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Information on EC 3.5.4.16 - GTP cyclohydrolase I

for references in articles please use BRENDA:EC3.5.4.16
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IUBMB Comments
The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic. This enzyme is involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 (sepiapterin reductase) and EC 4.2.3.12 (6-pyruvoyltetrahydropterin synthase) .
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
gtpch, gtp cyclohydrolase, gtp-ch, gtp-cyclohydrolase i, gtp cyclohydrolase 1, gtpch i, gch-1, guanosine triphosphate cyclohydrolase i, gtpch1, gtpch-1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate
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