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2.3.2.13: protein-glutamine gamma-glutamyltransferase

This is an abbreviated version!
For detailed information about protein-glutamine gamma-glutamyltransferase, go to the full flat file.

Word Map on EC 2.3.2.13

Reaction

protein glutamine
+
alkylamine
=
protein N5-alkylglutamine
+
NH3

Synonyms

AcTG-1, BmTGA, chloroplast transglutaminase, chlTGase, cold active transglutaminase, cold-active transglutaminase, EPB42, factor XIII, factor XIIIa, fibrin stabilizing factor, fibrinoligase, Galphah, glutamine:amine gamma-glutamyl-transferase, glutaminylpeptide gamma-glutamyltransferase, glutamyltransferase, glutaminylpeptide gamma-, gpTGase 2, gTG2, hfXIIIa, hTG2, hTGase 1, hTGase 2, hTGase 3, hTGase 6, KALB, KalbTG, KALB_7456, Laki-Lorand factor, mammalian transglutaminase, microbial transglutaminase, microbial transglutaminases, MsTGase, MTG, MTG-TX, MTGase, mTGase 2, OlTGT, plastidial transglutaminase, polyamine transglutaminase, protein 4.2, protein-glutamine gamma-glutamyltransferase, R-glutaminyl-peptide:amine gamma-glutamyl transferase, R-glutaminylpeptide-amine gamma-glutamyltransferase, SCTG, SMTG, STG I, t-TG, TG-2, TG1, TG2, TG3, TG4, TG5, TG6, TG7, tGA, TGase, TGase 1, TGase 2, Tgase 3, TGase 6, Tgase II, TGase-2, TGase2, TGB, TGK1, TGK2, TGL, TGM1, TGM2, TGM3, TGM4, TGM5, TGM6, TGM7, TGZ, tgz15, TGZo, tissue transglutaminase, tissue transglutaminase 2, tissue-TG, transglutaminase, transglutaminase 1, transglutaminase 2, transglutaminase 3, transglutaminase 6, transglutaminase C, transglutaminase factor XIII, transglutaminase type II, transglutaminase-2, transglutaminase-like protein, transglutaminase2, tTG, tTG-2, type 2 transglutaminase, type I transglutaminase, type-2 transglutaminase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.13 protein-glutamine gamma-glutamyltransferase

Turnover Number

Turnover Number on EC 2.3.2.13 - protein-glutamine gamma-glutamyltransferase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00035
alpha-carbobenzoxy-lysine
-
1-N-(carbobenzoxy-L-glutaminylglycyl)-5-N-(5'-N'-N'-dimethylamino-1'naphthalenesulfonyl)diamidopentane as glutamine donor
16.1
beta-casein
-
-
-
0.00055
Butylamine
-
1-N-(carbobenzoxy-L-glutaminylglycyl)-5-N-(5'-N',N'-dimethylamino-1'-naphthalenesulfonyl)diamidopentane as glutamine donor
51
CBz-Gln-Ala
-
37°C, pH 7.0
0.088 - 96
CBz-Gln-Gly
102
CBz-Gln-Gly-Gly
-
37°C, pH 7.0
27.37 - 33.92
CBZ-Gln-Gly-OH
127
CBz-Gln-Leu
-
37°C, pH 7.0
54
CBZ-Gln-Phe
-
37°C, pH 7.0
66
CBz-Gln-Ser
-
37°C, pH 7.0
71
CBz-Gln-Val
-
37°C, pH 7.0
0.00055
ethylamine
-
1-N-(carbobenzoxy-L-glutaminylglycyl)-5-N-(5'-N',N'-dimethylamino-1'-naphthalenesulfonyl)diamidopentane as glutamine donor
1.83
hydroxylamine
pH 6.0, 37°C
0.00233
involucrin
-
recombinant transglutaminase 5
78
LGPQSKVIG
-
37°C, pH 7.4
44
LGPQSLVIG
-
37°C, pH 7.4
0.0035
loricrin
-
recombinant transglutaminase 5
-
0.32 - 1.86
methylamine
1.5
N,N'-dimethyl casein glutamine
pH 7.5, 37°C, recombinant TG2 without DNAJA1
-
0.532
N,N'-dimethylcasein
-
-
-
16.6 - 31.5
N-Cbz-Gln-Gly
1.83
N-CBZ-Glu-Gly
pH 6.0, 37°C
0.17 - 0.19
Nalpha-benzyloxycarbonyl-L-Gln-Gly
35.48
Nalpha-benzyloxycarbonyl-L-glutaminylglycine
-
in 250 mM Tris acetate buffer (pH 8.0), at 37°C
147
NQENVSPLTLLKLGN
-
37°C, pH 7.4
2.8 - 77.3
NQENVSPLTLLRLGN
175
NQEQVSPLTLLKLGN
-
37°C, pH 7.4
0.0065 - 0.064
pentylamine
0.0004
Propylamine
-
1-N-(carbobenzoxy-L-glutaminylglycyl)-5-N-(5'-N',N'-dimethylamino-1'-naphthalenesulfonyl)diamidopentane as glutamine donor
0.00433
small proline-rich protein 3
-
recombinant transglutaminase 5
-
0.6 - 0.85
Z-Gln-Gly
0.33
Z-Glu(HC)-Gly-OH
pH 8.0, 30°C
0.32
Z-Glu(HMC)-Gly-OH
pH 8.0, 30°C
0.52
Z-Phe-gamma-Abu-7-hydroxy-4-methylcoumarin
pH 8.0, 30°C
0.3
Z-Phe-gamma-Abu-7-hydroxycoumarin
pH 8.0, 30°C
additional information
additional information
-