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Literature summary for 3.5.4.16 extracted from

  • Yoneyama, T.; Hatakeyama, K.
    Ligand binding to the inhibitory and stimulatory GTP cyclohydrolase I/GTP cyclohydrolase I feedback regulatory protein complexes (2001), Protein Sci., 10, 871-878.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
L-phenylalanine feed-forward stimulation at subsaturating concentration of GTP mediated by GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin i.e. BH4, feedback inhibition mediated by GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP, inhibition is enhaced by dGTP Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin and Phe ligand binding kinetics of the enzyme complex at pH 6.0 and pH 7.2 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Rattus norvegicus first step of the biosynthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, i.e. BH4 formate + D-erythro-dihydroneopterin triphosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
Rattus norvegicus formate + D-erythro-dihydroneopterin triphosphate
-
?
GTP + H2O first step of the biosynthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, i.e. BH4 Rattus norvegicus formate + D-erythro-dihydroneopterin triphosphate
-
?
additional information enzyme is complexed with the GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP, in a ratio of 1:2, complex formation is induced by phenylalanine and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, i.e. BH4 Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
decamer GTP cyclohydrolase I Rattus norvegicus
pentamer GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP Rattus norvegicus