Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-phenylalanine | feed-forward stimulation at subsaturating concentration of GTP mediated by GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin | i.e. BH4, feedback inhibition mediated by GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP, inhibition is enhaced by dGTP | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin and Phe ligand binding kinetics of the enzyme complex at pH 6.0 and pH 7.2 | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Rattus norvegicus | first step of the biosynthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, i.e. BH4 | formate + D-erythro-dihydroneopterin triphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Rattus norvegicus | formate + D-erythro-dihydroneopterin triphosphate | - |
? | |
GTP + H2O | first step of the biosynthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, i.e. BH4 | Rattus norvegicus | formate + D-erythro-dihydroneopterin triphosphate | - |
? | |
additional information | enzyme is complexed with the GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP, in a ratio of 1:2, complex formation is induced by phenylalanine and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, i.e. BH4 | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
decamer | GTP cyclohydrolase I | Rattus norvegicus |
pentamer | GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP | Rattus norvegicus |