BRENDA - Enzyme Database show
show all sequences of 3.5.4.16

Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection

Ionova, I.A.; Vasquez-Vivar, J.; Cooley, B.C.; Khanna, A.K.; Whitsett, J.; Herrnreiter, A.; Migrino, R.Q.; Ge, Z.D.; Regner, K.R.; Channon, K.M.; Alp, N.J.; Pieper, G.M.; Am. J. Physiol. Heart Circ. Physiol. 299, H88-H96 (2010)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression of GTPCH under the control of a 935-bp fragment of the mouse myosin heavy chain gene promoter
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
additional information
wild-type and transgenic human GTPCH-overexpressing murine donor hearts are transplanted into BALB/c recipient mice via pronuclear injection of oocytes. Cardiac myocyte GTPCH overexpression inhibits cardiac graft rejection, phenotype, overview
Homo sapiens
additional information
wild-type and transgenic human GTPCH-overexpressing murine donor hearts are transplanted into BALB/c recipient mice via pronuclear injection of oocytes. Cardiac myocyte GTPCH overexpression inhibits cardiac graft rejection, phenotype, overview
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
-
Homo sapiens
5634
-
nucleus
-
Mus musculus
5634
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Mus musculus C57BL6
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
cardiac myocyte
-
Homo sapiens
-
cardiac myocyte
-
Mus musculus
-
heart
-
Homo sapiens
-
heart
-
Mus musculus
-
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of GTPCH under the control of a 935-bp fragment of the mouse myosin heavy chain gene promoter
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
wild-type and transgenic human GTPCH-overexpressing murine donor hearts are transplanted into BALB/c recipient mice via pronuclear injection of oocytes. Cardiac myocyte GTPCH overexpression inhibits cardiac graft rejection, phenotype, overview
Homo sapiens
additional information
wild-type and transgenic human GTPCH-overexpressing murine donor hearts are transplanted into BALB/c recipient mice via pronuclear injection of oocytes. Cardiac myocyte GTPCH overexpression inhibits cardiac graft rejection, phenotype, overview
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
-
Homo sapiens
5634
-
nucleus
-
Mus musculus
5634
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
cardiac myocyte
-
Homo sapiens
-
cardiac myocyte
-
Mus musculus
-
heart
-
Homo sapiens
-
heart
-
Mus musculus
-
General Information
General Information
Commentary
Organism
malfunction
decreases in GTPCH activity and expression in late stages of acute cardiac rejection due to a deficit in BH4. Mechanism of the decreased rejection appears related to decreased T cell proliferation and modulation of immune function by higher expression of genes involved in hematopoietic/stromal cell development and recruitment
Homo sapiens
malfunction
decreases in GTPCH activity and expression in late stages of acute cardiac rejection due to a deficit in BH4
Mus musculus
metabolism
GTP cyclohydrolase I is the rate-limiting enzyme for tetrahydrobiopterin synthesis
Homo sapiens
metabolism
GTP cyclohydrolase I is the rate-limiting enzyme for tetrahydrobiopterin synthesis
Mus musculus
additional information
adult cardiac myocytes despite expression of GTPCH mRNA and protein have a defective basal and cytokine-stimulated synthesis of BH4 via the de novo synthesis pathway and impaired synthesis via the salvage pathway in contrast with that typically seen in neonatal cardiac myocytes
Homo sapiens
physiological function
GTP cyclohydrolase I is the rate-limiting enzyme for tetrahydrobiopterin synthesis. Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection
Homo sapiens
physiological function
GTP cyclohydrolase I is the rate-limiting enzyme for tetrahydrobiopterin synthesis. Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
decreases in GTPCH activity and expression in late stages of acute cardiac rejection due to a deficit in BH4. Mechanism of the decreased rejection appears related to decreased T cell proliferation and modulation of immune function by higher expression of genes involved in hematopoietic/stromal cell development and recruitment
Homo sapiens
malfunction
decreases in GTPCH activity and expression in late stages of acute cardiac rejection due to a deficit in BH4
Mus musculus
metabolism
GTP cyclohydrolase I is the rate-limiting enzyme for tetrahydrobiopterin synthesis
Homo sapiens
metabolism
GTP cyclohydrolase I is the rate-limiting enzyme for tetrahydrobiopterin synthesis
Mus musculus
additional information
adult cardiac myocytes despite expression of GTPCH mRNA and protein have a defective basal and cytokine-stimulated synthesis of BH4 via the de novo synthesis pathway and impaired synthesis via the salvage pathway in contrast with that typically seen in neonatal cardiac myocytes
Homo sapiens
physiological function
GTP cyclohydrolase I is the rate-limiting enzyme for tetrahydrobiopterin synthesis. Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection
Homo sapiens
physiological function
GTP cyclohydrolase I is the rate-limiting enzyme for tetrahydrobiopterin synthesis. Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection
Mus musculus
Other publictions for EC 3.5.4.16
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
734606
Kuempornsin
Biochemical and functional cha ...
