2.3.2.13: protein-glutamine gamma-glutamyltransferase

This is an abbreviated version!
For detailed information about protein-glutamine gamma-glutamyltransferase, go to the full flat file.

Reaction

Synonyms

AcTG-1, BmTGA, chloroplast transglutaminase, chlTGase, cold active transglutaminase, cold-active transglutaminase, EPB42, factor XIII, factor XIIIa, fibrin stabilizing factor, fibrinoligase, Galphah, glutamine:amine gamma-glutamyl-transferase, glutaminylpeptide gamma-glutamyltransferase, glutamyltransferase, glutaminylpeptide gamma-, gpTGase 2, gTG2, hfXIIIa, hTG2, hTGase 1, hTGase 2, hTGase 3, hTGase 6, KALB, KalbTG, KALB_7456, Laki-Lorand factor, mammalian transglutaminase, microbial transglutaminase, microbial transglutaminases, MsTGase, MTG, MTG-TX, MTGase, mTGase 2, OlTGT, plastidial transglutaminase, polyamine transglutaminase, protein 4.2, protein-glutamine gamma-glutamyltransferase, R-glutaminyl-peptide:amine gamma-glutamyl transferase, R-glutaminylpeptide-amine gamma-glutamyltransferase, SCTG, SMTG, STG I, t-TG, TG-2, TG1, TG2, TG3, TG4, TG5, TG6, TG7, tGA, TGase, TGase 1, TGase 2, Tgase 3, TGase 6, Tgase II, TGase-2, TGase2, TGB, TGK1, TGK2, TGL, TGM1, TGM2, TGM3, TGM4, TGM5, TGM6, TGM7, TGZ, tgz15, TGZo, tissue transglutaminase, tissue transglutaminase 2, tissue-TG, transglutaminase, transglutaminase 1, transglutaminase 2, transglutaminase 3, transglutaminase 6, transglutaminase C, transglutaminase factor XIII, transglutaminase type II, transglutaminase-2, transglutaminase-like protein, transglutaminase2, tTG, tTG-2, type 2 transglutaminase, type I transglutaminase, type-2 transglutaminase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.2 Aminoacyltransferases

                2.3.2.13 protein-glutamine gamma-glutamyltransferase

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Results	in table
53	Activating Compound
1511	AA Sequence
60	Application
1	CAS Registry Number
72	Cloned(Commentary)
2	Cofactor
16	Crystallization (Commentary)
14096	Disease/ Diagnostics
11	Expression
108	General Information
21	General Stability
237	IC50 Value
865	Inhibitors
20	kcat/KM [mM/s]
151	Ki Value [mM]
133	KM Value [mM]
108	Localization
170	Metals/Ions
108	Molecular Weight [Da]
159	Natural Substrates/ Products (Substrates)
8	Organic Solvent Stability
467	Organism
1	Oxidation Stability
73	PDB ID
58	pH Optimum
12	pH Range
14	pH Stability
4	pI Value
33	Posttranslational Modification
189	Protein Variants
98	Purification (Commentary)
24	Reaction
1	Reaction Type
322	Reference
1	Renatured (Commentary)
361	Source Tissue
88	Specific Activity [micromol/min/mg]
25	Storage Stability
602	Substrates and Products (Substrate)
100	Subunits
392	Synonyms
1	Systematic Name
65	Temperature Optimum [°C]
11	Temperature Range [°C]
40	Temperature Stability [°C]
49	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 2.3.2.13 - protein-glutamine gamma-glutamyltransferase

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

3.2 - 9.1

CBZ-Gln-Gly-OH

3 entries

1.34

hydroxylamine

Streptomyces mobaraensis

P81453

pH 6.0, 37°C

759632

85.2

N,N'-dimethyl casein glutamine

Homo sapiens

P21980

pH 7.5, 37°C, recombinant TG2 without DNAJA1

758750

-

0.079

N-CBZ-Glu-Gly

Streptomyces mobaraensis

P81453

pH 6.0, 37°C

759632

0.00083 - 0.017

Nalpha-benzyloxycarbonyl-L-Gln-Gly

4 entries

0.67

Nalpha-benzyloxycarbonyl-L-glutaminylglycine

Streptomyces mobaraensis

-

in 250 mM Tris acetate buffer (pH 8.0), at 37°C

720000

2.26 - 3.31

pentylamine

3 entries

0.073 - 0.143

Z-Gln-Gly

2 entries

130.4

Z-Glu(HC)-Gly-OH

Cavia porcellus

H0VXN6

pH 8.0, 30°C

759049

48.5

Z-Glu(HMC)-Gly-OH

Cavia porcellus

H0VXN6

pH 8.0, 30°C

759049

456.1

Z-Phe-gamma-Abu-7-hydroxy-4-methylcoumarin

Cavia porcellus

H0VXN6

pH 8.0, 30°C

759049

204.1

Z-Phe-gamma-Abu-7-hydroxycoumarin

Cavia porcellus

H0VXN6

pH 8.0, 30°C

759049

3.2

CBZ-Gln-Gly-OH

Streptomyces mobaraensis

P81453

recombinant wild-type enzyme, pH 6.0, 37°C

758632

8.4

CBZ-Gln-Gly-OH

Streptomyces mobaraensis

P81453

recombinant mutant S2P, pH 6.0, 37°C

758632

9.1

CBZ-Gln-Gly-OH

Streptomyces mobaraensis

P81453

recombinant mutant TG16, pH 6.0, 37°C

758632

0.00083

Nalpha-benzyloxycarbonyl-L-Gln-Gly

Homo sapiens

-

Km above 0.03 mM, mutant enzyme C371A, in 1 M MOPS, 5 mM EDTA, and 50 mM 2-oxoglutarate (pH 7.2), 100 mM CaCl2, at 37°C

719877

0.0055

Nalpha-benzyloxycarbonyl-L-Gln-Gly

Homo sapiens

-

Km above 0.03 mM, mutant enzyme C370A, in 1 M MOPS, 5 mM EDTA, and 50 mM 2-oxoglutarate (pH 7.2), 100 mM CaCl2, at 37°C

719877

0.015

Nalpha-benzyloxycarbonyl-L-Gln-Gly

Homo sapiens

-

mutant enzyme C230A, in 1 M MOPS, 5 mM EDTA, and 50 mM 2-oxoglutarate (pH 7.2), 100 mM CaCl2, at 37°C

719877

0.017

Nalpha-benzyloxycarbonyl-L-Gln-Gly

Homo sapiens

-

wild type enzyme, in 1 M MOPS, 5 mM EDTA, and 50 mM 2-oxoglutarate (pH 7.2), 100 mM CaCl2, at 37°C

719877

2.26

pentylamine

Pacifastacus leniusculus

Q964D3

pH 8.5, 4°C

759209

3.15

pentylamine

Cavia porcellus

A0A286XL02

pH 8.5, 22°C

759209

3.31

pentylamine

Pacifastacus leniusculus

Q964D3

pH 8.5, 22°C

759209

0.073

Z-Gln-Gly

Streptomyces mobaraensis

P81453

recombinant wild-type enzyme, pH 7.2, 37°C

758966

0.143

Z-Gln-Gly

Streptomyces mobaraensis

P81453

recombinant mutant S2P, pH 7.2, 37°C

758966