Literature summary for 3.5.4.16 extracted from

Nandi, M.; Kelly, P.; Vallance, P.; Leiper, J.
Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production (2008), Vasc. Med., 13, 29-36.

Search for more literature for 3.5.4.16

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	reduction in GTP-CH1 regulatory protein expression following proinflammatory stimulation is necessary for optimal GTP-CH1 activity	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	GTP-CH1 activity can be inhibited by tetrahydrobiopterin through its protein-protein interactions with GTP-CH1 regulatory protein	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	-	Mus musculus	formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate	-	?

Synonyms

Synonyms	Comment	Organism
GTP-CH1	-	Mus musculus
GTP-cyclohydrolase 1	-	Mus musculus

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Release 2023.1 (January 2023)