Plasmodium falciparum
Malar. J.
13
150
2014
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1
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1
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1
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1
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1
1
1
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735125
Wolkow
GTP cyclohydrolase I gene poly ...
Homo sapiens
PLoS ONE
9
e108587
2014
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1
1
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720858
Du
The protein partners of GTP cy ...
Rattus norvegicus, Rattus norvegicus Sprague Dawley
PLoS ONE
7
e33991
2012
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1
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11
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2
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1
1
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711917
Hu
A novel missense mutation in G ...
Homo sapiens
Eur. J. Neurol.
18
362-364
2011
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1
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718553
Sun
C-terminus of heat shock prote ...
Ovis aries
Am. J. Respir. Cell Mol. Biol.
45
163-171
2011
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1
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3
3
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719914
Higgins
The N-terminal peptide of mamm ...
Rattus norvegicus
J. Biol. Chem.
286
11919-11928
2011
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1
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3
1
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1
2
1
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1
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1
3
3
1
-
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720551
Ferdousy
Drosophila Ube3a regulates mon ...
Drosophila melanogaster
Neurobiol. Dis.
41
669-677
2011
-
1
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5
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1
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1
3
8
3
-
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718548
Ionova
Cardiac myocyte-specific overe ...
Homo sapiens, Mus musculus, Mus musculus C57BL6
Am. J. Physiol. Heart Circ. Physiol.
299
H88-H96
2010
-
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1
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2
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2
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14
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5
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5
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7
7
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719308
Li
GTP cyclohydrolase I phosphory ...
Homo sapiens
Circ. Res.
106
328-336
2010
1
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3
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2
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2
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1
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2
2
-
-
-
698211
Peterson
Guanosine triphosphate cyclohy ...
Mus musculus
Hypertension
53
189-195
2009
-
-
-
-
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-
1
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2
-
1
1
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2
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2
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698891
Tatham
GTP cyclohydrolase I expressio ...
Mus musculus
J. Biol. Chem.
284
13660-13668
2009
1
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1
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4
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1
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1
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699378
Chavan
H2O2 increases de novo synthes ...
Homo sapiens
J. Inherit. Metab. Dis.
32
86-94
2009
2
-
1
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1
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2
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1
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1
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701141
Chiarini
Proteomic analysis of GTP cycl ...
Homo sapiens
Proteomics
9
1850-1860
2009
3
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2
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2
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1
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1
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710814
Tie
Endothelium-specific GTP cyclo ...
Mus musculus
Am. J. Physiol. Endocrinol. Metab.
296
E1423-E1429
2009
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3
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2
2
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710818
Kumar
GTP cyclohydrolase I expressio ...
Ovis aries
Am. J. Physiol. Lung Cell Mol. Physiol.
297
L309-L317
2009
-
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1
1
1
1
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711040
Du
Identification and functional ...
Rattus norvegicus
Arterioscler. Thromb. Vasc. Biol.
29
2161-2168
2009
-
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1
-
6
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2
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1
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1
1
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711068
Du
Identification of proteins int ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
385
143-147
2009
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1
1
1
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712290
Sankaran
Zinc-independent folate biosyn ...
