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Literature summary for 7.2.2.3 extracted from
- PKA-mediated effect of MAS receptor in counteracting angiotensin II-stimulated renal Na+-ATPase (2010), Arch. Biochem. Biophys., 496, 117-122.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| angiotensin II | stimulates the renal Na+-ATPase, reversed by Ang-(1-7) via MAS and the A779-sensitive MAS receptor in a Gs/PKA pathway, molecular mechanism, overview | Sus scrofa |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ouabain | - |
Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Sus scrofa | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Sus scrofa | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Na+/in | Sus scrofa | - |
ADP + phosphate + Na+/out | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Sus scrofa | - |
| renal tubule | basolateral membranes of kidney proximal tubule cells | Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Na+/in | - |
Sus scrofa | ADP + phosphate + Na+/out | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Na+-ATPase | - |
Sus scrofa |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Sus scrofa |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | important regulatory role of Ang-(1-7) in the action of angiotensin II on the Na+-ATPase activity of proximal tubule cells by activation of MAS receptor. The MAS receptor plays an important role as a regulator of the effects mediated by AT1 receptor on proximal tubule sodium reabsorption and renal sodium excretion, overview | Sus scrofa |
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Release 2023.1 (January 2023)
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