium pump Ena1p, sodium-pump ATPase, TcENA, vacuolar-type ATPase
ECTree
7.2.2.3 P-type Na+ transporterAdvanced search results
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General Information on EC 7.2.2.3 - P-type Na+ transporter
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
malfunction
deletion of ENA1 has no effect on the tolerance to potassium and rubidium. Mutant cells are unable to grow on media containing higher concentrations of sodium and lithium cations
metabolism
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important regulatory role of Ang-(1-7) in the action of angiotensin II on the Na+-ATPase activity of proximal tubule cells by activation of MAS receptor. The MAS receptor plays an important role as a regulator of the effects mediated by AT1 receptor on proximal tubule sodium reabsorption and renal sodium excretion, overview
physiological function
additional information
physiological function
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the Na+-ATPase is involved in Na+ reabsorption in the kidney. Ouabain-insensitive Na+-ATPase is considered the fine tuner of cytosolic Na+, the selective key roles of ceramide under Na+-induced osmotic stress
physiological function
isoform KPA1 plays an important role in alkali and cold stress tolerance
physiological function
isoform KPA2 plays an important role in alkali and cold stress tolerance
physiological function
Na+ATPase is involved in Candida glabrata tolerance to high concentrations of Na+ and Li+
physiological function
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the enzyme functions as an electrogenic Na+ pump which transports only Na+ upon hydrolysis of ATP. Na+- and ATP-dependent H+ efflux from proteoliposomes, is driven by the electric potential generated by Na+-stimulated ATPase
physiological function
cardiomyocyte ATP1A2 is a target of anoxia-reoxygenation injury
physiological function
the sodium pump alpha1 subunit potentially mediates various antiglioblastoma signaling pathways and affects the sensitivity of glioblastoma cells to drugs
physiological function
Neopyropia yezoensis TU-1
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isoform KPA2 plays an important role in alkali and cold stress tolerance
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physiological function
Neopyropia yezoensis TU-1
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isoform KPA1 plays an important role in alkali and cold stress tolerance
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additional information
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Cer acts as a potent physiological modulator of the Na+-ATPase, participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta
additional information
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increase in sodium reabsorption on the proximal tubule in essential hypertension. Na+-ATPase activity is enhanced in14-week-old but not in 6-week-old spontaneously hypertensive rats. correlation between AT1 receptor activation in spontaneously hypertensive rats and increased ouabaininsensitive Na+-ATPase activity. Ang II interacts with different receptors in spontaneously hypertensive rats and WKY wild-type rats. The AT1 receptor is responsible for activation in spontaneously hypertensive rats. Role of the AT2 receptor in counteracting the AT1 receptor to achieve hydroelectrolytic balance in normotensive rats
additional information
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inosine-induced inhibition of Na+-ATPase activity could be involved in the increased renal sodium excretion during short periods of ischemia
