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Literature summary for 7.2.2.3 extracted from

  • De Souza, A.M.; de Carvalho, T.L.; Lara, L.d.a..S.; Gomes-Quintana, E.; Lopes, A.G.; Caruso-Neves, C.
    The stimulatory effect of angiotensin II on Na+-ATPase activity involves sequential activation of phospholipases and sustained PKC activity (2010), Biochim. Biophys. Acta, 1798, 354-359.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
angiotensin II stimulates the proximal tubule Na+-ATPase through the AT1 receptor/phosphoinositide phospholipase Cbeta/protein kinase C pathway, molecular mechanisms, overview. Ang II induces fast and correlated activation of Na+-ATPase and PKC activities with the maximal effect of 115% activation observed at 1 min and sustained for 30 min. Involvement of phospholipase A2, PLA2, on the modulation of Na+-ATPase activity by Ang II, and modulation of the effect of Ang II on Na+-ATPase activity by PLA2 inhibitors, e.g. quinacrine, PACOCF3 and a specific inhibitor, BEL, overview Sus scrofa
lysophosphatidic acid stimulates the enzyme to 120% at 0.01 nM. Protein kinase C mediates the modulation of Na+-ATPase activity by lysophosphatidic acid Sus scrofa
additional information phopshatidic acid stimulates the enzyme via activation of phospholipase A2, PLA2, which is inhibited by specific PLA2 inhibitors, overview Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Sus scrofa 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+/in Sus scrofa
-
ADP + phosphate + Na+/out
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from kidney cortex and basolateral membranes from renal outer cortex Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Sus scrofa
-
renal tubule basolateral membranes from the outer cortex Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in
-
Sus scrofa ADP + phosphate + Na+/out
-
?

Synonyms

Synonyms Comment Organism
Na+-ATPase
-
Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Sus scrofa