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7.2.2.3: P-type Na+ transporter

This is an abbreviated version!
For detailed information about P-type Na+ transporter, go to the full flat file.

Word Map on EC 7.2.2.3

Reaction

ATP
+
H2O
 + n Na+[side 1] =
ADP
 +
phosphate
 + n Na+[side 2]

Synonyms

adenosine 5'-triphosphatase, adenosine triphosphatase, ATP hydrolase, ATP1A2, ATP4, ATPase, complex V (mitochondrial electron transport), EC 3.6.3.7, EC 3.6.3.9, ENA, Ena1, Ena1p, KPA1, KPA2, Na+ stimulated P-type ATPase, Na+,K+-ATPase, Na+-ATPase, Na+-exporting ATPase, Na+-K+-ATPase alpha-2 subunit, Na+-stimulated ATPase, Na+/K+-ATPase, Na+/K+-ATPase sodium pump, NtpK, ouabain-insensitive Na+-ATPase, P-type ATPase, P-Type Na+ ATPase, P-type Na+-ATPase, P2-type ATPase, renal Na+-ATPase, sodium ATPase, sodium pump, sodium pump alpha1 subunit, sodium pump Ena1p, sodium-pump ATPase, TcENA, vacuolar-type ATPase

ECTree

     7 Translocases
         7.2 Catalysing the translocation of inorganic cations
             7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
                7.2.2.3 P-type Na+ transporter

Expression

Expression on EC 7.2.2.3 - P-type Na+ transporter

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
cells grown at 2 M NaCl show higher enzyme activity than those grown at 0.5 M NaCl. ATPase activity in is slightly increased upon increasing the pH from 5.0 to 7.6
-
enzyme expression is induced as response to salt stress in the rim101 mutant which is sensitive to both alkaline pH and salt stress
expression of the sodium pump alpha1 subunit in glioblastoma tissues is generally higher than that in normal tissues
isoform KPA2 transcript is down-regulated (0.2fold) in gametophytes during exposure to alkali stress (pH 9.5)
isoforms KPA1 transcript is up-regulated 2.3fold in gametophytes during exposure to alkali stress (pH 9.5). Transcription of isoform KPA1 in gametophytes is also induced by cold stress (15°C, 3.3fold increase of expression)
Na+-ATPase activity increases more than 2fold in the adult progeny of rats that are undernourished during lactation. Its physiological activation by angiotensin II is completely abolished
-
subunit ATP1A2 expression is downregulated upon anoxia-reoxygenation injury
the Ena1 Na+-ATPase gene is highly upregulated by an increased osmotic pressure or sodium concentration (25fold increase of expression during the first 60 min of exposure to 1000 mM NaCl and then expression partly drops (12fold higher expression after 90 min))
transcription of isoform KPA2 in gametophytes is also induced by cold stress (15°C, 3.6fold increase of expression)