EC Number |
Inhibitors |
Structure |
---|
3.5.4.16 | (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin |
i.e. BH4, feedback inhibition mediated by GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP, in complex with the enzyme, binding site structure |
|
3.5.4.16 | (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin |
i.e. BH4, feedback inhibition mediated by GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP, inhibition is enhaced by dGTP |
|
3.5.4.16 | 2'-deoxy-GTP |
- |
|
3.5.4.16 | 2,4-Diamino-6-hydroxypyrimidine |
direct inhibitition at higher concentrations |
|
3.5.4.16 | 2,4-Diamino-6-hydroxypyrimidine |
DAHP, the inhibition mechanism involves the GTP cyclohydrolase I feedback regulatory protein GFRP, overview, the inhibition is fully reversible by L-phenylalanine |
|
3.5.4.16 | 2,4-Diamino-6-hydroxypyrimidine |
- |
|
3.5.4.16 | 7-deaza-GTP |
- |
|
3.5.4.16 | 7-methyl-GTP |
36% inhibition at 2 mM GMP |
|
3.5.4.16 | 8-Aminoguanosine triphosphate |
- |
|
3.5.4.16 | 8-Azaguanine |
43% inhibition at 2.9 mM |
|