Bacillus subtilis, Neisseria gonorrhoeae
J. Bacteriol.
191
6936-6949
2009
-
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1
1
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11
1
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3
2
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7
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1
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3
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11
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3
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1
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2
2
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684313
Seujange
Role of angiotensin II on dihy ...
Rattus norvegicus
Am. J. Nephrol.
28
692-700
2008
1
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695498
Wang
Endotoxemia-related acute kidn ...
Homo sapiens
Am. J. Physiol. Renal Physiol.
294
F571-F576
2008
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1
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3
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696398
Chiou
Hsp27 decreases inclusion body ...
Homo sapiens
Biochim. Biophys. Acta
1782
169-179
2008
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1
1
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1
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1
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1
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1
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697359
Du
Endothelium-specific GTP cyclo ...
Homo sapiens
Circulation
117
1045-1054
2008
-
1
1
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-
-
-
-
-
1
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3
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1
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1
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1
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1
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-
698049
Wenzel
AT1-receptor blockade by telmi ...
Rattus norvegicus
Free Radic. Biol. Med.
45
619-626
2008
-
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1
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3
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1
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698116
Souza
Mutation in intron 5 of GTP cy ...
Homo sapiens
Genet. Mol. Res.
7
687-694
2008
-
1
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698205
Wang
Acute inhibition of guanosine ...
Bos taurus, Mus musculus
Hypertension
52
484-490
2008
-
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4
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2
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5
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4
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4
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-
698598
Phillips
Biosynthesis of 7-deazaguanosi ...
Escherichia coli, Haloferax volcanii
J. Bacteriol.
190
7876-7884
2008
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2
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7
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4
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698830
Bowling
Direct binding of GTP cyclohyd ...
Drosophila melanogaster
J. Biol. Chem.
283
31449-31459
2008
1
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1
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1
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2
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-
701372
Nandi
Over-expression of GTP-cyclohy ...
Mus musculus
Vasc. Med.
13
29-36
2008
1
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1
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3
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1
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685163
Grochowski
Characterization of an Fe(2+)- ...
Methanocaldococcus jannaschii, Methanocaldococcus jannaschii MJ0775
Biochemistry
46
6658-6667
2007
-
-
1
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4
-
6
-
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2
2
2
1
5
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1
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12
1
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1
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1
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1
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4
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6
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2
2
2
1
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1
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12
1
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1
-
1
-
-
-
-
-
-
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686181
Liao
Endothelium-targeted transgeni ...
Mus musculus, Mus musculus C57BL/6
Clin. Exp. Pharmacol. Physiol.
34
1260-1266
2007
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-
-
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142
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4
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4
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2
-
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687971
Zhang
Discovery of common human gene ...
Homo sapiens
J. Clin. Invest.
117
2658-2671
2007
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2
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1
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1
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-
-
-
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-
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688532
Lopez-Laso
Dopa-responsive infantile hypo ...
Homo sapiens
J. Neurol. Sci.
256
90-93
2007
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-
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1
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1
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668946
Futahashi
Expression of one isoform of G ...
Papilio xuthus
Insect Biochem. Mol. Biol.
36
63-70
2006
-
-
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2
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2
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3
-
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3
-
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-
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670416
Serova
Estrogen-triggered activation ...
Rattus norvegicus
Neuroscience
140
1253-1263
2006
2
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1
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-
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1
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3
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670478
Nandi
Developmental regulation of GT ...
Sus scrofa
Pediatr. Res.
59
767-772
2006
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3
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685890
Eells
Reduced tyrosine hydroxylase a ...
Mus musculus
Brain Res. Bull.
70
186-195
2006
-
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2
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1
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1
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687523
Funderburk
A typical N-terminal extension ...
Drosophila melanogaster
J. Biol. Chem.
281
33302-33312
2006
-
-
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1
-
1
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3
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3
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1
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1
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1
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1
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1
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1
-
-
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-
-
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668507
Christensen
Characterization of transgenic ...
Mus musculus
Exp. Dermatol.
