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2.3.2.13: protein-glutamine gamma-glutamyltransferase

This is an abbreviated version!
For detailed information about protein-glutamine gamma-glutamyltransferase, go to the full flat file.

Word Map on EC 2.3.2.13

Reaction

protein glutamine
+
alkylamine
=
protein N5-alkylglutamine
 +
NH3

Synonyms

AcTG-1, BmTGA, chloroplast transglutaminase, chlTGase, cold active transglutaminase, cold-active transglutaminase, EPB42, factor XIII, factor XIIIa, fibrin stabilizing factor, fibrinoligase, Galphah, glutamine:amine gamma-glutamyl-transferase, glutaminylpeptide gamma-glutamyltransferase, glutamyltransferase, glutaminylpeptide gamma-, gpTGase 2, gTG2, hfXIIIa, hTG2, hTGase 1, hTGase 2, hTGase 3, hTGase 6, KALB, KalbTG, KALB_7456, Laki-Lorand factor, mammalian transglutaminase, microbial transglutaminase, microbial transglutaminases, MsTGase, MTG, MTG-TX, MTGase, mTGase 2, OlTGT, plastidial transglutaminase, polyamine transglutaminase, protein 4.2, protein-glutamine gamma-glutamyltransferase, R-glutaminyl-peptide:amine gamma-glutamyl transferase, R-glutaminylpeptide-amine gamma-glutamyltransferase, SCTG, SMTG, STG I, t-TG, TG-2, TG1, TG2, TG3, TG4, TG5, TG6, TG7, tGA, TGase, TGase 1, TGase 2, Tgase 3, TGase 6, Tgase II, TGase-2, TGase2, TGB, TGK1, TGK2, TGL, TGM1, TGM2, TGM3, TGM4, TGM5, TGM6, TGM7, TGZ, tgz15, TGZo, tissue transglutaminase, tissue transglutaminase 2, tissue-TG, transglutaminase, transglutaminase 1, transglutaminase 2, transglutaminase 3, transglutaminase 6, transglutaminase C, transglutaminase factor XIII, transglutaminase type II, transglutaminase-2, transglutaminase-like protein, transglutaminase2, tTG, tTG-2, type 2 transglutaminase, type I transglutaminase, type-2 transglutaminase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.13 protein-glutamine gamma-glutamyltransferase

Temperature Stability

Temperature Stability on EC 2.3.2.13 - protein-glutamine gamma-glutamyltransferase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0 - 20
purified recombinant AcTG-1 is stable up to a temperature of 20°C. Above 20°C, AcTG-1 starts to lose activity and is completely inactivated at 70°C
0 - 50
-
purified enzyme, stable at for at least 60 min
30
-
30 min, pH 6.0, about 10% loss of activity
30 - 50
-
the enzyme is stable after incubation for 30 min below 50°C. Purified enzyme maintains almost full activity after incubation at 30°C for 30 min and retains about 80% of its initial activity after incubation at 40°C for the same time. The activity decreases dramatically when the enzyme is incubated above 50°C
37 - 50
the half-life of the recombinant wild type pro-enzyme at 37°C reaches 34 min. The zymogen retains approximately 80% of the activity after incubation at 20°C for 30 min and is approximately inactivated after the same time at 50°C
4
-
at least 20 min stable, pH 9.0
44
-
inactivation within 20 min
45
melting temperature
45.5 - 56.3
melting temperature of enzyme mutant S2P
45.8
Tm of the wild-type enzyme
51.7
Tm of the wild-type enzyme
52
-
inactivation within 4 min
55
-
purified enzyme, loss of 40% activity after 60 min
55.8
melting temperature of wild-type enzyme
95
-
the enzyme is inactive after 10 min at 95°C
additional information