2.3.2.13: protein-glutamine gamma-glutamyltransferase

This is an abbreviated version!
For detailed information about protein-glutamine gamma-glutamyltransferase, go to the full flat file.

Reaction

Synonyms

AcTG-1, BmTGA, chloroplast transglutaminase, chlTGase, cold active transglutaminase, cold-active transglutaminase, EPB42, factor XIII, factor XIIIa, fibrin stabilizing factor, fibrinoligase, Galphah, glutamine:amine gamma-glutamyl-transferase, glutaminylpeptide gamma-glutamyltransferase, glutamyltransferase, glutaminylpeptide gamma-, gpTGase 2, gTG2, hfXIIIa, hTG2, hTGase 1, hTGase 2, hTGase 3, hTGase 6, KALB, KalbTG, KALB_7456, Laki-Lorand factor, mammalian transglutaminase, microbial transglutaminase, microbial transglutaminases, MsTGase, MTG, MTG-TX, MTGase, mTGase 2, OlTGT, plastidial transglutaminase, polyamine transglutaminase, protein 4.2, protein-glutamine gamma-glutamyltransferase, R-glutaminyl-peptide:amine gamma-glutamyl transferase, R-glutaminylpeptide-amine gamma-glutamyltransferase, SCTG, SMTG, STG I, t-TG, TG-2, TG1, TG2, TG3, TG4, TG5, TG6, TG7, tGA, TGase, TGase 1, TGase 2, Tgase 3, TGase 6, Tgase II, TGase-2, TGase2, TGB, TGK1, TGK2, TGL, TGM1, TGM2, TGM3, TGM4, TGM5, TGM6, TGM7, TGZ, tgz15, TGZo, tissue transglutaminase, tissue transglutaminase 2, tissue-TG, transglutaminase, transglutaminase 1, transglutaminase 2, transglutaminase 3, transglutaminase 6, transglutaminase C, transglutaminase factor XIII, transglutaminase type II, transglutaminase-2, transglutaminase-like protein, transglutaminase2, tTG, tTG-2, type 2 transglutaminase, type I transglutaminase, type-2 transglutaminase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.2 Aminoacyltransferases

                2.3.2.13 protein-glutamine gamma-glutamyltransferase

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Results	in table
53	Activating Compound
1511	AA Sequence
60	Application
1	CAS Registry Number
72	Cloned(Commentary)
2	Cofactor
16	Crystallization (Commentary)
14096	Disease/ Diagnostics
11	Expression
108	General Information
21	General Stability
237	IC50 Value
865	Inhibitors
20	kcat/KM [mM/s]
151	Ki Value [mM]
133	KM Value [mM]
108	Localization
170	Metals/Ions
108	Molecular Weight [Da]
159	Natural Substrates/ Products (Substrates)
8	Organic Solvent Stability
467	Organism
1	Oxidation Stability
73	PDB ID
58	pH Optimum
12	pH Range
14	pH Stability
4	pI Value
33	Posttranslational Modification
189	Protein Variants
98	Purification (Commentary)
24	Reaction
1	Reaction Type
322	Reference
1	Renatured (Commentary)
361	Source Tissue
88	Specific Activity [micromol/min/mg]
25	Storage Stability
602	Substrates and Products (Substrate)
100	Subunits
392	Synonyms
1	Systematic Name
65	Temperature Optimum [°C]
11	Temperature Range [°C]
40	Temperature Stability [°C]
49	Turnover Number [1/s]

Temperature Range

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Temperature Range on EC 2.3.2.13 - protein-glutamine gamma-glutamyltransferase

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TEMPERATURE RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

0 - 65

2 entries

15 - 65

Bos taurus

-

activity range, over 40% of maximal activity at 30-60°C

758664

20 - 60

Streptomyces mobaraensis

P81453

activity range, wild-type and mutant enzyme, profiles overview

758740

20 - 70

Streptomyces mobaraensis

P81453

activity range, profile overview

759632

30 - 50

Streptomyces hygroscopicus

-

at pH 6.0, 30°C: about 70% of maximal activity, 50°C: about 70% of maximal activity

686843

35 - 40

Patinopecten sp.

-

muscle enzyme

658477

4 - 22

Pacifastacus leniusculus

Q964D3

at 4°C, crayfish TGase shows high activity due to a decreasing Km value for pentylamine as a substrate, the kcat value is not affected at 22°C

759209

4 - 37

Cavia porcellus

A0A286XL02

the guinea pig liver enzyme shows very low activity at 4°C and high activity at 37°C

759209

40 - 60

Nemipterus sp.

-

40°C: about 50% of maximal activity, 60°C: about 90% of maximal activity

688114

additional information

Euphausia superba

-

cold-active enzymes have more flexible structures compared with their mesophilic and thermophilic counterparts. This flexibility contributes to the high catalytic activity as well as the high temperature instability of cold active enzymes

759212

0 - 65

Euphausia superba

-

most active at 0-10°C, the relative activity at 45°C, 55°C and 65°C declined to 50%, 47% and 44%, respectively

759212

0 - 65

Gadus morhua

V9I378

the transglutaminase is active between 0 and 65°C, but is completely inactivated after 20 min at 70°C. The enzyme displays cold-adapted features, such as temperature instability combined with high catalytic efficiency at low temperatures (8-16°C), and optimal activity at 50°C

759197