2.3.2.13: protein-glutamine gamma-glutamyltransferase

This is an abbreviated version!
For detailed information about protein-glutamine gamma-glutamyltransferase, go to the full flat file.

Reaction

Synonyms

AcTG-1, BmTGA, chloroplast transglutaminase, chlTGase, cold active transglutaminase, cold-active transglutaminase, EPB42, factor XIII, factor XIIIa, fibrin stabilizing factor, fibrinoligase, Galphah, glutamine:amine gamma-glutamyl-transferase, glutaminylpeptide gamma-glutamyltransferase, glutamyltransferase, glutaminylpeptide gamma-, gpTGase 2, gTG2, hfXIIIa, hTG2, hTGase 1, hTGase 2, hTGase 3, hTGase 6, KALB, KalbTG, KALB_7456, Laki-Lorand factor, mammalian transglutaminase, microbial transglutaminase, microbial transglutaminases, MsTGase, MTG, MTG-TX, MTGase, mTGase 2, OlTGT, plastidial transglutaminase, polyamine transglutaminase, protein 4.2, protein-glutamine gamma-glutamyltransferase, R-glutaminyl-peptide:amine gamma-glutamyl transferase, R-glutaminylpeptide-amine gamma-glutamyltransferase, SCTG, SMTG, STG I, t-TG, TG-2, TG1, TG2, TG3, TG4, TG5, TG6, TG7, tGA, TGase, TGase 1, TGase 2, Tgase 3, TGase 6, Tgase II, TGase-2, TGase2, TGB, TGK1, TGK2, TGL, TGM1, TGM2, TGM3, TGM4, TGM5, TGM6, TGM7, TGZ, tgz15, TGZo, tissue transglutaminase, tissue transglutaminase 2, tissue-TG, transglutaminase, transglutaminase 1, transglutaminase 2, transglutaminase 3, transglutaminase 6, transglutaminase C, transglutaminase factor XIII, transglutaminase type II, transglutaminase-2, transglutaminase-like protein, transglutaminase2, tTG, tTG-2, type 2 transglutaminase, type I transglutaminase, type-2 transglutaminase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.2 Aminoacyltransferases

                2.3.2.13 protein-glutamine gamma-glutamyltransferase

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Results	in table
53	Activating Compound
1511	AA Sequence
60	Application
1	CAS Registry Number
72	Cloned(Commentary)
2	Cofactor
16	Crystallization (Commentary)
14096	Disease/ Diagnostics
11	Expression
108	General Information
21	General Stability
237	IC50 Value
865	Inhibitors
20	kcat/KM [mM/s]
151	Ki Value [mM]
133	KM Value [mM]
108	Localization
170	Metals/Ions
108	Molecular Weight [Da]
159	Natural Substrates/ Products (Substrates)
8	Organic Solvent Stability
467	Organism
1	Oxidation Stability
73	PDB ID
58	pH Optimum
12	pH Range
14	pH Stability
4	pI Value
33	Posttranslational Modification
189	Protein Variants
98	Purification (Commentary)
24	Reaction
1	Reaction Type
322	Reference
1	Renatured (Commentary)
361	Source Tissue
88	Specific Activity [micromol/min/mg]
25	Storage Stability
602	Substrates and Products (Substrate)
100	Subunits
392	Synonyms
1	Systematic Name
65	Temperature Optimum [°C]
11	Temperature Range [°C]
40	Temperature Stability [°C]
49	Turnover Number [1/s]

pH Stability

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pH Stability on EC 2.3.2.13 - protein-glutamine gamma-glutamyltransferase

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3 - 10

Zea mays

-

the enzyme is stable over a broad pH range of 5.0 to 8.0 at -20°C for 12 h. At pH 9.0-10.0, the residual activity is almost 60% and the activity declines rapidly under acidic conditions (pH 3.0-5.0)

736699

3.5

Streptomyces hygroscopicus

-

30 min, 50% loss of activity

686843

4 - 8.5

Bos taurus

-

the purified enzyme is stable between pH 6.5 and 8.0 when incubated for 30 min at 35°C. 70% residual activity above pH 7.0, loss of activity below pH 4.0 and above pH 8.5

758664

5 - 10

Streptomyces mobaraensis

P81453

the high-salt resistent isozyme MTG-TX exhibits a broad range of pH and temperature stability

759632

5 - 8

Streptomyces hygroscopicus

-

30 min, stable at 10°C

686843

5 - 9

2 entries

6 - 9

Rattus norvegicus

-

stable at 25°C

487837

7

Streptomyces mobaraensis

P81453

after treatment at 50°C and pH 7.0 for 60, 80, 100, and 120 min, respectively, recombinant mutant E164L maintains 60%, 41%, 29%, and 16% of its original activity

758740

7 - 9

Penaeus monodon

Q6YNC7

labile outside this range

672389

7.5 - 9

Loligo sp.

-

in the absence of Ca2+

487873

9

3 entries

5 - 9

Streptomyces mobaraensis

-

the enzyme is stable within a pH range from 5.0 to 10.0 at 4°C for 12 h and within a pH range from 5.0 to 9.0 at 37°C for 30 min

720112

5 - 9

Streptomyces sp.

-

10 min stable, 37°C

487856

9

Homo sapiens

-

t1/2: 1-2 min stable at 37°C, at least 20 min stable at 4°C

487831

9

Mus musculus

-

thermolabile: t1/2: 3-4 min, 37°C, retinoic acid induced enzyme, 20% loss of activity within 20 min, epidermal enzyme

487851

9

Streptomyces hygroscopicus

-

30 min, 20% loss of activity

686843