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Literature summary for 3.5.4.16 extracted from

  • Blau, N.; Niederwieser, A.
    GTP-cyclohydrolases: a review (1985), J. Clin. Chem. Clin. Biochem., 23, 169-176.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Cu2+
-
Escherichia coli
Cu2+
-
Geobacillus stearothermophilus
Cu2+
-
Rattus norvegicus
Cu2+
-
Serratia indica
Fe3+
-
Serratia indica
GTP substrate inhibition above 0.2 mM Rattus norvegicus
Hg2+
-
Escherichia coli
Hg2+
-
Geobacillus stearothermophilus
Hg2+
-
Serratia indica
Mg2+
-
Lactiplantibacillus plantarum
Mg2+
-
Rattus norvegicus
PO43-
-
Escherichia coli
Zn2+
-
Serratia indica

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Mammalia
additional information
-
additional information
-
Lactiplantibacillus plantarum
additional information
-
additional information
-
Escherichia coli
additional information
-
additional information
-
Rattus norvegicus
additional information
-
additional information
-
Geobacillus stearothermophilus
additional information
-
additional information
-
Serratia indica
additional information
-
additional information
-
Comamonas sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
105000
-
gel filtration Geobacillus stearothermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Mammalia first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
?
GTP + H2O Lactiplantibacillus plantarum first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
?
GTP + H2O Escherichia coli first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
?
GTP + H2O Rattus norvegicus first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
?
GTP + H2O Geobacillus stearothermophilus first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
?
GTP + H2O Serratia indica first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
?
GTP + H2O Comamonas sp. first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
?

Organism

Organism UniProt Comment Textmining
Comamonas sp.
-
-
-
Escherichia coli
-
-
-
Geobacillus stearothermophilus
-
-
-
Lactiplantibacillus plantarum
-
-
-
Mammalia
-
-
-
Rattus norvegicus
-
-
-
Serratia indica
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
Mammalia formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
?
GTP + H2O
-
Lactiplantibacillus plantarum formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
?
GTP + H2O
-
Escherichia coli formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
?
GTP + H2O
-
Rattus norvegicus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
?
GTP + H2O
-
Geobacillus stearothermophilus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
?
GTP + H2O
-
Serratia indica formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
?
GTP + H2O
-
Comamonas sp. formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
?
GTP + H2O first step in pathway of pterins Mammalia formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
?
GTP + H2O first step in pathway of pterins Lactiplantibacillus plantarum formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
?
GTP + H2O first step in pathway of pterins Escherichia coli formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
?
GTP + H2O first step in pathway of pterins Rattus norvegicus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
?
GTP + H2O first step in pathway of pterins Geobacillus stearothermophilus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
?
GTP + H2O first step in pathway of pterins Serratia indica formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
?
GTP + H2O first step in pathway of pterins Comamonas sp. formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
-
Mammalia
additional information
-
-
Lactiplantibacillus plantarum
additional information
-
-
Escherichia coli
additional information
-
-
Rattus norvegicus
additional information
-
-
Geobacillus stearothermophilus
additional information
-
-
Serratia indica
additional information
-
-
Comamonas sp.