EC Number   |
Activating Compound |
Reference |
|---|
    3.5.4.16 | 17beta-estradiol |
can regulate GTPCH gene expression via transcriptional mechanisms |
670416 |
| 3.5.4.16 | H2O2 |
0.1 mM H2O2 is the optimum concentration for the activation of GTPCHI |
699378 |
| 3.5.4.16 | interferon-gamma |
GCH1 expression is strongly induced by a mixture of interleukin-1beta, tissue necrosis factor-alpha, and interferon-gamma released by microglia under brain-damaging conditions |
701141 |
| 3.5.4.16 | interleukin-1beta |
GCH1 expression is strongly induced by a mixture of interleukin-1beta, tissue necrosis factor-alpha, and interferon-gamma released by microglia under brain-damaging conditions |
701141 |
| 3.5.4.16 | L-phenylalanine |
feed-forward stimulation at subsaturating concentration of GTP mediated by GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP |
657288 |
| 3.5.4.16 | L-phenylalanine |
feed-forward stimulation at subsaturating concentration of GTP mediated by GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP, in complex with the enzyme, binding site structure |
657188 |
| 3.5.4.16 | L-phenylalanine |
feedback regulation via L-phenylalanine |
699378 |
| 3.5.4.16 | L-phenylalanine |
stimulates the enzyme via mediation of GFRP which forms a complex with the enzyme |
656261 |
| 3.5.4.16 | lipolysaccharide |
commercially isolated from Escherichia coli serotype 026:B6, activates and upregulates the enzyme in adipose tissue, but in cultured 3T3-L1 adipocytes lipolysaccharide addition only increases the enzyme expression level in presence of TNFalpha and interferon gamma, overview |
667769 |
| 3.5.4.16 | more |
estrogen-triggered activation of GTP cyclohydrolase 1 gene expression, time course in transfected cells and mechanism, overview |
670416 |