14
535-542
2005
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1
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1
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1
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1
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1
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2
-
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-
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-
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669149
Tanaka
Novel reaction mechanism of GT ...
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
J. Biochem.
138
263-275
2005
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3
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1
1
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3
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1
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2
1
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5
-
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1
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1
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4
5
3
-
1
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1
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1
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-
-
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3
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
655489
Suzuki
GTP cyclohydrolase I utilizes ...
Homo sapiens
Eur. J. Biochem.
271
349-355
2004
-
-
1
-
-
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5
-
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1
-
1
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3
-
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1
-
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2
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1
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1
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1
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5
-
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1
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1
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1
-
-
-
2
-
1
-
-
-
1
-
-
-
-
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-
-
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656261
Maita
Structural basis of biopterin- ...
Rattus norvegicus
J. Biol. Chem.
279
51534-51540
2004
1
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1
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2
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1
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3
2
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1
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1
2
2
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-
-
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3
2
-
-
-
-
-
-
-
-
-
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-
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657273
He
Cloning, expression, purificat ...
Nocardia iowensis, Nocardia iowensis NRRL 5646
Protein Expr. Purif.
35
171-180
2004
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1
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1
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2
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8
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1
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6
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4
2
1
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1
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1
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3
2
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1
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6
-
4
2
1
-
-
-
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-
-
-
-
-
-
-
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667025
Hung
Change in expression of the gu ...
Rattus norvegicus
Acta Anaesthesiol. Taiwan.
42
23-31
2004
1
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4
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3
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3
-
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2
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-
-
-
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-
-
-
-
-
-
-
-
-
667769
Fujiwara
Tetrahydrobiopterin biosynthes ...
Mus musculus
Biochim. Biophys. Acta
1670
181-198
2004
1
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-
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-
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1
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2
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4
1
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2
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1
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1
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4
1
-
2
-
-
-
-
-
-
-
-
-
-
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-
-
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669268
Kolinsky
The mechanism of potent GTP cy ...
Rattus norvegicus
J. Biol. Chem.
279
40677-40682
2004
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1
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-
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2
2
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1
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1
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-
1
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-
-
-
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2
-
1
-
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-
1
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1
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-
1
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-
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2
1
2
-
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1
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1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
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670660
Diaz de la Garza
Folate biofortification in tom ...
Mus musculus
Proc. Natl. Acad. Sci. USA
101
13720-13725
2004
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2
1
-
1
-
-
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3
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2
1
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1
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-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
670924
Gibson
-
The synthesis of 7-deazaguanin ...
Escherichia coli
Tetrahedron
60
943-959
2004
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-
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5
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1
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1
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2
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1
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1
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5
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1
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2
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1
-
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1
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656511
Rebelo
Biosynthesis of pteridines. Re ...
Escherichia coli
J. Mol. Biol.
326
503-516
2003
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2
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1
4
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1
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1
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2
-
3
-
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-
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-
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655934
Lee
Biochemical characterization o ...
Escherichia coli
J. Biochem. Mol. Biol.
35
255-261
2002
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14
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1
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1
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6
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1
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14
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1
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5
1
-
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1
1
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1
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2
1
9
-
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6
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-
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656499
Schramek
Reaction mechanism of GTP cycl ...
Escherichia coli
J. Mol. Biol.
316
829-837
2002
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1
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1
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3
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1
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1
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1
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1
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1
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-
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
657188
Maita
Crystal structure of the stimu ...
Rattus norvegicus
Proc. Natl. Acad. Sci. USA
99
1212-1217
2002
1
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1
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1
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1
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1
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1
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1
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-
-
-
-
2
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-
-
-
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-
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660407
Basset
Folate synthesis in plants: th ...
Arabidopsis thaliana, Solanum lycopersicum
Proc. Natl. Acad. Sci. USA
99
12489-12494
2002
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2
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7
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3
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5
1
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-
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-
-
-
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1
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-
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-
2
-
-
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1
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1
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209553
Burg
The biosynthesis of folic acid ...
Escherichia coli
J. Biol. Chem.
243
2349-2358
1968
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