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2.3.2.13: protein-glutamine gamma-glutamyltransferase

This is an abbreviated version!
For detailed information about protein-glutamine gamma-glutamyltransferase, go to the full flat file.

Word Map on EC 2.3.2.13

Reaction

protein glutamine
+
alkylamine
=
protein N5-alkylglutamine
 +
NH3

Synonyms

AcTG-1, BmTGA, chloroplast transglutaminase, chlTGase, cold active transglutaminase, cold-active transglutaminase, EPB42, factor XIII, factor XIIIa, fibrin stabilizing factor, fibrinoligase, Galphah, glutamine:amine gamma-glutamyl-transferase, glutaminylpeptide gamma-glutamyltransferase, glutamyltransferase, glutaminylpeptide gamma-, gpTGase 2, gTG2, hfXIIIa, hTG2, hTGase 1, hTGase 2, hTGase 3, hTGase 6, KALB, KalbTG, KALB_7456, Laki-Lorand factor, mammalian transglutaminase, microbial transglutaminase, microbial transglutaminases, MsTGase, MTG, MTG-TX, MTGase, mTGase 2, OlTGT, plastidial transglutaminase, polyamine transglutaminase, protein 4.2, protein-glutamine gamma-glutamyltransferase, R-glutaminyl-peptide:amine gamma-glutamyl transferase, R-glutaminylpeptide-amine gamma-glutamyltransferase, SCTG, SMTG, STG I, t-TG, TG-2, TG1, TG2, TG3, TG4, TG5, TG6, TG7, tGA, TGase, TGase 1, TGase 2, Tgase 3, TGase 6, Tgase II, TGase-2, TGase2, TGB, TGK1, TGK2, TGL, TGM1, TGM2, TGM3, TGM4, TGM5, TGM6, TGM7, TGZ, tgz15, TGZo, tissue transglutaminase, tissue transglutaminase 2, tissue-TG, transglutaminase, transglutaminase 1, transglutaminase 2, transglutaminase 3, transglutaminase 6, transglutaminase C, transglutaminase factor XIII, transglutaminase type II, transglutaminase-2, transglutaminase-like protein, transglutaminase2, tTG, tTG-2, type 2 transglutaminase, type I transglutaminase, type-2 transglutaminase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.13 protein-glutamine gamma-glutamyltransferase

Expression

Expression on EC 2.3.2.13 - protein-glutamine gamma-glutamyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
after infection with white spot syndrome baculovirus and Vibrio harveyi, the gene expression initially increases up to 24 h and then falls down
antral t-TG activity is significantly increased in Helicobacter pylori positive patients compared to Helicobacter pylori negative patients. The activity of t-TG is higher in patients harboring cagA positive strains vs. cagA negative strains
enzyme expression is significantly lower in melanoma cells than in control keratinocytes
enzyme expression is up-regulated in the brains of Huntington’s disease patients
eposure of renal proximal tubule cells to hydrogen peroxide resultsin apoptosis and an increase in TGase activity
-
hypoxia induces TG2 expression through an HIF-1 dependent pathway and concurrently activates intracellular TG2
-
identification of a cold-adapted calcium-activated transglutaminase
in developing and mature chloroplasts enzyme activity is significantly higher than that measured in the dark (27fold higher in light with respect to dark, in mature chloroplasts)
-
protein expression is regulated by kinetin. Enzyme activity of kinetin-treated samples increases very strongly at 6 h, to about 128% and 60% of that of the kinetin sample at 0 h and the control at 6 h, respectively
-
the enzyme plays a key role in homocysteine-induced activation of THP-1 monocytes, involving oxidative as well as endoplasmic resticulum stress and inflammation
-